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Elsevier

Books in Life sciences

  • In Vitro Methods in Cell-Mediated Immunity

    • 1st Edition
    • Barry R. Bloom + 1 more
    • English
    In Vitro Methods in Cell-Mediated Immunity focuses on methods for approaching cell-mediated immune responses in vitro. This book provides, in simplified in vitro systems, a basis for understanding the mechanism of the in vivo response and discusses useful and reliable in vitro tests for cell-mediated immune responses in humans, where in vivo testing is often not possible. The topics discussed include factors and activities produced in vitro by lymphocytes; biological implications of in vitro phenomena; and requirements and prospects for improved methodology. The leucocyte migration technique for in vitro detection of cellular hypersensitivity in man; proliferation of human blood lymphocytes stimulated by antigen in vitro; and virus plaque assay for antigen-sensitive are also elaborated in this text. This publication is a good reference for microbiologist and immunologists, including medical students researching on in vitro models for cell-mediated immune reactions.

  • Current Topics in Bioenergetics

    Volume 14
    • 1st Edition
    • C. P. Lee
    • English
    Current Topics in Bioenergetics, Volume 14 provides information pertinent to the structure and function relationship of energy-transducing membranes. This book presents a number of biochemical and biophysical approaches that are valuable in some systems. Organized into five chapters, this volume begins with an overview of cytochrome oxidase, a noncrystallizable membrane protein. This text then determines the interaction of small organic molecules with biological membranes on a molecular level. Other chapters consider the various physical techniques that are used to investigate the structural and dynamic properties of proteins, lipids, and membranes, including neutron diffraction, X-ray diffraction, electron microscopy, optical rotatory dispersion, nuclear magnetic resonance, fluorescence spectroscopy, and Raman spectroscopy. This book discusses as well the biological importance of metal ions. The final chapter deals with optical activity spectroscopy as a recognized tool for the examination of the conformation of biological macromolecules. This book is a valuable resource for biochemists, biophysicists, and biologists.

  • Psychoneuroimmunology

    • 1st Edition
    • Robert Ader
    • English
    Psychoneuroimmunolog... Second Edition presents reports on the relationship between the nervous and immune systems. The book is divided into four sections. The first section details the role of neural structures and neurotransmitter signals in communication with the immune system. It documents the extensive neural connections with organs of the immune system; the dynamics of noradrenergic sympathetic innervation of spleen and thymus; and the evidence for immune signaling of the CNS. Part II elaborates the role of hormones in the modulation of immune functions; the basis for bidirectional communication between the neuroendocrine and immune systems; and the potential physiological implications of these neuroendocrine-immun... system interactions. The third part addresses behavioral influences on immune response; the effects of conditioning, stress and social interactions in modulating immune responses; and the behavioral consequences of experimentally altered or genetically determined immunologic states. The final section presents the effects of psychosocial factors on immune responses and the potential impact of behavioral interventions in modulating immunity in healthy human subjects and in patients with AIDS. Neuroscientists, endocrinologists, and immunologists will find the book interesting.

  • The Oxygen Evolving System of Photosynthesis

    • 1st Edition
    • Yorinao Inoue + 2 more
    • English
    The Oxygen Evolving System of Photosynthesis documents the proceedings of an international symposium entitled ""Photosynthetic Water Oxidation and Photosystem II Photochemistry,"" held at The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama, Japan, 15-17 March 1983. Several other papers from authorities in this field are also included. This book provides in a systematic fashion the most current thoughts and insights into the field of photosynthetic oxygen evolution. The volume contains 46 chapters organized into five parts. Part I deals with the subunit structure of photosystem II reaction center pigment proteins and the charge separation (generation of positive and negative charges, P680+ and Pheo-). Part II examines the components and their function on the donor side. Part III discusses the biochemistry of the water oxidation enzyme system, polypeptide composition, and functional reconstitution. Part IV take up the functions of chloride and bicarbonate in electron transport and the mechanism of photoactivation in latent or Tris-inactivated chloroplasts. Part V discusses the fate of reducing equivalents going through the two-electron gate mechanism, together with the biochemistry of the quinone components on the acceptor side.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 9
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 9 is a seven-chapter text that highlights the advances in methodology to steroid chemistry. The opening chapter describes the important aspect of autoradiography and its coupling with light and electron microscopic analysis. The next chapters deal with the carbon source in the fatty acid biosynthesis, with particular emphasis on the biosynthesis by the aortic the issue. These topics are followed by discussions of the membrane structure and the lipids in membranes. Other chapters consider the biochemistry and analysis of glycosphingolipids and the progress in the in lipid chemistry, including pregnane derivatives and C21 steroids. The concluding chapter reviews the composition of vegetable oil and other aspects of fat metabolism, specifically cholesterol metabolism. This book will prove useful to lipid chemists, biochemists, and organic chemists.

