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Elsevier

Books in Life sciences

  • Food Structures, Digestion and Health

    • 1st Edition
    • Mike Boland + 2 more
    • English
    This selection of key presentations from the Food Structures, Digestion and Health conference is devoted to the unique and challenging interface between food science and nutrition, and brings together scientists across several disciplines to address cutting-edge research issues. Topics include modeling of the gastrointestinal tract, effect of structures on digestion, and design for healthy foods. New knowledge in this area is vital to enable the international food industry to design of a new generation of foods with enhanced health and sensory attributes. The multidisciplinary approach includes research findings by internationally renowned scientists, and presents new research findings important and pertinent to professionals in both the food science and nutrition fields.

  • Laboratory Methods in Enzymology: Protein Part C

    • 1st Edition
    • Volume 541
    • English
    In this volume we have brought together a number of core protocols concentrating on Protein, carefully written and edited by experts.

  • Preservation and Shelf Life Extension

    UV Applications for Fluid Foods
    • 1st Edition
    • Tatiana Koutchma
    • English
    Preservation and Shelf Life Extension focuses on the basic principles of ultraviolet light technology as applied in low-UV transmittance treatments of food fluids and solid foods. It describes the features of UV light absorption in food fluids and available commercial systems, and provides case studies for UV treatment of fresh juices, dairy products, wines, and beer. The book also includes information on various continuous and pulsed UV sources and processing systems, as well as examples of specific treatments for fruits, vegetables, meat and poultry products.

  • Colour Atlas of Ophthalmology

    • 2nd Edition
    • Arthur Lim Siew Ming + 1 more
    • English
    Colour Atlas of Ophthalmology, Second Edition provides information pertinent to the fundamental aspects of ophthalmology. This book provides the correct diagnosis and treatment of many ocular disorders. Organized into 11 chapters, this edition begins with an overview of the process of assessment of a patient with eye disease, which includes taking a good history, examining the eyes with adequate illumination, and testing the visual function. This text then describes exophthalmos, which is the most common condition of the orbit and indicates the possibility of thyroid disease or a space-occupying lesion. Other chapters consider the common causes of ocular injuries, including injury from flying particles, sharp instruments, chemicals, and ocular injury associated with head injury. The final chapter deals with the common, therapeutic, and diagnostic ocular drugs. This book is a valuable resource for ophthalmologists, physicians, nurses, students, and all those paramedical personnel who have to deal with common eye disease.

  • Toxicological Aspects of Drug-Facilitated Crimes

    • 1st Edition
    • Pascal Kintz
    • English
    Toxicological Aspects of Drug-Facilitated Crimes provides readers with an overview of the field of DFC: its history, toxicological effects, analysis, interpretation of results, the roles that age, gender and race may play, and clinical presentations of these drugs. The most commonly used drugs in DFC are addressed (alcohol, cannabis, MDMA, and cocaine), as well as an emerging range of pharmaceuticals (benzodiazepines, hypnotics, sedatives, neuroleptics, histamine H1-antagonists, or anesthetics), which are becoming more widely used, but are more difficult to detect. Edited by a world-renowned expert in the field of Forensic and Analytical Toxicology, Pascal Kintz, this book investigates toxicants of emerging concern and brings together a number of experts in the field to address the most recent discoveries on DFC toxicology.

  • Cancer Theranostics

    • 1st Edition
    • Xiaoyuan Chen + 1 more
    • English
    Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives.

  • Microbiology for Surgical Infections

    Diagnosis, Prognosis and Treatment
    • 1st Edition
    • Kateryna Kon + 1 more
    • English
    Microbiology for Surgical Infections: Diagnosis, Prognosis and Treatment explores current trends in etiology and antibiotic resistance of pathogens responsible for devastating and complex surgical infections. Clinicians and researchers report the most recent advances in diagnostic approaches to bacterial and non-bacterial surgical infections, including invasive fungal infections. Current guidelines for prophylaxis of community-acquired and nosocomial infections, complications in surgery, and improvement of diagnosis and treatment of these devastating surgical infections are also discussed. The work gives specific attention to intra-abdominal and wound infections, as well as infections in cardiac surgery and neurosurgery. Taken together, these explorations inform the work of specialists in different surgical arenas, as well as those working in microbiology. Microbiology for Surgical Infections provides a resource to those working to improve outcomes in this complicated arena by discussing prospects for future study and identifying targets for future research.

