Skip to main content
Elsevier
View Cart

Books in Life sciences

BooksJournals

    • Ureases

      Functions, Classes, and Applications
      • 1st Edition
      • Rodrigo Ligabu Braun + 1 more
      • English
      Ureases: Foundations, Classes, and Applications provides a thorough, practical analysis of ureases—enzymes of growing relevance across a range of biotechnological applications and drug discovery. Unique in many aspects, ureases are one of the few enzymes to have nickel in their active sites. This book covers all aspects of this enzymatic class starting with foundational overview and then providing historical urease research and current state, from basic biochemistry to the use of ureases as hallmarks in enzymology, crystallography, and bioinorganic chemistry. The different classes of ureases, structurally diverse but chemically equivalent, are individually discussed.The multi-protein, multi-step activation of ureases (with chemical modification of residues, transport, and transfer of nickel ions) are examined in-depth, along with the catalytic mechanisms of ureolysis and its inhibitors. The final two sections of the book address multiple applications of ureases in health and biotechnology, respectively, going from gastric ulcer treatment to architectural uses in buildings and engineering. Future applications and next steps in research are also considered.

    • Neurología

      • 7th Edition
      • Juan José Zarranz Imirizaldu
      • Spanish
      Texto eminentemente docente para el período de formación de grado y, sobre todo, para los residentes que van a especializarse en Neurología. Especialistas en otras disciplinas, como medicina interna, psiquiatría y neurocirugía, entre otras, pueden encontrar en este libro un libro de referencia y de consulta. Mantiene su estructura básica, con los primeros 14 capítulos destinados las bases del diagnóstico clínico, los fundamentos de las exploraciones complementarias, y los grandes síndromes o trastornos neurológicos. Las cefaleas, el dolor y los trastornos de la consciencia forman también parte de estos primeros capítulos. Los siguientes 15 capítulos se ocupan de las entidades nosológicas (enfermedades infecciosas o vasculares, epilepsias, las que cursan con movimientos anormales, los tumores, las enfermedades desmielinizantes o las neurodegenerativas que afectan a las motoneuronas, a los sistemas espinocerebelosos o las que culminan con deterioro cognitivo y demencia). Se cierra con tres capítulos dedicados a la neurogenética, los mecanismos de la neurodegeneración (en un capítulo nuevo) y la bioética en neurología. El texto ha sido revisado y actualizado con la adición de nuevas figuras, tablas y algoritmos de diagnóstico, y se ha puesto al día la bibliografía. El material online, además de contar también con nuevas figuras, tablas y algoritmos de diagnóstico, se ha ampliado con nuevos casos clínicos para el razonamiento del problema, más vídeos de semiología y preguntas de autoevaluación.

    • Fundamentals of Weed Science

      • 6th Edition
      • Robert L Zimdahl + 1 more
      • English
      Fundamentals of Weed Science, Sixth Edition, places weed management in the context of weed research and science, presenting the latest advances in the role, control, and potential uses of weed plants. This book uses an ecological framework to explore the role of responsible and effective weed control in agriculture from the emergence and genetic foundation of weeds to the latest means of control and environmental effects.Fully revised, updated, and expanded, Fundamentals of Weed Science now includes insights into international trad eand consumer preferences, weed seedbanks, advancements in robotic weeding, weed flaming, and the potential of precision agriculture in weed science.

    • RNA Therapeutics Part A

      • 1st Edition
      • Volume 203
      • English
      RNA Therapeutics, Part A, Volume 203 presents the latest on a new class of medication based on RNA molecules. The book includes timely chapters that focus on An introduction to RNA therapeutics and potentials, The development and technologies of RNA therapeutics, Types of RNA therapeutics, Molecular mechanisms of RNA therapeutics, IT, and AI applications in RNA therapeutics, The application of data sciences and bioinformatics in RNA therapeutics, RNA therapeutics history and future perspectives, Recent applications of RNA therapeutic in clinics, Advantages and disadvantages of RNA therapeutics, RNA therapeutics for neurological disease, RNA therapeutics for metabolic disorders, and RNA therapeutics for metabolic disorders.

