Conceptual Development of Industrial Biotechnology for Commercial Production of Vaccines and Biopharmaceuticals
- 1st Edition - March 9, 2023
- Latest edition
- Author: Basanta Kumara Behera
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 7 4 8 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 7 4 9 - 0
Conceptual Development of Industrial Biotechnology for Commercial Production of Biopharmaceuticals and Vaccines provides insights on how to bring sustainability into biologic… Read more
Conceptual Development of Industrial Biotechnology for Commercial Production of Biopharmaceuticals and Vaccines provides insights on how to bring sustainability into biologic drug production. The cumulative facts and figures within in the book are helpful to promoters in monitoring value chain transfer process of super quality biologics for better return in profits. In addition, this is a useful reference for students, researchers and scientists in biotechnology, pharmaceutical science, medical sciences, and the R&D division of biotechnology-based industries. Conceptual development of biotechnology has taken new avenues with the integration of medical sciences, physical science, and engineering, hence this is a timely source.
The current global market for vaccines, especially COVID-19, is tremendous. Bivalent oral polio vaccine, diphtheria, tetanus-containing, and measles-containing vaccines have a high demand internationally and recombinant DNA technology and protein engineering are helpful in the production of quality bio-products.
- Informs how biotechnology and pharmaceutical industries act as central pillars for the stable production of value-added biological drugs and vaccines from genetically engineered suitable vectors like microbe or cell lines from animals, mammals or plants
- Highlights various traditional and modern techniques used for improvising the quality of suitable vectors to produce biologic drugs and vaccines under GMP manufacturing facilities
- Provides updated information on the latest microchip-based bioreactors, disposable bag bioreactors, and animal systems as bioreactors to produce biologic drugs like Smart Biomolecules (next generation therapeutics), Bio-similar drugs, Bio-betters, and antibody-drug conjugates
- Explains how the closed bioreactors with proper mechanical amendments are used for vaccine production
students and research in biotechnology, pharmaceutical sciences, medical sciences, biochemical engineering who want to get into depth in the subject and its future prospective to develop biotechnology-based start-up, as an entrepreneur or working in the front-line in biotechnology industries
business communities in biotechnology-based industry for biologic drugs and vaccines production and marketing. Administrators and decision-making bodies to understand the future prospects of biotechnology by going through the global demand of biological drugs in the international market and it value related to GDP of a specific nation.
business communities in biotechnology-based industry for biologic drugs and vaccines production and marketing. Administrators and decision-making bodies to understand the future prospects of biotechnology by going through the global demand of biological drugs in the international market and it value related to GDP of a specific nation.
