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    • RAS: Past, Present, and Future

      • 1st Edition
      • Volume 153
      • January 29, 2022
      • English
      • Hardback
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      • eBook
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      Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once “undruggable” RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.

    • Integrated Methods in Protein Biochemistry: Part A

      • 1st Edition
      • Volume 675
      • October 9, 2022
      • English
      • Hardback
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      • eBook
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      Integrated Methods in Protein Biochemistry: Part A, Volume 677, the latest release in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as DNA and protein engineering to create protein bioswitches with new functions, Interaction and cross-talk of prelamin A with integral membrane zinc metalloproteases, An experimental protocol to study lipid transfer proteins, Synthesis of small heat shock proteins, Druggable p-p interacting sites for Co-chaperone DNAJA1 and its partner proteins, An experimental protocol for glycoconjugate analysis, Methods for proximity-based biotinylation combined with Mass Spectrometry, and more. Additional chapters cover Synthetic antibody fragments as conformational sensors of protein activation and trafficking, Expression, purification, functional analysis and crystallization of Rag GTPase, Purification of bacterial transcription elongation complexes by photoreversible immobilization, Inhibition of c-Myc-MAX heterodimerization, Fluorogenic RNA aptamers to probe transcription by multi-subunit RNA polymerases, and much more.

    • Imagerie de l'orbite, du labyrinthe membraneux et de la base du crâne

      • 1st Edition
      • September 14, 2022
      • Francis Veillon + 1 more
      • French
      • Paperback
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      • eBook
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      L’interprétation radiologique de la base du crâne est délicate car la structure anatomique de la région est singulièrement complexe.Ce nouveau volume de la collection des Syllabus de la Société française de radiologie propose un état de l’art de l’imagerie de l’orbite, du labyrinthe membraneux et de la base du crâne. Les connaissances à maîtriser pour réaliser les IRM et tomodensitométries de ces différentes régions sont détaillées. Pour chaque zone topographique sont abordées la radioanatomie et les pathologies de type infectieux, tumoral, malformatif et lésionnel. Sont également présentés la place des techniques avancées dans le diagnostic et la prise en charge des pathologies ophtalmiques, ainsi que les progrès en cours ou attendus grâce à l’intelligence artificielle dans l’étude des troubles cochléovestibulaires... plus de 500 clichés, cet ouvrage constitue la référence pédagogique actuelle sur le sujet. Il est indispensable pour les internes et radiologues qui interprètent cette région anatomique, ainsi que pour les neurologues, neurochirurgiens, ORL et ophtalmologues désireux de mieux demander et mieux comprendre les examens d’imagerie. LES AUTEURSFrancis Veillon est professeur des universités et praticien hospitalier au service d’imagerie médicale 2 à l’hôpital de Hautepierre, CHRU de Strasbourg.Augustin Lecler est maître de conférences des universités et praticien hospitalier au service de radiodiagnostic et imagerie médicale de l’hôpital Fondation Adolphe de Rothschild à Paris.Arnaud Attyé est praticien hospitalier au service de neuro-imagerie et d’IRM de l’hôpital Michallon du CHU Grenoble Alpes, laboratoire GeodAIsics à Grenoble.Anne-Laure Gaultier est praticien hospitalier au service d’imagerie de l’hôpital européen Georges Pompidou à Paris.

    • Epilepsy, An Issue of Neurologic Clinics

      • 1st Edition
      • Volume 40-4
      • October 22, 2022
      • Steven C. Schachter
      • English
      • Hardback
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      • eBook
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      In this issue of Neurologic Clinics, guest editor Dr. Steven C. Schachter brings his considerable expertise to the topic of Epilepsy. Top experts in the field cover key topics such as telemedicine and epilepsy care; wearable technologies and mobile apps in the evaluation and treatment of epilepsy; effects of maternal use of AEDs on child development; sleep and epilepsy; dietary treatments for epilepsy; and more.

    • Advances in Biomolecular EPR

      • 1st Edition
      • Volume 666
      • April 22, 2022
      • English
      • Hardback
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      • eBook
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      Advances in Biomolecular EPR, Volume 666 in the Methods of Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Magnetic Resonance Characterization of Physiologically Important Metal Ion Binding Sites in the Prion and Related Proteins, The catalytic role of metal-radical/protei... radicals in heme enzymes, Rigid Cu2+-based spin labels for the study of higher-order DNA G-quadruplex structures, Orthogonal spin labeling and membrane proteins: increasing the information content and going towards in cell applications, Spectroscopic investigation of mono- and di-Mn-containing centers in biochemistry with an emphasis on application of paramagnetic resonance techniques, and more. Additional chapters cover In Vivo pO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance, an Update, EPR contributions to understanding molybdenum-containin... enzymes, EPR spectroscopy of Type I reaction centers, Characterization of a substrate-derived radical in the NosN reaction during the biosynthesis of nosiheptide, and much more.

    • Helicase Enzymes Part B

      • 1st Edition
      • August 12, 2022
      • English
      • Hardback
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      • eBook
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      Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

    • One, No One, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part B

      • 1st Edition
      • Volume 368
      • May 20, 2022
      • English
      • Hardback
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      • eBook
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      One, No One, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part B, Volume 369 provides in-depth reviews on the last progresses on the role of macrophages in health and diseases, with a special focus on the role of macrophages during development. New chapters cover The role of salivary gland macrophages in infection, disease and repair, Reprogramming or replacing brain macrophages to treat neurodegenerative disease, Targeting macrophages for cancer immunotherapy, Heart Macrophages at steady-state and disease: simple bystanders or active players?, Macrophages in the liver, and Developmental programming of macrophages.

    • Advances in Applied Microbiology

      • 1st Edition
      • Volume 120
      • September 27, 2022
      • Geoffrey M. Gadd + 1 more
      • English
      • Hardback
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      • eBook
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      Advances in Applied Microbiology, Volume 120 continues the comprehensive reach of this widely read and authoritative review source in microbiology, providing invaluable references and information on a variety of areas relating to the topics of microbiology.

    • Disorders of Protein Synthesis

      • 1st Edition
      • Volume 132
      • September 7, 2022
      • Rossen Donev
      • English
      • Hardback
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      • eBook
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      Disorders of Protein Synthesis, Volume 132 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

    • DNA Damage and Double Strand Breaks

      • 1st Edition
      • Volume 51
      • October 19, 2022
      • English
      • Hardback
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      • eBook
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      DNA Damage and Double Strand Breaks, Volume 51 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters that provide an update on female and male genital schistosomiasis and a call to integrate efforts to escalate diagnosis, treatment and awareness in endemic and non-endemic settings, vertebrates as uninfected disseminators of helminth eggs and larvae, and combatting anthelmintic resistance in ruminants.

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