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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

BooksJournals

    • Pharmacology in Clinical Practice

      • 1st Edition
      • October 22, 2013
      • Richard Lancaster
      • English
      • Paperback
        9 7 8 1 4 8 3 1 7 7 1 3 7
      • eBook
        9 7 8 1 4 8 3 1 9 2 9 4 9
      Pharmacology in Clinical Practice describes basic pharmacology, clinical pharmacology, including the pharmacology of important drug groups. The author reviews the general principles of clinical pharmacology including drug actions, absorption, disposition, and excretion. Most drugs are xenobiotics—compound... foreign and harmful to human living tissues. Drugs should be properly metabolized and converted to nontoxic substance before being excreted either through spontaneous changes not mediated by enzymes or through transformation by enzyme systems. The author also discusses pharmacokinetics, including drug plasma concentration, absorption, first-pass metabolism, distribution and elimination. The author addresses pharmacogenetics that deal with possible different responses to drug intake due to factors such as age, sex, liver or renal disease, smoking, diet. The book tackles other drugs, their uses, and characteristics such as antibacterial agents, obesity drug, cytotoxic drugs or those used in chemotherapy medicine. The author explains the diagnosis of drug ingestion, clinical signs of overdose, clinical course, and prophylactic measures for users to avoid drug overdose or self-poisoning. This book is intended for medical undergraduates, pharmaceutical technicians, pharmacists, students or professors in pharmacology or general medicine.

    • Aspirin and the Salicylates

      • 1st Edition
      • October 22, 2013
      • K. D. Rainsford
      • English
      • Paperback
        9 7 8 1 4 8 3 1 7 6 1 8 5
      • eBook
        9 7 8 1 4 8 3 1 9 1 9 9 7
      Aspirin and the Salicylates focuses principally on aspirin. Topics ranging from analytical chemistry and pediatric medicine, taxonomy and cartels, enzymology and toxicity, to renal functions and rheumatology are also included in this compilation. This book emphasizes that salicylates are polycompetent drugs that influence a large number and variety of biological processes. Their multifactorial actions, in relation to the known therapeutic and toxic effects are clearly described. This text likewise provides a refreshing multidisciplinary approach to aspirins that cover the whole extent from chemical to clinical aspects. This publication is a good reference for clinicians, pharmacists, and students intending to acquire general knowledge of the aspirin and salicylates.

    • Pharmacology for Student and Pupil Nurses and Student Pharmacy Technicians

      • 1st Edition
      • October 22, 2013
      • Bernard R. Jones
      • English
      • Paperback
        9 7 8 0 4 3 3 1 7 5 4 0 7
      • eBook
        9 7 8 1 4 8 3 1 4 1 3 2 9
      Pharmacology for Student and Pupil Nurses and Student Pharmacy Technicians is based on lectures presented to nurses in training for the State Registration and State Enrollment Examinations and to Students in Dispensing. The book presents an account of drugs that are in use or are very likely to be used. The text includes description of drug administration; antacids, gastric sedatives, laxatives, antidiarrheal, and diuretics are discussed in detail. The intravenous infusions, cardiovascular drugs, anti-anemics, hemostatics, and anticoagulants are described as to their effects and functions. A brief anatomy of the human circulatory process is presented. The next types of drugs discussed are those that target the respiratory system — expectorants and cough sedatives. The effects of sedatives, stimulants, analgesics, and anesthesia on the nervous system are discussed in detail. Antibiotics, drugs combating infection, tropical diseases, sera, and vaccines as prophylactic and therapeutic remedies are explained. Other drugs, such as antiseptic and disinfectants, drugs used in endoctrine therapy and malignant diseases, as well as drugs that are locally applied and those used in diagnosis are explained. The process of ordering, storage, and administration of drugs; calculations used in determining safe dosages; and the poisons regulations concerning dangerous and potentially harmful drugs are covered in detail. Pharmacists, student pharmacy technicians, professors of pharmacology, practitioners of general medicines, and specialists with interests in drug therapy will find this reference valuable.

