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Elsevier

Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Prostanoids

    Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
    • 1st Edition
    • ValĂ©ria KecskemĂ©ti
    • English
    Prostanoids, Volume VI, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. Prostaglandin research is an exciting and rapidly developing field in chemical and biological sciences. It is the recently discovered prostacyclin that has brought about a breakthrough in prostaglandin research giving new impetus to clinical investigation. This volume contains 22 papers read at the ""Prostanoids Symposium"" by participants from eight different countries. Numerous new data concerning the synthesis of prostacyclin and different stable prostacyclin analogues are presented. Besides the problems of synthetic chemistry, data are given about the pharmacological properties of these prostacyclin analogues, analyzing their effects on heat and smooth muscles. Several papers dealing with the involvement of different pharmacologically active agents and hormones in the biosynthesis of prostaglandins emphasize the important role of prostanoids in various pathophysiological processes and diseases. The clinical use of prostacyclin, having already earned an outstanding position in medicine, is stressed.

  • Monoamine Oxidases and Their Selective Inhibition

    Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
    • 1st Edition
    • K. Magyar
    • English
    Monoamine Oxidases and Their Selective Inhibition, Volume IV, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The discovery of the selective monoamine oxidase (MAO) inhibitors, such as clorgyline and deprenyl, has given a new impetus to MAO research as well as to the clinical applicability of these compounds. This volume contains 21 papers by researchers and clinicians from eight different countries. It begins with papers on the pharmacological effects and the biochemical mode of actions of deprenyl as well as some other new selective inhibitors. This is followed by communications concerning the biochemical methods applied in the study of the nature of MAO in the mitochondrial membrane. Finally, the neurologists provide an account of their experience with the clinical application of deprenyl, and other inhibitors in Parkinsonian patients. They also discuss the essential role of the dopaminergic mechanism with respect to the disease.

  • The Toxicology of Radioactive Substances

    Volume 5
    • 1st Edition
    • A. A. Letavet + 1 more
    • English
    The Toxicology of Radioactive Substances, Volume 5: Zinc-65 deals with the toxic properties of the radioisotope zinc-65 as well as its biological effects. Emphasis is placed on the role of stable zinc in the reaction of the body to the administration of zinc-65. Some of the results of laboratory studies on the toxic effects of zinc-65 on animals, primarily rabbits, are presented. This volume is comprised of 18 chapters and opens with an overview of certain aspects of the toxicology of radioactive zinc-65, followed by a discussion on the behavior of zinc-65 in the rat body. Subsequent chapters explore the distribution of zinc-65 in the body of rabbits following chronic oral administration; bioelectrical activity of the cerebral cortex in rabbits in conditions of prolonged administration of radioactive zinc; the effect of prolonged internal irradiation with G5ZnCl2 on the functional state of the rabbit heart; and aspects of hemopoiesis following chronic intake of radiozinc. Morphological changes in experimental animals following chronic exposure to radioactive zinc are also considered. This book will be of interest to chemists and toxicologists.

  • The Actions and Uses of Ophthalmic Drugs

    A Textbook for Students and Practitioners
    • 2nd Edition
    • P. H. O'Connor Davies
    • English
    The Actions and Uses of Ophthalmic Drugs: A Textbook for Students and Practitioners, Second Edition provides pertinent information in relation to concepts in pharmacology, the formulation and application of ophthalmic drugs, and adverse ocular effects of systemic medication. This book discusses the preparations used in contact lens practice. Organized into 17 chapters, this edition begins with an overview of the primary systems of drug classification according to their actions or effects, or on the basis of their chemistry. This text then presents a detailed discussion on the actions and uses of ophthalmic autonomic drugs. Other chapters consider the structure and function of the involuntary nervous system in the orbital region. This book discusses as well the two main classifications of ophthalmic drugs, namely, therapeutic and diagnostic. The final chapter deals with the clinical significance of medication-induced ocular adverse effects. This book is a valuable resource for ophthalmologists, students, and practitioners.

  • Basic Pharmacology

    • 2nd Edition
    • R W Foster
    • English
    Basic Pharmacology, Second Edition, similar to the first edition, talks about the relationship between the human body and therapeutic drugs. A large part of this book discusses the nervous system and the way certain drugs operate and affect it. The first part of this book covers the importance of having a firm understanding of the organ system, especially the nervous system. Understanding the systems is the initial step in learning how a drug affects the body, both internally and externally. This book also clarifies that a drug's impact occurs when it comes in contact with a chemical component of the body (enzymes, hormones, membranes, etc.). The next sections of this book discuss miscellaneous topics of the human anatomy, such as the brain, eyes, lungs, and various muscles. This edition also explains how a drug acts on each of those body parts. This book serves as a great reference to students affiliated in the anatomy, biology, pharmacy, and related fields.

