Preface
Acknowledgments
Acknowledgment of Permissions from Publishers and Organizations
Section 1 Descriptions of Hematologic Diseases or Syndromes
Chronic Cyanosis, with Polycythemia and Enlarged Spleen: A New Clinical Entity
American Journal of the Medical Sciences 126:187-201
Commentary
Landmark Paper
Ueber paroxysmale H~iemoglobinurie [Concerning Paroxysmal Hemoglobinuria]
Muenchener Medizinische Wochenschrift 51:1590-1593
Commentary
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Translation
Pathog6ne de l'ict6re cong6nital de l'adulte [Pathogenesis of Congenital Jaundice of Adults]
Semaine Mddicale 27:25-29
Commentary
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Translation
Peculiar Elongated and Sickle-Shaped Red Corpuscles in a Case of Severe Anemia
Archives of Internal Medicine 6:517-521
Commentary
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Hereditare h~iemorrhagische Thrombasthenie. Ein Beitrag zur Pathologie der B lutpl~ittchen [Hereditary Hemorrhagic Thrombasthenia: A Contribution on the Pathology of Blood Platelets]
Jahrbuch fiir Kinderheilkunde 88:113-141
Commentary
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Translation
Mononuclear Leukocytosis in Reaction to Acute Infections ("Infectious Mononucleosis")
Johns Hopkins Hospital Bulletin 31:410-417
Commentary
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Chronic Arthritis in the Adult, Associated with Splenomegaly and Leucopenia
Johns Hopkins Hospital Bulletin 35:16-20
Commentary
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A Series of Cases of Splenomegaly in Children with Anemia and Peculiar Bone Changes
Transactions of the American Pediatric Society 37:29-30
Commentary
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An Acute Febrile Pleiochromic Anemia with Hyaline Thrombosis of Terminal Arterioles and Capillaries: An Undescribed Disease
Archives of Internal Medicine 36:89-93
Commentary
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Famili~e infantile perniziosaartige Anamie (pernizi6ses Blutbild und Konstitution) [Familial Infantile Pernicious-Like Anemia (Pernicious Blood Picture and Constitution)]
Jahrbuch fiir Kinderheilkunde 117:257-280
Commentary
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Translation
o , Uber hereditare Pseudoh~imophilie [On Hereditary Pseudohemophilia]
Acta Medica Scandinavica 76:521-549
Commentary
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Translation
The Etiology of Primary Granulocytopenia (Agranulocytic Angina)
Journal of the American Medical Association 102:755-758
Commentary
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Tropical Macrocytic Anemia: Its Relation to Pernicious Anaemia
Lancet 2:416--421
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Incipient Myelomatosis or "Essential" Hyperglobulinemia with Fibrinogenopenia: A New Syndrome?
Acta Medica Scandinavica 117:216-247
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Agammaglobulinemia
Pediatrics 9:722-728
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Nouvelle anomalie leucocytaire de caract6re constitutionnel familial [New Leukocyte Abnormality: Constitutional and Familial]
Revue d'Hdmatologie 7:362-366
Commentary
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Translation
Splenic Studies. 1. Susceptibility to Infection after Splenectomy Performed in Infancy
Annals of Surgery 136:239-242
Commentary
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Preleukemic Acute Human Leukemia
Journal of the American Medical Association 152:1018-1028
Commentary
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Histiocytosis X: Integration of Eosinophilic Granuloma of Bone, Letterer-Siwe Disease and Schuller-Christian Disease as Related Manifestations of a Single Nosologic Entity
American Medical Association Archives of Pathology 56:84-102
Commentary
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A Fatal Granulomatosis of Childhood: The Clinical Study of a New Syndrome
Minnesota Medicine 40:309-312
Commentary
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Leukemic Reticuloendotheliosis
Blood 13:609-629
Commentary
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A Sarcoma Involving the Jaws in African Children
British Journal of Surgery 46:218-223
Commentary
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Experimental Nutritional Folate Deficiency in Man
Transactions of the Association of American Physicians 75:307-320
Commentary
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Inherited Antithrombin Deficiency Causing Thrombophilia
Thrombosis et Diathesis Haemorrhagica 13:516-530
Commentary