    • Proteomics Mass Spectrometry Methods

      Sample Preparation, Protein Digestion, and Research Protocols
      • 1st Edition
      • Paula Meleady
      • English
      Proteomics Mass Spectrometry Methods: Sample Preparation, Protein Digestion, and Research Protocols shares best practices collected across key laboratories and core facilities, taking the reader through key tactics for executing the most usual mass spectrometry experiments. Sections review research making use of MS proteomics experiments, focus on critical sample preparation, cover mammalian cell lines and samples from clinical tissue and biological fluids, discuss subcellular fractionation, provide methods for protein digestion both for in gel and in solution, and delve into key MS proteomics analysis protocols, including label-free LC-MS, TMT and iTRAQ labelled LC-MS, phosphorylation enrichment, ubiquination enrichment, and more. This book is the perfect lab manual for research teams or for use as a new staff training material. Core facility managers may also find it useful for sharing best practices with their staff and researchers.

    • Epigenetic Regulation of Cancer - Part B

      • 1st Edition
      • Volume 383
      • English
      Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer.

    • Rare and Complex Urology

      • 1st Edition
      • Jen Tidman + 1 more
      • English
      Rare and Complex Urology has been produced by the European Reference Network (ERN) for rare urogenital diseases and complex conditions, ERN eUROGEN.The book combines information on network developments and clinical and surgical aspects, allowing for better diagnoses, treatments, and patient outcomes.The expertise areas covered include those relating to the bladder, stone and kidney diseases, congenital malformations, pelvic floor disorders, the urethra, reconstruction, and rare cancers and tumours.This is a must-have reference for clinicians and basic scientists interested in translational urology and surgery, including urologists, paediatric surgeons, and multidisciplinary team members seeking guidance on how to implement novel research.

    • Systems Biology Approaches for Host-Pathogen Interaction Analysis

      • 1st Edition
      • Mohd. Tashfeen Ashraf + 2 more
      • English
      Application and utilization of data science approaches has revolutionized scientific research including host–pathogen interaction analyses. Host–pathogen interactions are generally considered highly specific interactions, resulting in a variety of consequences. Data science approaches coupled with network biology has taken host–pathogen interaction analysis from specific interaction to a new paradigm of understanding the consequences of these interactions within a biological network. Unfortunately, basic biological researchers are mostly unaware of these advancements. Conversely, data scientists are not familiar with biological aspects of such data.Systems Biology Approaches for Host–Pathogen Interaction Analyses benefits biological researchers by expanding the scope of their research and utilization of their accumulated data using recent technological advancements. In addition, the book also opens avenues for bioinformatics and computer science researchers to utilize their expertise in biologically meaningful ways.

    • DNA Damage and Chromosomal Instability

      • 1st Edition
      • Volume 182
      • English
      DNA Damage and Chromosomal Instability, Volume 182 in the Methods in Cell Biology series, presents interesting chapters on a variety of timely topics, including Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation, Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents, Genetic reporters to detect and quantify homologous recombination in yeast, Mapping histone variant genomic distribution: exploiting SNAP- Tag labelling to follow the dynamics of incorporation of H3 variants, Enrichment of DNA replication intermediates by EdU pull down, Nascent DNA sequencing and its diverse applications in genome integrity research, and much more. Additional chapters cover Enrichment of DNA replication intermediates by EdU pull down, DNA curtains for studying phase separation mechanisms of DNA-organizing proteins, Visualizing the Dynamics of DNA Replication and Repair at the Single-Molecule Molecule Level, Cloning and Expansion of Repetitive DNA Sequences, Using an ImageJ-based script to detect replication stress and associated cell cycle exit from G2 phase by fluorescence microscopy Arne Lindqvist

    • A Comprehensive Guide to Toxicology in Nonclinical Drug Development

      • 3rd Edition
      • Ali S. Faqi
      • English
      **Selected for 2025 Doody’s Core Titles® in Toxicology**A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology