Foreword IntroductionPart I Antibiotics Produced by Micro-Organisms of the Order Euhacteriales A. Antibiotics Isolated from the Genus Pseudomonas (Pseudomonadaceae) Pyocyanine Hemipyocyanine Antibiotic Ρχ Chlororaphin Antibiotic Substances from Pseudomonas Aeruginosa Pyoluteorin Comirin Pyolipic Acid Pyocyanase Pyoklastin Viscosin B. Antibiotics Isolated from the Genus Micrococcus (Micrococcaceae), Streptococcus, Diplococcus (Lactobacteriaceae), Chromobacterium, Escherichia and Proteus (Enterobacteriaceae) Micrococcin Nisin Diplococcin Streptostasin Diplomycin Mycobactocidin Lactobacillin Prodigiosin Iodinin Violacein Marcescin Xerosin Coliformin Colicines Protaptins Antibiotic from Escherichia Coli Toxoflavin C. Antibiotics Isolated from the Genus Bacillus (Bacillaceae) Gramicidin S Gramicidin, Tyrocidine, Tyrothricin Gramicidin J Bacitracin, syn. Ayfivin Subtilin Licheniformins Polymyxins—Aerosporin, Bacillosporin, Circulins Colistin, syn. Colimycin Alvein Bacilipin, Bacilysin Bacillin Globicin Brevin Brevolin Bacimethrin Edein Antifungal Antibiotics Produced by Micro-Organisms of Genus Bacillus Bacillomyxin Bacillomycin Antifungal Antibiotics from Bacillus Subtilis Fungocin Eumycin Toximycin Antifungal Agents from Bacillus Subtilis Datemycin Fungistatin, syn. Antibiotic XG Mycosubtilin Rhizobacidin Simplexin Polypeptin Laterosporins Fluvomycin, syn. Efsiomycin, Vivicil, Riomycin Cerein Tetaine Pumilin Subtenolin Megacine Xanthellin Esperin Iturine Neocidin Obutin Biocerin Endosubtilysine Colistatin Subtilysine, Analysine Mycobacillin Petrin Nigrin Antibacterial Substance Produced by Bacillus Natto Trypanotoxin Polysaccharidases Antibiotic Substances from MyxococcaceaePart II Antibiotics Produced By Micro-Organisms of the Order Actinomycetales A. Macrolides Picromycin Argomycin Methymycin Neomethymycin Amaromycin Narbomycin Oleandomycin, syn. Antibiotic P.A. 105, Matromycin Erythromycin, syn. Ilotycin Magnamycin, syn. Carbomycin, Antibiotic M-4209 Spiramycin, syn. Foromacidin, Rovamycin Angolamycin Lankamycin and Lankacidin Chalcomycin, syn. Miconomycin Substance 446 Mesenterin Griseomycin, syn. Lomycin Miamycin Albomycetin Leucomycin Tertiomycin Macrolide-Type Antibiotics: PA-108, PA-133A, PA-133B and PA-148 Tylosin Macrocin Proactinomycins Acumycin Cirramycin B. Antibiotics Active Against Grampositive Micro-Organisms Granaticin Novobiocin, syn. Cathomycin, Cathocin, Streptonivicin, Albamycin, Antibiotic P.A.93, Cardelmycin Rifamycins Amicetin, syn. Sacromycin, Allomycin Amicetin Β Bamicetin Plicacetin Actinorhodin Thermorubin Antibiotic BA-6903 Indolmycin, Syn. Antibiotic PA-155 A Althiomycin Teomycic Acid Totomycin Nitrosporin Ramnacin Resistomycin Exfoliatin Sulfactin Celesticetin Lincomycin Proceomycin Aureolic Acid Monazomycin Aburamycin Antibiotic Μ 5-18903 Antibiotic 24-10 Nocardianin Rubidin Julymycin B-II Rubromycin Sarcidin Bundlins A and Β Pulvomycin Vancomycin Frenolicin Antibiotic K-288 Thermoviridin Actiduins Ristocetin, syn. Spontin Vinacetin Antibiotic L.A. 7017 Monamycin Erigrisin Elaiophylin Melanosporin Antibiotic SKCC 1377 Antibiotic J4 Antibiotic 1943 Bandamycin Actinoidin Cladomycin Actinomycelin Coelicolorin Colinomycin Fuscomycin Antibiotic A 116 Streptin Thermomycin Antibiotic 19A Sax 10 Substance Antibiotic from Streptomyces Sp. 340 Raisnomycin Antibiotic 721 Microsin Antibiotic Κ 125a Mycetin Phthiocol C. Polypeptide Antibiotics Echinomycin Quinomycins Bottromycin Griseoviridin and Viridogrisein, syn. Etamycin Valinomycin Leucopeptin Amidomycin Sideromycins Succinimycin Nocardamine Grisein Albomycin Danomycin Antibiotic LA 5352 and LA 5937 Staphylomycin, syn. Antibiotic 899, Virginiamycin Streptogramin Mikamycins Antibiotic PA 114 