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An Inherited Abnormality of Neutrophil Adhesion
New England Journal of Medicine 302:1163-1169
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Resistance to Activated Protein C as a Basis for Venous Thrombosis
New England Journal of Medicine 330:517-522
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Section 2 Insights Into the Pathophysiology of Hematologic Disorders
Observations of the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia: The Effect of Administration to Patients with Pernicious Anemia of the Contents of Normal Human Stomach after Ingestion of Beef Muscle
American Journal of the Medical Sciences 178:748-763
Commentary
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Chronic Hemolytic Anemia with Paroxysmal Nocturnal Hemoglobinuria. A Study of the Mechanism of Hemolysis in Relation to Acid-Base Equilibrium
New England Journal of Medicine 217:915-917
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Absorption and Excretion of Iron
Lancet 2:680-684
Commentary
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The Role of Isoimmunization in the Pathogenesis of Erythroblastosis Fetalis
American Journal of Obstetrics and Gynecology 42:925-937
Commentary
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Hemolytic Icterus (Acholuric Jaundice) Congenital and Acquired
Lancet 1:812-814
Commentary
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Sickle Cell Anemia, a Molecular Disease
Science 110:543-548
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Studies on the Mechanism of Erythropoietic Stimulation in Parabiotic Rats during Hypoxia
Blood 5:372-380
Commentary
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Demonstration of a Thrombocytopenic Factor in the Blood of Patients with Thrombocytopenic Purpura
Journal of Laboratory and Clinical Medicine 39:1-10
Commentary
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Pr6sence d'une leuco-agglutine dans le s6rum d'un cas d' agranulocytose chronique [The Presence of a Leuko-Agglutinin in the Serum of a Case of Chronic Agranulocytosis]
Comptes Rendus des Sdances de la Soci~t~ de Biologie et de ses Filiales 149:1539-1541
Commentary
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Translation
Humoral Regulation of Red Cell Production
Blood 8:349-387
Commentary
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The Hemolytic Effect of Primaquine. 1. The Localization of the Drug-Induced Hemolytic Defect in Primaquine-Sensitive Individuals
Journal of Laboratory and Clinical Medicine 43:303-309
Commentary
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A Minute Chromosome in Human Chronic Granulocytic Leukemia
Science 132:1497-1497
Commentary
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The Normal Human Female as a Mosaic of X-Chromosome Activity: Studies Using the Gene for G-6-PD-Deficiency as a Marker
Proceedings of the National Academy of Sciences 48:9-16
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Waterfall Sequence for Intrinsic Blood Clotting
Science 145:1310-1311
Commentary
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An Enzyme Cascade in the Blood Clotting Mechanism, and Its Function as a Biochemical Amplifier
Nature 202:498--499
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A New Consistent Abnormality in Chronic Myelogenous Leukemia Identified by Quinacrine Fluorescence and Giemsa Staining
Nature 243:290-293
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Clinical Importance of Lymphoblasts with T Markers in Childhood Acute Leukemia
New England Journal of Medicine 92:828-832
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Detection and Isolation of Type C Retrovirus Particles from Fresh and Cultured Lymphocytes of a Patient with Cutaneous T-Cell Lymphoma
Proceedings of the National Academy of Sciences 77:7415-7419
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Helicobacter Pylori-Associated Gastritis and Primary B-Cell Gastric Lymphoma
Lancet 338:1175-1176
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Section 3 Advances in Treatment of Hematologic Disease
A New and Greatly Simplified Method of Blood Transfusion
Medical Record 87:141-142
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Treatment of Pernicious Anemia by a Special Diet
Journal of the American Medical Association 87:470--476
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Hemophilia: Some Properties of Substance Obtained from Normal Human Plasma Effective in Accelerating Coagulation of Hemophilic Blood
Journal of Clinical Investigation 16:113-124
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A Preparation from Spoiled Sweet Clover (3,Y-Methylene-Bis-(4-Hydroxycoumarin))