  • Essays in Toxicology

    Volume 6
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 6 approaches toxicology by very different routes; two essays with materials (plastics and tobacco alkaloids), one deals with the effects of abnormal pressure, one considers the biochemistry of the lung, and one discusses poison control centers and other mechanisms for limiting the injury done by toxic materials. The book presents essays on the topological problems and untoward effects from plastic devices used in medical applications; the metabolism of tobacco alkaloids; and poisons control center. The text also includes essays on the toxicology of hypobaric and hyperbaric environments; as well as the exploitable biochemical approaches for the evaluation of toxic lung damage. Biochemists, physical chemists, neurophysiologists, epidemiologists, and social scientists will find the book invaluable.

  • Epidemiology in Country Practice

    • 1st Edition
    • William Norman Pickles
    • English
    Epidemiology in Country Practice presents the development of the catarrhal jaundice and myalgia. It discusses the epidemiological and clinical observations of country doctors. It addresses the conditions of life of a country doctor. Some of the topics covered in the book are the appeal to improved medical research; methods of communicating medical research; techniques in acquisition of clinical data; types of diseases of the people living in the country; description of influenza, measles, scarlet fever, whooping-cough, and mumps; and diagnosis and behavior of chicken-pox and shingles. The description of sonne dysentery is fully covered. An in-depth account of the diagnosis, symptoms, and treatment of undulant fever are provided. The characteristic mononucleosis of glandular fever is completely presented. A chapter is devoted to the classification and description of different skin conditions. Another section is focus on the diagnosis of malignant disease. The book can provide useful information to doctors, students, and researchers.

  • Toxicology

    Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
    • 1st Edition
    • Y. Cohen
    • English
    Advances in Pharmacology and Therapeutics, Volume 9: Toxicology is a collection of papers that tackles advances in toxicological research in context of pharmacology. The text first covers reactive metabolites and their implications for toxicology. Next, the selection deals with the experimental and clinical correlations of behavioral toxicology. The text also tackles toxicology and pharmacology of topical application. The book will be of great use to researchers and practitioners of health related disciplines.

  • Pharmacology of the Coronary Circulation

    Volume 10
    • 1st Edition
    • Natalia V. Kaverina
    • English
    Pharmacology of the Coronary Circulation focuses on the effects of pharmacological substances on the circulation of the heart, physiology of coronary circulation, effects of adrenomimetic, cholinergic, and ganglion-blocking agents, phenothiazine derivatives, analgesics, nitrites, and nitrates on cardiac vessels and results of clinical trials on Chloracizine. The publication first offers information on the physiology of the coronary circulation and the effects of pharmacological substances on the coronary circulation, including myotropic and neutropic substances and other substances. The book then examines the effects of adrenomimetic substances and cholinergic substances on the coronary circulation. The manuscript evaluates the effects of ganglion-blocking substances and analgesic substances on the coronary circulation. Topics include nicotine, etraethylammonium, hexamethonium, pentamine, and mecamine. The publication then takes a look at the effects of phenothiazine derivatives on the coronary circulation; importance of reflex reactions in connection with the development of acute coronary insufficiency; and effects of pharmacological substances on reflex reactions in the coronary vessels. The book is a dependable reference for readers interested in the pharmacology of the coronary circulation.

  • Monographs on Fragrance Raw Materials

    A Collection of Monographs Originally Appearing in Food and Cosmetics Toxicology
    • 1st Edition
    • D. L. J. Opdyke
    • English
    Monographs on Fragrance Raw Materials contains a collection of monographs originally appearing in Food and Cosmetics Toxicology from the first issues in 1973 to the last ones in 1978. The monographs are organized in alphabetical order, as a regular feature of Food and Cosmetics Toxicology. This monograph will prove valuable to many readers of Food and Cosmetics Toxicology, as well as to the wider community of scientists and interested consumers.

