Skip to main content

Books in Life sciences

Nonsense Mutation Correction in Human Diseases
An Approach for Targeted Medicine
1st Edition
Fabrice Lejeune + 2 more
English
Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD). It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine.
Profiles of Drug Substances, Excipients and Related Methodology
1st Edition
Volume 41
English
Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.
The Cytology of Effusions
Pleural, Pericardial and Peritoneal and of Cerebrospinal Fluid
2nd Edition
A. I. Spriggs + 1 more
English
The Cytology of Effusions: Pleural, Pericardial and Peritoneal and of Cerebrospinal Fluid, Second Edition provides information pertinent to the cytology of effusion in various conditions. This book discusses the cytology of cerebrospinal fluid wherein the appropriate methods for studying this material are much the same as for serous fluids. Organized into nine chapters, this edition begins with an overview of the differential cell count from a serous fluid. This text then presents the nomenclature and descriptions of cells of serous effusions. Other chapters consider the cytological examinations of pleural or peritoneal fluid, which often shed light on the diagnosis in leukemias and lymphomas. This book discusses as well the general features of malignant effusions that may suggest the diagnosis. The final chapter deals with the distinction between polymorphonuclear and lymphocytic types of meningeal exudate made from an examination of the cerebrospinal fluid. This book is a valuable resource for pathologists and clinicians.
G Protein-Coupled Receptors
Signaling, Trafficking and Regulation
1st Edition
Volume 132
English
G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation.
Genes, Environment and Alzheimer's Disease
1st Edition
Orly Lazarov + 1 more
English
Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease.
Nitric Oxide and Signaling in Plants
1st Edition
Volume 77
English
Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 77th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology.
Tumor Immunology
1st Edition
Volume 130
English
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. This volume focuses on tumor immunology.
Chemokines
1st Edition
Volume 570
English
Chemokines, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in chemokines, and includes sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokines, recognition of GAG-bound chemokines, and the production of chemokine receptor complexes for structural and biophysical studies.
Epi-Informatics
Discovery and Development of Small Molecule Epigenetic Drugs and Probes
1st Edition
Jose Medina-Franco
English
Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes.
Pharmacological Mechanisms and the Modulation of Pain
1st Edition
Volume 75
English
Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

Related subjects