Proceedings of the Staff Meetings of the Mayo Clinic 16:388-395
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Nitrogen Mustard Therapy: The Use of Methyl-Bis(13-Chlorethyl) Amine Hydrochloride and Tris(13-Chlorethyl) Amine Hydrochloride for Hodgkin's Disease, Lymphosarcoma, Leukemia and Certain Allied and Miscellaneous Disorders
Journal of the American Medical Association 132:126--132
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Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist 4-Aminopteroyl-Glutamic Acid (Aminopterin)
New England Journal of Medicine 238:787-793
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ACTH- and Cortisone-Induced Regressions of Lymphoid Tumors in Man. A Preliminary Report
Cancer 2:943-945
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Erythroblastosis Fetalis. VII. Treatment with Exchange Transfusion
New England Journal of Medicine 244:39-49
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The Treatment of Patients Suffering from Early Myocardial Infarction with Massive and Prolonged Streptokinase Therapy
Transactions of the Association of American Physicians 71:287-296
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The Radical Radiotherapy of Regionally Localized Hodgkin's Disease
Radiology 78:553-561
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Quadruple Combination Therapy (VAMP) for Acute Lymphocytic Leukemia of Childhood
Proceedings of the American Association for Cancer Research 5:20
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Prevention of Rh Immunization
Journal of the American Medical Association 199:390-394
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Impaired Platelet-Connective Tissue Reaction in Man after Aspirin Ingestion
Lancet 2:495-497
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Immunological Reconstitution of Sex-Linked Lymphopenic Deficiency
Lancet 2:1366-1369
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Combination Chemotherapy in the Treatment of Advanced Hodgkin's Disease
Annals of lnternal Medicine 73:881-895
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Central Nervous System Therapy and Combination Chemotherapy of Childhood Lymphocytic Leukemia
Blood 37:272-281
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Cytosine Arabinoside and Daunorubicin Therapy in Acute Nonlymphocytic Leukemia
Cancer Chemotherapy Reports 52:485-488
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Treatment of Aplastic Anaemia by Antilymphocyte Globulin with and without Allogeneic Bone-Marrow Infusions
Lancet 2:1145-1148
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One Hundred Patients with Acute Leukemia Treated by Chemotherapy, Total Body Irradiation, and Allogeneic Bone Marrow Transplantation
Blood 49:511-533
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Antileukemic Effect of Chronic Graft Versus Host Disease
New England Journal of Medicine 304:1529-1533
Commentary
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New Eng land Journal of Medicine 310:15-18
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Use of All-Trans Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia
Blood 72:567-572
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Use of Monoclonal Antibody Directed against the Platelet Glycoprotein Ilb/Illa Receptor in High-Risk Coronary Angioplasty
New England Journal of Medicine 330:956-961
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Section 4 Diagnostic or Clinical Laboratory Innovations
Ober Agglutinationserscheinungen normalen menschlichen B lutes [On the Agglutination of Normal Human Blood]
Wiener Klinische Wochenschrift 14:1132-1134
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Translation
The Relation of Blood Platelets to Hemorrhagic Disease: Description of a Method for Determining the Bleeding Time and the Coagulation Time and Report of Three Cases of Hemorrhagic Disease Relieved by Transfusion
Journal of the American Medical Association 55:1185-1192
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The Determination of the Length of Life of Transfused Blood Corpuscles in Man
Journal of Experimental Medicine 29:267-281
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Reticulosis-Increased Percentage in the Peripheral Blood
Journal of Laboratory andClinical Medicine 8:11-18
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Die intravitale Untersuchungsmethodik des Knochenmarks [The Intravital Research Methodology of the Marrow of a Bone]
Folia Haematologica 38:233-240
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Translation