  • Silk Biomaterials for Tissue Engineering and Regenerative Medicine

    • 1st Edition
    • Subhas C. Kundu
    • English
    Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties of silk that make it useful for medical purposes and its applications in this area. Part one introduces silk biomaterials, discussing their fundamentals and how they are processed, and considering different types of silk biomaterials. Part two focuses on the properties and behavior of silk biomaterials and the implications of this for their applications in biomedicine. These chapters focus on topics including biodegradation, bio-response to silk sericin, and capillary growth behavior in porous silk films. Finally, part three discusses the applications of silk biomaterials for tissue engineering, regenerative medicine, and biomedicine, with chapters on the use of silk biomaterials for vertebral, dental, dermal, and cardiac tissue engineering. Silk Biomaterials for Tissue Engineering and Regenerative Medicine is an important resource for materials and tissue engineering scientists, R&D departments in industry and academia, and academics with an interest in the fields of biomaterials and tissue engineering.

  • The Value of BCG and TNF in Autoimmunity

    • 1st Edition
    • Denise Faustman
    • English
    The Value of BCG and TNF in Autoimmunity provides an overview of current research and thinking related to tumor necrosis factor (TNF) induction and the use of the bacillus Calmette-Guérin (BCG) vaccine as potential treatment approaches to diverse forms of autoimmunity. BCG, commonly known as an anti-tuberculosis vaccine, is being explored in worldwide clinical trials as an approach to the treatment of certain forms of autoimmunity. The scope of research behind this therapeutic approach spans from the basic science of TNF signaling to research in diverse autoimmune disciplines, such as type 1 diabetes and multiple sclerosis. Overall, the book focuses on the lessons that can be learned from the researchers' individual experiences and data, and provides a rationale for bringing the inexpensive, generic BCG vaccine to the forefront of clinical trials in different forms of autoimmunity.

  • Diabetes Mellitus: Associated Conditions, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 43-1
    • Leonid Poretsky
    • English
    This issue of the Endocrinology and Metabolism Clinics, guest edited by Drs. Leonid Poretsky and Emilia Pauline Liao, will focus on Diabetes Mellitus: Associated Conditions. Articles in this issue include Metabolic syndrome; The role of glucocorticoids and insulin resistance in adipose tissue function and lipid metabolism; Cardiovascular disease; The Relationships between Cardiovascular Disease and Diabetes: Focus on Pathogenesis; Interventions for coronary artery disease; Peripheral Arterial Disease; Hypertension; Sleep apnea; Osteoporosis; Vitamin D deficiency; Diabetes and cancer; Dementia; Depression; and Polycystic Ovary Syndrome.

  • Therapeutic Risk Management of Medicines

    • 1st Edition
    • Stephen J. Mayall + 1 more
    • English
    Therapeutic risk management of medicines is an authoritative and practical guide on developing, implementing and evaluating risk management plans for medicines globally. It explains how to assess risks and benefit-risk balance, design and roll out risk minimisation and pharmacovigilance activities, and interact effectively with key stakeholders.A more systematic approach for managing the risks of medicines arose following a number of high-profile drug safety incidents and a need for better access to effective but potentially risky treatments. Regulatory requirements have evolved rapidly over the past decade. Risk management plans (RMPs) are mandatory for new medicinal products in the EU and a Risk Evaluation and Mitigation Strategy (REMS) is needed for certain drugs in the US.This book is an easy-to-read resource that complements current regulatory guidance, by exploring key areas and practical implications in greater detail. It is structured into chapters encompassing a background to therapeutic risk management, strategies for developing RMPs, implementation of RMPs, and the continuing evolution of the risk management field.The topic is of critical importance not only to the pharmaceutical and biotechnology industries, but also regulators and healthcare policymakers.Some chapters feature contributions from selected industry experts.

  • Food Plant Safety

    UV Applications for Food and Non-Food Surfaces
    • 1st Edition
    • Tatiana Koutchma
    • English
    Food Plant Safety: UV Applications for Food and Non-Food Surfaces discusses the fundamental principles of ultraviolet (UV) light technology, and gives practical recommendations on UV processes and systems design for specific processing operations, as well as how microbial efficacy of UV light can improve the quality of existing product lines. Innovative research of ultraviolet light for food applications has been growing worldwide. With increased consumer demand for fresher, minimally processed but safe foods, comes the need for novel technologies to meet that demand. Ultraviolet technology has been taking its niche in food production as a non-chemical treatment to control and enhance safety of processing plants and storage facilities. This concise resource covers the fundamentals of this promising technology and its applications; it will benefit a broad audience of professionals in food engineering, processing, and product development, as well as graduate level students.

