Life sciences print books and ebooks | Elsevier

Cisplatin

1st Edition
October 22, 2013
Archie W. Prestayko
English
eBook
9 7 8 1 4 8 3 2 8 9 0 0 7

Cisplatin: Current Status and New Developments is a collection of papers presented at a symposium sponsored by the University of Alabama in Birmingham Comprehensive Cancer Center and the Bristol Laboratories in Syracuse, ?ew York, and held on September 27-28, 1979, in Atlanta, Georgia. The symposium provided a forum for assessing developments with regards to cisplatin as an anticancer drug, with emphasis on its clinical application in a wide variety of adult and pediatric malignancies as well as the mechanism by which the drug appears to cause tumor cell death. Comprised of 39 chapters, this book begins with a preclinical overview of cisplatin, focusing on its mechanism of action, pharmacology, antitumor activity, analogs, and toxicity. The discussion then turns to the effects of cisplatin on DNA and the possible relationships to cytotoxicity and mutagenicity in mammalian cells; lethal activity of platinum compounds in combination with pyrimidine derivatives; and ultrastructural effects of cisplatin. Subsequent chapters focus on the rationale of combination chemotherapy; toxic side effects of platinum analogs; radiopharmacokinetic... of cisplatin; and the use of cisplatin for the treatment of malignancies such as ovarian cancer and advanced adenocarcinoma of the prostate. This monograph will be useful to oncologists and pharmacologists.

MATLAB for Neuroscientists

2nd Edition
November 18, 2013
Pascal Wallisch + 5 more
English
Hardback
9 7 8 0 1 2 3 8 3 8 3 6 0
eBook
9 7 8 0 1 2 3 8 3 8 3 7 7

MATLAB for Neuroscientists serves as the only complete study manual and teaching resource for MATLAB, the globally accepted standard for scientific computing, in the neurosciences and psychology. This unique introduction can be used to learn the entire empirical and experimental process (including stimulus generation, experimental control, data collection, data analysis, modeling, and more), and the 2nd Edition continues to ensure that a wide variety of computational problems can be addressed in a single programming environment. This updated edition features additional material on the creation of visual stimuli, advanced psychophysics, analysis of LFP data, choice probabilities, synchrony, and advanced spectral analysis. Users at a variety of levels—advanced undergraduates, beginning graduate students, and researchers looking to modernize their skills—will learn to design and implement their own analytical tools, and gain the fluency required to meet the computational needs of neuroscience practitioners.

International Cooperation, Convergence and Harmonization of Pharmaceutical Regulations

1st Edition
December 5, 2013
Pierre-Louis Lezotre
English
Hardback
9 7 8 0 1 2 8 0 0 0 5 3 3
eBook
9 7 8 0 1 2 8 0 0 5 6 9 9

International Cooperation, Convergence and Harmonization of Pharmaceutical Regulations: A Global Perspective provides the current status of the complex and broad phenomenon of cooperation, convergence and harmonization in the pharmaceutical sector (Part I), thoroughly evaluates its added value and its critical parameters and influencing factors (Part II) in order to recommend actions and measures to support the next steps for cooperation, convergence and harmonization (Part III). All of these recommendations in the book support the establishment of a better coordinated global pharmaceutical system which represents the best realistic alternative to fulfill the objective to establish a global coalition of regulators and to respond to an increased demand to further cooperation in the pharmaceutical sector. This proposed framework, which leverages all of the ongoing positive cooperation initiatives and uses as foundations all of the numerous harmonization projects developed over the years, presents advantages for all stakeholders and would definitively have significant added value to the promotion and protection of global public health.

Laboratory Animals

1st Edition
September 23, 2013
Javier Guillen
English
Hardback
9 7 8 0 1 2 3 9 7 8 5 6 1
eBook
9 7 8 0 1 2 3 9 7 8 6 9 1

Laboratory Animals: Regulations and Recommendations for Global Collaborative Research is the only publication to offer a compilation of standards across the world in the care, welfare and use of animals in research. Timely in the new legislation in numerous regions of the world, this book provides the information in easily accessible, readable language. For professionals across laboratory animal science and biomedical research, Laboratory Animals: Regulations and Recommendations for Global Collaborative Research provides a broad picture of the regulations required in other areas of the world and is essential to appropriately manage animal care and use programs.

Sexual Selection

1st Edition
September 25, 2013
Regina H. Macedo + 1 more
English
Hardback
9 7 8 0 1 2 4 1 6 0 2 8 6
eBook
9 7 8 0 1 2 3 9 1 4 5 6 9

Sexual Selection: Perspectives and Models from the Neotropics presents new sexual selection research based upon neotropical species. As neotropical regions are destroyed at an alarming rate, with an estimated 140 species of rainforest plants and animals going extinct every day, it is important to bring neotropical research to the fore now. Sexual selection occurs when the male or female of a species is attracted by certain characteristics such as form, color or behavior. When those features lead to a greater probability of successful mating, they become more prominent in the species. Although most theoretical concepts concerning sexual selection and reproductive strategies are based upon North American and European fauna, the Neotropical region encompasses much more biodiversity, with as many as 15,000 plant and animal species in a single acre of rain forest. This book illustrates concepts in sexual selection through themes ranging from female cryptic choice in insects, sexual conflict in fish, interaction between sexual selection and the immune system, nuptial gifts, visual and acoustic sexual signaling, parental investment, to alternative mating strategies, among others. These approaches distinguish Sexual Selection from current publications in sexual selection, mainly because of the latitudinal and taxonomic focus, so that readers will be introduced to systems mostly unknown outside the tropics, several of which bring into question some well-established patterns for temperate regions.

