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Elsevier

Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Experiments with Drugs

    Studies in the Relation between Personality, Learning Theory and Drug Action
    • 1st Edition
    • H. J. Eysenck
    • English
    Experiments With Drugs: Studies in the Relation between Personality, Learning Theory and Drug Action provides a report of a series of experiments, conducted to test the effects of certain groups of drugs, depressants and stimulants, on human behavior. The book presents a number of experiments, together with the theoretical rationale underlying their development. The text begins with a chapter that sets the stage for the exposition of the various concepts and findings on drug effects on behavior. Subsequent chapters deal with particular subjects such as personality and drug effects; the effects of stimulant and depressant drugs on visual and auditory masking; excitation-inhibitio... and the theory of neurosis; interaction effects of drugs; and the influence of stimulant and depressant drugs on the central nervous system. Psychologists, biochemists, and researchers in the field of psychopharmacology will find the book useful and incisive.

  • Nitrogen and Phosphorus Solvents

    • 2nd Edition
    • Volume 2
    • D.R. Buhler + 1 more
    • English
    This particular volume, Nitrogen and Phosphorus Solvents, is the second in a comprehensive and up-to-date series. The introduction of new nitrogen- and phosphorus- containing solvents used in industry has been accompanied by an explosion of knowledge about their properties, toxicity and metabolism. Even a relatively simple compound such as N-methylformamide undergoes a complex metabolic transformation in mammals. Such information, and other considerations contained in this volume will supply researchers and students with an excellent information source on modern mechanistic toxicology, while helping to provide a sound scientific basis for accurate health risk assessment.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 3
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume III covers the mode of action of biologically active compounds. The book discusses microbial transformations that have been used in the preparation of drugs or closely related substances; the use of linear free energy parameters and other experimental constants in structure-activity studies; and the mode of action of anticoagulants structurally and functionally related to vitamin K. The text also describes the design of beta-blocking drugs, biologically active acridines, local anesthetics, and insect chemosterilants. The molecular approach for designing inhibitors to enzymes involved in blood clotting is also considered. Chemists, pharmacologists, and people involved in drug design.

  • Man and Biologically Active Substances

    The Effect of Drugs, Diet and Pollution on Health
    • 1st Edition
    • I. I. Brekhman
    • English
    Man and Biologically Active Substances: The Effect of Drugs, Diet and Pollution on Health discusses the theory and the aims of pharmacosanation; the pharmacosanation medicaments; and the future of pharmacosanation.

  • Natural Toxins

    Characterization, Pharmacology and Therapeutics
    • 1st Edition
    • C.L. Ownby + 1 more
    • English
    The 9th World Congress on Animal, Plant and Microbial Toxins was sponsored by the International Society on Toxinology which recently celebrated its 25th anniversary. The Society was organized to promote research into all aspects of natural toxins, and to help with the dissemination of knowledge. This book presents the most recent information on natural toxins from animal, plant and microbial origins and describes the state of research and clinical studies in the field. The material included is illustrated, referenced and fully indexed.

  • Neurotransmission

    Proceedings of the Sixth International Congress of Pharmacology
    • 1st Edition
    • Liisa Ahtee
    • English
    Neurotransmission is the second volume of the proceedings of the Sixth International Congress of Pharmacology, organized by the Finnish Pharmacological Society and held in Helsinki, Finland, on July 20-25, 1975. The papers focus on the developments in neurotransmission and cover topics ranging from novel transmitter substances and extraneuronal uptake of catecholamines to axonal transport mechanisms and nerve growth factor. This volume has 28 chapters divided into five sections. After discussing the possible functional role of certain tryptaminergic pathways, this book turns its attention to the metabolism of endogenous noradrenaline, with emphasis on the role of 3,4-dihydroxyphenylg... (DOPEG). The chapters that follow focus on amino acids as possible neurotransmitters, including histamine and glutamate. This text discusses as well the mechanisms underlying extraneuronal amine uptake and metabolism in the salivary glands; the effect of oxytetracycline on the responses of various tissue preparations to added noradrenaline and to field stimulation; and how axoplasmic transport is blocked by pharmacological agents. This book will be of interest to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as interdisciplinary areas related to physiology, biochemistry, and endocrinology. Many of the topics will also appeal to internists, psychiatrists, neurologists, and anaesthesiologists.

