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Elsevier

Academic Press

  • Integrating Artificial Intelligence with Virtual Screening

    A New Era in Drug Discovery
    • 1st Edition
    • Vivek Asati + 1 more
    • English
    Integrating Artificial Intelligence with Virtual Screening: A New Era in Drug Discovery addresses the evolving landscape of drug discovery by combining traditional virtual screening with cutting-edge artificial intelligence technologies. This volume offers an interdisciplinary guide to AI-driven ligand and structure-based screening methods, including machine learning, deep learning, and generative models, thus enabling faster and more accurate identification of drug candidates. It covers mathematical models, computational workflows, and optimization strategies such as Pareto-based and physics-based approaches.Sections also discuss challenges in navigating ultra-large chemical libraries and present practical case studies that demonstrate real-world applications. Edited by leading researchers, the book provides authoritative insights suited for graduate students, researchers, and industry professionals. Users will be empowered by the latest tools and knowledge to innovate drug discovery pipelines and support the development of precision medicines and foster advancements in pharmaceutical sciences.

  • Generative AI Risks and Benefits within Human-Machine Teams

    • 1st Edition
    • William Lawless + 1 more
    • English
    Generative AI Risks and Benefits within Human-Machine Teams delves into the foundational principles, metrics, and applications of human-machine systems, addressing the legal ramifications of autonomy, public trust, and bidirectional AI systems. This book brings together world-class researchers, engineers, philosophers, social scientists, and other experts to discuss the critical aspects of generative AI, its risks, and benefits. The authors aim to establish a shared context between humans and machines, regulators, the public, and other stakeholders, exploring how these systems impact targeted audiences and society at large. The book combines human-centered computing and autonomous human-machine teams to provide a comprehensive understanding of generative AI's potential and challenges. The book is structured to guide readers through a detailed exploration of these topics. It begins with an introduction to the core concepts of human-machine collaboration and the next generation of large language models. The discussion then moves to practical applications, such as Human-AI collaboration for energy communities, autonomous human-machine team advances, and human-AI collaboration in the design process. The book also delves into adaptive collaboration patterns for logic modeling, assessing multimodal large language models in resolving visual ambiguities, and developing team context-aware collaborative AI assistants. Additionally, it explores the taxonomy of teamwork support for collaborative AI efforts, trust management in human-AI collaboration, and provides a distributed teaming testbed for human-machine collaboration in space missions. Finally, it addresses the limits of classical team science in interdependent human-machine teams.Generative AI Risks and Benefits within Human-Machine Teams is an essential resource for computer scientists and systems engineers focused on designing and theorizing about the development of autonomous systems. By providing in-depth insights into the integration of generative AI within human-machine teams, this book equips professionals with the knowledge to navigate the complexities of AI autonomy, enhance collaboration, and address the ethical and technical challenges associated with these advanced technologies.

  • Biomarkers in Neurological Disorders and Treatment

    • 1st Edition
    • Arun Kumar Singh + 3 more
    • English
    Decoding the Brain: Biomarkers in Neurological Disorders and Treatment provides a comprehensive exploration of the latest advances in neurological biomarkers, detailing their discovery, validation, and application in clinical practice. By offering insights into the biological underpinnings of various neurological disorders, this book aims to bridge the gap between cutting-edge biomarker research and its practical implementation in patient care.

  • Knowledge Graphs and Large Language Models

    Current Approaches, Challenges, and Future Directions
    • 1st Edition
    • Sanju Tiwari + 3 more
    • English
    Knowledge Graphs and Large Language Models: Current Approaches, Challenges, and Future Directions explores the cutting-edge fusion of two powerful artificial intelligence technologies: Large Language Models (LLMs) and Knowledge Graphs (KGs). The book is structured to provide a comprehensive understanding of this emerging field. Chapters introduce the synergy between LLMs and KGs, delve into the capabilities and challenges of LLMs, focus on the structure, function, and significance of KGs, present a conceptual framework for bridging LLMs and KGs, discuss techniques for their integration, explore how LLMs can enhance KGs and vice versa, and showcase applications of LLM-KG synergy across various domains.Final sections addresses ethical, social, and technical challenges and future innovations. The book concludes by summarizing key insights and advancements in intelligent systems. This is an essential resource for graduate students, researchers, and professionals in computer science. It offers valuable insights for adopting LLMs, KGs, and their advanced applications in research and product development. By bridging the gap between these technologies, this book equips readers with the knowledge to drive innovation and enhance the capabilities of intelligent systems.

  • Nutritional Epigenetics

    Food-Derived microRNAs in Health and Disease
    • 1st Edition
    • Shariful Islam + 3 more
    • English
    Nutritional Epigenetics: Food-Derived microRNAs in Health and Disease offers perspective on the role of dietary microRNAs as pivotal epigenetic regulators influencing health trajectories and disease susceptibility. The book brings together current research on the bioavailability and molecular mechanisms by which plant and food-derived microRNAs modulate gene expression, including their crosstalk with DNA methylation, histone modifications, and gut microbiota. Detailed food-specific chapters examine the epigenetic impact of key dietary sources such as Brassicaceae (crucifers), rice, milk, and fermented products, highlighting their transgenerational and life-stage effects. Practical insights into food processing, culinary traditions, and the design of microRNA-fortified products bridge the gap between bench science and real-world applications. Nutritional Epigenetics equips researchers, clinicians, and industry innovators with a resource that advances the understanding of microRNA-mediated nutritional epigenomics, while guiding the development and safety assessment of microRNA-enhanced functional foods. By integrating molecular biology with population-level evidence and translational strategies, this text fosters the development of novel dietary interventions aimed at optimizing health across the lifespan and mitigating chronic disease risk.

