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Elsevier

Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Mechanisms of Drug Resistance in Neoplastic Cells

    Bristol-Myers Cancer Symposia, Vol. 9
    • 1st Edition
    • Paul V. Woolley + 1 more
    • English
    Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.

  • Essays in Toxicology

    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 3 covers the significant advances in several areas of toxicology, including inhalation toxicology and the tests for toxicity measurement. This volume contains four chapters, and begins with discussion of the mechanisms of pulmonary toxicology, such as the deposition of respirable materials and the cellular role in pulmonary clearance. The subsequent chapter examines the impact of physical environmental factors on drug response, including the effect of ionizing radiation and atmospheric pressure and temperature. These topics are followed by surveys of several toxicological measures for determination of the effects of long-term toxicant exposure. The concluding chapter explores the molecular and biochemical studies of toxicants, specifically their interactions resulting in binding to proteins or nucleic acids. This book will be of value to toxicologists, researchers, teachers, and students who wants to obtain a clearer view of the various aspects of toxicology.

  • The Lung Circulation

    Physiology and Pharmacology
    • 1st Edition
    • Domingo M. Aviado
    • English
    The Lung Circulation deals with important aspects of the lung circulation, with emphasis on the physiology of the pulmonary and bronchial circulation and autonomic pharmacology. Topics covered range from the role of anoxia in pulmonary circulation to reflexes arising from the pulmonary circulation and neighboring structures. The release of chemical substances from the pulmonary and bronchial circulation is also discussed. This volume is comprised of 10 chapters and begins with a review of the influence of anoxia on pulmonary circulation as well as four pertinent effects of anoxemia, namely, respiratory stimulation; cardiac stimulation; systemic vasoconstriction and vasodilatation; and pulmonary vasoconstriction and vasodilatation). The following chapters focus on the regulation of bronchial circulation; autonomic nervous control of pulmonary circulation involving acetylcholine, anticholinesterases, and atropine; and the pharmacology of sympathomimetic drugs, sympathetic blocking drugs, ganglion stimulants, and blocking drugs. The final chapter is devoted to the pharmacology of the autonomic nervous system and considers drugs that stimulate chemoreflexes arising from the lung circulation, including veratrum alkaloids. This book will appeal to physiologists and pharmacologists.

  • Neurotransmitters, Receptors

    Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981
    • 1st Edition
    • H. Yoshida + 2 more
    • English
    Advances in Pharmacology and Therapeutics II, Volume 2: Neurotransmitters-Re... is the second of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into seven parts, this book begins with an invited lecture on the kinetic analysis of the neuronal and extraneuronal uptake and metabolism of catecholamines. Subsequent parts discuss the regulation of receptor-mediated events; presynaptic receptors in the peripheral and central nervous system; neurotransmitters; and receptor antibodies. The isolated nervous systems in the research of neurotransmission and trophic interactions between nerve and muscle are also discussed.

  • A Textbook of Medical Jurisprudence and Toxicology

    • 6th Edition
    • Rai Bahadur Jaising P. Modi
    • English
    A Textbook of Medical Jurisprudence and Toxicology, Sixth Edition discusses medico-legal points concerning the different causes of death, examination of evidence, and crimes that merit medical attention and advice. The author reviews the legal procedures in criminal courts of medical jurisprudence, including the inquest procedures, the difficulties encountered in detecting crime, medical evidence, rules for presenting evidence, and the powers of criminal courts. The post-mortem examination concerns the external and internal examination of the deceased to establish identity (if unknown), to determine time and cause of death. Under the written orders of the court, an exhumation can take place when suspicions of foul play arises after death. The author discusses death in terms of somatic (physical) or molecular (tissues and cells dying individually after vital organs have stopped functioning). The book also describes in detail the primary modes of dying, namely, syncope, asphyxia, and coma. The book explains the medico-legal aspects of injuries, pregnancy, legitimacy, rape, miscarriage, infanticide, and insanity. This book is intended for medical students, but can also benefit students in law courses, and practitioners of legal jurisprudence and of the medical sciences.