  • Mechanisms of Drug Toxicity

    Proceedings of the Third International Pharmacological Meeting
    • 1st Edition
    • H. Rašková
    • English
    Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

  • Ions-Cyclic Nucleotides-Cholinergy

    Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
    • 1st Edition
    • J.C. Stoclet
    • English
    Advances in Pharmacology and Therapeutics, Volume 3: Ions – Cyclic Nucleotides – Cholinergy covers the proceedings of the Seventh International Congress of Pharmacology, held in Paris in 1978. This book mainly focuses on studying ions, cyclic nucleotides, and cholinergy. Specifically, this text discusses the pharmacology of calcium homeostasis and presents lectures given in the symposium. The role of cyclic nucleotides in the regulation of muscular tissue functions and the evaluation of cyclic AMP and cyclic GMP are also looked into. This text presents in its latter part papers on chemical structure and cholinergic activity. This volume will be valuable to students and experts in the field of pharmacology, therapeutics, and related fields.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 6
    • 1st Edition
    • E. J. AriĂ«ns
    • English
    Drug Design, Volume VI covers practical approaches to the development of bioactive compounds, with focus on antiradiation agents, organ-imaging radiopharmaceuticals... X-ray contrast media, proteinase inhibitors, and pesticide formulations. The book discusses the chemical routes available for the synthesis of diphenhydramine derivatives, the biological activities, the relationships between structure and activity, and the phase of manipulation in the design of diphenhydramine derivatives. The text also describes the design of antiradiation agents, organ-imaging radiopharmaceuticals... and X-ray contrast media, as well as the rational approach to proteinase inhibitors. The chemical and physical methods of formulation of agricultural pesticides are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design and manufacture will find the book invaluable.

  • Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

    • 1st Edition
    • T.E. Gram
    • English
    Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.

  • In Vitro Biological Systems

    Methods in Toxicology, Vol. 1
    • 1st Edition
    • Charles A. Tyson + 1 more
    • English
    Methods in Toxicology, Volume 1: In Vitro Biological Systems, Part A provides basic techniques employed by widely recognized scientists to prepare and maintain the biological components of in vitro model systems. The book discusses the in vitro models of neural and neuromuscular systems; ocular system; respiratory system; cardiovascular system; and gastrointestinal system. The text also describes liver slices; liver hepatocytes; other liver cell systems; proximal tubule fragments; kidney cell culture; reproductive and developmental systems; immune system; and skin. Pharmacologists, toxicologists, cell biologists, physiologists, immunotoxicologists, and molecular toxicologists will find the book invaluable.

  • Pharmacology of Central Synapses

    • 1st Edition
    • V. V. Zakusov
    • English
    Pharmacology of Central Synapses deals with the pharmacology of the central nervous system and the mode of action of neurotropic drugs based on their influence on synaptic transmission. The neuronal structure of the nervous system, the structure of the synapses, and the phenomena of electrochemical transmission are discussed in this context. The main propositions of the synaptic theory of the action of neurotropic drugs, based on morphological, physiological, and biochemical findings, form the conceptual basis of this book. Comprised of eight chapters, this book examines the effect of neurotropic drugs on the synaptic transmission in reflex, projection, and association (commissural) tracts. The specific effects of various narcotics, neuroleptics, tranquillizers, analgesics, antidepressants, and stimulants on synaptic transmission in various structures of the central nervous system and at its different levels are described. This text also considers the differences in the sensitivity to such drugs of various synapses and their influence on the selectivity of drug action. This book explains the influence of neurotropic drugs on such aspects of nervous activity as impulse summation, after-discharge and functional lability, central inhibition, and the neurochemical mechanisms, particularly those involving monoaminergic, cholinergic, serotoninergic, and GABA-ergic components of synaptic transmission. The final chapter focuses on the effect of psychotropic drugs on behavior. This book will be helpful to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.

  • Evaluating Alcohol and Drug Abuse Treatment Effectiveness

    Recent Advances
    • 1st Edition
    • Linda Carter Sobell + 2 more
    • English
    Evaluating Alcohol and Drug Abuse Treatment Effectiveness: Recent Advances is a collection of papers that covers the advancement in rehabilitation of individuals with a history of substance abuse. The title aims to find ways in identifying the treatment that best fits a specific patient. The text first provides a historical account of alcohol and drug treatment outcome research. Next, the selection considers the use of multiple measures of life health to assess alcohol treatment. Chapter 3 deals with the behavioral assessment and treatment evaluation of narcotic addiction, while Chapter 4 talks about the evaluation of behavioral and traditional treatment of alcoholics. The fifth chapter tackles the contingency contracting with drug abusers, and the sixth chapter covers the development of a prototype for the evaluation of alcohol treatment. The text also details the problems in alcohol treatment along with the improvement of confidence in treatment of substance abuse. The book will be of great use to behavioral scientists, social workers, and mental health specialists.

