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Aspects of Cell Regulation
1st Edition - March 28, 1983
Editors: G. H. Bourne, J. F. Danielli
eBook ISBN:9781483266664
9 7 8 - 1 - 4 8 3 2 - 6 6 6 6 - 4
Aspects of Cell Regulation deals with the various aspects of cellular control mechanisms. The book begins with a discussion of the role of hormones in the control of cell… Read more
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Aspects of Cell Regulation deals with the various aspects of cellular control mechanisms. The book begins with a discussion of the role of hormones in the control of cell differentiation and biochemical control over the life of an organism. This is followed by separate chapters on an intracellular control problem, namely, the proper reproduction of cellular organelles and their apportionment between daughter cells at cell mitosis; cell mutants with different temporal order for macromolecular synthesis; and the control of a plant enzyme that converts triglycerides into carbohydrate during the early stages of postgerminative growth within seed cotyledon. Subsequent chapters deal with the possible role of mitochondria in changing the control mechanism of cells to that associated with carcinogenesis; the possibility of transforming genes being detectable in the genome after the transformation to neoplastic cell; the correlation between viruses and tumor cells; and whether viruses can originate from cells rather than coming before cells.
Contributors
Preface
Supplements in Series
Cellular Factors Which Modulate Hormone Responses: Glucocorticoid Action in Perspective
I. Introduction
II. Cell Entry
III. Steroid-Receptor Interaction
IV. Receptor Activation and Nuclear Translocation
V. Nuclear Binding Sites of the Steroid-Receptor Complex
VI. Mechanism of Gene Activation
VII. Summary
References
Regulation of Genetic Activity by Thyroid Hormones
I. Introduction
II. Thyroid Hormones Participate in Cell Differentiation via Regulation of Nucleic Acid and Protein Syntheses
III. Binding of Thyroid Hormones to the Nuclear Receptor
IV. Binding of Thyroid Hormones to the Cytoplasmic Receptor
V. Binding of Thyroid Hormones to Other Intracellular Components
VI. Major Working Hypothesis on the Mechanisms of Genetic Activity Regulation by Thyroid Hormones
VII. Properties of the Thyroxine Cytoplasmic Receptor
VIII. The Role of the Thyroxine Cytoplasmic Receptor in Translocation of the Hormone from the Nucleus and Acceptance by Chromatin
IX. The Cytoplasmic Receptor as Mediator for the Action of Thyroid Hormones in the Nucleus
X. Interaction of the Hormone-Receptor Complex with DNA
XI. The TBPA-like Cytosol Receptor is a Universal Intracellular Receptor of Thyroid Hormones
References
The Partitioning of Cytoplasmic Organelles at Cell Division
I. Introduction
II. A Note on Terminology: Segregation and Partitioning
III. Numerical Partitioning of Organelles
IV. Compensating Replication
V. Numerical Partitioning of Organelle DNA
VI. Genetic Partitioning of Organelles
VII. Summary
References
Cell Cycle Mutants
I. Introduction
II. Cell Cycle Concept
III. Cell Cycle Mutants
IV. Future Considerations
V. Conclusions
References
Formation of Glyoxysomes
I. Introduction
II. Characterization of Glyoxysomes
III. Origin of Glyoxysomal Components
IV. General Conclusions
References
Mitochondria, Cell Surface, and Carcinogenesis
I. Introduction
II. The Mitochondrial System
III. Tumor Mitochondria
IV. Antimitochondrial Activity of Carcinogens
V. Mitochondria and Cell Surface Characteristics
VI. Mitochondria and Intracellular Systems
VII. Mechanism of Mitochondrial Control
VIII. Conclusions and Prospects
References
Transforming Genes of Tumor Cells
I. Demonstration of Altered DNA in Nonvirally Transformed Cells
II. Transforming DNA of Tumors Induced by Slowly Oncogenic Viruses
III. The Discrete Nature of These Transforming Sequences
IV. The Discovery of Tissue-Specific Oncogenes
V. Isolation of Active Oncogenes
VI. The Relationship of These Tumors to Other Known Oncogenes
VII. Additional Roles of one Genes
VIII. Perspectives
References
Viral Carcinogenesis
I. Introduction
II. Oncogenic DNA Viruses
III. Retroviruses
References
The Origin of Viruses from Cells
I. Introduction
II. Historical
III. Mechanisms for Change in Viruses
IV. The Evolutionary Age of Viruses
V. The Kinds of Cells
VI. The Kinds of Viruses
VII. Chlamydiae and Viruses Compared
VIII. Would a Cell → Virus Transition Be Possible?
IX. Origin of Viruses from Cellular Genetic Elements
X. Conclusions
References
Index
No. of pages: 298
Language: English
Published: March 28, 1983
Imprint: Academic Press
eBook ISBN: 9781483266664
GB
G. H. Bourne
Affiliations and expertise
Department of Anatomy, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia
JD
J. F. Danielli
Affiliations and expertise
Department of Biochemical Pharmacology,School of Pharmacy,State University of New York at Buffalo,Buffalo, New York