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Elsevier

Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Polydrug Abuse

    The Results of a National Collaborative Study
    • 1st Edition
    • Donald R. Wesson + 2 more
    • English
    Polydrug Abuse: The Results of a National Collaborative Study reports on the findings of a national study of polydrug users, initiated and organized by the Special Action Office of Drug Abuse Prevention. This book provides a comprehensive demographic, sociological, psychological, and medical study of polydrug cases. The chapters in the text cover the varieties and classification of polydrug abusers; an estimation of the magnitude of polydrug abuse; certain central nervous system consequences to chronic drug use; and the impact of polydrug abuse on physicians and other deliverers of health care. Physicians, epidemiologists, drug enforcers, and government policy makers will find the book interesting.

  • Pharmacology of Cardiac Function

    Section of Pharmacology of the International Union of Physiological Sciences
    • 1st Edition
    • Otto Krayer
    • English
    Pharmacology of Cardiac Function brings together the proceedings of the Second International Pharmacological Meeting of the International Union of Physiological Sciences, held in Prague, Czechoslovakia, on August 20-23, 1963. The meeting provided a forum for discussing advances in the understanding of the pharmacology of cardiac function and addressed topics ranging from the link between muscle physiology and the heart to the development of tension in cardiac muscle. This volume is comprised of 21 chapters and begins with an overview of the structural aspects of contraction in cardiac and skeletal muscle, followed by a description of muscle physiology and its effect on the heart. The next section deals with the effects of drugs on the interval-strength relationship of heart muscle, paying particular attention to acetylstrophanthidin... levarterenol, and carbacliol as well as metabolic inhibitors. The nature of the restitution process occurring between beats in cardiac muscle is also considered. Subsequent chapters explore how the heart is affected by the action of the vagus and of acetylcholine and other parasympathomimetic drugs; membrane effects of epinephrine and digitalis; and the mode of action of antifibrillatory drugs. This book will be of particular value to pharmacologists and physiologists.

  • Symptomatology and Therapy of Toxicological Emergencies

    • 1st Edition
    • William B. Deichmann + 1 more
    • English
    Symptomatology and Therapy of Toxicological Emergencies is a handbook on toxicological emergencies that includes much new material and discusses many new substances which have become available since the second edition, entitled ""Signs, Symptoms, and Treatment of Certain Acute Intoxications,"" was published in 1958. When compared with the second edition, this volume covers a considerably larger number of drugs and chemicals, presents urgently needed information on poisonous plants, lists the compounds implicated in blood dyscrasias, and includes accepted threshold limit values for chemicals, the maximum permissible concentrations of various chemicals in food, drugs, and cosmetics, as well as tables on the acute toxicity of numerous chemicals. This handbook will be helpful to teachers of chemistry, biochemistry, pharmacology, toxicology, radiation medicine, etc., who instruct students or supervise the work of technicians. It will be of particular value to those industries and operations which have an active industrial hygiene program. Finally, but most important, this volume was written for the physician who needs toxicological information on a drug or a chemical, who may need a reference book which will quickly review for him the major side effects he may expect in a patient, or who requires additional information for the treatment of an intoxication.

  • Pharmacology of Conditioning, Learning and Retention

    Proceedings of the Second International Pharmacological Meeting
    • 1st Edition
    • M. Ya. Mikhel'son + 1 more
    • English
    Proceedings of the Second International Pharmacological Meeting, Volume 1: Pharmacology of Conditioning, Learning and Retention is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This book is organized into two sections encompassing 28 chapters. The first section defines the main problem in psychopharmacology, which is the establishment of methods that will enable to appreciate in animals the value of psychotropic drugs in the therapy of human mental diseases. This section also describes the specific activation of the central nervous system and its significance in psychopharmacologica... research. The second section explores the electrophysiological phenomena observed during pharmacological conditioning, with emphasis on the modifications of electrical activity during the establishment and the performance of the conditioned responses. This section also deals with the electrical correlated of various kinds of conditioned behavior in animals and the alterations of spontaneous rhythm and evoked potentials. This book is of value to psychopharmacologist... and electrophysiologists...