  • Molecular Biology of Plant Tumors

    • 1st Edition
    • Günter Kahl + 1 more
    • English
    Molecular Biology of Plant Tumors provides an opportunity to learn in detail about the latest insights into the mechanism of transformation of plant cells by Agrobacterium tumefaciens. The study of the molecular mechanism responsible for the crown gall phenomenon (induced by Agrobacterium tumefaciens) illustrates the point that the fundamental study of the cause(s) and mechanism(s) of abnormal growth might be one of the most efficient ways to understand cellular differentiation and the molecular basis of gene expression. The book is organized into three parts that contain research on abnormal plant growth, crown gall tumors, and potential vectors for genetic engineering in agriculture. The genetic structure responsible for the neoplasmic transformation of plant cells in crown galls is a bacterial plasmid (called Ti for tumor-inducing). Research described in this volume demonstrates that these Ti plasmids were designed by evolution as natural gene vectors with which some bacteria can introduce active genes into plants. These transferred genes are maintained by integration in the plant genome and their expression is directly or indirectly responsible for the tumorous growth pattern.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 22
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 22 provides information pertinent to the fundamental aspects of lipid research. This book covers a variety of topics, including lipid secretion, lipids in platelet function, lipid transfer proteins, serum cholesterol, and cholesterol metabolism. Organized into five chapters, this volume begins with an overview of the lipid secretion of the meibomian glands, with emphasis on its chemical composition and physical properties. This text then explains the influence of lipids in platelet function and considers the metabolism of arachidonic acid in disease states, such as diabetes, nephrosis, and atherosclerosis. Other chapters examine the manner in which dietary cholesterol contributes to regulation of cholesterol metabolism. This book discusses as well the identification, isolation, and metabolism of sterol carrier proteins and lipid transfer proteins. The final chapter deals with the underlying problems that militate against a simple dose–response relationship. This book is a valuable resource for biologist, biochemists, and clinicians.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 11
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 11 is a seven-chapter text that discusses a wide range of topics in the field, including steroid metabolism, phytosterols, and fatty acid transport. The first chapter reviews the metabolic role of lecithin: cholesterol acyltransferase. The next chapter deals with the simple means of separation and quantitation of serum lipoproteins. This chapter describes the variations of the reaction involving lipoproteins, divalent cations, and polyanionic substances, both organic and inorganic. Other chapters discuss the fatty acid metabolism by brain tissue, the concept of the blood-brain barrier and its role in fatty acid uptake, as well as the many alterations in bile acid structure due to their interaction with the intestinal microflora. A chapter focuses on the multiple aspects of plant sterol chemistry, function, and metabolism. The last chapters examine the mechanism of insect utilization and metabolism of dietary sterol. These chapters also cover the role of lipids in viral structure and metabolism. This book will prove useful to lipid chemistry, biochemists, and researchers.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 1
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 1 provides information pertinent to the structure and behavior of lipids through sulfolipids. This book presents the advances on fat absorption and transport. Organized into 10 chapters, this volume begins with an overview of the methods for the analysis of glycerine mixtures that require the determination of the fatty acid composition of the whole mixture and of its component fraction. This text then examines lipids as molecules of biological interest having little or no solubility in water. Other chapters cover the advances in cholesterol metabolism, Vitamin E as it affects lipid metabolism, and a discussion on atherosclerosis. This book discusses as well all areas of lipid research ranging from physical chemistry to physiology and pathology. The final chapter deals with sulfolipid, which appears to be concentrated in the lamellar membranes of the chloroplasts of plants. This book is a valuable resource for physical chemists, biologists, and pathologists.

