Regulation of Downstream Targets
- 1st Edition, Volume 134 - March 2, 2023
- Editor: Rossen Donev
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 1 8 1 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 1 8 2 - 0
Regulation of Downstream Targets, Volume 134 in the Advances in Protein Chemistry and Structural Biology series, presents interesting chapters on topics such as Transcrip… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteRegulation of Downstream Targets, Volume 134 in the Advances in Protein Chemistry and Structural Biology series, presents interesting chapters on topics such as Transcriptional regulatory mechanisms and signaling networks in Viral Infections, Identification of potential key genes associated with pathogenesis and prognosis of endometrial cancer based on Integrated Bioinformatics Approaches, Differential regulation of genes in stage IB pancreatic cancer associated with increased risk of metastasis, AMPK-related LKB1-downstream targets, A compilation of bioinformatic approaches to identify novel downstream targets for the detection and prophylaxis of cancer, Protein phosphatases and their targets: Critical determinants of signaling pathway in plants, and more.
Other sections cover Calcium decoders and their targets: The holy alliance that regulate cellular responses, Importin alpha family NAAT/IBB domain: functions of a multi-faceted long chameleon sequence, Aurora Kinase A and related downstream molecules: A Potential Network for Cancer Therapy, Emerging Role of Heat Shock Proteins in Cardiovascular Diseases, Function, Structure, Evolution, Regulation and Drug Target Relevance of Arylalkylamine N-acetyltransferase, and Analysis of signaling cascades from myeloma cells treated with pristimerin.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Advances in Protein Chemistry and Structural Biology series
- Updated release includes the latest information on the Regulation of Downstream Targets
Researchers and students
- Cover image
- Title page
- Table of Contents
- Advances in PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY
- Copyright
- Contributors
- Chapter One: Transcriptional regulatory mechanisms and signaling networks in cancer
- Abstract
- 1 Introduction
- 2 Transcriptional mechanism
- 3 Trans-factors
- 4 Cis-elements
- 5 Genes and enhancer elements
- 6 Representative signaling pathways and cancer
- 7 Transcriptional factors
- 8 Tumor-suppressor genes
- 9 Concluding remarks
- Acknowledgment
- References
- Chapter Two: Identification of dysregulated canonical pathways associated with pathogenesis and progression of Amyotrophic Lateral Sclerosis—An integrated bioinformatics approach
- Abstract
- Abbreviations
- 1 Introduction
- 2 Methodology
- 3 Preliminary analysis and DEG identification
- 4 PPI network generation and network enrichment
- 5 Preliminary functional annotation
- 6 Pathway analysis and biomarker filter analysis
- 7 Results
- 8 PPI network maps generation and gene enrichment analysis
- 9 ClueGO preliminary functional analysis
- 10 Pathway enrichment analysis
- 11 Discussion
- 12 Conclusion
- References
- Chapter Three: Elucidating the mechanism of antimicrobial resistance in Mycobacterium tuberculosis using gene interaction networks
- Abstract
- 1 Introduction
- 2 Materials and methodology
- 3 Results and discussion
- 4 Conclusion
- References
- Further reading
- Chapter Four: A compilation of bioinformatic approaches to identify novel downstream targets for the detection and prophylaxis of cancer
- Abstract
- 1 Introduction
- 2 Comparison of gene expression profiles
- 3 Tools for single cell sequencing analysis
- 4 Gene enrichment analysis
- 5 Resource collection database
- 6 Protein-protein interaction analysis
- 7 Conclusion
- References
- Chapter Five: AURORA KINASE A and related downstream molecules: A potential network for cancer therapy
- Abstract
- Nomenclature
- 1 Introduction
- 2 Cell cycle regulation and cancer
- 3 Aurora kinase in cell cycle
- 4 Aurora kinase A interactome and cancer
- 5 AURKA and cancer signaling pathways
- 6 AURKA and cancer stem cells (CSCs)
- 7 AURKA and oncoproteins
- 8 AURKA and kinome rewiring
- 9 AURKA and tumor suppressor genes
- 10 Mechanism of action of AURKA in therapy-resistance cancer cells
- 11 Therapeutic intervention
- 12 Conclusion and future perspective
- References
- Chapter Six: Analysis of signaling cascades from myeloma cells treated with pristimerin
- Highlights
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- 5 Conclusions
- References
- Chapter Seven: Importin alpha family NAAT/IBB domain: Functions of a pleiotropic long chameleon sequence
- Abstract
- 1 Introduction
- 2 Sequential nuclear transport cycle
- 3 Function switching through interaction switching
- 4 Factors that raise or lower the probability of microscopic elementary processes
- 5 IBB as a long chameleon sequence
- 6 Towards a new interpretation paradigm of complex formation for downstream control
- 7 Conclusion
- Acknowledgements
- References
- Chapter Eight: Function, structure, evolution, regulation of a potent drug target, arylalkylamine N-acetyltransferase
- Abstract
- 1 Introduction
- 2 Physiological functions and regulation of VT-aaNAT
- 3 Physiological functions and regulation of insect aaNAT
- 4 Structural characteristics of the aaNATs
- 5 Evolutionary analysis of aaNAT
- 6 iaaNAT as a potential target for pest control
- References
- Chapter Nine: Mixed lineage kinase domain-like pseudokinase: Conventional (necroptosis) and unconventional (necroptosis-independent) functions and features
- Abstract
- 1 Introduction
- 2 Structure and functions of MLKL
- 3 MLKL modulators
- 4 Known mutations and dysregulated expression of MLKL in diseases
- 5 Conclusions
- References
- Further reading
- Chapter Ten: AMPK-like proteins and their function in female reproduction and gynecologic cancer
- Abstract
- 1 Introduction
- 2 LKB1
- 3 AMPK, a master cellular energy gauge: structure and function
- 4 Function of AMPK-like proteins in female reproduction
- 5 Function of AMPK-like proteins in gynecologic cancer
- 6 Conclusion
- References
- Further reading
- Chapter Eleven: Emerging role of heat shock proteins in cardiovascular diseases
- Abstract
- 1 Introduction
- 2 Heat shock proteins
- 3 Factors regulating the expression of HSPs
- 4 Role of heat shock proteins in cardiovascular and cardiometabolic diseases
- 5 Genetic variations in HSPs contribute to development of cardiovascular diseases
- 6 Conclusions and perspectives
- References
- Chapter Twelve: Protein phosphatases and their targets: Comprehending the interactions in plant signaling pathways
- Abstract
- 1 Introduction
- 2 Ser/Thr phosphatases
- 3 Protein tyrosine phosphatases
- 4 Conclusion and future perspective
- Acknowledgment
- References
- Chapter Thirteen: Calcium decoders and their targets: The holy alliance that regulate cellular responses in stress signaling
- Abstract
- 1 Introduction
- 2 Structural glance at Ca2+ sensor proteins and recent advancements in their identification in plants
- 3 Ca2+ decoding mechanism, conformational changes and different target regulation of Ca2+ sensor proteins in plants
- 4 Extreme temperature stress
- 5 Drought stress
- 6 Oxidative stress
- 7 Abscisic acid (ABA)
- 8 Auxin
- 9 Ethylene, Brassinosteroids (BR) and Gibberellic Acid (GA)
- 10 Conclusion and future perspective
- Acknowledgment
- References
- Further reading
- No. of pages: 456
- Language: English
- Edition: 1
- Volume: 134
- Published: March 2, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443131813
- eBook ISBN: 9780443131820
RD
Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.
Affiliations and expertise
Head of Research, MicroPharm Limited, UKRead Regulation of Downstream Targets on ScienceDirect