  • Recent Advances in the Pharmacology of Toxins

    Proceedings of the First International Pharmacological Meeting Stockholm, 22-25 August, 1961
    • 1st Edition
    • H. W. Raudonat
    • English
    Recent Advances in the Pharmacology of Toxins brings together the proceedings of the Second International Pharmacological Meeting of the International Union of Physiological Sciences, held in Prague, Czechoslovakia, on August 20-23, 1963. The meeting provided a forum for discussing advances in the understanding of the pharmacology of toxins and addressed topics ranging from antagonists of bradykinin to the mode of the spread of tetanus toxin in experimental animals. This volume is comprised of 28 chapters and begins with an analysis of the effects of toxins from microorganisms on mammalian cellular metabolism and structure, followed by a review of SRS-A, a slow-reacting substance of anaphylaxis, as a potential factor in the symptoms produced by venoms and toxins. Subsequent chapters explore the release of pharmacologically active lipids by enzymes contained in toxins; the structure and function of some enzymes in snake venoms, with reference to disulfide linkages; biochemistry and pharmacology of small-molecular compounds of cobra venom; and the role of ganglioside in the mode of action of tetanus toxin. This book will be of particular value to pharmacologists and physiologists.

  • Chemical Structure–Biological Activity Relationships: Quantitative Approaches

    Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
    • 1st Edition
    • F. Darvas
    • English
    Chemical Structure-Biological Activity Relationships: Quantitative Approaches, Volume III, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. This volume focuses on the methodological aspects of QSAR. It also aims to inform the reader about the QSAR research conducted in East-European countries. This volume contains 38 presentations organized into six sections. Several lecturers deal with ""real prediction"" cases, i.e. activity estimation prior to the synthesis of the compounds. A particularly abundant section is devoted to the question of how the receptor models can be built up by means of QSAR calculations. Other sections present mathematical models and algorithms which could be applied to improve further the effectiveness of QSAR calculations. As another unique feature, a separate section treats the quantitative aspects of peptide structure-activity relationships—a field seemingly backward despite its evident importance. Hydrophobicity and its influence on biological potency along with the relationship of steric properties and biological activity are also discussed.

  • Neurotransmitters, Receptors

    Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981
    • 1st Edition
    • H. Yoshida + 2 more
    • English
    Advances in Pharmacology and Therapeutics II, Volume 2: Neurotransmitters-Re... is the second of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into seven parts, this book begins with an invited lecture on the kinetic analysis of the neuronal and extraneuronal uptake and metabolism of catecholamines. Subsequent parts discuss the regulation of receptor-mediated events; presynaptic receptors in the peripheral and central nervous system; neurotransmitters; and receptor antibodies. The isolated nervous systems in the research of neurotransmission and trophic interactions between nerve and muscle are also discussed.

  • Essays in Toxicology

    Volume 7
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 7 presents essays on toxicology and related topics. The book presents essays on the effects of toxicants on reproductive performance; an overall view of carcinogenesis from an epidemiological viewpoint and the potentialities and limitations of the epidemiological method in cancer control; and the activity of cytochrome P450 and mixed-function oxidase in target and nontarget organisms. The text also includes essays on the toxicity of hexachlorophene and the use of hexachlorophene as an antibacterial agent; the methodology, dose measurement, and respiratory function assessment in respiratory toxicology; as well as behavioral toxicology, with focus on early warning and worker safety and health. Pharmacologists, biochemists, pathologists, neurophysiologists, epidemiologists, and toxicologists will find the book invaluable.

  • Pharmacology of Histamine Receptors

    • 1st Edition
    • C. R. Ganellin + 1 more
    • English
    Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances. Some of the topics covered in the book are the classification of histamine receptors; mepyramine and related histamine antagonists; activity relationships of drugs acting at histamine receptors; chemical structure of histamine; effects of methyl substituents in histamine; enzymes involved in histamine metabolism; and histamine in body fluids. The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites. The pathological conditions in man are presented completely. A chapter is devoted to the fundamental properties of adenylate cyclase and its measurement. The book can provide useful information to pharmacists, doctors, chemists, students, and researchers.