  • Immunodermatology

    • 1st Edition
    • D. M. Macdonald
    • English
    Immunodermatology presents a comprehensive examination of the proceedings that resulted from the International Immunodermatology Symposium which happened in London. It discusses the relationship of immuno-histochemical study to skin disease. It addresses the function and recognition of lymphocytes. Some of the topics covered in the book are the immunological observations in 12 cases of Kaposi’s herpetic eruption; anti-inflammatory effects of adrenoceptor agonists in patients with atopic eczema; a study of the sensitivity and specificity of cutaneous vascular immunofluorescence; and functional activity of granulocytes from patients with neutrophilic dermatoses. The mechanisms of cutaneous lupus erythematosus are fully covered. An in-depth account of the cytochemical and immunological findings in cutaneous multilobated cell lymphoma are provided. The immunohistological analysis of dermal leprous granulomas is completely presented. A chapter is devoted to the study of human epidermal cell differentiation using monoclonal antibodies. Another section focuses on the prognostic significance of melanoma-associated antigens in primary and metastatic melanomas. The book can provide useful information to doctors, dermatologists, students, and researchers.

  • The Role of Products of the Histocompatibility Gene Complex in Immune Responses

    • 1st Edition
    • David H. Katz + 1 more
    • English
    The Role of Products of the Histocompatibility Gene Complex in Immune Responses documents the proceedings of a conference held on 3-7 November 1975, which brought together an international group of scientists spanning three independent disciplines—genetics and immunogenetics, molecular biochemistry, and immunobiology—with clinical medicine overlapping these disciplines. This volume contains 42 papers organized according to the eight sessions held at the conference. The papers in Session I examined the genetics of the major histocompatibility complex. Session II presented studies on the biology of mixed lymphocyte interactions and cell-mediated cytotoxicity reactions. Session III discussed immune response gene systems while Session IV dealt with the genetic control of cell interactions. The papers in Session V covered idiotypic determinants on T cell receptors. Session VI investigated the properties of histocompatibility gene products involved in regulation of immune responses. Session VII focused on the biochemistry and immunocytology of cell surface products of the major histocompatibility complex. Finally, Session VIII discussed interrelationships between products of the major histocompatibility complex and their relevance to disease.

  • Nucleotide Metabolism

    An Introduction
    • 1st Edition
    • J. Frank Henderson + 1 more
    • English
    Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the aspects of nucleotide metabolism. The book intends to present the chemistry and metabolism of nucleotides, one of the oldest subjects of biochemistry. The text is divided in two parts. Part I considers the general aspects of nucleotide metabolism such as the history of the discovery of nucleotides; functions of nucleotides in cells; and group-transfer reactions during nucleotide metabolism. Part II deals with the synthesis, formation, and conversion of purine ribonucleotides. Biochemists, pharmacologists, and researchers in the fields of medicine and pharmaceuticals will find the book invaluable.

  • Multiple Equilibria in Proteins

    • 1st Edition
    • Jacinto Steinhardt + 1 more
    • Bernard Horecker + 2 more
    • English
    Multiple Equilibria in Proteins covers the multiple interactions between small ions and molecules and a protein molecule. The book also deals with the physicochemical mechanisms of this interaction and the information about protein structure and the forces stabilizing that structure. The text discusses the mathematical description of complex formation, the thermodynamic analysis of binding data, and various theoretical models which can be used to describe the phenomena of small molecule-macromolecu... interactions. The measurement of complex formation; the binding of neutral molecules; and hydrogen-ion equilibria are also considered. The book further tackles metal-ion binding; the binding of organic ions by proteins; as well as protein-protein interaction. Chemists and biochemists will find the book useful.

