Natural Products in Vector-Borne Disease Management

1st Edition - March 2, 2023
Imprint: Academic Press
Editors: Nagendra Singh Chauhan, Durgesh Nandini Chauhan
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 9 4 2 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 2 9 0 - 7

Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the globa… Read more

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Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis.

With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Foreword
Preface
Chapter 1: Potentials of natural products in vector-borne diseases management: Current and future perspectives
Abstract
Introduction
Vector-borne disease and its management
Natural products
Mechanism of action of phytochemicals in target insect body
Epidemiology
WHO guidelines for vector-borne diseases
Future prospects
Current trends, opportunities, and knowledge gaps in vector-borne diseases management with botanical products
Conclusion
References
Chapter 2: Evidence-based review of medicinal plants for the management of onchocerciasis
Abstract
Introduction
Plants used for treating onchocerciasis
Conclusion
References
Chapter 3: Plant-derived compounds as potential treatment for arboviruses
Abstract
Introduction
Alphaviruses
Flaviviruses
Plant-derived antivirals against arboviruses infections
References
Chapter 4: Natural products in the management of onchocerciasis
Abstract
Introduction
Conventional drugs for onchocerciasis and their resistance
Secondary plant metabolites with antionchocerca activity
Pure natural products with antionchocerca activity
Safety and toxicity profiles of the natural products agents
Mode of action of natural plant products
Inhibit polymerization of structural protein
Disturb membrane fluidity
Conclusion
References
Chapter 5: Combating the vectors and management of vector-borne diseases with essential oil nanoemulsions
Abstract
Introduction
What is vector?
Essential oils
Nanoemulsion
Concluding remarks
References
Chapter 6: Natural product for management of babesiosis
Abstract
Conflict of interest
Introduction
Clinical information on babesiosis
Role of natural products in management of babesiosis
Conclusion
References
Further reading
Chapter 7: Antimicrobial peptides, nanocarrier systems, and databases: Therapeutic platform against leishmaniasis
Abstract
Introduction
Global leishmaniasis surveillance: WHO report
Currently available leishmaniasis drugs
Antimicrobial peptides: An overview
AMPs as antileishmanial agents
Nanotechnology-based treatment of leishmaniasis
Databases toward developing new antileishmanial drugs
Conclusions and future perspective
References
Chapter 8: Marine organisms as natural drug leads in combating vector-borne diseases
Abstract
Introduction
Shedding the light on leishmaniasis
Seaweeds (macro-algae) with promising antileishmanial activity
Marine invertebrates with a promising antileishmanial activity
Shedding the light on malaria
Marine organisms with promising antimalarial activity
Shedding the light on trypanosomiasis
Marine organisms with promising antitrypanosomal activity
References
Chapter 9: Plant and marine-derived antimalarial agents
Abstract
Introduction
Experiments to assess antimalarial activities of various agents
Mechanisms of action (MOA) proposed for isolated antimalarial compounds from natural products
Overview of numerous plant and marine-derived antimalarial agents
Natural products with malaria transmission blocking activity
Concluding remarks
References
Chapter 10: Natural products in the management of schistosomiasis
Abstract
Introduction
Schistosoma life cycle
Pathophysiology
Current treatment
Conclusion
References
Further reading
Chapter 11: An update on antileishmanial agents from natural resources
Abstract
Introduction
Life cycle
Conclusion
References
Chapter 12: Plants with antidengue properties: A systematic review
Abstract
Introduction
Plant species used to treat dengue
Conclusion
References
Chapter 13: Natural products in Japanese encephalitis
Abstract
Introduction
Plant extracts in vector control
Isolated phytochemicals in vector control
Antiviral activity of plant-derived agents and their mechanism of action
Conclusion
References
Chapter 14: Algae natural products for potential vector-borne disease management
Abstract
Introduction
Vector-borne diseases characterization and context
Algae importance
Algae-derived agents against VBD
Alga-based extracts and fractions
Alga-based vaccine strategies
Alga-based larvicidal strategy
Challenges and perspectives
References
Chapter 15: Natural products in the management of trypanosomiasis
Abstract
Conflict of interest
Acknowledgment
Introduction
About trypanosomiasis
Epidemiology
Current therapeutic approaches and associated challenges
Natural products in the management of trypanosomiasis
Marine sources
Patents
Mode of actions
Conclusion
References
Further reading
Chapter 16: Concept of vector-borne diseases in Ayurveda: A review
Abstract
Introduction
Conclusion
References
Chapter 17: Medically important vector-borne disease control through seaweeds against the chikungunya
Abstract
Acknowledgments
Vector-borne disease
Mosquito-borne diseases
Chikungunya
Vector-borne disease control
Vector control
Natural products
Seaweed
References
Chapter 18: Nanobiomaterials as novel modules in the delivery of artemisinin and its derivatives for effective management of malaria
Abstract
Introduction
ARTM derivatives
ARTM and derivatives: Pharmacokinetics
Delivery systems loaded with ARTM and its derivatives
Conclusions
References
Chapter 19: Scientific and ethnopharmacological evidence of Carica papaya for the effective management of vector-borne disease
Abstract
Introduction
Ethnomedical considerations
Pharmacognostical character
Phytochemistry
Medicinal use of Carica papaya Linn. in vector-borne diseases
Conclusion
References
Further reading
Chapter 20: Nanoemulsion as a promising carrier of plant-derived repellents for mosquito-borne malaria control: Nanotechnology aspects
Abstract
Introduction
Mosquito repellents for malaria prevention
Controlled release nanotechnology
Nanoemulsion as carrier of essential oils (EOs)
Characterization of nanoemulsions
Stability of the nanoemulsion
Application of nanoemulsion in malaria control
Conclusions and recommendations
References
Chapter 21: Insect repellent plants: A recent update
Abstract
Acknowledgment
Introduction
Alkaloids
Terpenoids
Saponins
Essential oils
Conclusion
References
Chapter 22: Natural products employed in the management of malaria
Abstract
Acknowledgment
Introduction
First-generation natural products against malaria
Exploration of antiplasmodial drugs: Discovery of diverse pharmacophores
Conclusion
References
Index