  • Advances in Drug Research

    Volume 12
    • 1st Edition
    • N. J. Harper + 1 more
    • English
    Advances in Drug Research, Volume 12 covers articles on advances in drug research. The book presents articles on cyclic nucleotides as targets for drug design; the opposing regulatory roles of cyclic nucleotides in the heart; and the integrated control of trematode diseases. The text also includes articles about the chemical and biological studies on indomethacin, sulindac and their analogs; as well as the pharmacokinetics, pharmacodynamics, toxicity, and the effects of bromocriptine. Toxicologists, pharmacologists, physicians, and drug researchers will find the book invaluable.

  • Opiate Receptors and the Neurochemical Correlates of Pain

    Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
    • 1st Edition
    • Susanna FĂĽrst
    • English
    Opiate Receptors and the Neurochemical Correlates of Pain, Volume V, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The congress offered a good opportunity to stimulate discussions and exchange of ideas between scientists from various countries who approach the problem of narcotics and pain mechanisms in different ways. The 27 contributions in this volume have enriched knowledge in this rapidly expanding field of pharmacology. This volume begins with a discussion of opiate receptors. The results suggest the interaction of various morphine-like drugs with different opiate receptor populations. The existence in nerve tissue of specific opiate receptors binding morphine and other opioids has led to the assumption of endogenous ligand for opiate receptors. One section of the present volume is devoted to enkephalins and endorphins, their structure-activity relationships, interactions with transmitter and other systems, their behavioral effects, and to factors controlling their release. Some other aspects of nociception; the pathways involved in the mode of action of different types of analgesics, e.g. narcotics and non-narcotics; and their relations to inflammation and active substances, such as prostaglandins and substance P, are discussed from various aspects.

  • Development of Anti-Asthma Drugs

    • 1st Edition
    • Derek R. Buckle + 1 more
    • English
    Development of Anti-Asthma Drugs reviews existing asthma treatments and novel approaches currently under investigation, in the context of their mode of action and clinical effectiveness, in the hope that this might lead to a greater understanding of the factors involved in the expression of the disease and, therefore, in the design of better drugs. It is planned based on the concept of the causes and treatment of asthma, This book is organized in three main parts. Part I deals with the nature of asthma, its pathological mechanisms, natural history and epidemiology. Part II discusses mediators associated with asthma including platelet-activating factor, leukotrienes and histamine. Part II covers pharmaceutical approaches in the development of anti-asthma drugs and includes sections on inhibitors of mediator release and competitive and functional antagonists. This book will be of interest to persons dealing with studies on anti-asthma drugs and those interested in pharmacological development.

  • Essays in Toxicology

    Volume 4
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay. The second essay discusses the time-course of enzyme inhibition at single-inhibitor concentrations and the effect of various inhibitor concentrations on the rate constants governing inhibition. The third essay is about the recondite toxicity of trace elements, taking into consideration the effects of these trace elements on body weight, survival, and longevity, clues to mechanisms of toxicity, and the production of chronic diseases simulating human disorders. Toxicologists, oncologists, biochemists, and pharmacologists will find the book invaluable.

  • Drugs in Psychiatric Practice

    • 1st Edition
    • Sam Stuart
    • English
    Drugs in Psychiatric Practice present a comprehensive examination of the drug treatment in psychiatry. It discusses certain ways in which drugs behaved. It addresses the advances in pharmacology and the basis of prescription. Some of the topics covered in the book are the classification of psychotropic drugs; basic principles of pharmacokinetics and drug metabolism; anti-schizophrenic drugs; evaluation of psychotropic drugs; unconventional chemotherapy; anti-parkinsonian and anti-dyskinetic drugs; introduction of amitriptyline; and tricyclic antidepressants. The role of tricyclic drugs in the treatment of enuresis and the drug treatment of organic brain syndrome are fully covered. An in-depth account of the monoamine oxidase inhibitors and amine precursors are provided. The tolerance and pharmacological dependence on alcohol are completely presented. A chapter is devoted to the factors involve in ethanol metabolism. Another section focuses on the unwanted effects of psychotropic drugs. The book can provide useful information to doctors, pharmacists, psychologists, students, and researchers.

