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Smart Nanomaterials to Combat the Spread of Viral Infections
Advanced Strategies for the Prevention of Viral Infections
- 1st Edition - March 4, 2023
- Editors: Raju Khan, Mohd. Abubakar Sadique
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 1 4 8 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 3 7 9 - 1
Smart Nanomaterials to Combat the Spread of Viral Infections comprises nanotechnology-based approaches with detailed preventive and treatment methodology for enabling their app… Read more
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Request a sales quoteSmart Nanomaterials to Combat the Spread of Viral Infections comprises nanotechnology-based approaches with detailed preventive and treatment methodology for enabling their application in antiviral systems. This book discusses the role of metal nanoparticles in the treatment of and prevention of viral infections and nanotechnology advancements in antiviral coatings to combat affected surfaces. It also covers the use of nanomaterials for the efficient intracellular delivery of antiviral agents to disinfect and treat viral infections. This is a timely coverage of how nanotechnologies and materials as well as the utilization of artificial intelligence and Internet of things–based smart nano-systems are used to control and manage viral infections during the COVID-19 pandemic. Advances in smart research and future antimicrobial applications round out the book.
This book provides a comprehensive overview of smart nanomaterials and advanced nano-system applications to researchers and academics in virology, microbiology, chemistry, material science, nanotechnology, and biotechnology as well as those in industries interested in their virucidal properties to prevent viral infections.
- Encompasses the novel synthesis of nanostructures and cost-effective nanosystems from functional hybrid materials with special emphasis on their effective virucidal properties being biocompatible and economic
- Examines mechanisms of advanced nanomaterials as effective virucidal agents in disinfectants, coatings, treatment, and preventive approaches
- Discusses possible advancements and upcoming smart research in antimicrobial applications
- Offers timely coverage of SARS-CoV-2 pandemic management strategies
Researchers and academics in virology, microbiology, chemistry, material science, nanotechnology, and biotechnology; industrialists involved in the research and development (R&D) of antimicrobial applications, virucidal agents, coatings, textiles, personal protective equipment, therapeutics, disinfectants, and preventive measures, Pharma-industrialists engaged in R & D on virucidal nanomaterials for their use in antiviral applications
1. Infectious diseases: overview, challenges, and perspectives
Roberto Vazquez-Munoz
1.1 Introduction to infectious diseases
1.2 Challenges
1.2.1 The rise of emerging multidrug-resistant germs
1.2.2 Infections and the environment
1.2.3 Sociocultural component of infections
1.2.4 Advances of science and technology to combat infections
1.3 Novel and alternative solutions to combat infectious diseases
1.3.1 New antimicrobial and antiviral drugs
1.3.2 Antimicrobial surfaces and coating
1.3.3 Drug repurposing
1.3.4 Nanotechnology
1.4 Nanotechnology against infectious diseases
1.4.1 Antimicrobial nanomaterials
1.4.2 Antiviral nanomaterials
1.5 Perspectives
1.6 Book outline
References
2. Viral structure and stability in various biotic and abiotic environments
Arif Jamal Siddiqui<, Ritu Singh<, Sadaf Jahan, Nawaf Alshammari, Andleeb Khan, Riadh Badraoui, Deepika Arora and Mohd Adnan
2.1 Introduction
2.2 Animal viruses
2.2.1 Adenovirus
2.3 Plant viruses
