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Elsevier

Books in Immunology

Elsevier's Immunology collection equips researchers with valuable insights to address the complexities of the immune system and its role in health and disease, offering original research, insightful analysis, and current theory on diagnosing, managing, and advancing treatments for allergies, asthma, and immunologic disorders.

  • Tending Adam's Garden

    Evolving the Cognitive Immune Self
    • 1st Edition
    • Irun R. Cohen
    • English
    Tending Adam's Garden describes and explains the way in which our immune system works from a novel perspective. The book uses metaphors and examples to bring the immune system to life and explores the fundamental miracle of nature. Written in plain language for a broad audience, this book encompasses much more than just immunology, exploring more fundamental matters such as causality, information, energy, evolution, cognition and individuality, as well as the strategy of the immune system and its role in health and disease.

  • T Cell Subsets

    Cellular Selection, Commitment and Identity
    • 1st Edition
    • Volume 83
    • English
    This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity.T Cell Subsets is a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers

  • Systemic Lupus Erythematosus

    • 4th Edition
    • Robert G. Lahita
    • English
    Systemic Lupus Erythematosus, Fourth Edition, provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. This book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnormailities, issues concerning pathogenetic fit with SLE, and newest methods of therapy of APLS are given in this newest edition of a classic reference.

  • Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas

    Molecular Genetics; Lung and Breast Carcinomas
    • 1st Edition
    • M. A. Hayat
    • English
    The various cell types have traditionally been recognized and classified according to their appearance in the light microscope following the process of fixing, processing, sectioning, and staining tissues that is known as histology. Classical histology has been augmented by immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today, ensuring a wide audience for this book.

  • Advances in Immunology

    • 1st Edition
    • Volume 82
    • Frederick W. Alt
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • The Heart in Systemic Autoimmune Diseases

    • 1st Edition
    • Volume 14
    • Andrea Dorea
    • English
    This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune diseases comprise a family of conditions that share common pathogenetic mechanisms as well as a multi-organ involvement including the heart. This volume has been subdivided into three parts. In the first part, the immune mechanisms involved in cardiac damage have been considered. The role of proinflammatory and regulatory cytokines in driving an autoimmune response to cardiac self-tissues has been analysed. Moreover, the prevalence, the clinical meaning and the hypothetical pathogenicity of a broad spectrum of organ and non-organ specific autoantibodies have been discussed in detail. In the second part of the volume, the role of humoral and innate immunity in promoting the development of atherosclerotic plaque has been extensively reviewed, along with the newly discovered anti-inflammatory properties of statins. These two parts of the volume deal with exciting aspects of this topic, suggesting a very close connection between heart diseases and immunology. Finally, in the third part, the cardiac manifestations observed in the major systemic autoimmune conditions have been comprehensively examined.This book yields an impressive body of well ordered information, highlighting key references and summarising the experience of a selected panel of distinguished physician-scientists actively involved in the field of cardiovascular disease and systemic autoimmunity.

  • The Flaviviruses: Pathogenesis and Immunity

    • 1st Edition
    • Volume 60
    • English
    Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts.

  • Advances in Immunology

    • 1st Edition
    • Volume 81
    • English
    Volume 81 of Advances in Immunology contains articles on a vast range of immunology topics including the regulation of the immune response by the interaction of chemokines and proteases as well as roles of the Semaphorin Family in immune regulation. It has a chapter devoted to B Lymphoid Neoplasms of Mice and another on the Zebrafish as a model organism to study development of the immune system. This volume will be of interest to immunologists in all industries.

  • Advances in Parasitology

    • 1st Edition
    • Volume 56
    • English
    Advances in Parasitology is a serial containing in-depth reviews on current topics of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as trypanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

  • The Blood Group Antigen FactsBook

    • 2nd Edition
    • Marion E. Reid + 1 more
    • English
    The second edition of The Blood Group Antigen FactsBook provides key information relating to human red blood cell membrane components carrying blood group antigens, the molecular basis of the antigens, their serological characteristics, and the clinical significance of blood group antibodies. The data on this group of molecules has expanded greatly since the previous edition was published five years ago. Topics include: history and information on terminology, expression, chromosomal assignment, carrier molecule description, molecular basis of antigens, effect of enzymes/chemicals, clinical significance, disease association, phenotypes, glycotypes and key references.