  • Tabacologia

    Hoc est, Tabaci, seu nicotianae descriptio medico-cheirurgico-pharmaceutica
    • 1st Edition
    • Johann Neander
    • English

  • Principles, Methods, and General Applications

    Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Vol. 1
    • 1st Edition
    • Gunter Zweig
    • English
    Analytical Methods for Pesticides, Plant Growth Regulators, and Food Additives, Volume 1: Principles, Methods, and General Applications provides information on analytical techniques useful for the determination of pesticides, plant growth regulators, and food additives. The book discusses the potential hazard of minute residues to human and animal health; the principles of formulation and residue analyses; and the principles of food additive analysis. The text also describes the extraction and clean-up procedures; and the principles of toxicological testing methods. The methods for pesticide analysis in meat products; and the formulation and residue analysis in government laboratories are also considered. The book further tackles other methods, such as spectrophotometric methods, chromatography, isotope methods, enzymatic methods; and bioassay. Agricultural toxicologists and people studying pesticides and food additives will find the text invaluable.

  • Abstracts

    Sixth International Congress of Pharmacology
    • 1st Edition
    • Sam Stuart
    • English
    Abstracts of the Sixth International Congress of Pharmacology deals with papers submitted during the pharmacology congress held at Helsinki in 1975. This collection of papers deals with research and development in pharmacology and biotherapeutic drugs. The wide array of subjects deals with the therapeutic implications of controlled drug delivery and the methods of drug application, including pharmacological investigations on cell in a culture. The book also contains papers about the interactions of neurotransmitters and the hypothalamic releasing hormones and toxins as tools in receptor studies. Some papers also deal with behavioral pharmacology that covers drug dependence, narcotic analgesics, and anesthetics. The text explains the method seminar concerning animal models simulating pathological conditions. Other papers discuss the pharmacology of emotive behavior with some volunteer papers dealing with subjects of toxicology, neurochemistry, and clinical psychopharmacology. The book also contains papers on cancer chemotherapy, hypertension, neurochemistry, and hematology. One paper evaluates the effects of cardiovascular drugs in humans. This book is suitable for pharmacologists, drug researchers, micro-chemists, oncologists, and specialists in many fields of medicine.

  • Antibiotics

    Origin, Nature and Properties
    • 1st Edition
    • Tadeusz Korzybski + 2 more
    • English
    Antibiotics; Origin, Nature and Properties, Volume II focuses on the principles of the classification of antibiotic substances. This volume is divided into four main topics—antibiotics produced by Fungi imperfecti, antibiotics produced by fungi belonging to the basidiomycetes and ascomycetes, antibiotics produced by lichens and algae, and antibiotics from higher plants. The antibiotics covered in this book include penicillin, viridicatin, cyclopaldic acid, cephalosporin P, bongkrek acid, chlamydosporine, and flammulin. The diploicin, chlorellin, chlorophorin, ethyl gallate, anacardic acid, and echinacosid are also described. Other antibiotics include the tuberosine, antifungal substance from field corn, fulvoplumerin, plumericin, and chinoc acid. This publication is recommended for pharmacists and specialists interested in the classification of antibiotics.

  • Antibiotics

    Origin, Nature and Properties
    • 1st Edition
    • Tadeusz Korzybski + 2 more
    • English
    Antibiotics: Origin, Nature and Properties, Volume I is a systematic coverage of the sources, varieties, and properties of the antibiotics. This book is organized into two main parts encompassing 13 chapters. This book considers the antibiotics according to their sources. It describes the antibiotics produced by bacteria, Actinomycetes,Fungi imperfecti, Basidiomycetes, algae, lichens and green plants, and those from animal sources. This group of antibiotics includes, streptomycin, the tetracyclines, chloromycetin, the macrolide family of compounds of which erythromycin, magnamycin and spiramycin are members, and the antifungal polyene compounds. The members of each group are arranged according to their chemical and biological similarity. Sections on each antibiotic present complete information, including the name, description of the producing strains, composition of the media, methods of culture, isolation and purification of the antibiotic principle, its physical and chemical properties, antibiotic spectrum, toxicity for laboratory animals, results of treatment of experimental infections, and possible clinical applications. This book is of value to researchers and workers in various medical fields.

  • Renal Disease in Cancer Patients

    • 1st Edition
    • Kevin W. Finkel + 1 more
    • English
    Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more.

  • Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics

    • 1st Edition
    • Lisa M. Plitnick + 1 more
    • English
    Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics.