  • A Guide to Alcohol and Drug Dependence

    • 2nd Edition
    • J. S. Madden
    • English
    A Guide to Alcohol and Drug Dependence, Second Edition provides information on the recognition of alcohol misuse, on alcohol dependence among the elderly, and on outpatient withdrawal from opioids. This book emphasizes the detection and early treatment of alcohol misuse, the detoxification of drug users followed by drug-free counseling, and preventive measures. Organized into nine chapters, this edition begins with an overview of the various types of dependence-producing drugs, including morphine, cocaine, cannabis, alcohol-barbiturate, amphetamine, hallucinogen, and inhalants and volatile solvents. This text then explains the depressant actions of alcohol on the central nervous system that affects first the higher cerebral functions responsible for concern about personal behavior and for self-restraint. Other chapters consider the physical disabilities that heavy drinkers are prone to develop. The final chapter deals with the preventive measures directed against the problems presented by drugs and alcohol. This book is a valuable resource for social workers, nurses, occupational therapists, and clinical psychologists.

  • Screening Methods in Pharmacology

    • 1st Edition
    • Robert Turner
    • English
    Screening Methods in Pharmacology focuses on the methods for screening substances for pharmacological activities and discussions of organization of screening programs. The manuscript first offers information on the biochemistry of the nervous system and organization of screening, as well as mechanisms of drug effects within the autonomic system; mechanisms within the parasympathetic and symphatetic systems; and neuropharmacological tests in blind screening. The book also takes a look at general and quantal responses. The publication reviews depressants of the central nervous system and ataractic (tranquillizing, neuroleptic) agents. Topics include natatory exhaustion, motor deficit, righting reflex, pentylenetetrazol (metrazol) antagonism, head-withdrawal reflex, and avoidance of electrical shock. The book also ponders on analgesics and oxytoxic, antiserotonin, and anti-inflammatory agents. Discussions focus on narcotic and nonnarcotic analgesics, erythema, inhibition of ascites, and pleural fluid. The manuscript is a valuable reference for readers interested in the screening methods in pharmacology.

  • Biological and Environmental Aspects of Chromium

    • 1st Edition
    • Volume 5
    • S. Langård
    • English
    Biological and Environmental Aspects of Chromium focuses on the biological and environmental aspects of chromium and its compounds, with emphasis on the most important aspects of their toxicology and physiology. Topics covered range from the production and occupational exposure of chromium compounds to the presence of chromium in air, soil, and natural waters. The applications of chromium in cell biology and medicine are also discussed. Comprised of 11 chapters, this volume begins with an overview of the toxic and carcinogenic effects of chromium and chromium compounds, followed by a discussion on the production and occupational exposure of chromium compounds. The reader is then introduced to the more common analytical methods used in the determination of chromium in environmental and biological samples. Subsequent chapters explore the nutritional role of chromium; absorption, transport, and excretion of chromium in humans and animals; mutagenic and cytogenetic effects of chromium compounds; and organ toxicity of chromium in animals. The carcinogenic effects of chromium, including its effects on the skin, are also considered. This monograph will be of interest to students, practitioners, and researchers in the fields of biology, physiology, and chemistry, as well as those with an objective interest in the ways in which chromium and its compounds act in biological materials and in the human environment.

  • The Toxicology of Radioactive Substances

    Volume 5
    • 1st Edition
    • A. A. Letavet + 1 more
    • English
    The Toxicology of Radioactive Substances, Volume 5: Zinc-65 deals with the toxic properties of the radioisotope zinc-65 as well as its biological effects. Emphasis is placed on the role of stable zinc in the reaction of the body to the administration of zinc-65. Some of the results of laboratory studies on the toxic effects of zinc-65 on animals, primarily rabbits, are presented. This volume is comprised of 18 chapters and opens with an overview of certain aspects of the toxicology of radioactive zinc-65, followed by a discussion on the behavior of zinc-65 in the rat body. Subsequent chapters explore the distribution of zinc-65 in the body of rabbits following chronic oral administration; bioelectrical activity of the cerebral cortex in rabbits in conditions of prolonged administration of radioactive zinc; the effect of prolonged internal irradiation with G5ZnCl2 on the functional state of the rabbit heart; and aspects of hemopoiesis following chronic intake of radiozinc. Morphological changes in experimental animals following chronic exposure to radioactive zinc are also considered. This book will be of interest to chemists and toxicologists.

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