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Books in Life sciences

BooksJournals

  • Opioids

    • 1st Edition
    • Volume 4
    • George F. Koob + 3 more
    • English
    A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/antici...

  • Pancreatic Cancer: Basic Mechanisms and Therapies

    • 1st Edition
    • Volume 159
    • English
    Pancreatic Cancer: Basic Mechanisms and Therapies, Volume 159 in the Advances in Cancer Research, presents the latest release in this ongoing, well-regarded serial with invaluable information on the exciting and fast-moving field of cancer research. Pancreatic cancer (PC) is the third leading cause of cancer-related deaths in the United States. Greater than 90% PCs are Pancreatic ductal adenocarcinomas (PDAC) which have a dismal estimated 5-year overall survival of only 11%. PDAC is predicted to become the second leading cause of mortality in the United States by 2030. In the clinic, the PDAC patients often present with incurable disease at the time of first diagnosis. This cancer is particularly lethal because of its propensity to spread quickly to distant organs including the lymphatic system. PDAC metastasis occurs shortly after tumor initiation and is caused by a complex interaction between autonomous tumor cells and cellular elements of the tumor microenvironment. Although PDAC remains a challenging disease to treat and a leading cause of cancer-related deaths, progress is being made in disease etiology and pathogenesis, and intensive research is focused on developing optimal treatment approaches for patients. Considering the continuous progress being made in understanding PDAC pathogenesis and designing new therapies, it was considered timely to develop an up-to-date thematic issue of Advances in Cancer Research (ACR) focused on PDAC. In this thematic issue, we have included ten review articles by experts that cover cancer disparities, PDAC pathobiology, the roles of the tumor microenvironment, tumor heterogeneity, PC stem cells, genetic and signaling events critical for PDAC pathogenesis, Immunotherapy and chemoresistance in PDAC, and different PDAC mouse models. This special issue highlights recent research progress in PDAC, which bridges the gap between basic and clinical research.

  • Mitochondria and Bacterial Pathogens - Part B

    • 1st Edition
    • Volume 377
    • English
    Mitochondria and Bacterial Pathogens, Part B, Volume 375 discusses different pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells. Chapters in this new release include Interaction between host cell mitochondria and Coxiella Burnetii, Control of mitochondrial functions by Pseudomonas aeruginosa in cystic fibrosis, Mitochondrial and bacterial ATP synthase: Structural similarities and divergences to exploit in the battle against M. tuberculosis, Role of mitochondria in the enteropathogenic Escherichia coli disease, Mitochondria dynamics and antibiotic resistance, and more.

  • Accelerating Strategic Changes for Digital Transformation in the Healthcare Industry

    • 1st Edition
    • Patricia Ordonez de Pablos + 1 more
    • English
    Accelerating Strategic Changes for Digital Transformation in the Healthcare Industry discusses innovative conceptual frameworks, tools and solutions to tackle the challenges of mitigating major disruption caused by COVID-19 in the healthcare sector and society. It emphasizes global case studies and empirical studies, providing a comprehensive view of best lessons on digital tools to manage the health crisis. The book focuses on the role of advances in digital and collaborative technologies to offer rapid and effective tools for better health solutions for new and emerging health problems. Researchers, students, policymakers and members of the biomedical and medical fields will find this information invaluable. Specially, it pays attention to how information technologies help us in the current global health emergency and the coronavirus epidemic response, gaining more understanding of the new coronavirus and helping to contain the outbreak. In addition, it explores how these new tools and digital health solutions can support the economic and social recovery in the post-pandemic world.

  • Environmental Contaminants and Endocrine Health

    • 1st Edition
    • Oliana Carnevali + 1 more
    • English
    Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat. This content will be a foundational resource for academic and research staff in endocrinology and hormone toxicology as well as for professors, researchers and students in these areas.