    • Drug Therapy During Pregnancy

      • 1st Edition
      • October 22, 2013
      • Tom K. A. B. Eskes + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 3 0 5 6 9
      • Hardback
        9 7 8 0 4 0 7 0 2 3 0 1 7
      • eBook
        9 7 8 1 4 8 3 1 6 2 9 8 0
      Drug Therapy During Pregnancy is a collection of papers dealing with the risks and benefits of drug treatment for both mother and fetus. One paper notes that the total use of medication during pregnancy in the Netherlands has decreased from 82.7 % to 71.7 %. The paper also points out the lack of a relationship between the number or type of congenital anomalies and the use of medication. Another paper assesses fetal drug exposure in two ways: firstly, through the physicochemical characteristics of the drug and the way it is handled by the mother in order to estimate placental passage and fetal exposure. Secondly, through the utilization of pharmacokinetic models estimating the probable time course of drug concentrations in the feto-maternal unit. One paper investigates the effects of hypertension during pregnancy, in which the etiology of hypertension, a group of disorders with one common abnormality, remains unsolved with a clinical diagnosis that is not always accurate. Treatment differs widely depending on the type: chronic hypertension, albuminuric hypertension, and hypertensive crises during pregnancy. One paper suggests that to prove any environmental exposure to a particular substance affecting pregnancy, the exact timing of exposure must be established, large samples are necessary, possibly on a national or international scale. The paper cites as example the four-year documentation period of the 50% to 80% incidence of malformations due to thalidomide. General medicine practitioners, obstetricians, gynecologists, and researchers dealing with pharmacology, pharmocokinetics, toxicology, or embryology will find the collection valuable.

    • Presystemic Drug Elimination

      • 1st Edition
      • October 22, 2013
      • Charles F. George + 1 more
      • English
      • Hardback
        9 7 8 0 4 0 7 0 2 3 2 2 2
      • Paperback
        9 7 8 1 4 8 3 1 3 1 1 8 4
      • eBook
        9 7 8 1 4 8 3 1 6 3 6 0 4
      Butterworths International Medical Reviews, Clinical Pharmacology and Therapeutics 1: Presystemic Drug Elimination explores the principles of presystemic drug metabolism in human based on animal studies. This book is divided into four sections encompassing 10 chapters that specifically describe the extent of metabolism occurring in the gastrointestinal tract, liver, and lung. Section 1 focuses on presystemic elimination by the gastrointestinal tract. This section discusses the enzymatic biotransformation in the gastrointestinal mucosa and the ability of the microflora to metabolize drugs. Section 2 considers the contribution of the liver to presystemic drug elimination, with a particular emphasis on the physiological factors, which determine the rate of breakdown of drugs in vivo. This section also deals with the effects of hepatic cirrhosis on presystemic drug elimination. Section 3 presents first a brief outline of the knowledge of pulmonary structure and relevant physiology, followed by a discussion on “first-pass” metabolism of endogenous substrates and drugs across the pulmonary circulation and of environmental chemicals after inhalation. This section also provides the methods for distinguishing between the contribution of the various sites to presystemic drug elimination and the problems associated with attempts to analyze available pharmacokinetic data. This work is an ideal source for clinical pharmacologists and researchers.

    • Pharmaceutical and Cosmetic Products for Topical Administration

      • 1st Edition
      • October 22, 2013
      • N. J. Van Abbé + 2 more
      • J. B. Stenlake
      • English
      • Paperback
        9 7 8 0 4 3 3 3 3 6 4 5 7
      • eBook
        9 7 8 1 4 8 3 1 8 3 0 4 6
      Pharmaceutical and Cosmetic Products for Topical Administration , Volume 9 provides the product characteristics, formulation, and rationale of topical therapeutic preparations. The book attempts to take the reader logically from the physiological and pathological aspects through to the reasoning behind topical medication. The text discusses such topics as the physiology and structure of the skin; the differential diagnosis of various skin diseases; the theoretical basis of emulsion technology; and the mechanism of percutaneous absorption. Undergraduate students and teachers of pharmacy and allied subjects will find the monograph very useful.