  • Antigenic Variation

    • 1st Edition
    • Alister G. Craig + 1 more
    • English
    The topic of antigenic variation is important in both biology and medicine. It is of enormous interest, as it describes the process(es) whereby microorganisms 'shift shape', by genetic rearrangement or otherwise. In medical terms, this has a major impact on the infectious disease process, since the immune system has great difficulty in keeping up with this variation, and thus eliminating the infectious agent. Antigenic variation is a major method by which microbes evade the immune response, and persist in the body.The broad scope of the book appeals to all those working in the field of infectious disease, immunology of infection, pathogenesis, molecular biology and also to evolutionary biologists. Topics covered include not only bacterial species, and viruses such as influenza, HIV, Rotavirus, but also eukaryotic parasites - one of the most fascinating groups of organisms exhibiting this behaviour.

  • Advances in Parasitology

    • 1st Edition
    • Volume 52
    • English
    First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Now edited by J.R. Baker (Royal School of Tropical Medicine and Hygiene, UK), R. Muller (International Institute of Parasitology, UK) and D. Rollinson (The Natural History Museum, UK), supported by an international Editorial Board, Advances in Parasitology includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on such topics as Remote Sensing and Geographical Information Systems in Epidemiology.

  • Neurobiology of the Immune System

    • 1st Edition
    • Volume 52
    • Angela Clow + 1 more
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • The Vaccine Book

    • 1st Edition
    • Barry R. Bloom + 1 more
    • English
    The Vaccine Book provides comprehensive information on the current and future world of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases such as AIDS, tuberculosis, and malaria. The Vaccine Book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines.

  • Immunology of Infection

    • 2nd Edition
    • Volume 32
    • English
    Immunology of Infection, 2nd Edition, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the Microbiologist interested in analysing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology.This new edition of Immunology of Infection provides ready-to-use "recipes", and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition.Methods in Microbiologyis the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research.

  • Mechanisms of Cardiovascular Aging

    • 1st Edition
    • Volume 11
    • T. Hagen
    • English
    This volume of Advances in Cell Aging and Gerontology provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression. This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan.

  • The Antiphospholipid Syndrome II

    Autoimmune Thrombosis
    • 1st Edition
    • R. Cervera + 2 more
    • English
    This book provides the reader with a comprehensive overview of the Antiphospholipid syndrome. One of the most important advances in rheumatology and connective tissue diseases of the last decade. It provides an explanation for many previously undefined conditions with no clear pathogenesis encompassing all subspeculations in internal medicine as well as obstetrics. Clotting problems leading to strokes and myocardial infarctions (in younger people) as well as a large variety of other syndromes such as chorea, hyproadrenalism, pulmonary problems are now being understood.

  • Advances in Immunology

    • 1st Edition
    • Volume 80
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles in this volume address topics such as protein degradation and the generation of MHC class I-presented peptides, proteolysis and antigen presentation by MHC Class II molecules, cytokine memory of T-helper lymphocytes, Ig gene hypermutation, generalization of single immunological experiences by idiotypically mediated clonal connections, and aging of the immune system. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Universes in Delicate Balance: Chemokines and the Nervous System

    • 1st Edition
    • R.M. Ransohoff + 4 more
    • English
    It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development.Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue.This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts.The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis.Underst... human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.

  • Practical Guidelines in Antiviral Therapy

    • 1st Edition
    • G.J. Galasso + 3 more
    • English
    This text was developed with the practicing physician in mind, however, it will be of considerable interest to the virologist, pharmacologist, chemist and all scientists interested in antiviral agents. Progress in the field of antiviral development is now moving rapidly and there is hope that one day there will be successful treatment modalities for most viral diseases. This work contains contributions from experts around the world, capturing worldwide practices. An online version providing the current status of antiviral research is planned for the near future.

  • Advances in Immunology

    • 1st Edition
    • Volume 79
    • Frank J. Dixon
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Paul Ehrlich's Receptor Immunology

    The Magnificent Obsession
    • 1st Edition
    • Arthur M. Silverstein
    • English
    Paul Ehrlich's Receptor Immunology: The Magnificent Obsession describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field.