  • Assembly Instructions for Polypeptide Models

    Academic Press/Molecular Design Inc. Precision Molecular Models
    • 1st Edition
    • Edward J. Barrett
    • English
    Assembly Instructions for Polypeptide Models provides assembly procedures for? polypeptide chains and for modeling the ?-helix and the parallel and antiparallel ?-pleated sheets. This text is divided into nine chapters and starts with a brief introduction to the basic unit of polypeptide or protein structure, which is the amino acid. The subsequent chapters deal with the components of the model system, including the torsion angles and the asymmetric ?-carbon atom. The remaining chapters present specific instructions for the construction of free amino acids, polypeptide end groups, side chain groups, secondary structures, and side chain torsion angles. This book will prove useful to protein and peptide scientists, organic chemists, and biochemists.

  • Current Topics in Bioenergetics

    Volume 11
    • 1st Edition
    • D. Rao Sanadi
    • English
    Current Topics in Bioenergetics, Volume 11 provides information pertinent to the ATP utilizing or synthesizing parts of the major bioenergetics reactions of cells. This book discusses the individual proteins comprising each of the energy-transducing ATPases and their organization into a functional structure. Organized into six chapters, this volume begins with an overview of the role of ATPases in the production and utilization of the H+ gradient from a genetic and biochemical viewpoint. This text then examines the ATPase associated with bacterial membranes, which is known to have an analogous function and a similar structure to that found in membranes of chloroplasts and mitochondria. Other chapters consider the composition and the biogenesis of chromaffin granules. This book discusses as well the models for the mode of action of peptide molecules. The final chapter deals with the various forms of energy transduction. This book is a valuable resource for biologists, physiologists, and pharmacologists.

  • Structure and Function of Biological Membranes

    • 1st Edition
    • Lawrence I. Rothfield
    • English
    Structure and Function of Biological Membranes explains the membrane phenomena at the molecular level through the use of biochemical and biophysical approaches. The book is an in-depth study of the structure and function of membranes. It is divided into three main parts. The first part provides an overview of the study of the biological membrane at the molecular level. Part II focuses on the detailed description of the overall molecular organization of membranes. The third part covers the relationship of the molecular organization of membranes to specific membrane functions; discusses catalytic membrane proteins; presents the role of membranes in important cellular functions; and looks at the membrane systems in eukaryotic cells. Biochemists, cell physiologists, biologists, researchers, and graduate and postdoctoral students in the field of biology will find the text a good reference material.

  • Prehistoric Hunter-Gatherers

    The Emergence of Cultural Complexity
    • 1st Edition
    • RABIGER
    • English
    Prehistoric Hunters–Gatherers: The Emergence of Cultural Complexity focuses on the emergence of cultural complexity among hunter–gatherers. This book presents the demographic, ecological, and social perspectives that add to the understanding of the emergence of more elaborate organization. Organized into four parts encompassing 17 chapters, this book begins with an overview of previous perspectives on cultural complexity and suggests directions in the study of change. This text then proposes a synthesis of both ecological and social approaches as a more powerful interpretative framework for the study of complexity. Other chapters consider the relationship between population and social complexity in an elaboration of major argument regarding demographic pressure and cultural change. This book provides as well an intriguing look at the regional consequences of their focus on whaling. The final chapter characterizes approaches to hunter–gatherer complexity and reiterates the significance of change in human society prior to the adoption of domesticated animals and plants. This book is a valuable resource for archeologists and anthropologists.