  • Computational Toxicology

    Methods and Applications for Risk Assessment
    • 1st Edition
    • Bruce A. Fowler
    • English
    Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns.

  • Persistent Organic Pollutants and Toxic Metals in Foods

    • 1st Edition
    • Martin Rose + 1 more
    • English
    Persistent organic pollutants (POPs) and toxic elements, such as dioxins, flame retardants, lead and mercury, are substances of major concern for the food industry, the regulator and the public. They persist in the environment, accumulate in food chains and may adversely affect human health if ingested over certain levels or with prolonged exposure. Persistent organic pollutants and toxic metals in foods explores the scientific and regulatory challenges of ensuring that our food is safe to eat.Part one provides an overview of regulatory efforts to screen, monitor and control persistent organic pollutants and heavy metals in foods and includes case studies detailing regulatory responses to food contamination incidents. Part two moves on to highlight particular POPs, toxic metals and metalloids in foods, including dioxins and polychlorinated biphenyls (PCBs), mercury, polycyclic aromatic hydrocarbons (PAHs) and phthalates.Persisten... organic pollutants and toxic metals in foods is a standard reference for those in the food industry responsible for food safety, laboratories testing for food chemical safety, regulatory authorities responsible for ensuring the safety of food, and researchers in industry and academia interested in the science supporting food chemical safety.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology

    • 3rd Edition
    • Brad Bolon + 4 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more.

  • Drug-Induced Liver Disease

    • 3rd Edition
    • Neil Kaplowitz + 1 more
    • English
    This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease.

  • Nonclinical Study Contracting and Monitoring

    A Practical Guide
    • 1st Edition
    • William F. Salminen + 2 more
    • English
    Nonclinical Study Contracting and Monitoring: A Practical Guide offers a systematic and straightforward handbook for obtaining high quality preclinical Good Laboratory Practice (GLP) studies. This book is full of real-world examples, processes, procedures, useful templates, checklists and sample reports to provide readers with a better understanding of exactly what happens during all stages of a GLP study and the critical aspects of GLP study design and conduct. Designed for both the novice and experienced scientist, this book covers the GLP regulations and how they impact preclinical studies, the differences between GLP, non-GLP and peer-reviewed studies, preclinical GLP study design, laboratory selection, contracts and business ethics, how to obtain test material for the study, animal sourcing and release for study, preparation of a draft report and much more. By illustrating the overall big picture and tying it together with the individual steps, this book is an essential resource to help scientists ensure a high quality GLP study that passes both scientific and regulatory scrutiny.

  • Agricultural and Industrial Applications Environmental Interactions

    An Advanced Treatise
    • 1st Edition
    • Dewayne Torgeson
    • English
    Fungicides, Volume I: Agricultural and Industrial Applications, Environmental Interactions discusses the application, use, and environmental interactions of fungicides. This book is organized into 15 chapters that cover the commercial development of fungicide and the organism's interaction with the environment. After discussing the history of fungicides, the book presents data on world fungicide usage and how this usage is influenced by epidemiology. It then describes procedures and approaches for commercial fungicide development; practical tests and laboratory techniques for agricultural fungicide toxicity; and significance of fungicide formulation that is determined by a variety of factors, including cost and biological efficiency. The following chapters discuss technological evolution, both in chemical fungicides and in the machinery for their application for soil and seed treatment. The application of foliar and postharvest fungicides and the use of other fungicides as industrial and wood preservatives is also tackled. The last four chapters are concerned with the various interactions between fungicides and the environment which may cause them to be more or less effective. The book will be useful to researchers, advanced students, and professional workers in the fungicide field of study who are concerned with the synthesis and development of better fungicides or their mode of action.

  • Titrations in Nonaqueous Solvents

    • 1st Edition
    • Huber Walter
    • English
    Titrations in Nonaqueous Solvents discuss the theory, practice, and data on acidic and basic strength of nonaqueous solvents. This book is organized into three parts encompassing six chapters. The first part considers the general principles of acids and bases and methods of end-point determination. This part also covers the fundamentals, advantages, and limitations of titration instruments, such as potentiometers, burets, titration vessels, and electrodes. The classification of titration solvents according to their functions as color indicators and titrant solutions is provided in this part. The remaining parts describe the analytical procedures for acidity and basicity of nonaqueous solvents. These parts also provide a tabulated data on the acidic and basic strengths, stability, and dissociation constants of various titration solvents. Analytical chemists, and analytical chemistry teachers and students will find this book invaluable.

