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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Poulsson's Text-Book of Pharmacology and Therapeutics

    • 1st Edition
    • Stanley Alstead
    • English
    Poulsson’s Text-Book of Pharmacology and Therapeutics, Second English Edition covers the considerable progress in understanding the basic principles, applications, and classifications of drugs and other organic compounds of therapeutic interest. This text is divided into six chapters, each dealing with a specific classification of drugs. The first chapter describes the so-called protoplasmic poisons, which are organic substances that are characterized by their specific effects after absorption on the nervous and muscular systems, while local effects are altogether absent or insignificant. The second chapter examines the organic remedies that principally act locally, such as at the point of application, while the action after absorption is unimportant or is not utilized in medicine. The third and fourth chapters explore the main groups containing the inorganic bodies. These chapters demonstrate that the inorganic compounds differ from the organic, whose activity is due to the unchanged entire molecules, and they are subjected to dissociation. The fifth chapter considers the digestive ferments and foodstuffs, while the sixth chapter is concerned with antitoxins and bacterial products. This book will be of value to pharmacologists, pharmacists, researchers, and pharmacology and pharmacy students.

  • Drugs in Cerebral Palsy

    Based on a Symposium Held at Dallas, 24-26 November, 1963
    • 1st Edition
    • Eric Denhoff + 2 more
    • Eric Denhoff
    • English
    Clinics in Developmental Medicine No. 16: Drugs in Cerebral Palsy: Based on a Symposium held at Dallas, 24-26 November, 1963 is a collection of papers of the 1963 Symposium on Drugs in Cerebral Palsy, arranged by the American Academy. This book is composed of nine chapters that cover the various components and treatment options involved in cerebral palsy. This text begins with a presentation of the many problems of drug evaluation, with an emphasis on the issue that human responses to a drug cannot be predicted from those of animals and that the response of one human to a drug may differ quite sharply from that of another. The next chapters deal with the historical developments and pharmacology of drugs in cerebral palsy, as well as the two aspects of drug evaluation, namely, the immediate or direct effects of the drug on patients and the double-blind test. The discussion the shifts to the pharmacological capacity of muscle relaxants and anti-convulsant drugs. The last chapter considers the possible toxic drug reactions, which are the result of individual idiosyncrasy and may occur regardless of drug dosage. This book will be of value to pharmacologists, neurologists, clinicians, and researchers who are interested in drug evaluation in cerebral palsy.

  • Neuro-Psychopharmacology

    Proceedings of the 11th Congress of the Collegium Internationale Neuro-Psychopharmacologicum, Vienna, July 9-14, 1978
    • 1st Edition
    • B. Saletu + 2 more
    • English
    Neuro-psychopharmaco... covers the proceedings of the 11th Congress of the Collegium Internationale Neuro-psychopharmaco... held in Vienna on July 9-14, 1978. The book focuses on the processes, methodologies, and approaches in neuropsychopharmacol... The selection first offers information on the long-lasting effects of electroconvulsive therapy (ECT) on monoaminergic mechanisms and enhanced monoamine behavioral responses following repeated electroconvulsive shock to rats and their relevance to ECT. The book also underscores the ECT effects on mineral metabolism and neuroendocrine function. The publication reviews the genetic components in the mechanism of action of lithium; genetics and lithium ion metabolism in affective disorders; and pharmacogenetics and the pharmacologic challenge strategy in clinical research. The text also examines the influence of peptides in affective disorders and HLA antigens in affective disorders and cycloid psychoses. Discussions also focus on the biological and clinical basis of the therapeutic effects of benzodiazepines; effects of benzodiazepines on the electrical activity of the central nervous system; and diazepam metabolism in healthy subjects and patients with heart failure, renal failure, and hepatic cirrhosis. The selection is a dependable reference for readers interested in neuropsychopharmacol...

  • Advances in Drug Delivery Systems, 6

    Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 21-24, 1993
    • 1st Edition
    • James M. Anderson + 2 more
    • English
    Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.

  • Algal and Fungal Toxins

    A Comprehensive Treatise
    • 1st Edition
    • Solomon Kadis + 2 more
    • English
    Microbial Toxins, Volume VII: Algal and Fungal Toxins reviews research and investigations on algal and fungal toxins. This book discusses the distribution of poisonous dinoflagellates; pharmacology of blue-green algal toxins; control of Prymnesium and detection of toxin in nature; and F-2 (zearalenone) estrogenic mycotoxin from Fusarium. The effect of Fusarium toxins in animals; mycotoxins produced by Fusarium tricinctum NRRL 3249; and mold growth and production and isolation of trichothecenes are also elaborated. This publication likewise covers the chemistry of scirpene toxic substances of Fusarium nivale; isolation of salivation factor; and mammalian toxicity of epidithiadioxopipera... This volume is a useful reference for scientists and graduate students in various disciplines —microbiology, biochemistry, pharmacology, epidemiology, oncology, and related fields.

