Tumor Immunology

Chapter One: Mouse Models of Tumor Immunotherapy

• Abstract
• 1 Introduction
• 2 Transplantable Tumor Models
• 3 Genetically Engineered Tumor Models
• 4 Carcinogen-Induced Tumor Models
• 5 Humanized Mouse Tumor Models
• 6 Perspectives
• 7 Materials and Methods
• Acknowledgments

Chapter Two: The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer

• Abstract
• 1 Introduction
• 2 Cancer Immunoediting as an Encompassing Model of Immune System–Tumor Interactions
• 3 Antigenic Targets of Cancer Immunoediting
• 4 Setting the Groundwork: Genomic Approaches to Cancer Antigen Identification
• 5 Developing Cancer Immunotherapies Based on Genomic Identification of Tumor-Specific Neoantigens
• 6 Neoantigens as Therapeutic Targets in Human Cancer
• 7 Concluding Remarks
• Acknowledgments

Chapter Three: Tumor and Host Factors Controlling Antitumor Immunity and Efficacy of Cancer Immunotherapy

• Abstract
• 1 Rationale for Studying Regulation of the T Cell-Inflamed Tumor Microenvironment Phenotype
• 2 Molecular and Cellular Drivers of the T Cell-Inflamed Tumor Microenvironment
• 3 Tumor-Intrinsic Oncogene Pathways Mediating the Non-T Cell-Inflamed Tumor Microenvironment
• 4 Environmental Factors Influencing the Tumor Microenvironment: The Host Microbiota
• 5 Germline Genetic Differences as an Additional Source of Interpatient Heterogeneity
• 6 Conclusions and Implications

Chapter Four: Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

• Abstract
• 1 Introduction
• 2 The Immune Microenvironment of Different Cancer Subtypes
• 3 Classification of Tumors in the Era of Omic Techniques
• 4 The Tumor Microenvironment and the Molecularly Defined Subgroups of Human Cancers
• 5 Conclusions: From the Immune Contexture of Tumor Subgroups to Precision Medicine
• Acknowledgments

Chapter Five: Advances in Therapeutic Cancer Vaccines

• Abstract
• 1 Introduction
• 2 Cancer Antigens
• 3 Approaches to Cancer Vaccines: What We Have Learned
• 4 In Situ Vaccination
• 5 Engineering Approaches
• 6 Concluding Remarks

Chapter Six: Combinatorial Cancer Immunotherapies

• Abstract
• 1 Introduction
• 2 Combinations of Coinhibitory Checkpoints
• 3 Combinations with Costimulatory Checkpoints
• 4 Combinations with Other Molecules in the Tumor Microenvironment
• 5 Other Anticancer Treatment Modalities in Combination with T Cell Checkpoint Blockade
• 6 Conclusions

Chapter Seven: Adoptive T-Cell Therapy for Cancer

• Abstract
• 1 Identifying Tumor-Associated Antigens Recognized by T-Cells
• 2 Cell Therapy with Genetically Engineered T-Cells
• 3 Cell Therapy with TIL
• 4 Cell Therapy Targeting Mutated “Neoantigens”
• 5 The Future of ACT