Nagendra Singh Chauhan

Dr. Nagendra Singh Chauhan obtained his MPharm and PhD from the Department of Pharmaceutical Sciences at Dr. Harisingh Gour University in Sagar, India. He has about 15 years of research experience and has professional expertise in natural product isolation. He is presently working as a senior scientific officer grade-II and government analyst at Drugs Testing Laboratory Avam Anusandhan Kendra, Raipur, Chhattisgarh, India. He has written more than 65 articles and 24 book chapters and has edited 4 books with publishers like Academic Press, CRC, and Wiley. He is a member of various professional and academic bodies like the Society of Pharmacognosy, International Natural Product Sciences Taskforce (INPST), Società Italo-Latinoamericana di Etnomedicina (SILAE), Institutional Human Ethics Committee, and Association of Pharmaceutical Teachers of India (APTI).

Affiliations and expertise

Senior Scientific Officer Grade-II and Government Analyst, Drugs Testing Laboratory avam Anusandhan Kendra Raipur, India

Durgesh Nandini Chauhan

Durgesh Nandini Chauhan is presently working as an assistant professor at the Columbia Institute of Pharmacy, Raipur, Chhattisgarh, India. Mrs. Durgesh Nandini Chauhan has 15 years of academic (teaching) experience in pharmaceutical sciences at various institutes in India. She has taught subjects such as pharmaceutics, pharmacognosy, traditional concepts of medicinal plants, and drug delivery phytochemistry. She is a member of the Association of Pharmaceutical Teachers of India (APTI) and Società Italo-Latinoamericana di Etnomedicina (SILAE). She has written more than 10 publications in national and international journals and 15 book chapters and has edited 9 books. She is also active as a reviewer for several international scientific journals and an active participant in national and international conferences such as the International Convention of Society of Pharmacognosy.

Affiliations and expertise

Assistant Professor, Columbia Institute of Pharmacy, Raipur, Chhattisgarh, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health