Ostreogricin, syn. Antibiotic E-129 Pristinamycin, syn. Antibiotic 7293 R.P., Pyostacin Duramycin Telomycin Crystallomycin Amphomycin Stendomycin Zaomycin Aspartocin Glumamycin Cinnamycin Thiostrepton Siomycin Bryamycin Substance A-59 and A-59B Viomycin Capreomycin, syn. Capromycin Ilamycins Rufomycins Vinactins Actinogan Peptimycin Antibiotic 1415 Cranomycin Phytoactin and Phytostreptin Phleomycin Antibiotic from Actinomyces 1-21 Antibiotic from Actinomyces Strain 300 Evericin Aminomycin Antibiotic from Streptomyces Sp. (Sackman) Antibiotic 6613 Micromonosporin Antibiotic X-5079C Actinomycetin Geminimycin Grizin, syn. Grizemin, Antibiotic IEM I Mycomycetin Lysozyme of Actinomycetes Antibiotic BU 306 Antibiotic BU 271 D. The Broad-Spectrum Antibiotics Chloramphenicol, syn. Chloromycetin Tetracyclines Chlortetracychne, syn. Aureomycin, Duomycin Oxytetracycline, syn. Terramycin Tetracycline, syn. Achromycin, Terracin Tetracycline Derivatives Synthesis of Tetracyclines Biosynthesis of Tetracyclines Chelocardin Rhodomycins Cinerubins Pyrromycin Rutilantin Quinocyclines Streptomycin Hydroxystreptomycin, syn. Reticulin Antibiotic U-12898, syn. Bluensomycin Glebomycin Trehalosamine Hygromycin Hygromycin Β Homomycin Antibiotic 1703-18 Β Actinospectacin Streptothricin Antibiotic A 4788 Streptohn Geomycin Roseothricin Racemomycins Lavendulin Actinorubin Pleocidin Amycin Polymycin Mycothricin Antibiotic 587/13 Antibiotic A 20 Antibiotic Ax 18 Antibiotic 136 Antibiotic 156 Phytobacteriomvcin Antibiotic EI5 Neomycins Paromomycin, syn. Humatin Monomycin Zygomycins Kanamycins Eurymycin Colimycin Antibiotic 956 Antibiotic from Streptomyces Sp. (Mukherjee) Roseomycin Novomycin Flavomycin Soframycin, syn. Framycetin Antibiotic A 6 Mycerin Dextromycin Catenulin Aminosidin, syn. Crestomycin, Antibiotic 1600, Antibiotic F.I. 5853, Farmiglucin Hydroxymycin, Syn. Antibiotic 4915 Antibiotic GB/229 Antibiotic Ac 3 Azomycin Antibiotic HA-9 Thiolutin Isobutyrylpyrrothine Aureothricin Holomycin 1,6-Dihydroxyphenazine N-Acetyltyramine Thioaurin Thiomycin Bleomycin Griseolutein Chartreusin Primycin Mycospocidin Litmocidin Mycorhodin Luteomycin Xanthomycins Levomycin Streptozotocin Ractinomycin Streptolydigin Azalomycins Β and F Nigericin Cyanomycin Matamycin Violacetin Xanthothricin Emimycin Antibiotic from Streptomyces Tanashiensis Ruticin Streptocardin Rhodocidin Flaveolin Antibiotic from Streptomyces Sp. (Rolland) Antibiotic 10 CM Antibiotic from Actinomyces Flavus Strain 2 Antibiotics from Streptomyces Sp. 1900-IAUR Phalamycin Actinonin Speciomycin Miramycin Enteromycin Fluorin Griseococcin Gougerotin Longisporin Monamycin Microcins Actinolysin Primocarcin Nocardorubin Neonocardin E. Antibiotics Active Against Acid-Fast Bacilli Acetomycin Cycloserine, syn. Seromycin, Oxamycin, Antibiotic P.A. 94, Orientomycin, D-4-Amino-3-Isoxazolidone O-Carbamyl-D-Serine Actithiazic Acid, Syn. Mycobacidin, Acidomycin Elaiomycin Mycomycin, Isomycomycin Antibiotic HON Tubermycins Tuberin Bovinocidin Tubercidin Angustmycins Psicofuranine Antitumour Antibiotic from Helminthosporium Grisamine Pyridomycin, syn. Antituberculous Antibiotic Streptovaricin, syn. Dalacin Griseoflavin Antibiotic WR 3/17 Antibiotic D-13 Anti-Phlei Factor Anti-Smegmatis Factor Phthiomycin Antituberculous Substance From Streptomyces Strain Nocardin Globisporin Antibiotics of Mycobacteria F. Antifungal Antibiotics (Polyenes) Tetraene Antibiotics Fungicidin, syn. Nystatin, Mycostatin Pimaricin Tennecetin Antifungal Antibiotic from Streptomyces 3569, syn. Antimycoin Rimocidin Chromin Protocidine Antifungal Antibiotic from a Strain of Streptomyces Sp. Ac2 435 Tetrin Lucensomycin, syn. Etruscomycin, Antibiotic 1163 F.I. Sistomycosin Antifungal