  • Biochemical and Neurophysiological Correlation of Centrally Acting Drugs

    Second International Pharmacological Meeting
    • 1st Edition
    • E. Trabucchi + 2 more
    • English
    Section on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume 2: Biochemical and Neurophysiological Correlation of Centrally Acting Drugs focuses on the composition, reactions, and applications of centrally acting drugs. The selection first offers information on the physiology of striopallidum in relation to extrapyramidal function and disorders and actions of dopa and dopamine in relation to function of the central nervous system. Discussions focus on correlation of behavioral and clinical states with metabolism of dopamine, functions of dopamine in the brain, and the central pharmacology of dopamine. The text then examines the role of brain dopamine (3-hydroxytyramine) in Parkinsonism, including behavior of dopamine in the extrapyramidal centers in patients with Parkinson's disease; brain dopamine and the extrapyramidal symptomatology of Parkinson's disease; and parallelism between Parkinson's disease and the Parkinson-like state induced by reserpine in man. The publication ponders on pharmacological studies on tremorine and metabolism of tremorine. The manuscript also takes a look at the contribution on the pathophysiology of intentional tremor; failure of Antiparkinson drugs to antagonize hypothermia in tremorine-treated rats; and significance of dopamine in psychomotor stimulant action. The selection is a dependable source of data for readers interested in centrally acting drugs.

  • CNS and Behavioural Pharmacology

    Proceedings of the Sixth International Congress of Pharmacology
    • 1st Edition
    • M. Airaksinen
    • English
    CNS and Behavioural Pharmacology is the third volume of the proceedings of the Sixth International Congress of Pharmacology, organized by the Finnish Pharmacological Society and held in Helsinki, Finland, on July 20-25, 1975. Contributors focus on the findings concerning the central nervous system (CNS) and on the developments in behavioral pharmacology and related areas of research. This volume has 33 chapters divided into five sections. After discussing the application of psychopharmacology to the conservation of wild animals such as ungulates, this book turns its attention to alcohol dependence and the interactions between neurotransmitters and the hypothalamic releasing hormones. The reader is methodically introduced to the pharmacology of emotive behavior, with emphasis on drug effects in mental and emotional disorders as well as the action of psychotropic drugs on emotions, motivations, and social behavior of animals. The final section is devoted to the pharmacological aspects of the cerebrospinal fluid-transport system. This section covers topics such as the metabolism of biogenic amines in the human CNS; the importance of dopamine metabolism for the clinical effects and side effects of neuroleptics; and composite transport systems for organic acids and bases in choroid plexus. This book will be of interest to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.

  • Essays in Toxicology

    Volume 4
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay. The second essay discusses the time-course of enzyme inhibition at single-inhibitor concentrations and the effect of various inhibitor concentrations on the rate constants governing inhibition. The third essay is about the recondite toxicity of trace elements, taking into consideration the effects of these trace elements on body weight, survival, and longevity, clues to mechanisms of toxicity, and the production of chronic diseases simulating human disorders. Toxicologists, oncologists, biochemists, and pharmacologists will find the book invaluable.

  • Clinical Ocular Pharmacology

    • 2nd Edition
    • Jimmy D. Bartlett
    • English
    Clinical Ocular Pharmacology, Second Edition covers the diagnostic and therapeutic clinical procedures in the administration of drugs to the eye. This book is organized into five parts encompassing 35 chapters that evaluate the basic pharmacologic principles that govern the different types of ophthalmic drugs. It addresses the pharmacologic agents useful in the diagnosis and treatment of ocular diseases. Some of the topics covered in the book are the basic science of ocular pharmacology; clinical administration of ocular drugs; drugs affecting the autonomic nervous system; types of local anesthetics; review of anti-inflammatory drugs; and examination of inhibitors of aqueous formation. Other parts deal with the development of contact lens solution in clinical practice and the pharmacologic management of strabismus. These topics are followed by discussions of the legal basis of using drugs in optometry and the systemic effects of ocular drugs. The concluding part is devoted to the diseases of the optic nerve. The book can provide useful information to doctors, optometrists, pediatricians, students, and researchers.

  • Neurotransmitters

    Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
    • 1st Edition
    • P. Simon
    • English
    Advances in Pharmacology and Therapeutics, Volume 2: Neurotransmitters contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of neurotransmitters, their pharmacology, and their therapeutic applications. Topics covered range from the functions of GABA to the interdependence of neurotransmitter systems in the central nervous system (CNS). This volume is comprised of 24 chapters and opens with a discussion on the role of GABA systems in Huntington's disease and schizophrenia. The reader is then introduced to the stereospecific actions of GABA analogues; interactions between serotonin and noradrenalin containing neurons; immunofluorescent staining of serotonin in the CNS; and plasticity of transmitter functions in sympathetic neurons developing in cell culture. The following chapters explore the molecular mechanisms underlying the modulation of catecholamine release from the adrenal medulla; pre-and postsynaptic regulation of catecholamine neurotransmitters; the role of GABA-ergic component in the mechanism of action of neurotropic drugs; and pre-and postsynaptic action of GABA in the mammalian spinal cord. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

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