  • Aptamers for Food Applications

    Safety, Authenticity, and Integrity
    • 1st Edition
    • Yiyang Dong
    • English
    Aptamers for Food Applications: Safety, Authenticity, and Integrity outlines the main applications of aptamers to ensure food safety, quality and compliance that are crucial for food science, public health and human sustainability. Aptamers or aptamer-based analytical devices are comprehensively summarized to tackle various food contamination or food adulteration problems. Topics covered in this book include aptamers for foodborne microbial pathogens, pesticide or veterinary drug residues, heavy metals, biotoxins, abused food additives, illegal food adulterants, POPs, GMOs, food allergens and food contact material migrants. It is therefore of interest for not only analytical investigators and food safety inspectors, but also regulatory practitioners and risk assessors in various food science and research fields.

  • The Role of Gasotransmitters In the Amelioration of Arsenic Toxicity in Plants

    Biology and Biotechnology
    • 1st Edition
    • Bruno Lemos Batista + 2 more
    • English
    The Role of Gasotransmitters In the Amelioration of Arsenic Toxicity in Plants: Biology and Biotechnology, in the Plant Gasotransmitter series, provides research on how gasotransmitters can reduce the stress faced by plants through arsenic contamination. With a strong focus on metabolic processes, the book presents the various pathways and mechanisms associated with gasotransmitters as part of arsenic amelioration. Initial chapters discuss the effects of arsenic on the plant genome and metabolome, as well as the mechanisms behind the uptake and translocation of arsenic in plants. The book then takes a deep dive into the role of gasotransmitters, highlighting plant physiological responses. This is an essential resource for students, researchers and agronomists interested in plant physiology, biochemistry and plant hormones.

  • Stem Cell Laboratory Techniques

    A Guide for Researchers and Students
    • 1st Edition
    • Suresh Kumar Kailasa + 2 more
    • English
    Stem Cell Laboratory Techniques: A Guide for Researchers and Students introduces the reader to stem cell culture, handling techniques and versatile applications used by researchers. Sections introduce stem cells, including definitions, types and basic use of stem cells in biomedical science research. The book explains laboratory procedures and techniques ranging from the extraction of stem cells from animals, cell seeding and culture, harvest and maintenance of stem cells, stem cell characterization, accurate recording, quality control, and more. In addition, it guides researchers on topics such as transcriptome analysis, proliferation study analysis, and microphysiological study. Final sections cover useful and recent applications in stem cells, such as gene editing techniques and the preparation of stem cells for in vitro study, as well as stem cell lab design and equipment used in the lab. Lastly, human and animal research ethics are discussed.

  • New Experimental Probes for Enzyme Specificity and Mechanism

    • 1st Edition
    • Volume 685
    • English
    New Experimental Probes for Enzyme Specificity and Mechanism, Volume 685, the latest release in the Methods of Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics including Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis, New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransfera... Phosphonate and α Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase, Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses, Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces, and more. Additional chapters cover Kinetics and Mechanism for Reactions of Enzyme Pieces, Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phos... synthase and chorismate mutase, Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase, Innovative and emerging modalities of EGFR kinase inhibitors, Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases, and much more.

  • Microbial Inoculants

    Recent Progress and Applications
    • 1st Edition
    • Vijay Kumar Sharma + 4 more
    • English
    In the recent past, beneficial microorganisms have been sustainably used in agriculture as a safe, economic, and effective alternative to chemical fertilizers or pesticides. These beneficial microbes, including bacteria, actinomycetes, and yeast, were efficiently applied in soil, seeds, fruits, or plants as inoculants, to achieve the optimum agricultural yield.An efficient delivery method or enhanced shelf life of microbial inoculants in the soil or seed is still a matter of concern. The response of local genetic or ecological factors, after microbial applications, are also unknown and less studied. Therefore, Microbial Inoculants: Recent Progress and Applications fulfills the need to explore and learn about an efficient delivery mechanism, selection of microbial strain as inoculants, and related technological advances, for the efficient and productive use of microbial inoculants. Moreover, factors like methods of formulation, interaction between host plant and microbe, impact of inoculation on the metabolomics of plants, the effect of microbial inoculants on soil dynamics, proteomics approach of plant-microbe interaction, as well as the registration and regulation process of bio inoculants for commercial production are described in 16 chapters by the leading academicians and researchers from different parts of the world.

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