  • Thrombosis and Bleeding Disorders

    Theory and Methods
    • 1st Edition
    • Nils U. Bang + 2 more
    • English
    Thrombosis and Bleeding Disorders compiles the laboratory and research aspects of thrombosis and hemorrhagic disorders in humans. This book presents reviews of the underlying theory, physiology, and biochemistry of hemostasis and thrombosis, including the enzymology of blood coagulation and fibrinolysis. This compilation is divided into three levels of specific purposes. First is to provide the most reliable and widely accepted laboratory assays of undisputed diagnostic clinical value, which provides newcomers in the field and experienced workers in the coagulation laboratory with a reference manual to everyday work in a clinically-oriented environment. Second is to review and sketch in outline the theoretical sections focusing on mechanisms. Finally, this text aims to include a systematic review of the most successful purification techniques for individual coagulation factors and moieties of the fibrinolytic enzyme system. This publication is beneficial to medical students and clinicians concerned with human blood coagulation.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 13
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 13 is a four-chapter text that emphasizes the biological aspects of lipoproteins. The first chapter reviews the status of lipoprotein metabolism, specifically the functional, structural, and metabolic interrelationships of lipoproteins. The second chapter covers aspects of lipid metabolism in diabetes and the stresses that can cause alterations in carbohydrate metabolism. The third chapter discusses the developments in understanding the physicochemical basis of gallstone formation. The fourth chapter deals with the biosynthesis and composition of milk fat. This chapter also presents a summary of some of the important features of milk fat production processes. This book will prove useful to lipid chemists, biochemists, physicians, and researchers.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 10
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 10 is a six-chapter text that is devoted to several special areas of lipid research, including significant progress in established areas of interest in the field. The introductory chapter surveys the application of electron microscopic techniques to the analysis of plasma lipoproteins. The subsequent chapter deals with the possible modification of reticuloendothelial functions by lipids and the role of lipids in cellular, humoral, and immune responses. These topics are followed by discussions of the microsomal enzymes of sterol biosynthesis and the enzymatic synthesis and degradation of glycerol lipids, which contain ether bonds. The remaining chapters focus on lipid neurochemistry. These chapters specifically examine particular brain lipids, such as fatty acids, phospholipids, sphingolipids, galatosyl lipids, and sterols. A discussion of lipids of the entire nervous system and their variation with age is also included. This book will prove useful to lipids chemists, biochemists, and organic chemists.

  • The Structure of Mitochondria

    • 1st Edition
    • E. A. Munn
    • English
    The Structure of Mitochondria provides an extensive account of the structure of mitochondria. This book illustrates the variety of mitochondrial structure revealed by electron microscopy of intact cells. Organized into nine chapters, this book begins with an overview of the application of electron microscopy to the study of the structure of cells and their mitochondria. This text then explains the short-term changes of the type revealed by phase contrast microscopy of living cells. Other chapters consider the rationale behind the procedures generally employed for the isolation of mitochondria and other sub-cellular components. This book discusses as well the important component of mitochondria. The final chapter describes the interesting similarities of mitochondria, chloroplasts, and bacteria and the bearing these have on the concept about the way in which the relationships between mitochondria and the rest of the eukaryotic cell have evolved. This book is a valuable resource for biologists, physiologists, and bacteriologists.

  • Viral Immunology and Immunopathology

    • 1st Edition
    • Abner Louis Notkins
    • English
    Viral Immunology and Immunopathalogy covers topics concerning the role of cellular and humoral immunity in viral infections, factors responsible for the persistence and recurrence of viral infections in the presence of immunity, mechanisms of viral immunopathology, and concepts in the development of vaccines. The book describes the history of viral immunology; the synthesis and properties of viral antigens; and the humoral immune response to viruses. The text also discusses the mechanisms of viral neutralization; cellular immunity; the role of inflammatory cells and effector molecules in combating viral infections; and the genetic control of resistance. The book concludes with chapters on herd immunity; viral immunopathology; and viral immunology and immunopathology. Immunologists, pathologists, virologists, and microbiologists will find the book useful.

  • The Retinoids: v. 2

    • 1st Edition
    • BAERT ET BAERT ET AL
    • English
    The Retinoids is a collection of papers that deals with the biochemistry and metabolism of the retinoids and of specific retinoid-binding proteins that are found in plasma and in cells. Some papers describes the biosynthesis and metabolism of retinol, with plasma retinol-binding protein, with intracellular retinoid-binding proteins, as well as with the metabolism and role of retinoids in the eye. Other papers review the metabolism of retinoic acid and synthetic retinoids, the cellular and molecular mechanisms of action of the retinoids, and applied biology of the retinoids. Several papers discuss toxicology, teratology, immunology, and the applications of retinoids in the fields of cancer and dermatology. One paper describes the transport of retinoic acid and other acidic retinoids in plasma in association with serum albumin. Another paper hypothesizes that vitamin A affects differentiation at the cellular level and addresses how tissue specificity of this action can arise. One paper examines the role of retinoid-binding proteins in vertebrate visual system, particularly how these proteins transport retinoids in the serum, cell sap, and interstitial spaces of the eye. The collection can prove useful for biologists, microbiologists, cellular biologists, students and professors of biology, oncology, ophthalmology or dermatology.