  • Dendritic Cells

    Biology and Clinical Applications
    • 2nd Edition
    • Michael T. Lotze + 1 more
    • English
    Dendritic Cells, Second Edition is the new edition of the extremely successful book published in 1998. With the volume of literature on dendritic cells doubling every year, it is almost impossible to keep up. This book provides the most up-to-date synthesis of the literature, written by the very best authors. It is essential reading for any scientist working in immunology, cell biology, infectious diseases, cancer, transplantation, genetic engineering, or the pharmaceutical/biote... industry.

  • New Foundation of Biology

    • 1st Edition
    • Volume 1
    • I. Berczi + 1 more
    • English
    A new scientific discipline, acknowledged 65 years after its discovery, was the focus of the first Conference on Neuroimmune Biology in Canada. The papers presented at the conference, and in this volume, are dedicated to Dr. Hans Selye who is recognized as discovering the existence of a hypothalamic-pituita... axis. This axis plays an important role in the adaptation of higher animals and man to various physical, chemical, biological and emotional challenges.The conference and participants also honored Dr. Andor Szentivanyi whose opening paper, "Studies on the hypothalamic regulation of histamine synthesis", is contained in the introduction to this book. Dr. Szentivanyi has dedicated his long research career to the clarification of the role of the central nervous system in immune and inflammatory reactions, and his experimental results are presented here.With an ultimate goal to achieve a more thorough understanding of higher organisms in their entire complexity, this book, the first in the series http://serval.elsevi... Biology presents a coordinated and integrated view of the growing body of knowledge rapidly accumulating in this area.

  • The T Cell Receptor FactsBook

    • 1st Edition
    • Marie-Paule Lefranc + 1 more
    • English
    The T Cell Receptor FactsBook contains entries on all the 176 functional variable, diversity, joining, and constant regions of the human T cell receptor, including alpha, beta, gamma, and delta loci. Introductory chapters summarize information of T cell receptor chain synthesis, chromosomal location, and an overview of the human T cell receptor loci.

  • Advances in Immunology

    • 1st Edition
    • Volume 78
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that constitue immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.Immunology is vital to the understanding of infection and disease. Application of this information may lead to resistance and cures for higher animals and humans.

  • The Immunoglobulin FactsBook

    • 1st Edition
    • Marie-Paule Lefranc + 1 more
    • English
    The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field.The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.

  • Advances in Immunology

    • 1st Edition
    • Volume 77
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Atherosclerosis and Autoimmunity

    • 1st Edition
    • Yehuda Shoenfeld + 2 more
    • English
    Presenting further studies in the prevention and treatment of coronary artery disease, this book brings together the knowledge accrued in the past decade concerning the role of immunity in the initiation and perpetuation of atherosclerosis. A strong group of international contributors summarize the diverse aspects of the interrelationship between the immune system and atherosclerosis.

  • Advances in Immunology

    • 1st Edition
    • Volume 76
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • The Leukemia-Lymphoma Cell Line Factsbook

    • 1st Edition
    • Hans G. Drexler
    • English
    The Leukemia-Lymphoma Cell Line Factsbook represents an essential reference manual for all of the well-characterized leukemia-lymphoma cell lines currently available. It provides the most important facts, using the succinct and user-friendly format that has made the FactsBooks so popular with scientists and clinical researchers. Introductory chapters provide background and perspective for culturing malignant hematopoietic (blood forming) cell lines. These chapters are followed by over 400 comprehensive individual entries. Each cell line entry highlights essential clinical, immunological, genetic, and functional features and includes a comprehensive listing of references.

  • Cytokine Reference, Two-Volume Set (Individual Version)

    A Compendium of Cytokines and Other Mediators of Host Defense
    • 1st Edition
    • Joost J. Oppenheim + 5 more
    • English
    The Cytokine Reference is the most complete work for anyone interested in the role of cytokines in host defense processes. With essential and comprehensive information on all known cytokines, including chemokines, growth factors and neuropeptides, the database will include hundreds of entries with detailed descriptions of cytokine genes, proteins, cell sources, activities, receptors, receptor signal transduction, gene activation, pathophysiology, therapeutics and techniques. This encyclopedic reference is written by a panel of global experts and will include extensive tables and diagrams. This book/online bundle consists of a two-volume print set, plus a regularly updated and searchable Online Database. Cytokines are produced by virtually all the cells in our bodies, and they regulate the systems that defend us against infection, tumors, and trauma. This publication and database will enable all those working in the field to find the information they need about this ever-expanding field.