  • Advances in Agronomy

    • 1st Edition
    • Volume 125
    • English
    Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial.

  • Advances in Protein Chemistry and Structural Biology

    • 1st Edition
    • Volume 94
    • English
    This eclectic volume features two major topics: applications of mass spectrometry in bioscience; and computational methods for analysis of protein structure and interactions with other macromolecules. Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

  • The Role of 5-HT Systems on Memory and Dysfunctional Memory

    Emergent Targets for Memory Formation and Memory Alterations
    • 1st Edition
    • Alfredo Meneses
    • English
    Drugs acting through 5-HT (5-hydroxytryptamine... or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory.

  • From an Antagonistic to a Synergistic Predator Prey Perspective

    Bifurcations in Marine Ecosystem
    • 1st Edition
    • Tore Johannessen
    • English
    From an Antagonistic to a Synergistic Predator Prey Perspective: Bifurcations in Marine Ecosystems is a groundbreaking reference that challenges the widespread perception that predators generally have a negative impact on the abundance of their prey, and it proposes a novel paradigm — Predator-prey Synergism — in which both predator and prey enhance abundance by their co-existence. Using this model, the text explains a number of issues that appear paradoxical in the case of a negative predator-prey relationship, including observed ecosystem bifurcations (regime shifts), ecosystem resilience, red tides in apparently nutrient depleted water, and the dominance of grazed phytoplankton over non-grazed species under high grazing pressure. This novel paradigm can also be used to predict the potential impact of global warming on marine ecosystems, identify how marine ecosystem may respond to gradual environmental changes, and develop possible measures to mitigate the negative impact of increasing temperature in marine ecosystems. This book approaches the long-standing question of what generates recruitment variability in marine fishes and invertebrates in an engaging and unique way that students and researchers in marine ecosystems will understand.

  • Reconstituting the Cytoskeleton

    • 1st Edition
    • Volume 540
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers cytoskeletal structure, including such topics as rotational movement of formins studied by fluorescence polarization microscopy, in vitro assembly assays for bacterial actin filaments, and modulators of microtubule plus end growth.

  • Starch Polymers

    From Genetic Engineering to Green Applications
    • 1st Edition
    • P. Halley + 1 more
    • English
    This book focuses on starch polymers including starch genetics, biotechnological and chemical modification, nanostructures, processing, characterization, properties and applications. This books topic is in a cutting edge and emerging technology area of biomaterials, nanomaterials and renewable materials, and will involve international experts in diverse fields from genetic engineering to applications.

  • Erectile Dysfunction as a Cardiovascular Impairment

    • 1st Edition
    • Robert Fried
    • English
    Erectile Dysfunction as a Cardiovascular Impairment organizes and summarizes the many aspects of biology and metabolism in cardiovascular and sexual function. Coverage includes how blood vessels are discovered to work, their role in hypertension, atherosclerosis, type-2 diabetes, oxidative stress, metabolic syndrome, and erectile dysfunction.

  • Pattern Recognition and Signal Analysis in Medical Imaging

    • 2nd Edition
    • Anke Meyer-Baese + 1 more
    • English
    Medical imaging is one of the heaviest funded biomedical engineering research areas. The second edition of Pattern Recognition and Signal Analysis in Medical Imaging brings sharp focus to the development of integrated systems for use in the clinical sector, enabling both imaging and the automatic assessment of the resultant data. Since the first edition, there has been tremendous development of new, powerful technologies for detecting, storing, transmitting, analyzing, and displaying medical images. Computer-aided analytical techniques, coupled with a continuing need to derive more information from medical images, has led to a growing application of digital processing techniques in cancer detection as well as elsewhere in medicine. This book is an essential tool for students and professionals, compiling and explaining proven and cutting-edge methods in pattern recognition for medical imaging.

  • Aging

    Oxidative Stress and Dietary Antioxidants
    • 1st Edition
    • Victor R. Preedy
    • English
    Aging: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging.

  • Side Effects of Drugs Annual

    A worldwide yearly survey of new data in adverse drug reactions
    • 1st Edition
    • Volume 35
    • Jeffrey K Aronson
    • English
    The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia, Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.