Anemia: Classification and Treatment on the Basis of Differences in the Average Volume and Hemoglobin Content of Red Corpuscles
Archives of lnternal Medicine 54:256-280
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A Study of the Coagulation Defect in Hemophilia and in Jaundice
American Journal of the Medical Sciences 190:501-511
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A New Test for the Detection of Weak and "Incomplete" Rh Agglutinins
British Journal of Experimental Pathology 26:255-266
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Morphology and Enumeration of Human Blood Platelets
Journal of Applied Physiology 3:365-377
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Effect of Antihemophilic Factor on One-Stage Clotting Tests: A Presumptive Test for Hemophilia and Simple One-Stage Antihemophilic Factor Assay Procedures
Journal of Laboratory and Clinical Medicine 41:637-647
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High Speed Automatic Blood Cell Counter and Cell Size Analyzer
Proceedings of the National Electronics Conference 12:1034-1040
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Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Radiation Research 14:213-222
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Aggregation of Blood Platelets by Adenosine Diphosphate and Its Reversal
Nature 194:927-929
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The Chemotactic Effect of Mixtures of Antibody and Antigen on Polymorphonuclear Leukocytes
Journal of Experimental Medicine 115:453-457
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Separation and Collection of Leukocytes
Cancer Research 25:1516-1520
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The Cloning of Normal "Mast" Cells in Tissue Cultures
Journal of Cellular and Comparative Physiology 66:319-324
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The Growth of Mouse Bone Marrow Cells In Vitro
Australian Journal of Experimental Biology and Medical Science 44:287-289
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Detection of the Sickle Gene in the Human Fetus: Potential for Intrauterine Diagnosis of Sickle Cell Anemia
New England Journal of Medicine 287:1-5
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Appendix
Figure 1 Charles Mayo Depicts His Technique of Splenectomy
2 Demonstration of In Vitro Sickle Cell Formation in a Heterozygote
3 Deformation of the Skull by Excessive Erythropoiesis in a Patient of Cooley
4 Introduction of the Hematocrit Tube to Measure Packed Red Cell Volume
5 Application of Ashby Technique to Measurement of Red Cell Life-Span
6 Depiction of Siderocytes and Sideroblasts
7 Correlation of Red Cell Shape Alterations and Vascular Lesions in Microangiopathic Hemolytic Anemia
8 Mechanism of Exertional Hemoglobinuria
9 Polycythemia Resulting from an Inherited Abnormality of Hemoglobin
10 Mechanism for Premature Removal of Antibody-Coated Red Cells by the Mononuclear Phagocyte System
11 Use of Radioactive Iron to Study the Mechanism of Anemia in Man
12 Recombinant Human Erythropoietin Corrects the Anemia of End-Stage Renal Disease
13 Early Evidence for the Therapeutic Utility of Antihemophilic Globulin
14 Early Evidence for the Efficacy of Streptokinase to Lyse Clots
15 Homozygous Pelger-Hust Anomaly of Human Leukocytes
16 Early Depiction of "Fibrin Emboli" with Disseminated Intravascular Coagulation from Placenta Abruption
17 Introduction of Plastic Bags for Collection and Administration of Platelets for Transfusion
18 Depiction of Monstrous Granules in Human Leukocytes by Higashi
19 Purpura Fulminans Treated with Anticoagulation
20 Electron Micrograph of Viral Particles in Burkitt Lymphoma Cells
21 Description of Degradation Products of Fibrinogen Exposed to Plasmin
22 Characteristic Course of Heparin-Induced Thrombocytopenia
23 Depiction of the Giant Cell Characteristic of Hodgkin's Disease by Dorothy Reed
24 Salutary Effect of The "R6ntgen Ray" In The Treatment of Pseudoleukemia (Hodgkin Disease)
25 Introduction of Zonal Electrophoresis for Separation of Serum Proteins
26 Cytological Identification of Radiation Chimeras after Homologous Marrow Transplantation
27 Metaphase of Early Patient Carrying The Philadelphia Chromosome
28 Characteristic Depiction of The Hyperviscosity Syndrome
29 Introduction of a Method to Determine The Monoclonal Origin of Tumors
30 The Early Efficacy of Vamp in the Treatment of Childhood Lymphocytic Leukemia
31 Arabinosyl Cytosine (Cytarabine) in the Treatment of Acute Myelogenous Leukemia
Bibliography: Articles Cited in Commentaries
Sources Used in Preparation of Commentaries
Author Index
Subject Index