  • Cytokine Reference, Two-Volume Set (Institutional Version)

    A Compendium of Cytokines and Other Mediators of Host Defense
    • 1st Edition
    • Marc Feldman + 2 more
    • English
    The Cytokine Reference is the most complete work for anyone interested in the role of cytokines in host defense processes. With essential and comprehensive information on all known cytokines, including chemokines, growth factors and neuropeptides, the database will include hundreds of entries with detailed descriptions of cytokine genes, proteins, cell sources, activities, receptors, receptor signal transduction, gene activation, pathophysiology, therapeutics and techniques. This encyclopedic reference is written by a panel of global experts and will include extensive tables and diagrams. This book/online bundle consists of a two-volume print set, plus a regularly updated and searchable Online Database.Cytokines are produced by virtually all the cells in our bodies, and they regulate the systems that defend us against infection, tumors, and trauma. This publication and database will enable all those working in the field to find the information they need about this ever-expanding field.

  • Food Intolerance and the Food Industry

    • 1st Edition
    • T Dean
    • English
    Food intolerance and the food industry approaches the issue of food intolerance from an industry rather than a clinical perspective. This unique book has become an indispensable guide for production managers and nutritionists within the food industry as well as providing an authoritative source of information for all those concerned with understanding and managing food intolerance.

  • The New Public Health

    An Introduction for the 21st Century
    • 1st Edition
    • Theodore H. Tulchinsky + 1 more
    • English
    Countries around the world are engaged in health reform, which places great demands on health care providers and systems managers. From the managed care revolution in the United States to the rebuilding of health systems in postcommunist Russia, these reforms impact millions of health care workers, government officials, patients, and the public alike. The New Public Health will help students and practitioners understand factors affecting the reform process of health care organization and delivery. It links the classic public health issues such as environmental sanitation, health education, and epidemiology with the new issues of universal health care, economics, and management of health systems for the new century.

  • Emerging Infections

    • 1st Edition
    • Volume -
    • English
    Emerging Infections is a reprint of the inaugural volume of the thematic serial, Biomedical Research Reports Series that provides annual updates on hot topics of interest to a broad spectrum of the biomedical research community. This volume provides state-of-the-art reviews of the most important "new" and reemerging bacterial, viral, and parasitic infections, their life cycles, host defense evasion strategies, and clinical features. Emerging Infections includes in-depth coverage of the history of infectious disease outbreaks, population and evolutionary biology of human pathogens, and current epidemiological models that describe how ecological and demographic changes produce new epidemics. The book covers the major established pathogens as well as the new and sensational--mad cow disease, hantavirus pulmonary syndrome, pathogenic E-coli, and flesh-eating bacteria.

  • The War Within Us

    Everyman's Guide to Infection and Immunity
    • 1st Edition
    • Cedric A. Mims
    • English
    Infectious diseases are the leading cause of death worldwide. In The War Within Us, well-known author and infectious disease specialist Cedric Mims makes the intricacies of the immune system and infectious diseases less baffling for the general reader and answers the questions of how things work and why. The story is told in terms of the ancient conflict between the invader (the infectious disease) and the defender (the body's immune system) and the strategies and counter-strategies used by both sides, making it a book that is both informative and interesting to read. The War Within Us is an ideal introduction to the basics of immunity and infection for general readers and students. It also serves as a quick reference book for physicians, researchers, and other health workers.

  • Advances in Immunology

    • 1st Edition
    • Volume 75
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Mast Cells and Basophils

    • 1st Edition
    • Gianni Marone + 2 more
    • English
    Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

  • HLA in Health and Disease

    • 2nd Edition
    • Robert Lechler + 1 more
    • English
    This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry.

  • Molecular Protocols in Transfusion Medicine

    • 1st Edition
    • Gregory A. Denomme + 2 more
    • English
    This essential methods manual for immunohematologists (or hematologists and immunohematologists) provides information on genes that encode antigens on red blood cells, platelets and neutrophils. The book begins by covering general concepts in molecular biology and specific protocols such as DNA preparation, PCR-RFLP and allele-specific PCR. Information on the erythrocyte, platelet and neutrophil antigen systems and the molecular basis of polymorphisms are presented clearly in a gene facts sheet format. Database accession numbers and useful adjuncts such as Request forms, worksheets for PCR/enzyme digests also serve to benefit the user. The information is clearly presented and easily accessible and is complemented by the excellent diagrams and tabular material. This book is invaluable for both new and experienced researchers in the field and other related disciplines.