    • Evaluation of Drug Activities

      • 1st Edition
      • October 22, 2013
      • D R Laurence + 1 more
      • English
      • eBook
        9 7 8 1 4 8 3 2 6 2 8 4 0
      Evaluation of Drug Activities: Pharmacometrics, Volume 2 provides information pertinent to the fundamental aspects of pharmacometrics. This book covers a variety of topics, including anticholinesterases, antitussives, cardioactive agents, diuretics, dermatological agents, and estrogens. Organized into 21 chapters, this volume begins with an overview of anticholinesterases and its pharmacological and physiological actions. This text then examines the diversity of methods for evaluating antitussive drugs, which is related to the complexity of cough reflexes. Other chapters consider tests for cardioactive substances of three general classes, namely, the cardiac glycosides, the coronary vasodilators, and the anti-arrhythmics. This book discusses as well the introduction of many diuretics into therapeutic practice during the past years bears witness to the convenience and success of the tests available for assessing drugs of this class. The final chapter deals with drugs affecting lipid levels in plasma. This book is a valuable resource for chemists, physiologists, pharmacologists, and clinicians.

    • Advances in Drug Delivery Systems, 6

      • 1st Edition
      • October 22, 2013
      • James M. Anderson + 2 more
      • English
      • Hardback
        9 7 8 0 4 4 4 8 2 0 2 7 3
      • Paperback
        9 7 8 1 4 8 3 1 2 9 1 5 0
      • eBook
        9 7 8 1 4 8 3 1 6 1 5 7 0
      Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.

    • Poulsson's Text-Book of Pharmacology and Therapeutics

      • 1st Edition
      • October 22, 2013
      • Stanley Alstead
      • English
      • eBook
        9 7 8 1 4 8 3 2 2 5 8 4 5
      Poulsson’s Text-Book of Pharmacology and Therapeutics, Second English Edition covers the considerable progress in understanding the basic principles, applications, and classifications of drugs and other organic compounds of therapeutic interest. This text is divided into six chapters, each dealing with a specific classification of drugs. The first chapter describes the so-called protoplasmic poisons, which are organic substances that are characterized by their specific effects after absorption on the nervous and muscular systems, while local effects are altogether absent or insignificant. The second chapter examines the organic remedies that principally act locally, such as at the point of application, while the action after absorption is unimportant or is not utilized in medicine. The third and fourth chapters explore the main groups containing the inorganic bodies. These chapters demonstrate that the inorganic compounds differ from the organic, whose activity is due to the unchanged entire molecules, and they are subjected to dissociation. The fifth chapter considers the digestive ferments and foodstuffs, while the sixth chapter is concerned with antitoxins and bacterial products. This book will be of value to pharmacologists, pharmacists, researchers, and pharmacology and pharmacy students.

    • Pharmacology of Conditioning, Learning and Retention

      • 1st Edition
      • October 22, 2013
      • M. Ya. Mikhel'son + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 1 0 0 7 0
      • Hardback
        9 7 8 1 4 8 3 1 9 8 4 7 7
      • eBook
        9 7 8 1 4 8 3 2 2 3 5 0 6
      Proceedings of the Second International Pharmacological Meeting, Volume 1: Pharmacology of Conditioning, Learning and Retention is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This book is organized into two sections encompassing 28 chapters. The first section defines the main problem in psychopharmacology, which is the establishment of methods that will enable to appreciate in animals the value of psychotropic drugs in the therapy of human mental diseases. This section also describes the specific activation of the central nervous system and its significance in psychopharmacologica... research. The second section explores the electrophysiological phenomena observed during pharmacological conditioning, with emphasis on the modifications of electrical activity during the establishment and the performance of the conditioned responses. This section also deals with the electrical correlated of various kinds of conditioned behavior in animals and the alterations of spontaneous rhythm and evoked potentials. This book is of value to psychopharmacologist... and electrophysiologists...

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