  • Techniques in Protein Chemistry

    Published Under the Auspices of the Protein Society
    • 1st Edition
    • John W. Crabb
    • English
    Techniques in Protein Chemistry V highlights current methods in peptide and protein mass spectrometry, sequence and amino acid analysis, fragmentations, separations, protein folding and modeling, peptide and protein NMR, and peptide synthesis. This volume emerged from the manuscripts presented at the Seventh Symposium of the Protein Society, held in San Diego on July 24-28, 1993. This volume is organized into eight parts encompassing 61 chapters. The first part surveys the peptide and protein characterization, detection, and analysis by mass spectrometry. The subsequent parts describe the structural characterization and analysis of posttranslational processing events, as well as the characterization of protein and amino acid sequences using several analytical techniques. Other parts explore other analytical methods for peptide and protein separations; some aspects involved in protein design and functional domain analysis; and the evaluation of protein conformation, folding, and modeling. The last parts contain research papers on NMR analysis of peptide and protein solution structures. These parts also look into topics related to peptide synthesis and peptide libraries. This book is intended primarily for protein and analytical chemists.

  • Textbook of Medical Virology

    • 1st Edition
    • Erik Lycke + 1 more
    • English
    Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions. The book can provide useful information to virologists, microbiologists, students, and researchers.

  • Advances in Agronomy

    • 1st Edition
    • Volume 127
    • English
    Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial.

  • Interleukins in Cancer Biology

    Their Heterogeneous Role
    • 1st Edition
    • Arseniy Yuzhalin + 1 more
    • English
    Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. .

  • Advances in Marine Biology

    • 1st Edition
    • Volume 68
    • English
    Advances in Marine Biology has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963--over 40 years of outstanding coverage! The series is well known for its excellent reviews and editing. Now edited by Michael Lesser (University of New Hampshire, USA) with an internationally renowned Editorial Board, the serial publishes in-depth and up-to-date content on many topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography. Volumes cover all areas of marine science, both applied and basic, a wide range of topical areas from all areas of marine ecology, oceanography, fisheries management and molecular biology and the full range of geographic areas from polar seas to tropical coral reefs.

  • Telomeres in Health and Disease

    • 1st Edition
    • Volume 125
    • English
    This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field.

  • Redox and Cancer Part A

    • 1st Edition
    • Volume 122
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics — Volume 122 explores subjects related to redox, including: redox homeostasis in epithelial-derived cancers; reactive oxygen species in normal and tumor stem cells; and gamma-glutamyl transpeptidase and redox regulation.

  • Regulated Cell Death Part A

    Apoptotic Mechanisms
    • 1st Edition
    • Volume 544
    • Avi Ashkenazi + 2 more
    • English
    Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches.

  • Proteomics in Biomedicine and Pharmacology

    • 1st Edition
    • Volume 95
    • English
    Volume 95 of Advances in Protein Chemistry and Structural Biology focuses on advances in proteomic techniques and their application in biomedicine and pharmacology. This volume describes in detail the applications of these techniques in studying a number of diseases and specific protein modifications and profiles, including phosphoproteomics, glycoproteomics, and more. Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

  • Dopamine

    • 1st Edition
    • Volume 211
    • English
    Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more.Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences.

  • Adapting High Hydrostatic Pressure (HPP) for Food Processing Operations

    • 1st Edition
    • Tatiana Koutchma
    • English
    Adapting High Hydrostatic Pressure (HPP) for Food Processing Operations presents commercial benefits of HPP technology for specific processing operations in the food industry, including raw and ready-to-eat (RTE) meat processing, dairy and seafood products, drinks and beverages, and other emerging processes. The book presents high hydrostatic pressure processing (HPP) for treatment of different groups of raw and finished products, focusing on specific pressure-induced effects that will lead to different biological impacts, and the information necessary for specifying HPP process and equipment. It also discusses phenomena of compression heating, the HPP in-container principle, requirements for plastic materials, factors affecting efficacy of HPP treatments, and available commercial systems. Additionally, the book provides updated information on the regulatory status of HPP technology around the world. This book is an ideal concise resource for food process engineers, food technologists, product developers, federal and state regulators, equipment manufacturers, graduate students, and educators involved in research and development.

