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Elsevier

Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Essays in Toxicology

    Volume 6
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 6 approaches toxicology by very different routes; two essays with materials (plastics and tobacco alkaloids), one deals with the effects of abnormal pressure, one considers the biochemistry of the lung, and one discusses poison control centers and other mechanisms for limiting the injury done by toxic materials. The book presents essays on the topological problems and untoward effects from plastic devices used in medical applications; the metabolism of tobacco alkaloids; and poisons control center. The text also includes essays on the toxicology of hypobaric and hyperbaric environments; as well as the exploitable biochemical approaches for the evaluation of toxic lung damage. Biochemists, physical chemists, neurophysiologists, epidemiologists, and social scientists will find the book invaluable.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 5
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume V covers the fundamental approaches to the development of bioactive compounds. The book discusses the utilization of operational schemes for analog synthesis in drug design; the design of enzyme inhibitors (transition state analogs); and the significance of structure-absorption... relationships for drug design. The text describes the role of charge-transfer processes in the action of bioactive materials, as well as the approaches to the rational combination of antimetabolites for cancer chemotherapy. The physicochemical, quantum chemical, and other theoretical techniques for the understanding of the mechanism of action of central nervous system (CNS) agents, such as psychoactive drugs, narcotics, and narcotic antagonists and anesthetics, are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 7
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume VII covers the design of agents such as blood substitutes, pesticides derived from insect pheromones, and herbicides related to the auxin-type plant hormones. The book discusses the design of artificial blood substitutes and auxin-type herbicides; the use of insect pheromones as a basis for the development of more effective selective pest control agents; and the development and application of new steric substituent parameters in drug design. The text also describes the use of computer technology in drug design. Pharmacologists, chemists, biochemists, and people involved in drug design and manufacture will find the book invaluable.

  • Asthma

    Physiology, Immunopharmacology, and Treatment
    • 1st Edition
    • K. Frank Austen + 1 more
    • English
    Asthma: Physiology, Immunopharmacology, and Treatment is a collection of essays that discusses the clinical signs and symptoms of allergic bronchial asthma and the effects of a number of intricate sequences of biochemical reactions initiated by the combination of antigen and antibody. It presents such topic as the pathobiologic mechanisms of asthma. The book discusses the physiologic changes in the acute asthmatic attack. It focuses on the autonomic regulation of airway smooth muscle and the nervous regulation of respiration. Another topic of interest is the genetic aspects of asthma. The section that follows is a review of the biochemical, pharmacological, and immunological factors in the release of chemical mediators from human lung. The book also presents the characteristics of pharmacologic receptor systems and the role of parasympathetic nervous system in asthma. The text will provide valuable insights for physicians, scientists, students, and researchers in the field of human anatomy.

  • Clinical Pharmacology in Obstetrics

    • 1st Edition
    • Peter Lewis
    • English
    Clinical Pharmacology in Obstetrics presents an extensive examination of drug usage in pregnancy. It discusses the principles behind the adverse effects of drugs on the fetus. It addresses studies in the drug treatment of heart disease in pregnancy. Some of the topics covered in the book are the examination of pharmacokinetics in pregnancy; analgesia intake of pregnant women; drug treatment of gastrointestinal disorders; antibiotics and antimicrobial chemotherapy; anemia and hematinics of pregnant women, use of cytotoxic drugs; and treatment of threatened and recurrent abortion. The definition and description of antihypertensive drugs, therapy for asthma, and tocolytic therapy for pretern labor are fully covered. An in-depth account of the prophylactic treatment of idiopathic respiratory distress syndrome is provided. The drug treatment of thyroid and adrenal disease are completely presented. A chapter is devoted to description and effect of perinatal drugs on new born baby. Another section focuses on the treatment of renal disease. The book can provide useful information to obstetricians, doctors, students, and researchers.