2.3.1 Tobacco mosaic virus
2.4 Bacterial viruses (bacteriophages)
2.5 Structure of viruses
2.5.1 Icosahedral (cubical) symmetry
2.5.2 Helical symmetry
2.5.3 Complex symmetry
2.5.4 Nonenveloped viruses
2.5.5 Enveloped viruses
2.5.6 Envelope glycoproteins
2.5.7 Other structural proteins in enveloped viruses
2.5.8 Nucleocapsid
2.5.9 Structure of other enveloped viruses with round nucleocapsids
2.5.10 Enveloped viruses with helical nucleocapsids
2.6 Coronaviridae
2.6.1 SARS-CoV-2
2.6.2 Life cycle and transmission
2.6.3 COVID-19 clinical characteristics and complications
2.6.4 Structural and nonstructural proteins and role in pathogenesis
2.7 Viruses’ stability in the environment
2.8 Abiotic factors
2.8.1 Air
2.8.2 Temperature
2.8.3 Relative humidity
2.8.4 Water
2.8.5 Solid surfaces
2.9 Biotic factors
2.9.1 Age
2.9.2 Sex and gender
2.9.3 Population density
2.9.4 Blood group
References
3. General preventive measures to control the transmission and COVID-19 pandemic management: a public outreach
Karunendra Singh, Jaibir Kherb and Bhanu Pratap Singh
3.1 Introduction
3.2 COVID-19 virus
3.3 Different modes by which COVID-19 virus is transmitted
3.4 Preparedness and response to COVID-19
3.5 Financial management for COVID-19 pandemic
3.6 Management for communication and support for getting people vaccinated
3.7 Diagnostics management in clinical science
3.8 Outreach activities for the control of COVID-19
3.8.1 Available vaccine for COVID-19
3.9 Methods to prevent COVID-19 transmission
3.10 Conclusion
3.11 Prospects
References
4. Virucidal activity of nanomaterials for the viruses: a SARS-CoV-2 case study
Priya Chauhan and Annu Pandey
4.1 Introduction
4.2 Structural morphology of SARS-CoV-2
4.3 The mechanistic approach to infection: SARS-CoV-2
4.4 Nano-based technology for viral infections
4.5 The role of nanotechnology in the detection of SARS-CoV-2
4.5.1 Testing of nucleic acid
4.5.2 Point-of-care testing
4.5.3 Electrochemical sensors
4.5.4 Chiral biosensors
4.6 Virucidal activity of nanoparticles
4.7 Antiviral potential role of nanomaterials against CoV
4.7.1 Gold nanoparticles
4.7.2 Silver nanoparticles
4.7.3 Polymer-based materials
4.7.4 Quantum dots
4.8 Nanotechnology-based therapeutic approaches
4.9 Technologies based on nanomaterials for the treatment of SARS-CoV-2
4.10 Conclusion
References
5. Role of metal nanoparticles for treatment of and prevention of viral infections
Emine Yavuz, Sami Dursun, Meryem Kara and Saliha Dinc
5.1 Introduction
5.2 Synthesis methods of antiviral metal nanoparticles
5.2.1 Physical methods
5.2.2 Chemical methods
5.2.3 Bioassisted methods
5.3 Antiviral applications of metal nanoparticles
5.3.1 Silver nanoparticles in antiviral applications
5.3.2 Gold nanoparticles in antiviral applications
5.3.3 Other metal nanoparticles in antiviral applications
5.4 Metal nanoparticlebased immune-mediated approaches against viral infections
5.4.1 AuNP-based nanovaccines
5.4.2 AgNP-based nanovaccines
5.4.3 Other metal nanoparticlebased nanovaccines
5.5 Conclusions and future aspects
References
6. Nanotechnology advancements in antiviral coatings to combat viral infection surfaces
Leticia Tessaro, Adriano Aquino, Ana Carolina de Morais Mirres and Carlos Adam Conte-Junior
6.1 Introduction
6.2 Nanomaterials in surface antiviral coatings
6.2.1 Metal nanoparticles
6.2.2 Polymers
6.2.3 Carbon-based nanomaterials
6.2.4 Nanofibers
6.2.5 Quantum dots
6.3 Self-cleaning surfaces
6.4 Conclusion
Acknowledgments
References
7. Surface-modified biomaterials as disinfectants to combat viral infections: a SARS-COV-2 case study
Caifeng Ren and Jiangong Liang
7.1 Introduction
7.2 SARS-CoV-2 and its transmission in the environment
7.2.1 Morphology and structure
7.2.2 SARS-CoV-2 replication mechanism and infection route