  • Unity and Diversity in Biochemistry

    An Introduction to Chemical Biology
    • 1st Edition
    • Marcel Florkin
    • P. Alexander + 1 more
    • English
    International Series of Monographs on Pure and Applied Biology, Volume 1: Unity and Diversity in Biochemistry focuses on the advancements of processes, techniques, methodologies, and approaches involved in biochemistry. The publication first offers information on the constituents of the biosphere, modes of linkage by covalent bonds and macromolecules, general principles of biochemical energetics, and enzymes. The text then examines the destructive and non-destructive methods in modern biochemistry, priming reactions, and biosynthesis. Discussions focus on the mechanisms for the breakdown of amino acids, glycolysis and the hexosemonophosphate shunt, interrelations between priming reactions, respiratory chains, biochemical investigation and use of isotopes, and use of mutant strains micro-organisms. The manuscript takes a look at cellular topochemistry and regulation, aspects of biochemical diversity, inheritance of biochemical characteristics, and biochemical evolution. Topics include evolution of biochemical systems and constituents, control of biochemical characteristics by genes, biochemical differentiation of cells in a single organism, and factors which determine the velocity and path of enzymatic reaction chains. The selection is a dependable source of data for biochemists and readers interested in the different aspects of biochemistry.

  • Omega-3 Fatty Acids in Brain and Neurological Health

    • 1st Edition
    • Ronald Ross Watson
    • English
    Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis. This book encompasses some of the most recent research, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep, and neurodegenerative diseases. This collection helps to push research forward toward a complete understanding of omega-3 fatty acids' relationship to brain and neurological health.

  • Quantitative Imaging in Cell Biology

    • 1st Edition
    • Volume 123
    • English
    This new volume, number 123, of Methods in Cell Biology looks at methods for quantitative imaging in cell biology. It covers both theoretical and practical aspects of using optical fluorescence microscopy and image analysis techniques for quantitative applications. The introductory chapters cover fundamental concepts and techniques important for obtaining accurate and precise quantitative data from imaging systems. These chapters address how choice of microscope, fluorophores, and digital detector impact the quality of quantitative data, and include step-by-step protocols for capturing and analyzing quantitative images. Common quantitative applications, including co-localization, ratiometric imaging, and counting molecules, are covered in detail. Practical chapters cover topics critical to getting the most out of your imaging system, from microscope maintenance to creating standardized samples for measuring resolution. Later chapters cover recent advances in quantitative imaging techniques, including super-resolution and light sheet microscopy. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.

  • Applied Dermatotoxicology

    Clinical Aspects
    • 1st Edition
    • Howard I. Maibach + 1 more
    • English
    Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects. Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents.

  • Speech Motor Control

    Proceedings of an International Symposium on Speech Motor Control, Held at the Wenner-Gren Center, Stockholm, May 11 and 12, 1981
    • 1st Edition
    • Sten E. Grillner + 2 more
    • English
    Wenner-Gren Center International Symposium Series, Volume 36: Speech Motor Control covers the papers presented at an interdisciplinary conference on Speech Motor Control, held at the Wenner-Gren Center in Stockholm on May 11 to 12, 1981. The book focuses on the methodologies, approaches, processes, and techniques employed in speech motor control. The selection first offers information on the interdisciplinary challenge of speech motor control and analogies between central motor programs for speech and for limb movements. Discussions focus on regulation of cerebral motor cortex output by afferent input, goal-orientation and voluntary movement, interaction of transcortical and segmental reflexes, plasticity of speech gestures, and the task of the speech motor system. The text then takes a look at speech production mechanisms in aphasia and functional landscapes in the cerebral cortex related to speech, as well as motor errors and phonetic transcription studies and correlational analysis of consonant preferences in infants, languages, and aphasic errors. The publication ponders on functional landscapes in the cerebral cortex related to speech; comment on the partial roles of the cerebral hemispheres for speech; and speech breathing kinematics and mechanism inferences. The text also ponders on the aspects of voice production and motor control, vocal fold kinesiology, and oral mechanoreceptors. The text is a dependable reference for readers interested in speech motor control.