  • Cancer

    Oxidative Stress and Dietary Antioxidants
    • 1st Edition
    • Victor R. Preedy
    • English
    Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this. Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.

  • Environmental Microbiology

    • 3rd Edition
    • Ian Pepper + 2 more
    • English
    Designed for advanced undergraduate students, graduate students, and environmental professionals, this book builds upon the tremendous success of the previous editions with a comprehensive and up-to-date discussion of environmental microbiology as a discipline that has greatly expanded in scope and interest over the past several decades. From terrestrial and aquatic ecosystems to urban and indoor environments, this edition relates environmental microbiology to a variety of life science, ecology, and environmental science topics including biogeochemical cycling, bioremediation, environmental transmission of pathogens, microbial risk assessment, and drinking water treatment and reuse. The final chapter highlights several emerging issues including microbial remediation of marine oil spills, microbial contributions to global warming, impact of climate change on microbial infectious disease, and the development of antibiotic-resistant bacteria.

  • Human Milk Biochemistry and Infant Formula Manufacturing Technology

    • 1st Edition
    • English
    Since infant formula substitutes for human milk, its composition must match that of human milk as closely as possible. Quality control of infant formula is also essential to ensure product safety, as infants are particularly vulnerable food consumers. This book reviews the latest research into human milk biochemistry and best practice in infant formula processing technology and quality control.

  • Regulation of Water and Electrolytes

    • 1st Edition
    • Peter K.T. Pang
    • English
    Vertebrate Endocrinology: Fundamentals and Biomedical Implications, Volume 2: Regulation of Water and Electrolytes provides information pertinent to vertebrate endocrine systems, which has significant contributions to basic biological and biomedical research. This book discusses the practical implications of the endocrinological studies. Organized into 13 chapters, this volume starts with an overview of the comprehensive aspects of endocrinology in mammalian and nonmammalian vertebrates, with emphasis on those systems that affect salt and water balance. This book then discusses the control of secretion as well as the function and biomedical implications of knowledge of secretion and function. Other chapters discuss several topics, including neurohypophysis, adrenal hormones, and pancreatic hormones. This text discusses as well the renin–angiotensin system. The final chapter deals with the changes that occur during vertebrate evolution in smaller peptide hormones, such as the neurohypophysial peptides and the angiotensins. Endocrinologists, biologists, graduate students, and researchers will find this book extremely useful.

  • Regulation of Calcium and Phosphate

    • 1st Edition
    • Peter K.T. Pang
    • English

  • Nutrition in the Prevention and Treatment of Abdominal Obesity

    • 1st Edition
    • Ronald Ross Watson
    • English
    Nutrition in the Prevention and Treatment of Abdominal Obesity focuses on the important roles that exercise, dietary changes, and foods play in promoting as well as reducing visceral fat. Nutritionists, dieticians, and healthcare providers seeking to address the abdominal obesity epidemic will use this comprehensive resource as a tool in their long-term goal of preventing chronic diseases, especially heart, vascular, and diabetic diseases. Experts from a broad range of disciplines are involved in dealing with the consequences of excessive abdominal fat: cardiology, diabetes research, studies of lipids, endocrinology and metabolism, nutrition, obesity, and exercise physiology. They have contributed chapters that define a range of dietary approaches to reducing risk and associated chronic diseases. They begin by defining visceral obesity and its major outcomes; they also discuss the importance and the challenges of dietary approaches to reduce abdominal obesity, as compared to clinical approaches, with major costs and risks.

  • Nutraceutical and Functional Food Regulations in the United States and Around the World

    • 2nd Edition
    • Debasis Bagchi
    • English
    This fully revised and updated edition begins with insights into the scope, importance and continuing growth opportunities in the nutraceutical and functional food industries and explores the latest regulatory changes and their impacts. The book demonstrates the global scenario of the acceptance and demand for these products and explores the regulatory hurdles and claim substantiation of these foods and dietary supplements, as well as addressing the intricate aspects of manufacturing procedures. As the public gains confidence in the quality of these products based on sophisticated quality control, a broad spectrum of safety studies and GRAS, peer-reviewed publications and cutting-edge human clinical studies have emerged. An increasing number of additional populations around-the-world now recognize the efficacy and functions of nutraceuticals and functional foods as established by those scientific research studies. As a result, a number of structurally and functionally active novel nutraceuticals and several new functional beverages have been introduced into the marketplace around the world.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 87
    • English
    Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Impact factor for 2012: 4.974.