  • Basic Pharmacology

    • 2nd Edition
    • R W Foster
    • English
    Basic Pharmacology, Second Edition, similar to the first edition, talks about the relationship between the human body and therapeutic drugs. A large part of this book discusses the nervous system and the way certain drugs operate and affect it. The first part of this book covers the importance of having a firm understanding of the organ system, especially the nervous system. Understanding the systems is the initial step in learning how a drug affects the body, both internally and externally. This book also clarifies that a drug's impact occurs when it comes in contact with a chemical component of the body (enzymes, hormones, membranes, etc.). The next sections of this book discuss miscellaneous topics of the human anatomy, such as the brain, eyes, lungs, and various muscles. This edition also explains how a drug acts on each of those body parts. This book serves as a great reference to students affiliated in the anatomy, biology, pharmacy, and related fields.

  • Bacterial Endotoxins

    A Comprehensive Treatise
    • 1st Edition
    • George Weinbaum + 2 more
    • English
    Microbial Toxins, Volume IV: Bacterial Endotoxins covers a general introduction of bacterial endotoxins, as well as research concerning structure (both morphological and physical), chemistry, immunology, biosynthesis, and genetics of bacterial endotoxins. The book describes the general characteristics of bacterial endotoxins; the anatomy and chemistry of Gram-negative cell envelopes; and the physical structure of bacterial lipopolysaccharides. The text also discusses the isolation and chemical and immunological characterization of bacterial lipopolysaccharides; the chemistry of the unique carbohydrates of bacterial lipopolysaccharides; and the relation of bacteriophage attachment to lipopolysaccharide structure. The chemical and biological heterogeneity of endotoxins, as well as the biosynthesis of the core region of lipopolysaccharide are also considered. The book further tackles the biosynthesis of O-antigens and the genetic aspects of biosynthesis and structure of Salmonella lipopolysaccharide. Microbiologists, biochemists, bacteriologists, immunologists, and people involved in biochemical research will find the book useful.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 8
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume VIII covers a critical review and new extensions of quantitative methods in drug design, the design of particular types of agents, such as synthetic sweeteners, and selective ion binding compounds. The book discusses the advances in the methodology of quantitative drug design; the application of pattern recognition to drug design; and the design of controlled drug delivery systems. The text also describes the use of receptor binding as a tool in the development of new bioactive steroids; the design of synthetic sweeteners; and the prospective assessment of environmental effects of chemicals. The design of selective ion binding macrocyclic compounds and their biological applications are also encompassed. Chemists, pharmacologists, biochemists, and people involved in drug design and manufacture will find the book invaluable.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 6
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume VI covers practical approaches to the development of bioactive compounds, with focus on antiradiation agents, organ-imaging radiopharmaceuticals... X-ray contrast media, proteinase inhibitors, and pesticide formulations. The book discusses the chemical routes available for the synthesis of diphenhydramine derivatives, the biological activities, the relationships between structure and activity, and the phase of manipulation in the design of diphenhydramine derivatives. The text also describes the design of antiradiation agents, organ-imaging radiopharmaceuticals... and X-ray contrast media, as well as the rational approach to proteinase inhibitors. The chemical and physical methods of formulation of agricultural pesticides are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design and manufacture will find the book invaluable.

  • The Nervous System

    Autonomic Nervous System Drugs
    • 1st Edition
    • Walter S. Root + 1 more
    • English
    Physiological Pharmacology: A Comprehensive Treatise, Volume III: The Nervous System — Part C: Autonomic Nervous System Drugs focuses on the effects of drugs on the nervous system, including cardiovascular effects and metabolism. The selection first offers information on the cardiovascular effects of choline esters and the effects of choline esters on smooth muscles and secretions. Topics include actions of acetylcholine, physiological role of choline esters, and actions of cholinergic drugs on smooth muscles and secretions. The book also takes a look at the pharmacologic, toxicologic, and therapeutic properties of anticholinesterase agents, including the chemistry and metabolism of anticholinesterase substances and mechanisms of action of anticholinesterase agents and role of cholinesterases. The publication examines muscarinic blocking drugs and ganglion-blocking drugs. Discussions focus on actions on the secretory glands and cardiovascular system; distribution, metabolism, and excretion of atropine; substances that block ganglionic transmission; and cardiovascular effects. The text also elaborates on neuromuscular blocking drugs. The selection is a dependable reference for readers interested in the effects of drugs on the nervous system.

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