Advances in Drug Research

1st Edition
Volume 18
October 22, 2013
Bernard Testa
English
eBook
9 7 8 1 4 8 3 2 8 7 9 8 0

Each volume in this distinguished series presents authoritative reviews, both generally, on topics of broad interest in drug research, and specifically, on novel and established therapeutic classes. Acknowledged experts contribute in areas such as drug design, clinical and molecular pharmacology, drug metabolism, and mechanisms of action. Reviewers have consistently praised Advances in Drug Research for its comprehensive and lucid summaries of up-to-date knowledge.

Animal Biotechnology

1st Edition
October 22, 2013
L.A. Babiuk + 2 more
English
eBook
9 7 8 1 4 8 3 2 8 6 5 8 7

The advent of biotechnology has the potential to develop a variety of novel or better quality products for the treatment of a large number of diseases in livestock. In addition, as we understand more about the reproductive physiology of animals, the potential exists to dramatically increase the productivity of animals through better therapeutics and diagnostics for the control of many infectious diseases. Productivity can also be increased through animal breeding strategies including gene transfer, micromanipulation of embryos and gamete sex selection. As well as being a valuable reference to current knowledge in these areas, this first supplement to Comprehensive Biotechnology also looks at societal concerns over the use of antibiotics and chemical residues in meat and milk products, which are forcing biotechnologists to investigate more natural means of controlling infection by stimulating the animal's own immune system to combat infection. The identification of a variety of cytokines which are involved in regulating immune responses provides opportunities to use the animal's natural defence mechanisms to combat many infections or increase the animal's resistance to such infections. These approaches should provide tools for eventual elimination of specific diseases from counties, regions or whole continents.

Avian Biology

1st Edition
September 3, 2013
Donald S. Farner + 1 more
English
Hardback
9 7 8 0 1 2 2 4 9 4 0 3 1
eBook
9 7 8 1 4 8 3 2 6 9 4 3 6

Avian Biology, Volume III is a collection of articles that deals with the biology of birds such as their peripheral endocrine glands and reproductive system. One paper describes the avian reproductive system where physiological mechanisms that regulate gametogenesis get synchronized from stimuli in the environment, thus ensuring that the young are born at the appropriate season. Another paper correlates the morphology of the pituitary cells with the functions of the pituitary from physiological and chemical analyses. A couple of papers describes the peripheral endocrine glands and the process of neuroendocrinology that includes detailed analyses of the neurosecretory system anatomy and the ependymal function in the median eminence composed of the anterior and posterior divisions. One author describes the structure and refraction of avian vision, as well as the probable determination of visual pigments in the eye cones through in situ microspectrophotomet... The book then analyzes bird behavior through functional groups of bird activities. Bird enthusiasts, zoologists, and avian biologists will find this book interesting and informative.

Life Sciences and Space Research

1st Edition
October 22, 2013
R. Holmquist
English
Paperback
9 7 8 1 4 8 3 1 1 6 6 7 9
eBook
9 7 8 1 4 8 3 1 4 9 0 9 7

Life Sciences and Space Research, Volume XVII contains the proceedings of the Open Meeting of the Working Group on Space Biology of the Twenty-first Plenary Meeting of COSPAR, held in Innsbruck, Austria, from May 29 to June 10, 1978 and of the Symposium on Gravitational Physiology which also took place in Innsbruck, Austria, on June 2 and 3, 1978. The papers review the results of research in the life sciences with respect to space biology, including chemical data returned from the Viking Lander experiments. The engineering design of biologically closed ecological systems suitable for very long term space flight or space colonies is also described. This volume is comprised of 41 chapters and begins with a discussion on closed regenerative life support systems for space travel and their implications for ecological science. Subsequent chapters examine closed ecology in space from a bioengineering perspective; technology requirements for nonterrestrial ecosystems; carbon suboxide polymer as an explanation for the wave of darkening observed on Mars; and volcanism and soil mercury on Mars, along with their consequences for terrestrial microorganisms. The next sections focus on the biology of extreme environments such as Central Antarctica, radiation biology in space, and gravitational physiology in relation to humans and animals. This book will be of interest to space scientists, space biologists, and those engaged in the life sciences, space research, molecular biophysics, biochemistry, and physiology.

The Toxicology of Radioactive Substances

1st Edition
October 22, 2013
A. A. Letavet + 1 more
English
Paperback
9 7 8 1 4 8 3 1 2 0 6 3 8
eBook
9 7 8 1 4 8 3 1 5 3 0 5 6

The Toxicology of Radioactive Substances, Volume 5: Zinc-65 deals with the toxic properties of the radioisotope zinc-65 as well as its biological effects. Emphasis is placed on the role of stable zinc in the reaction of the body to the administration of zinc-65. Some of the results of laboratory studies on the toxic effects of zinc-65 on animals, primarily rabbits, are presented. This volume is comprised of 18 chapters and opens with an overview of certain aspects of the toxicology of radioactive zinc-65, followed by a discussion on the behavior of zinc-65 in the rat body. Subsequent chapters explore the distribution of zinc-65 in the body of rabbits following chronic oral administration; bioelectrical activity of the cerebral cortex in rabbits in conditions of prolonged administration of radioactive zinc; the effect of prolonged internal irradiation with G5ZnCl2 on the functional state of the rabbit heart; and aspects of hemopoiesis following chronic intake of radiozinc. Morphological changes in experimental animals following chronic exposure to radioactive zinc are also considered. This book will be of interest to chemists and toxicologists.

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