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Medicinal Chemistry of Chemotherapeutic Agents

A Comprehensive Resource of Anti-infective and Anti-cancer Drugs

  • 1st Edition - March 9, 2023
  • Latest edition
  • Editors: Pratap Chandra Acharya, Michio Kurosu
  • Language: English

Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved… Read more

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Description

Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure–activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any.

This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents.

Key features

  • Includes current research focused on drug resistance and methods to overcome problems
  • Outlines synthetic schemes and metabolic pathways of chemotherapeutic agents
  • Discusses molecules under clinical trials and newly approved drugs

Readership

Pharmaceutical and medicinal chemists working in the pharmaceutical industry and academia

Table of contents

1. Introduction to Chemotherapy: General and Clinical Considerations

Section A. ANTIMICROBIAL AGENTS
Unit I Antibacterial Agents

2. Sulfonamides, Quinolones, Antiseptics and Disinfectants
Unit II Antibacterial Antibiotics

3. Beta-Lactam Antibiotics: Penicillins, Cephalosporins, Monobactams, Carbapenems and Beta-lactamase Inhibitors

4. Tetracyclines and Chloramphenicol

5. Aminoglycoside Antibiotics

6. Macrolide, Lincosamide, Glycopeptide and Other Antibacterial Antibiotics
Unit III Antimycobacterial Agents

7. Antitubercular Drugs

8. Antileprotic Drugs
Unit IV Antifungal Agents

9. Topical and Systemic Antifungal Drugs
Unit V Antiviral Agents

10. Antiviral Drugs and Vaccines
Unit VI Antiprotozoal Agents

11. Antimalarial Drugs

12. Antiamoebic Drugs

13. Drugs for Giardiasis, Trichomoniasis and Leishmaniasis
UNIT VII Anthelmintics

14. Vermifuge and Vermicide Drugs

Section B ANTINEOPLASTIC AGENTS

15. Synthetic Cytotoxic Drugs as Cancer Chemotherapeutic Agents

16. Naturally Occurring Anticancer Cytotoxic Drugs

17. Hormones and Antihormones in Cancer Chemotherapy

18. Biologicals and Small Molecules as Target Specific Cancer Chemotherapeutic Agents

Review quotes

“...covers the wide body of medicinal chemistry behind modern anti-infective and anti-neoplastic agents in an engaging manner. Each chapter opens with a well-written exposition on the history, relevance, and current issues at play in the drug category before delving deep into synthesis, general structure, structure-activity relationship (SAR), natural origins, synthetic derivatives, and ongoing research. The book makes intelligent and logical use of figures and tables to organize and illustrate the information,…[with] a level of depth appropriate for its complexity. [A] worthwhile addition....[that] exquisitely details the mechanism of action, synthesis, SAR, and relation to the modern world for each drug category…[with] additional pearls on relevant disease pathophysiology or evolution of agent resistance throughout…. [A] useful book for multiple disciplines, including the larger range of researchers and health professionals who work directly with infectious or malignant diseases.” —©Doody’s Review Service, 2023, Forrest N Ridgway, PharmD (Temple University Health System)

Product details

  • Edition: 1
  • Latest edition
  • Published: March 9, 2023
  • Language: English

About the editors

PA

Pratap Chandra Acharya

Dr Pratap Chandra Acharya is presently working as Assistant Professor of Pharmaceutical Chemistry at the Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura (W) India. He received his PhD in Pharmaceutical Chemistry from Panjab University, Chandigarh and M.Pharm (Pharmaceutical Chemistry) from IIT (BHU), Varanasi, India. He has more than 10 years of teaching and research experience in the field of pharmaceutical chemistry. He has been the member of various learned academic bodies such as IUPAC and APTI and has served as a reviewer to several international journals. His current research work involves various drug discovery projects for the development of anticancer drug candidates especially for colon cancer.
Affiliations and expertise
Assistant Professor, Pharmaceutical Chemistry at the Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura (W), India

MK

Michio Kurosu

Michio Kurosu has completed his Ph.D. from Osaka University, Japan and postdoctoral studies from Harvard University, Chemistry and Chemical Biology. He is a Professor of Pharmaceutical Science at University of Tennessee Health Science Center (UTHSC), USA. He has been teaching medicinal chemistry courses for pharmacy and Ph. D. students at UTHSC. He has a long-term interest in identifying new drug targets for bacterial infections and cancer chemotherapeutics. His research includes antibacterial and anticancer drug discoveries associated with Gram-negative bacteria, Mycobacterium spp., spore-forming bacteria (e.g. Clostridioides difficile), and solid cancers (e.g., pancreatic, breast, and ovarian cancers). As principal investigator on several NIH- and internally-funded programs, he has studied essential enzymes for growth of Acinetobacter baumannii, Klebsiella pneumoniae, and Mycobacterium tuberculosis, and glycosyl transferases for pancreatic and cervical cancers. He has been serving as editorial board members of several international journals and scientific reviewers of the NIH study sections.
Affiliations and expertise
Professor, Pharmaceutical Science, University of Tennessee Health Science Center (UTHSC), USA

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