Antibiotics J4 A and J4 Β Antifungal Antibiotic 7071 R.P. Antibiotic PA 86 Albofungin Antifungal Antibiotic PA 166 Unamycins Pentaene Antibiotics Eurocidin Fungichromin, Fungichromatin Filipin Antibiotic A 246, syn. Lagosin Pentamycin Moldcidins Cabicidine Capacidin Aliomycin Antifungal Antibiotic PA 153 Antifungal Antibiotic A 228 Hexaene Antibiotics Cryptocidin Mediocidin Fradicin Mycelin Antifungal Antibiotic 1587-Z 2 Flavacid Endomycin Helixins Substance D Heptaene Antibiotics Amphotericin Candidin, Candidinin, Candidoin Candimycin Candicidin Ascosin Trichomycin Perimycin, syn. Antibiotic 1968, Antibiotic NC-1968 Hamycin Antibiotic 26/1, syn. Levorin Antibiotic 757 Antibiotic F-17-C Antifungal Antibiotic AYF Antifungal Antibiotic 1645 Antifungal Antibiotic PA 150 Ayfactin Aureofacin Antifungal Antibiotics from Streptomyces Sp. 1033 and 1038 Grubilin Antifungal Antibiotic G. Antifungal (Non-Polyene) Antibiotics Cycloheximide, syn, Actidione Viractin Protomycin Antitumour Substance E-73 Streptovitacins Inactone and Isoactidiones Actiphenol Streptimidone Niromycins Naramycin Niger Factor Nonactin Antibiotic FH 3582, syn. Werramycin Antibiotic SQ 15859 Antimycin, syn. Antibiotic 720 A, Virosin, Antipiricullin, Antibiotic from Streptomyces Kitazawaensis Blastmycin Toyocamycin Vengicid Fermicidin Ascomycin Hygroscopin Monilin Antibiotic PA 132 Mycoticin Cerevioccidin Anthelmycin Mycolutein Oligomycin Antibiotic A 272 Venturicidin Antibiotics from Streptomyces X 206, X 464 and X 537 A Humidin Hygrostatin Lustericin Dermostatin Musarin Eumycetin Blasticidins Blasticidin S Pathocidin Septacidin Cytomycin Cellostatin Flavensomycin Alomycin Euhcin Seligocidin Alboverticiuin Flavofungin Xanthicin Antifungal Substance from a Streptomycete (Thirumalachar) Cacaomycetin Moldin Actinon Camphomycin Mycelin Mycerin (Arai) Phaeophacin Rotaventin Antibiotic Β 74 Bulging Factor Antibiotic P-9 Antifungal Antibiotic S-39 Antibiotic A 67 Antibiotic 30-10 Vulgarin Amylocyanin H. Antibiotics Active Against Protozoa Puromycin, syn. Stylomycin Netropsin, syn. Sinanomycin, Congocidine Antibiotic 1142, Antibiotic T-1384 Distamycin A Antibiotic 2814 A, 2814 P, 2814 Κ Antibiotic IA 887 Nucleocidin Anisomycin, syn. Flagecidin Borrelidin Antitoxoplasmic Substance No. 534 Streptocin Antibiotic 7.080 R.P. Antibiotic X-948 Antibiotic X-1008 Antibiotic PA 128 Ascaricidin I. Antibiotics Active Against Plant and Animal Viruses Nybomycin Myxoviromycin Amidinomycin Chrysomycin Aklavin Phagolessin A-58 Phagostatin Phagomycin Phagocidin Grasseriomycin Abikoviromycin, syn. Latumcidin Achromoviromycin Ehrlichin Antibiotic Ε 300 Hehomycin Cerulomycin Antibiotic F 43 Antibiotic 1-81d-1s Flavocidin Virocidin Antibiotics from Actinomyces 1212 and 452-7 Antibiotic F 416 Cephalomycin Virusin 1609 Luridin Antibiotic F 256 Violarin Antivirubin Antiviral Agent from Nocardia Formica Cardicin J . Antibiotics With Antitumour Activity Azaserine 6-Diazo-5-Oxo-L-Norleucine, syn. DON Diazomycins, syn. Duazomycins Sarkomycin Actinomycins Lyomycin Actinoleukin Questiomycins A and Β Mitomycin Labilomycin Formycin Olivomycin Ayamycin Mitiromycin Porfiromycin Roseolic Acid Cellocidin Antitumour Substance from Streptomyces sp, 1418 Pillaromycin Antibiotic 6270 Alazopeptin Substance 289 Pluramycin Taitomycin Melanomycin Gancidin Antibiotic BA-180265 Carzinophilin Streptonigrin Minomycin Sulfocidin Sparsomycin Desertomycin Actinobolin Carzinocidin Mutomycin Cervicarcin Daunomycin, Rubidomycin Chromomycins Aurantin Actinoxanthin Enomycin Pactamycin Caryomycin Carzinostatin Raromycin Antitumour Antibiotic from Streptomyces Sp. 1683 Antitumour Antibiotic M-770 Actinoflocin Triostins Actinin, syn. Mycetin Marinamycin Showdomycin