  • Laboratory Methods in Enzymology: Protein Part B

    • 1st Edition
    • Volume 539
    • English
    Laboratory Methods in Enzymology: Protein Part B brings together a number of core protocols concentrating on protein, carefully written and edited by experts.

  • Fluorescence Microscopy

    Super-Resolution and other Novel Techniques
    • 1st Edition
    • Anda Cornea + 1 more
    • English
    Fluorescence Microscopy: Super-Resolution and other Novel Techniques delivers a comprehensive review of current advances in fluorescence microscopy methods as applied to biological and biomedical science. With contributions selected for clarity, utility, and reproducibility, the work provides practical tools for investigating these ground-breaking developments. Emphasizing super-resolution techniques, light sheet microscopy, sample preparation, new labels, and analysis techniques, this work keeps pace with the innovative technical advances that are increasingly vital to biological and biomedical researchers. With its extensive graphics, inter-method comparisons, and tricks and approaches not revealed in primary publications, Fluorescence Microscopy encourages readers to both understand these methods, and to adapt them to other systems. It also offers instruction on the best visualization to derive quantitative information about cell biological structure and function, delivering crucial guidance on best practices in related laboratory research.

  • The Pancreatic Beta Cell

    • 1st Edition
    • Volume 95
    • English
    First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell.

  • Aminoff's Neurology and General Medicine

    • 5th Edition
    • Michael J. Aminoff + 1 more
    • English
    Aminoff's Neurology and General Medicine is the standard and classic reference providing comprehensive coverage of the relationship between neurologic practice and general medicine. As neurologists are asked to consult on general medical conditions, this reference provides an authoritative tool linking general medical conditions to specific neurologic issues and disorders. This is also a valuable tool for the general practitioner seeking to understand the neurologic aspects of their medical practice. Completely revised with new chapters covering metastatic disease, bladder disease, psychogenic disorders, dementia, and pre-operative and post-operative care of patients with neurologic disorders, this new edition will again be the go-to reference for both neurologists and general practitioners.

  • Computational Neuroscience

    • 1st Edition
    • Volume 123
    • English
    Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. This volume brings together different aspects of, and approaches to, molecular and multi-scale modeling, with applications to a diverse range of neurological diseases. Mathematical and computational modeling offers a powerful approach for examining the interaction between molecular pathways and ionic channels in producing neuron electrical activity. It is well accepted that non-linear interactions among diverse ionic channels can produce unexpected neuron behavior and hinder a deep understanding of how ion channel mutations bring about abnormal behavior and disease. Interactions with the diverse signaling pathways activated by G protein coupled receptors or calcium influx adds an additional level of complexity. Modeling is an approach to integrate myriad data sources into a cohesive and quantitative model in order to evaluate hypotheses about neuron function. In particular, a validated model developed using in vitro data allows simulations of the response to in vivo like spatio-temporal patterns of synaptic input. Incorporating molecular signaling pathways into an electrical model, allows a greater range of models to be developed, ones that can predict the response to pharmaceuticals, many of which target neuromodulator pathways.

  • Approaches to Research on the Systematics of Fish-Borne Trematodes

    • 1st Edition
    • Jitra Waikagul + 1 more
    • English
    Approaches to Research on the Systematics of Fish-Borne Trematodes is a concise guide for systematic studies of the prevalence of fish-borne trematodes both in the endemic areas and experimental laboratories. It includes methods to identify species of fish-borne trematodes to enhance the precision of research studies based on the metacercarial stage. Misidentification of trematode species is a common occurrence when researchers are new to the field and have no guidance. Consequentially, sometimes publications report inaccurate prevalence rates of these parasites. This compact guide gives clear direction on: Collection of parasites in the final hosts Collection of cercaria from snail first intermediate hosts Collection of metacercaria from fish hosts Molecular identification of parasites Systematics of fish-borne trematodes

  • Biotechnology and Biology of Trichoderma

    • 1st Edition
    • Vijai G. Gupta + 5 more
    • English
    Biotechnology and Biology of Trichoderma serves as a comprehensive reference on the chemistry and biochemistry of one of the most important microbial agents, Trichoderma, and its use in an increased number of industrial bioprocesses for the synthesis of many biochemicals such as pharmaceuticals and biofuels. This book provides individuals working in the field of Trichoderma, especially biochemical engineers, biochemists and biotechnologists, important information on how these valuable fungi can contribute to the production of a wide range of products of commercial and ecological interest.