7.2.3 SARS-CoV-2 transmission in the environment
7.2.4 Role of biodisinfectants in inhibiting SARS-CoV-2
7.3 Functionalized biomaterial disinfection is a new strategy for antiviral infection
7.3.1 Polymer-functionalized biomaterials
7.3.2 Nanoparticle-functionalized biomaterials
7.4 Action mechanism for disinfectants based on surface-modified biomaterials
7.4.1 Direct interaction with S protein
7.4.2 Preventing the adsorption and invasion of viruses
7.4.3 Destroying the nucleic acid structure of the virus
7.5 Challenges and limitations of disinfectants based on surface-modified biomaterials
7.6 Summarization
Acknowledgments
References
8. Functional nanoparticles as novel emerging antiviral therapeutic agents
S. Uday, Bikash Chandra Jha, Deepshikha Gupta, Rajeev Gupta and Tejendra K. Gupta
8.1 Introduction
8.2 Functional nanoparticles used as antiviral therapeutic agents
8.2.1 Silver nanoparticles
8.2.2 Carbon-based nanomaterials
8.2.3 Gold nanoparticles
8.2.4 Polymers and dendrimers
8.2.5 Intermetallic nanoparticles
8.3 Surface modifications of nanocarriers
8.4 Applications of nanoparticles for antiviral actions
8.4.1 Application in COVID-19 virus
8.4.2 Application of silver nanoparticles against some deadly viruses
8.4.3 Antiviral activity of iron oxide nanoparticles in H1N1 influenza A virus
8.4.4 Application of nanoparticles as antiviral agents against adenoviruses
8.5 Antiviral mechanisms of nanoparticles
8.6 Limitations and conclusion
Acknowledgment
References
9. Potential of graphene-modified nanostructures for multifunctional personal protective clothing
Shovon Bhattacharjee, Rajib Chandra Das, Susmita Mondal, Md. Shafiul Islam and C. Raina MacIntyre
9.1 Introduction
9.2 Graphene and graphene derivatives
9.3 Properties of graphene and derivatives relevant to protective clothing
9.3.1 Mechanical properties
9.3.2 Thermal conductivity
9.3.3 Chemical activity
9.3.4 Flame retardancy
9.3.5 Electrical conductivity
9.3.6 Antimicrobial properties
9.3.7 Tribological behavior
9.4 Fabrication techniques of graphene-modified textile composites
9.4.1 In situ polymerization
9.4.2 Solution mixing
9.4.3 Melt compounding
9.5 Common graphene-modified textile composites
9.5.1 Polyester/graphene composites
9.5.2 Polyamide/graphene composites
9.5.3 Cotton/graphene composite
9.5.4 Silk/graphene and wool/graphene composites
9.5.5 Miscellaneous composites
9.6 Application of graphene-modified textile in personal protective equipment
9.6.1 Graphene textile-made personal protective equipment for pandemic control
9.6.2 Graphene textile for ultraviolet radiation protection
9.6.3 Ballistic application of graphene-modified textile in personal protective equipment
9.6.4 Miscellaneous application of graphene textile as personal protective equipment
9.7 Challenges
9.8 Conclusion
References
10. Role of nanocomposites for the prevention and treatment of viral infections in the health care system
Lakshmi Kanth Kotarkonda, Tej Prakash Sinha, Sanjeev Bhoi and Subhashini Bharathala
10.1 Introduction
10.2 Types of nanocomposites
10.2.1 Nonpolymeric nanocomposites
10.2.2 Polymeric nanocomposites
10.2.3 Biocomposites
10.3 Nanocomposites for the prevention of viral infections
10.3.1 Vaccines
10.3.2 Antiviral coatings
10.3.3 Masks and personal protective equipment
10.3.4 Nanosensors
10.3.5 Disinfection and sterilization
10.3.6 Molecularly imprinted polymers
10.4 Nanocomposites for treatment of viral infections
10.4.1 Replication inhibitors
10.4.2 Virus membrane inhibitors
10.4.3 Surface-functionalized nanocomposites
10.4.4 Nanocomposites coated with cell membranes
10.4.5 Antiviral nanomedicines
10.5 Antiviral mechanisms of nanocomposites
10.6 Applications of nanocomposites
10.6.1 Coronavirus (SARS-CoV-2)
