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Academic Press

  • Fifty Years of Peeling Away the Lead Paint Problem

    Saving Our Children's Future with Healthy Housing
    • 1st Edition
    • David E. Jacobs
    • English
    Fifty Years of Peeling Away the Lead Paint Problem: Saving Our Children's Future with Healthy Housing documents the history of childhood lead poisoning from paint between 1970 and 2022. Tracing the failure of the medical model (treatment after exposure) that marked the 1970s and 1980s and its replacement with a prevention housing-focused effort, the book documents the changes in health, housing and environmental science and policy. It is the first book to examine how the lead poisoning law in the U.S. was passed in 1992 and later implemented, with implications for the future, in particular, the emergence of a healthy housing movement. The book describes the roles played by Congress, various administrations, agencies, local governments, the private sector, researchers, and a popular citizen's movement, especially parents. The role of the courts is discussed, including a controversial lead paint case on research ethics in Baltimore through an environmental justice lens. This book is the first to examine another recent case in California, where ten local jurisdictions established a precedent by successfully suing the lead paint industry to help pay for abatement.
  • Meta Learning With Medical Imaging and Health Informatics Applications

    • 1st Edition
    • Hien Van Nguyen + 2 more
    • English
    Meta-Learning, or learning to learn, has become increasingly popular in recent years. Instead of building AI systems from scratch for each machine learning task, Meta-Learning constructs computational mechanisms to systematically and efficiently adapt to new tasks. The meta-learning paradigm has great potential to address deep neural networks’ fundamental challenges such as intensive data requirement, computationally expensive training, and limited capacity for transfer among tasks.This book provides a concise summary of Meta-Learning theories and their diverse applications in medical imaging and health informatics. It covers the unifying theory of meta-learning and its popular variants such as model-agnostic learning, memory augmentation, prototypical networks, and learning to optimize. The book brings together thought leaders from both machine learning and health informatics fields to discuss the current state of Meta-Learning, its relevance to medical imaging and health informatics, and future directions.
  • Human Microbiome in Health and Disease - Part A

    • 1st Edition
    • Volume 191
    • English
    Human Microbiome in Health and Disease, Volume 191, Part A presents updated knowledge on human microbiome as covered by renowned science faculty across the globe. Chapters in this volume include an introduction to human microbiome, Structure, functions and diversity of healthy human microbiome, Role of human microbiome in cancer, Gut microbiota and gastrointestinal cancer, Dysbiosis of human microbiome and metabolic diseases, Gut microbiome and type 2 diabetes, Gut microbiome and non-alcoholic fatty liver disease, Hepatic drug metabolism and intestinal microbiota, Emerging tools for understanding the human microbiome, and Microbiome therapeutics: Opportunity and challenges, and more. These chapters cover the composition, diversity, dynamics and functions of human microbiome in health and disease. This book will form an excellent and informative text on keystone, autochthonous, and exogenous microbiota important for human health in a simple to understand and easy to read format.
  • Viruses

    From Understanding to Investigation
    • 2nd Edition
    • Susan Payne
    • English
    Viruses: From Understanding to Investigation, Second Edition presents the definitions and unique characteristics of viruses. The book includes major topics such as virus lifecycle, structure, taxonomy, evolution, history, host-virus interactions, and methods to study. In addition, the book assesses the connections between the aforementioned topics and provides an integrated approach and in-depth understanding of how viruses work. The new edition also provides an expanded methods chapter containing new information on deep sequencing for in virus identification, mathematical formulas to calculate titers and a description of quantitiative PCR for enumerating viruses. The vaccine chapter has been updated to include vaccine efficacy, mRNA vaccines and SARS-CoV-2 vaccine development. The viral pathogenesis chapter has been expanded to include mechanisms of virally induced cancers. Viral taxonomy sections have been updated and chapters revised to accommodate new virus family designations. New chapters include nucleocytoplasmic viruses (very large DNA viruses), replication of viroids and COVID-19/SARS-CoV-2.
  • Role of TRPV4 Channels in Different Organ Systems