  • Behavioral Addictions

    Criteria, Evidence, and Treatment
    • 1st Edition
    • Kenneth Paul Rosenberg MD + 1 more
    • English
    DSM-V broke new ground in May of 2013, designating a new disorder called "behavioral addiction." Clinicians immediately wanted to know: how is a behavioral addiction different from an impulse control disorder? What are the criteria for determining that some behaviors are addictions rather than impulses? What, if anything, does this mean in terms of effective treatment?Behavioral Addictions is the first and most authoritative text ever written on the subject of behavioral addictions. This comprehensive work explains the criteria used to determine addiction, the evidence for identifying assorted behaviors as addictions, and the evidence-based treatment for each.With contributions from preeminent experts covering an exhaustive list of behavioral addictions, this book is unique in its coverage of behavioral addictions, their criteria, and treatment. It is a valuable and timely resource for any clinician treating addictions.

  • The Produce Contamination Problem

    Causes and Solutions
    • 2nd Edition
    • Karl Matthews
    • English
    Understanding the causes and contributing factors leading to outbreaks of food-borne illness associated with contamination of fresh produce is a worldwide challenge for everyone from the growers of fresh-cut produce through the entire production and delivery process. The premise of The Produce Contamination Problem is that when human pathogen contamination of fresh produce occurs, it is extremely difficult to reduce pathogen levels sufficiently to assure microbiological safety with the currently available technologies. A wiser strategy would be to avoid crop production conditions that result in microbial contamination to start. These critical, problem-oriented chapters have been written by researchers active in the areas of food safety and microbial contamination during production, harvesting, packing and fresh-cut processing of horticultural crops, and were designed to provide methods of contamination avoidance. Coverage includes policy and practices in the United States, Mexico and Central America, Europe, and Japan.

  • Evolution by Tumor Neofunctionalization

    The Role of Tumors in the Origin of New Cell Types, Tissues and Organs
    • 1st Edition
    • Andrei P. Kozlov
    • English
    Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution. This book will stimulate thinking on this topic by specialists in the fields of evolutionary biology, oncology, molecular biology, molecular evolution, embryology, evo-devo, tumor immunology, pathology and clinical oncology.

  • Micropatterning in Cell Biology, Part C

    • 1st Edition
    • Volume 121
    • English
    This new volume of Methods in Cell Biology looks at micropatterning in cell biology and includes chapters on protein photo-patterning on PEG with benzophenone, laser-directed cell printing and dip pen nanolithography. The cutting-edge material in this comprehensive collection is intended to guide researchers for years to come.

  • Food Security, Poverty and Nutrition Policy Analysis

    Statistical Methods and Applications
    • 2nd Edition
    • Suresh Babu + 2 more
    • English
    Food insecurity, the lack of access at all times to the food needed for an active and healthy life, continues to be a growing problem as populations increase while the world economy struggles. Formulating effective policies for addressing these issues requires thorough understanding of the empirical data and application of appropriate measurement and analysis of that information. Food Security, Poverty and Nutrition Policy Analysis, Second Edition has been revised and updated to include hands-on examples and real-world case studies using the latest datasets, tools and methods. Providing a proven framework for developing applied policy analysis skills, this book is based on over 30 years of food and nutrition policy research at the International Food Policy Research Institute and has been used worldwide to impart the combined skills of statistical data analysis, computer literacy and their use in developing policy alternatives.This book provides core information in a format that provides not only the concept behind the method, but real-world applications giving the reader valuable, practical knowledge.

  • Physiology and Biochemistry

    • 2nd Edition
    • Geoffrey Bourne
    • English
    The Structure and Function of Muscle, Second Edition, Volume III: Physiology and Biochemistry presents the physiology and biochemistry of muscle. This book discusses the various aspects of the structure of muscles and explores some aspects of muscle disease. Organized into 10 chapters, this edition begins with an overview of the transverse tubular system or T system of striated muscle. This text then examines the properties and function of membranes through electron microscopy. Other chapters consider in more detail from a biophysical viewpoint certain aspects of the series of events surrounding muscle contraction. This book discusses as well the significance of the central circulation and the amount of oxygen that can be delivered by the cardiovascular system. The final chapter deals with the heat output and chemical breakdown during an isometric twitch. This book is a valuable resource for scientists, neurobiologists, biologists, biochemists, physiologists, histologists, cytologists, and research workers.