  • Hematology

    Landmark Papers of the Twentieth Century
    • 1st Edition
    • Marshall A. Lichtman + 4 more
    • English
    This book is a centennial volume celebrating the enormous progress made in hematology in the 20th century. It is edited by Marshall Lichtman, a distinguished senior hematologist, past president of the American Society of Hematology, and co-editor of the leading text in the field. Hematology is a compendium, with commentaries, of the most important papers published in the field from 1900-1999. The book will be useful for reference--many of the older papers can no longer be found in most libraries, yet are still referred to in current publications, especially review articles--as well as teaching.The Editor and a team of associate editors have included the most important papers covering eight categories: anemia; phagocytic cells; platelets; coagulation and thrombosis; lymphocytes and immune disorders; transfusion medicine; hematologic malignancies and therapeutics; and laboratory developments. Each paper is accompanied by a 1-2 page commentary explaining its impact, and references to the developments that resulted.

  • Monoclonal Antibody Technology: The Production and Characterization of Rodent and Human Hybridomas

    • 1st Edition
    • Volume 13
    • A.M. Campbell
    • English
    This volume contains detailed, comprehensive advice on rat, mouse and human hybridoma production. It begins with a general introduction, then describes the practical applications of the technology with photographs and protocols for everything from animal dissection to epitope analysis of antigens.

  • Molecular Biology of B Cells

    • 1st Edition
    • Tasuku Honjo + 4 more
    • English
    Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.

  • The Eradication of Smallpox

    Edward Jenner and The First and Only Eradication of a Human Infectious Disease
    • 1st Edition
    • HervĂ© Bazin
    • English
    Simply, and with great humanity, The Eradication of Smallpox tells the story of smallpox - it's origins, the horror of the disease, and the millions of people killed or disfigured by it. During the 18th and 19th centuries, it is estimated that one out of every ten people died from the disease; some say one out of every seven. Smallpox attacked very young children in particular. The story progresses with the practice of variolation, the life of Edward Jenner who first proposed 'vaccination' with cow pox vaccine (little James Phipps was the first person ever vaccinated in this way), the years of debate about the efficacy of this novel method, and the later worldwide initiatives to rid the planet of this horrific disease. In 1979, the story culminates in the only total eradication of an infectious disease that mankind has ever accomplished. This year celebrates the 20th anniversary of this momentous achievement. In the intervening years, debate has raged about what we should do with the remaining smallpox viral stocks. Do we destroy them, so they can't fall into the hands of bioterrorists, or do we maintain them, in case they may be of use in some unexpected way, for therapeutic purposes? These questions are thoroughly discussed in the book.

  • The HLA FactsBook

    • 1st Edition
    • Steven G.E. Marsh + 2 more
    • English
    The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity.

  • Advances in Immunology

    • 1st Edition
    • Volume 74
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • The Complement FactsBook

    • 1st Edition
    • Scott R. Barnum
    • English
    The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies.

  • Encyclopedia of Virology

    • 2nd Edition
    • Allan Granoff + 1 more
    • English
    In recent years, progress in the field of virology has advanced at an unprecedented rate. Issues such as AIDS have brought the subject firmly into the public domain and its study is no longer confined solely to specialist groups.The Encyclopedia of Virology is the largest single reference source of current virological knowledge. It is also the first to bring together all aspects of the subject for a wide variety of readers. Unique in its use of concise 'mini-review' articles, the material covers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria, and insects. More general articles focus on the effects of viruses on the immune system, the role of viruses in disease, oncology, gene therapy, and evolution, plus a wide range of related topics. Drawing on the latest research, the editors have produced the definitive source for both specialist and general readers. Easy-to-use and meticulously organized, the Encyclopedia of Virology clarifies and illuminates one of the most complex areas of contemporary study. It will prove an invaluable addition to libraries, universities, medical and nursing schools, and research institutions around the world. The Second Edition has been thoroughly updated with approximately 40 new articles. This edition includes more illustrations and color plates in each volume.

  • Advances in Immunology

    • 1st Edition
    • Volume 73
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

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