  • Marijuana

    Effects on Human Behavior
    • 1st Edition
    • Loren L. Miller
    • English
    Marijuana: Effects on Human Behavior attempts to synthesize much of the existing experimentation concerning the acute and chronic effects of marijuana and its derivatives on human behavior. The book opens with a chapter on the strategies for conducting research on marijuana. It also describes a clinical study at the University of British Columbia. The next chapter discusses the issues that have beclouded the question of legalization of marijuana in the United States. This is followed by separate chapters on the effects of marijuana on motor and mental performance; marijuana-memory research; a model of attention which can be used to describe the effects of marijuana use on cognition; and the effects of marijuana on neuropsychological functioning and learning. Subsequent chapters examine the behavioral actions of cannabis in man; compare the behavioral actions of cannabinoids in humans with those found in infrahumans, with special reference to acquisition and retention processes, timing behavior, state-dependent learning, and attention; and investigate the long-term effects of cannabis use.

  • Toxicology of Chemical Mixtures

    Case Studies, Mechanisms, and Novel Approaches
    • 1st Edition
    • Raymond S.H. Yang
    • English
    Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content.Emphasis is on low-level, long-term exposure.

  • Bioreduction in the Activation of Drugs

    Proceedings of the Second Biochemical Pharmacology Symposium, Oxford, UK, 25-26 July 1985
    • 1st Edition
    • P. Alexander + 2 more
    • English
    Bioreduction in the Activation of Drugs covers the proceedings of the Second Biochemical Pharmacology Symposium. The book presents papers that cover the applications of bioreduction in drug activation, along with its concerns. The text first presents materials about enzymology, such as overview of enzyme systems involved in bioreduction of drugs and in redox cycling, and reductive role of glutathione in the redox cycling of oxidizable drugs. Next, the book covers papers on bacterial and parasites infection, which include reduction by the gut microflora of animals and human and reduction of nitroimidazoles in vitro and DNA damage. The remaining articles deal with cancer treatment, such as hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer, and the biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms. The text will be of great use to researchers and practitioners of medicine, pharmacology, and biochemistry.

  • The Lung Circulation

    Physiology and Pharmacology
    • 1st Edition
    • Domingo M. Aviado
    • English
    The Lung Circulation deals with important aspects of the lung circulation, with emphasis on the physiology of the pulmonary and bronchial circulation and autonomic pharmacology. Topics covered range from the role of anoxia in pulmonary circulation to reflexes arising from the pulmonary circulation and neighboring structures. The release of chemical substances from the pulmonary and bronchial circulation is also discussed. This volume is comprised of 10 chapters and begins with a review of the influence of anoxia on pulmonary circulation as well as four pertinent effects of anoxemia, namely, respiratory stimulation; cardiac stimulation; systemic vasoconstriction and vasodilatation; and pulmonary vasoconstriction and vasodilatation). The following chapters focus on the regulation of bronchial circulation; autonomic nervous control of pulmonary circulation involving acetylcholine, anticholinesterases, and atropine; and the pharmacology of sympathomimetic drugs, sympathetic blocking drugs, ganglion stimulants, and blocking drugs. The final chapter is devoted to the pharmacology of the autonomic nervous system and considers drugs that stimulate chemoreflexes arising from the lung circulation, including veratrum alkaloids. This book will appeal to physiologists and pharmacologists.

  • Drugs and Driving

    • 1st Edition
    • Herbert Moskowitz
    • English
    Drugs and Driving is a compendium of papers from a symposium of the same title presented at the U.S. Transportation Research Board. This collection reviews the effects of five classes of drugs on driving (amphetamines, tranquilizers, barbiturates, narcotics, cannabis), the other studies being made on drugs and driving, as well as some countermeasure programs against drunk driving. The papers report that amphetamines can induce risky driving behavior, tranquilizers can increase traffic accident risks, barbiturates can degrade driving skills especially when the drug is combined with alcohol, while marijuana use can impair important driving skills. Another paper evaluates drug use and driving risk among high school students in Toronto: results show that the total effect of infrequent use of drugs on accidents is small compared to alcohol use. A study of out-patients in Finland notes that the combined used of alcohol and drugs tend to increase accident frequency. One paper refutes that Alcohol Safety Action Programs in the United States are ineffective. This collection can be helpful for sociologist, psychologists, psychiatrists, traffic safety officers, and heads of urban safety and traffic divisions.

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