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 311
    • Kwang W. Jeon
    • English
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2012: 4.973.

  • Transgenic Animal Technology

    A Laboratory Handbook
    • 3rd Edition
    • Carl A. Pinkert
    • English
    Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer — from molecular methods to whole animal considerations — for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems.

  • The Molecular Genetics of Floral Transition and Flower Development

    • 1st Edition
    • Volume 72
    • English
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 72nd volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on the molecular genetics of floral transition and flower development.

  • Introductory Immunology

    Basic Concepts for Interdisciplinary Applications
    • 1st Edition
    • Jeffrey K. Actor
    • English
    Introductory Immunology quickly acquaints readers with natural immune responses manifesting in diseases and disorders. The book presents a complete picture of natural defenses to infectious agents, as well as the mechanisms that lead to autoimmune dysfunction. In addition, it examines immunologically based diseases, giving the reader sufficient knowledge to make sound clinical decisions leading to better treatment outcomes. Introductory Immunology is aimed at researchers, postgraduates, or any scientifically inclined reader interested in immunology. No prior expertise in medical, biochemical, or cellular science is needed to benefit from the clear presentation of immunology concepts in this book.

  • Pharmacology and Therapeutics of Constitutively Active Receptors

    • 1st Edition
    • Volume 70
    • Ya-Xiong Tao
    • English
    Volume 70 of Advances in Pharmacology presents the pharmacology and therapeutics of constitutively active receptors. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Advances in Pharmacology provides a rich collection of reviews on timely topics. The series places emphasis on the molecular bases of drug action, both applied and experimental.

  • Integrative Cardiovascular Chinese Medicine

    A Prevention and Personalized Medicine Perspective
    • 1st Edition
    • Anika Niambi Al-Shura
    • English
    Combining the research and study of integrative Chinese and Western Medicine, Integrative Cardiovascular Chinese Medicine: A Prevention and Personalized Medicine Perspective presents a clear, structured base to guide clinical practice and encourage collaboration between Chinese medicine and Western medicine practitioners. This complete reference work thoroughly covers the pathophysiology of cardiology-related diseases, and compares, juxtaposes, and integrates Western and traditional Chinese medicine (TCM). Anika Niambi Al-Shura provides a realistic scope of cardiology treatment and the integration of Western and Chinese medicine, establishing a basis for standardization and a rationale for the inclusion of TCM in cardiology, and identifying and inspiring ideas for future research.

  • Advances in Parasitology

    • 1st Edition
    • Volume 85
    • English
    First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on various topics, including control of human parasitic diseases and global mapping of infectious diseases. The 2012 impact factor is 3.778.

  • Cell-wide Metabolic Alterations Associated with Malignancy

    • 1st Edition
    • Volume 543
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.

  • Cellular and Molecular Immunology

    • 8th Edition
    • Abul K. Abbas + 2 more
    • English
    Popular for its highly visual, straightforward approach, Cellular and Molecular Immunology delivers an accessible yet thorough understanding of this active and fast-changing field. Drs. Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai present key updates in this new edition to cover the latest developments in antigen receptors and signal transduction in immune cells, mucosal and skin immunity, cytokines, leukocyte-endothelia... interaction, and more. With additional online features, this is an ideal resource for medical, graduate and undergraduate students of immunology who need a clear, introductory text for immunology courses.

  • Cerebellar Learning

    • 1st Edition
    • Volume 210
    • English
    Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences. This volume, The Cerebellum and Memory Formation: Structure, Computation and Function, covers topics including feedback control of cerebellar learning; cortico-cerebellar organization and skill acquisition; cerebellar plasticity and learning in the oculomotor system, and more.

  • Biased Signaling in Physiology, Pharmacology and Therapeutics

    • 1st Edition
    • Brian J Arey
    • English
    Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-depen... activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

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