  • Microsomes and Drug Oxidations

    • 1st Edition
    • James R. Gillette + 2 more
    • English
    Microsomes and Drug Oxidations documents the proceedings of symposium on microsomes and drug oxidations held at Bethesda, Maryland, 16-17 February 1968. The theme of the symposium centered on the morphology of the liver endoplasmic reticulum, the localization of enzyme systems, the mechanisms for regulating enzyme activity, and the mechanisms of enzyme action. The results of this symposium presented in this book illustrate the complexity of the enzyme systems under investigation and the multiplicity of the variables altering their function. It is hoped the information presented will serve as a stimulus to other investigators in the elucidation of these problems. The book contains 27 papers organized into four parts. The papers in Part I examine the morphological and biochemical characteristics of microsomes. Part II presents studies on electron transfer components. Part III examines alterations of microsomal enzymes while Part IV focuses on drugs and protein synthesis.

  • Pharmacology of Neuromuscular Function

    • 2nd Edition
    • William C. Bowman
    • English
    Pharmacology of Neuromuscular Function, Second Edition provides information pertinent to drugs that affect membrane potentials of the conduction of action potentials in nerve endings and muscle fibers. This book reviews, in a general way, some of the properties of excitable membranes. Organized into seven chapters, this edition begins with an overview of innervation of striated muscles by somatic efferent nerve fibers. This text then explains the transmission from nerve to muscle, which is mediated by acetylcholine that is synthesized and stored in the axon terminals. Other chapters consider the different steps in the transmission process that occur in the nerve endings, which may be modified by the actions of drugs and toxins. This book discusses as well the primary action of neuromuscular-blocki... agents. The final chapter deals with the cytoplasm of a muscle cell or fiber that contains all the usual subcellular organelles, including mitochondria and nuclei. This book is a valuable resource for pharmacologists and anesthetists.

  • The Actions and Uses of Ophthalmic Drugs

    • 3rd Edition
    • P. H. O'Connor Davies + 2 more
    • English
    The Actions and Uses of Ophthalmic Drugs, Third Edition discuses the application and discrimination in the use of ophthalmic drugs. The book reviews the general pharmacological principles including drug nomenclature, pharmacological classification, pharmacokinetics, pharmacodynamics, and the use of these drugs. Ophthalmic drugs (cycloplegics, mydriatics, miotics) directly or indirectly, stimulate or inhibit a part of the autonomic nervous system connected to the intra-ocular muscles. The text investigates in detail the structure and function of this involuntary nervous system in the orbital region as it is affected by these drugs. The book explains the different drug classifications, their therapeutic and diagnostic purposes, including the ideal properties, indications, contra-indications, mode of action, or adverse effects of cycloplegics, of mydriatics, and of miotics. The book also describes the uses and characteristics of local anesthetics, stains, anti-infective agents, and miscellaneous agents (antihistamines, vasoconstrictors). The text explains the different types of contact lens solutions, application of ocular first aid, as well as, the possible adverse ocular reactions that can occur during ophthalmic drug therapy. This book is suitable for optometrists, pharmacists, pharmacologists, students and professors related to the discipline of optometry and general medicine.

  • Mitochondrial Dysfunction

    Methods in Toxicology, Vol. 2
    • 1st Edition
    • Lawrence H. Lash + 1 more
    • English
    Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

  • Adverse Reactions to Drugs

    • 2nd Edition
    • O. L. Wade + 1 more
    • English
    Adverse Reactions to Drugs, Second Edition focuses on the problems posed by the adverse responses to drugs, as well as drug interactions, dosage, and drug metabolism. The publication first tackles adverse reactions and factors which predispose to adverse drug reactions. Topics include dose adjustment, overdose, renal failure, cumulation, side effects, drug allergy, cumulative overdose, and delayed effects. The text then ponders on drug interactions, including renal excretion, drug metabolism, mutual toxicity, and interactions affecting transport to site of action. The manuscript examines adverse reactions in dental practice, drugs used in pregnancy, the neonate, and lactation, and problems for the pharmaceutical industry before marketing a new drug. Discussions focus on ethical problems of drug studies in man, pregnancy, hemorrhage, oxygen toxicity, chloramphenicol, drugs and lactation, drugs used in dental practice, and local anesthetics. The book then elaborates on monitoring adverse reactions to drugs and the therapeutic audit and drug regulatory bodies and their problems. The publication is a valuable source of data for doctors and dentists wanting to focus on research on the adverse reaction to drugs.

  • Toxicology

    Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
    • 1st Edition
    • Y. Cohen
    • English
    Advances in Pharmacology and Therapeutics, Volume 9: Toxicology is a collection of papers that tackles advances in toxicological research in context of pharmacology. The text first covers reactive metabolites and their implications for toxicology. Next, the selection deals with the experimental and clinical correlations of behavioral toxicology. The text also tackles toxicology and pharmacology of topical application. The book will be of great use to researchers and practitioners of health related disciplines.

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