    • 1st Edition
    • Volume 89
    • English
    Role of TRPV4 Channels in Different Organ Systems, Volume 89, the latest release in the Current Topics in Membranes series, provides an in-depth description of the role of TRPV4 ion channels in different organ systems under healthy and disease conditions. Research over the last two decades shows crucial physiological and pathological roles for TRPV4 channels. In this volume, we present chapters focusing on TRPV4 channels in the vasculature, lungs, heart, kidney, bladder, skin, musculoskeletal system, eye, and immune cells. Understanding the behavior of TRPV4 channels in various organ systems will provide a big picture on their physiological roles and therapeutic targeting.
  • Peptide and Peptidomimetic Therapeutics

    From Bench to Bedside
    • 1st Edition
    • Nir Qvit + 1 more
    • English
    Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics.
  • Management of Infertility

    A Practical Approach
    • 1st Edition
    • Antonio Simone Laganà + 1 more
    • English
    Management of Infertility: A Practical Approach offers an accurate and complete reference for the management of infertility and a robust step-by-step guide for assisted reproduction technologies (ARTs), including how to plan, design and organize a clinical setting and laboratory. The book also provides an evidence-based, complete and practical description of the available methods for diagnosis and management of male and female infertility. This will be an ideal resource for researchers, students and clinicians who want to gain complete knowledge about both basic and advanced information surrounding the diagnosis and management of infertility and related disorders.
  • Breast MRI

    State of the Art and Future Directions
    • 1st Edition
    • Volume 5
    • Katja Pinker + 2 more
    • English
    Breast MRI: State of the Art and Future Directions provides a comprehensive overview of the current applications of breast MRI, including abbreviated MRI, as well as presenting technical recommendations, practical implementation and associated challenges in clinical routine. In addition, the book introduces novel MRI techniques, multimodality imaging, and advanced image processing coupled with AI, reviewing their potential for impeding and future clinical implementation. This book is a complete reference on state-of-the-art breast MRI methods suitable for MRI researchers, radiographers and clinicians.Breast cancer is one of the leading causes of death among women with early detection being the key to improved prognosis and survival. Magnetic resonance imaging (MRI) of the breast is undisputedly the most sensitive imaging method to detect cancer, with a higher detection rate than mammography, digital breast tomosynthesis, and ultrasound.
  • Aging

    From Fundamental Biology to Societal Impact
    • 1st Edition
    • Paulo J. Oliveira + 1 more
    • English
    Aging: From Fundamental Biology to Societal Impact examines the interconnection of the cellular and molecular basis of aging and societal-based challenges and innovative interventions. Sections take a societal-based angle on aging, describing several flagship initiatives for healthy living and active aging in different regions, cover the biology of aging which includes the hallmarks of aging, explain the pathophysiology of aging, describing different comorbidities associated with aging and possible interventions to decrease the impact of aging, and envision future and innovative measures to tackle aging-related morbidities.Contribu... from an interdisciplinary panel of experts cover such topics as the biology of aging to physical activity, nutrition, psychology, pharmacology, health care, social care and urban planning.
  • The Link Between Obesity and Cancer

    • 1st Edition
    • Raman Mehrzad
    • English
    The Link between Obesity and Cancer provides a comprehensive review on the relationship between obesity and cancer, presenting global perspectives on obesity and cancer incidence that are followed by in-depth discussions on cancers for which we have new evidence of a causal relationship with obesity. Readers will gain fundamental knowledge on which cancer types are related to obesity. In addition, this updated resource provides significant knowledge for clinicians on when to act, along with specific management guidelines for patients, as well as how to understand potential risk factors and how to directly or indirectly minimize these risks. The book also provides never-before-publish... scientific data for any researcher in the field, identifying molecular mechanisms and links behind the development of malignancy and promoting research in new and effective target pathways in developing therapeutic strategies.