10.6.2 Influenza virus
10.6.3 Human immunodeficiency virus
10.6.4 Hepatitis B virus
10.6.5 Herpes simplex virus
10.6.6 Hepatitis C virus
10.6.7 Human papillomavirus
10.7 Conclusion
References
11. Role of copper nanostructures in household and clinical settings: past to present outlook
Nishant Verma and Siddhartha Panda
11.1 Introduction
11.2 Fabrication process
11.3 Growth mechanism
11.4 Application of copper nanostructures
11.4.1 Nanofertilizers and nanopesticides
11.4.2 Antimicrobial agents
11.4.3 Medical sensors
11.4.4 Nanomedicine
11.4.5 Wastewater treatment
11.5 Conclusion
References
12. Recent advances in antiviral coatings on facemasks during the COVID-19 pandemic
Paresh Kumar Samantaray
12.1 Introduction
12.2 Contact-based antivirals
12.2.1 Metal and its oxides
12.2.2 Carbonaceous nanomaterials
12.2.3 Synthetic antivirals
12.2.4 Natural antivirals
12.2.5 Natural and synthetic coating polymer-based antivirals
12.3 Photocatalytic and photothermal antivirals
12.4 Current developments in antiviral masks
12.5 Conclusion and future outlook
References
13. Nanotechnology and materials science help fight against SARS-CoV-2
Sachin Mishra, Cansu Ilke Kuru and Fulden Ulucan-Karnak
13.1 Introduction
13.1.1 Economical perspective of COVID-19 for world economy
13.1.2 Information about SARS-CoV-2
13.2 Nanotechnology and material-based strategies to combat SARS-CoV-2
13.2.1 Surface disinfection and coatings
13.2.2 Disease diagnosis
13.2.3 Nucleic acid detection technology
13.2.4 Computed tomography scans
13.2.5 Nanotechnology-based sensors
13.3 Nanotechnology formulation aspects and their biomedical application
13.3.1 Drug carrier systems
13.3.2 Vaccines
13.4 Conclusions
References
14. Inorganicorganic hybrid capsules for efficient intracellular delivery of antiviral agents to disinfect and treat virus infections
Deepshikha Shahdeo and Sonu Gandhi
14.1 Introduction
14.2 Different organic and nonorganic nanoparticles
14.2.1 Organic nanomaterials
14.2.2 Inorganic nanomaterials
14.3 Antiviral theranostics developed from organic and inorganic nanohybrids
14.3.1 Influenza virus
14.3.2 Adenoviruses
14.3.3 Dengue virus
14.3.4 Herpes simplex virus
14.3.5 Hepatitis
14.3.6 Coronavirus
14.4 Future perspective
14.5 Conclusion
Acknowledgments
Conflicts of interest
References
15. Utilization of AI and IoT-based smart nanosystems for the control and management of COVID-19 pandemic
Gagan Kant Tripathi, Priyavand Bundela, Ambikesh Soni and Priyanka Dixit
15.1 Introduction
15.2 What is artificial intelligence
15.2.1 AI 1 IoT
15.2.2 Detection and diagnosis of COVID-19 using AI and IoT approaches
15.2.3 AI and IoT applications in COVID-19
15.2.4 Important role of AI and IoT in COVID-19
15.2.5 Challenges facing AI in IoT
15.3 Advanced nanosystems for diagnostic and therapeutic applications toward COVID-19
15.3.1 The causes of the second wave of COVID-19 as well as a strategy for preventing the third wave
15.3.2 Protocol fatigue
15.3.3 Mixed signal from the government
15.3.4 Urban mobility
15.3.5 Containment zones
15.3.6 Mutations
15.3.7 Increased testing
15.3.8 Asymptomatic persons
15.3.9 Inadequate health infrastructure
15.4 Meaning of wave at the time of pandemic
15.4.1 Reason for the occurrence of the waves
15.4.2 Global level situation of COVID-19 and application of AI and IoT and measures to control the pandemic
15.4.3 How to win the battle against COVID-19
15.5 Challenges and overcoming challenges
15.6 Conclusion
References
16. Potential socioeconomic approaches for commercialized antimicrobial applications
Priyanka Jangra, Geetanjali Negi, Anurag Sharma and Nagma Parveen
16.1 Introduction
16.2 Types of nanotechnology-based antivirals and antimicrobials
16.2.1 Self-cleaning superhydrophobic surfaces