  • Nanosensors for Chemical and Biological Applications

    Sensing with Nanotubes, Nanowires and Nanoparticles
    • 1st Edition
    • Kevin C. Honeychurch
    • English
    Nano-scale materials are proving attractive for a new generation of devices, due to their unique properties. They are used to create fast-responding sensors with good sensitivity and selectivity for the detection of chemical species and biological agents. Nanosensors for Chemical and Biological Applications provides an overview of developments brought about by the application of nanotechnology for both chemical and biological sensor development. Part one addresses electrochemical nanosensors and their applications for enhanced biomedical sensing, including blood glucose and trace metal ion analysis. Part two goes on to discuss spectrographic nanosensors, with chapters on the use of nanoparticle sensors for biochemical and environmental sensing and other techniques for detecting nanoparticles in the environment. Nanosensors for Chemical and Biological Applications serves as a standard reference for R&D managers in a range of industrial sectors, including nanotechnology, electronics, biotechnology, magnetic and optical materials, and sensors technology, as well as researchers and academics with an interest in these fields.

  • Cellular Endocrinology in Health and Disease

    • 1st Edition
    • Alfredo Ulloa-Aguirre + 1 more
    • English
    Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. Among these are those whose function was not obvious until recently, including the endocrine functions of bone and the adipose tissue. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and P. Michael Conn, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts.

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 309
    • Kwang W. Jeon
    • English
    International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology, both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Antioxidants in Food, Vitamins and Supplements

    Prevention and Treatment of Disease
    • 1st Edition
    • Amitava Dasgupta + 1 more
    • English
    Antioxidants in Food, Vitamins and Supplements bridges the gap between books aimed at consumers and technical volumes written for investigators in antioxidant research. It explores the role of oxidative stress in the pathophysiology of various diseases as well as antioxidant foods, vitamins, and all antioxidant supplements, including herbal supplements. It offers healthcare professionals a rich resource of key clinical information and basic scientific explanations relevant to the development and prevention of specific diseases. The book is written at an intermediate level, and can be easily understood by readers with a college level chemistry and biology background.

  • Methods of Adipose Tissue Biology Part B

    Methods of Adipose Tissue Biology
    • 1st Edition
    • Volume 538
    • English
    This book is a must-have for anyone interested in obesity or the physiology of white or brown adipose tissues. It contains state-of-the-art methods from researchers that are world leaders in this field. Detailed lab protocols range from methods to visualize adipocytes and adipose tissues in humans and experimental models, to convert stem cells into white and brown adipocytes in vitro, to evaluate aspects of adipocyte metabolism, to inducibly knock out genes in adipose tissues, and to evaluate transcriptional control of adipogenesis on a global scale.

  • Human Herpesviruses HHV-6A, HHV-6B and HHV-7

    Diagnosis and Clinical Management
    • 3rd Edition
    • Volume 12
    • Louis Flamand + 3 more
    • English
    Completely revised and updated, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition, delivers a contemporary and thorough review of HHV-6, beginning with foundational explorations of classification, molecular biology, and chromosomal integration of the virus, through to clinical details, including pathologic features of infection, and clinical effects on various organ systems. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis. The book examines the role of HHV-6 in myriad diseases, including cognitive disorders following bone marrow transplant, mesial temporal lobe epilepsy, multiple sclerosis, autoimmune disease, encephalitis, Hodgkin's disease lymphoma (HHV-6B), and glioma (HHV-6A). Descriptions of current and novel molecular and serological diagnostic assays, along with detailed protocols, are included to aid researchers and clinicians in discriminating potential false positives originating from chromosomally integrated HHV-6, and in differentiating between active and latent infection. Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition is a valuable reference for both clinical and basic scientists, including epidemiologists, virologists, practicing clinicians, infectious disease specialists, pathologists, and all scientists entering the field of herpes virus research. The work is a practical and thorough resource for a foundational understanding of HHV-6 and HHV-7, while providing a cutting-edge translational and clinical reference to those looking to understand and diagnose associated viral diseases.

  • Mechanisms of Regeneration

    • 1st Edition
    • Volume 108
    • English
    This new volume of Current Topics in Developmental Biology covers the area of mechanisms in regeneration. With an international board of authors, it provides a comprehensive set of reviews covering such topics as control of growth during regeneration, skeletal muscle degeneration and regeneration in mammals and flies, and suppression of regeneration in mammals.

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