1. From conical flax to industrial bioreactor
1.1 Product survey and design
1.2 Milligram level Product development and conformation
1.3 Gram level product at pilot plant level
1.4 Possible problem and remediation
1.5 Turnkey level production
1.6 Product quality analysis and control
1.7 Product packing, storage and marketing
2. Product Process Initiations
2.1 History of microbial process
2.2 Microbial and cell line process economies
2.2.1 Economic evaluation of microbial process
2.2.2 Overall capital expenses
2.2.3 Global market for biologic drugs and vaccines
3. Biological vectors Screening and Selection
3.1 Microbes, insects and cell lines
3.2Microbe screening and collection
3.2.1Cell line isolation
3. 2.2 Insect screening and collection
3.2.3 Preservation
3.3 Different vectors used for vaccines
3.3.1 Viral vector-based vaccines
3.3.2 Bacterial expression vectors
3.3.3 Types of vaccine
3.1.4 Methodology
3.1.5 Cell bank development and operation
4. Microbe or Cell line Quality Improvement
4.1Microbe quality improvement
4.2Nutrient enrich culture
4.3Chemical mutation
4.4 Physical mutation
4.5 Recombination DNA technology
4.6 Molecular docking for product quality
Rigeo-specific glycosylation for in vivo product solubility
Bacteria and Virus modification for vaccine production
5. Development Strategies for New Product
5.1 Microbial product developments
5.2Why develop new product
5.3 How to launch a new bioproduct
5.4 Speed-to-market further product improvement
5.5 Campaign and market capturing
6. Livestock Screening, Storage and Utilization
6.1 Livestock for culture broth
6.2 Quality livestock survey and screening
6.3 Livestock storage
6.4 Livestock for microbes
6.5 Livestock for animal cell culture
6.6 Livestock for insects
6.7 Livestock for Vaccine preparing vectors
7. Microbe and cell line culture methods
7.1 Microbe and cell line culture and propagation
7.2 Microbe culture
7.3 Plant cell culture
7.4 Animal and human cell line development and propagation
7.5 Insect cell culture and propagation
7.6 Stem Cell culture
7.7 Vaccine vector culture
7.8 Preparation
7.9 Broth composition
8. Sterilization processes of bioreactor and accessories.
8.1 Sterilization
8.2 Medium sterilization
8.3 Sterilization of glass wares
8.4 Bioreactor Sterilization process
8.5 Input of sterilized oxygen/inert gas
9. Type of bioreactor
9.1 Continuous Stirred Tank bioreactor vs Perfusion Bioreactor
9.2 Bubble column bioreactor
9.3 Airlift bioreactor
9.4 Fluidized bed bioreactor
9.5 Packed bed bioreactor
9.6 Photo-bioreactor
9.7 Disposable bioreactor (bag bioreactor)
9.8 Animal bioreactor
9.9 Perfusion Bioreactor
10. Material balances
10.1 Concept
10.2 Basic principle of thermodynamic and fermentation process
10.2.1 Batch process
10.2.2 Semi batch or Semi continuous process
10.2.3 Fed-batch process
10.2.4 Continuous process
1.1 Product survey and design
1.2 Milligram level Product development and conformation
1.3 Gram level product at pilot plant level
1.4 Possible problem and remediation
1.5 Turnkey level production
1.6 Product quality analysis and control
1.7 Product packing, storage and marketing
2. Product Process Initiations
2.1 History of microbial process
2.2 Microbial and cell line process economies
2.2.1 Economic evaluation of microbial process
2.2.2 Overall capital expenses
2.2.3 Global market for biologic drugs and vaccines
3. Biological vectors Screening and Selection
3.1 Microbes, insects and cell lines
3.2Microbe screening and collection
3.2.1Cell line isolation
3. 2.2 Insect screening and collection
3.2.3 Preservation
3.3 Different vectors used for vaccines
3.3.1 Viral vector-based vaccines
3.3.2 Bacterial expression vectors
3.3.3 Types of vaccine
3.1.4 Methodology
3.1.5 Cell bank development and operation
4. Microbe or Cell line Quality Improvement
4.1Microbe quality improvement
4.2Nutrient enrich culture
4.3Chemical mutation
4.4 Physical mutation
4.5 Recombination DNA technology
4.6 Molecular docking for product quality
Rigeo-specific glycosylation for in vivo product solubility
Bacteria and Virus modification for vaccine production
5. Development Strategies for New Product
5.1 Microbial product developments
5.2Why develop new product
5.3 How to launch a new bioproduct
5.4 Speed-to-market further product improvement
5.5 Campaign and market capturing
6. Livestock Screening, Storage and Utilization
6.1 Livestock for culture broth
6.2 Quality livestock survey and screening
6.3 Livestock storage
6.4 Livestock for microbes
6.5 Livestock for animal cell culture
6.6 Livestock for insects
6.7 Livestock for Vaccine preparing vectors
7. Microbe and cell line culture methods
7.1 Microbe and cell line culture and propagation
7.2 Microbe culture
7.3 Plant cell culture
7.4 Animal and human cell line development and propagation
7.5 Insect cell culture and propagation
7.6 Stem Cell culture
7.7 Vaccine vector culture
7.8 Preparation
7.9 Broth composition
8. Sterilization processes of bioreactor and accessories.
8.1 Sterilization
8.2 Medium sterilization
8.3 Sterilization of glass wares
8.4 Bioreactor Sterilization process
8.5 Input of sterilized oxygen/inert gas
9. Type of bioreactor
9.1 Continuous Stirred Tank bioreactor vs Perfusion Bioreactor
9.2 Bubble column bioreactor
9.3 Airlift bioreactor
9.4 Fluidized bed bioreactor
9.5 Packed bed bioreactor
9.6 Photo-bioreactor
9.7 Disposable bioreactor (bag bioreactor)
9.8 Animal bioreactor
9.9 Perfusion Bioreactor
10. Material balances
10.1 Concept
10.2 Basic principle of thermodynamic and fermentation process
10.2.1 Batch process
10.2.2 Semi batch or Semi continuous process
10.2.3 Fed-batch process
10.2.4 Continuous process
- Edition: 1
- Latest edition
- Published: March 9, 2023
- Language: English
BB
Basanta Kumara Behera
Dr. Basanta Kumara Behera was a Professor of Biotechnology at three distinguished Indian universities, where he taught and conducted research at the post-graduate level on medical biotechnology, biopharmaceutical, microbial process development, drug designing, bio-energy management, and biomass processing technology since 1978. In 2009, he joined an MNC company as an advisor for specialty chemicals production and drug design through microbial process technology. He is associated with national and international companies as a technical advisor to produce biopharmaceuticals under cGMP norms. Dr. Behera has authored and edited books with various publishers worldwide.
Affiliations and expertise
Former Director, Advanced Center for Biotechnology, Maharshi Dayanand University, Rohtak, Haryana, IndiaRead Conceptual Development of Industrial Biotechnology for Commercial Production of Vaccines and Biopharmaceuticals on ScienceDirect