16.2.2 Polymers with quaternary ammonium group as coating agents
16.2.3 Metal nanoparticle-coated surfaces
16.2.4 Light-induced surfaces for virus inactivation
16.2.5 Surface coating with antimicrobial peptides
16.2.6 Graphene derivatives as surface coatings
16.3 Effectiveness of the antiviral materials/coatings
16.3.1 Self-cleaning superhydrophobic surfaces
16.3.2 Polymeric coatings
16.3.3 Metal nanoparticle-coated surfaces
16.3.4 Light-induced surfaces
16.3.5 Antimicrobial peptides and their surface coatings
16.3.6 Graphene oxide derivatives and their surface coatings
16.4 Applications of the nanotechnology-based antiviral and antimicrobial materials and coatings: a socioeconomic perspective
16.4.1 Products in the market
16.4.2 Products in the pipeline and potential for commercialization
16.4.3 Challenges for the commercialization
16.5 Physiosocial and economic impacts of the nanotechnology-based antiviral and antimicrobial applications
16.5.1 Positive impacts
16.5.2 Negative impacts
16.6 Summary
References
- No. of pages: 448
- Language: English
- Edition: 1
- Published: March 4, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323991483
- eBook ISBN: 9780323993791
RK
Raju Khan
Raju Khan is a Senior Principal Scientist and Professor, at CSIR-Advanced Materials and Processes Research Institute, Bhopal. He did his PhD in Chemistry in 2005 from Jamia Millia Islamia, Central University, New Delhi, and Postdoctoral researcher at the “Sensor Research Laboratory” University of the Western Cape, Cape Town. His current research involved synthesizing novel materials to fabricate electrochemical and fluorescence-based biosensors integrated with microfluidics to detect target disease risk biomarkers for health care monitoring. He has published over 150 papers in SCI journal, which attracted over 5500 citations as per Google Scholar, published 45 book chapters in the reputed book Elsevier and Taylor Francis, editing of 28 books from Elsevier and Taylor Francis, and his research has been highlighted in Nature India. He has supervised 5 PhD and 30 undergraduate/postgraduate theses and has supervised 4 numbers of postdoctoral fellows under the scheme of N-PDF, CSIR-Nehru Fellowship, and DST-Women Scientist Projects.
Affiliations and expertise
Senior Principal Scientist & Professor, CSIR-Advanced Materials & Processes Research Institute, Bhopal, Madhya Pradesh, IndiaMS
Mohd. Abubakar Sadique
Mohd. Abubakar Sadique is a Ph.D. research scholar under the supervision of Dr. Raju Khan at CSIR-AMPRI, Bhopal. India. He has worked as a Senior Project Fellow at CSIR-CEERI, Pilani, Rajasthan, India, on a mission-mode project titled "Design and Fabrication of a Microfluidic-Based Bio-Sensor for Biochemical Detection." His recent research includes the use of nanotechnology for healthcare applications. Mr. Sadique’s research interests include green synthesis, electrochemical studies of nanomaterials, their characterization, and their healthcare applications. Mr. Sadique has a particular interest in carbon-based nanostructures for their effectiveness in the purview of bio-sensing, diagnostics, therapeutics, and healthcare applications. He has been associated with various research and development projects funded by different agencies, which include the Department of Science and Technology and the Council of Scientific and Industrial Research (CSIR), India. Mr. Sadique has published several review and research articles, three books edited, and numerous book chapters during his brief research tenure.
Affiliations and expertise
Junior Research Fellow, CSIR-Advanced Materials and Processes Research Institute, Bhopal, Madhya Pradesh, IndiaRead Smart Nanomaterials to Combat the Spread of Viral Infections on ScienceDirect