  • Nutritional Treatments for Liver Disease

    The Effects of Food and Plants
    • 1st Edition
    • Erika Ramos-Tovar + 1 more
    • English
    Nutritional Treatments for Liver Disease: The Effects of Food and Plants offers a comprehensive guide to leveraging nutritional science in the prevention and treatment of liver diseases. The book details the cellular and molecular mechanisms through which natural and synthetic nutritional compounds exert protective, anti-inflammatory, antifibrotic, and antiviral effects on the liver. Topics include the epidemiology of liver diseases, malnutrition complications, and the role of key bioactive compounds such as silymarin, curcumin, quercetin, coffee, and various vitamins. Designed for researchers, clinicians, nutritionists, and students, this authoritative resource combines scientific rigor with practical insights to foster advanced understanding and inspire novel therapeutic strategies.Authored by leading research experts in the fields of experimental liver disease, the effects of herbal compounds, and the pathophysiology and pharmacology of liver diseases, the book synthesizes cutting-edge research on the therapeutic efficacy of functional foods, medicinal plants, vitamins, and gut microbiota modulation for hepatic disorders.

  • Diabetic Neuropathy

    • 1st Edition
    • Shahidul Islam
    • English
    "Recent Therapeutic Targets for the Prevention and Management of Diabetic Complications: Neuropathy" covers recent research and therapeutic approaches of this diabetic complication for the management of diabetes. It is a detailed reference to understand the pathogenesis of diabetes to alleviate the overall complications of neuropathy to improve patient care. It is uniquely focused on the different aspects of neuropathy with a focus on the molecular and biological pathways (therapeutic target) to detect an early diagnosis to better manage the disease and improve patient care. The book is useful to anyone in the field particularly those who do research investigations, and day-to-day practice in the area of diabetes.

  • Principles and Practices of Model Risk Management (MRM)

    • 1st Edition
    • Charlie Lu + 1 more
    • English
    Principles and Practices of Model Risk Management (MRM) offers a thorough yet practical introduction to MRM, helping modern enterprises and financial engineers successfully navigate evolving, global markets. Initially developed within the financial industry, the advent of increasingly sophisticated computer models and AI have broadened the scope and necessity of model risk management. This textbook fills a critical gap by guiding readers in designing and implementing robust model risk frameworks across evolving scenarios and data landscapes. Authored by experts with extensive quantitative backgrounds and significant experience in model risk management within major banks, this book articulates modern MRM concepts and shares best practices from industry practitioners. Relevant for students of financial engineering, financial mathematics, and beyond, this essential resource is designed to benefit risk management professionals, financial analysts, regulatory compliance officers, and anyone involved in the development, validation, and oversight of financial models, providing them with the tools and understanding necessary to navigate and mitigate model risks effectively. Online hosted Jupyter notebooks offer various examples and datasets to put skills into practice across chapters. This book covers the regulatory background of model risk management across different jurisdictions, delves into the various types of model risk, and elucidates the tools and methodologies used for identifying, measuring, monitoring, and reporting model risk. It includes detailed sections on the principles of model risk management, enterprise risk management frameworks, model risk regulations and guidance, the three lines of defense in model risk management, and practical applications within the financial industry. Additionally, it addresses emerging trends and challenges, particularly in the context of generative AI models and future regulatory developments.

  • Epigenetic Mechanisms at the Crossroads of Development, Immune Response, and Neuropathology

    • 1st Edition
    • Varun Sasidharan Nair + 1 more
    • English
    Epigenetic Mechanisms at the Crossroads of Development, Immune Response, and Neuropathology offers an in-depth exploration of how epigenetic mechanisms shape neural development, immune interactions, and disease progression in the central nervous system. This interdisciplinary volume synthesizes current knowledge across neuroscience, immunology, and pathology, addressing the critical need for integrated frameworks that connect molecular regulation with clinical outcomes. The book covers foundational epigenetic processes such as DNA methylation, histone modifications, and non-coding RNAs, illustrating their roles in neural differentiation, circuit formation, and brain plasticity.It further examines how environmental factors influence epigenetic landscapes, impacting resilience and vulnerability to neuropsychiatric and neurodegenerative disorders. The volume also delves into the epigenetic drivers of neuropathologies including glioblastoma, neuroinflammation, and neurodegeneration, highlighting emerging therapeutic strategies. With contributions from leading international experts, this resource bridges basic science and translational research, providing valuable insights for researchers, clinicians, and advanced students seeking to understand and target complex CNS disorders.

  • Proteomics and Metabolomics in Drug Discovery

    • 1st Edition
    • Volume 155
    • English
    Proteomics and Metabolomics in Drug Discovery explores how large-scale protein and metabolite analysis is transforming the identification, validation, and development of new therapeutic targets. The book highlights emerging technologies, analytical strategies, and real-world applications that support biomarker discovery, mechanism-of-action studies, and precision medicine approaches in modern drug development.

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