  • Xenobiotics and Inflammation

    Roles of Cytokines and Growth Factors
    • 1st Edition
    • Schook + 1 more
    • English
    The affect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesises current information on how chemicals (xenobiotics) can affect the immune system to cuse dysfunction, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigation the mechanisms responsible for altered host resistance following exposture to xenobiotics. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume contains information pertinent to those exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites. This volume brings together experts in inflammation, cytokines, cell growth, immunology and toxicology to provide a highly yseful volume modulated by chemicals. Divided into three sections, the book offers an organ system approach to understanding inflammation and xenobiotics.

  • Enzymatic Basis of Detoxication Volume 2

    • 1st Edition
    • William B. Jakoby
    • English
    Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronos... glucuronosyltransfer... the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.

  • Pyrethrum

    The Natural Insecticide
    • 1st Edition
    • John Casida
    • English
    Pyrethrum: the Natural Insecticide covers the papers presented at the 1972 ""International Symposium on Recent Advances with Pyrethrum the Natural Insecticide"" held in conjunction with the American Institute of Biological Sciences Silver Anniversary Meeting at the University of Minnesota, Minneapolis. It deals with all aspects of pyrethrum, including its history, production, chemistry, biochemistry, toxicology, pharmacology, and agricultural applications. The introductory part addresses the early history of pyrethrum, its recognition as a modern insecticide, and its worldwide production. The chemistry and biochemistry parts discuss the composition, isolation, structure, synthesis, biosynthesis, metabolism, and action on enzyme systems of natural pyrethrins extracted from pyrethrum flower. The book also examines the toxicology of pyrethrum and its constituents to mammals, fish, and wildlife, as well as tests for possible teratogenic, carcinogenic, mutagenic, and allergenic activities. Finally, it discusses the domestic and agricultural applications of pyrethrum. Considering its desirable features, researchers find pyrethrum unsurpassed by any type of synthetic organic insecticide and even by the best synthetic analogs or pyrethroids.

  • Handbook of Mutagenicity Test Procedures

    • 2nd Edition
    • B.J. Kilbey + 3 more
    • English
    The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

  • Enzymatic Basis of Detoxication Volume 1

    • 1st Edition
    • William B. Jakoby
    • English
    Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.

  • Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products

    • 2nd Edition
    • R.D. Kimbrough + 1 more
    • English
    The chemical industry is increasingly faced with problems arizing from chemicals produced during the manufacture of halogenated biphenyls or phenols. Knowledge of these chemicals and their destructive properties is sporadic, and the acute toxicity of this group varies widely. This informative revised edition presents the chemistry, environmental pollution problems, animal toxicology and information about structure-activity relationships. A brief overview is given of worker exposure and occupational illness. The book is divided into three parts: chemistry and environmental contamination; experimental toxicology; and human exposure and effects. Because of the great deal of interest in these compounds much new research work has been conducted since the first edition of this book was published. This revised edition has retained the effectiveness and clarity of the first edition, while being supplemented with new information, condensed old information, and examples of recent incidents.

  • Advances in Molecular Toxicology

    • 1st Edition
    • Volume 6
    • English
    Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed.

  • Current Concepts in Drug Metabolism and Toxicology

    • 1st Edition
    • Volume 63
    • English
    This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

  • Nerve Agents Poisoning and its Treatment in Schematic Figures and Tables

    • 1st Edition
    • Jiri Bajgar
    • English
    Organophosphate compounds, first synthesized in the 1800s, have been used for insecticides, pesticides, and in war and terrorism, such as the 1995 Tokyo subway poisoning. This book provides an in-depth examination of the effects of organophosphates and nerve agents and offers therapeutic and prophylactic countermeasures. Beginning with an overview of milestones in the use of toxic chemicals and chemical warfare agents, the formulae and toxicities of compounds are given, along with tables outlining animal toxicities. Data on various compounds’ inhibitions and subsequent accumulations are also provided. Along with data on organophosphates and nerve agents, possible first aid and medical responses are compared among potential responses in the United States and other countries in the east and west. Using clear schematics and tables, this book provides a detailed account of the most common organophosphates and nerve agents, ideas of how to countermeasure their effects, and offers detailed suggestions for where research needs to proceed in the future. This book will prove useful to students, researchers, and military personnel needing to know more about how to deal with nerve agents.

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