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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Advances in Immunopharmacology

    Proceedings of the First International Conference on Immunopharmacology, July 1980, Brighton, England
    • 1st Edition
    • April 19, 2016
    • J. Hadden + 2 more
    • English
    Advances in Immunopharmacology documents the proceedings of the First International Conference on Immunopharmacology held in Brighton, England, in July 1980. The volume contains 60 papers organized into 10 parts. The papers in Part I examine the pharmacology of immunotherapeutic drugs and immunotoxicology. Part II presents studies on thymic hormones. Part III is devoted to immunopharmacologic approaches to diseases other than cancer. Part IV deals with mechanisms of chemotaxis degranulation and microbicidal action. Part V focuses on cancer immunopharmacology and immunotherapy while Part VI covers the mechanisms of inflammatory and allergic processes. Part VII takes up the immune testing of the actions of immunotherapeutic agents. Part VIII discusses prostaglandins and macrophage suppression. Part IX is devoted to selected topics such as mechanism of action of soluble immune response suppressor and new approaches to the therapy of allergic diseases. Part X presents discussions during the therapy communication sessions.

  • Abstracts

    Proceedings of the Seventh International Congress of Pharmacology
    • 1st Edition
    • April 19, 2016
    • J. R. Boissier + 2 more
    • English
    Abstracts contains the abstracts of work presented at the 7th International Congress of Pharmacology: invited lectures, symposia, methodological seminars, and free communications. The abstracts are organized in chronological order of presentation at the Congress. Some abstracts focus on chemistry and biochemistry of pituitary endorphins and their precursors; the biosynthesis and release of the enkephalins; enkephalin dynamics and neuronal localization; and physiological and pathophysiological relevance of the opiate receptors and their endogenous ligands. Other papers center on the mechanism of muscarinic receptor action; regulation of cholinergic receptor metabolism in skeletal muscle; the role of vitamin E in ozone-induced pulmonary toxicity; alcohol and electrophysiology of the central nervous system; and pharmacokinetic aspects of drug-alcohol interaction.

  • Chelation Therapy in the Treatment of Metal Intoxication

    • 1st Edition
    • April 15, 2016
    • Jan Aaseth + 2 more
    • English
    Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptos... acid (DMSA) and D,L-2,3-dimercapto-1... acid (DMPS).

  • Pharmacology of Reproduction

    Proceedings of the Third International Pharmacological Meeting July 24–30, 1966
    • 1st Edition
    • April 6, 2016
    • E. Diczfalusy + 1 more
    • English
    Pharmacology of Reproduction is the second volume of the proceedings of the Third International Pharmacological Meeting held in Sao Paulo in 1966. The volume presents papers about the pharmacological implications of the hypothalamic control of gonadotrophin and prolactin secretion and the factors affecting hypothalamic function, with focus on the pharmacology of puberty. The luteinizing hormone (LH)-like activity in the pituitary-hypothalam... complex of children and the chemistry and physiology of follicle-stimulating hormone-releasing factor and LH-release factor are studied as well in other papers presented. The volume then tackles papers about the factors affecting the testicular function in human; immunological factors affecting spermatogenesis; and the factors stimulating the ovarian function in human. The pharmacological inhibition of the ovarian function is also considered in the volume. Practicing endocrinologists and physiologists and students taking endocrinology courses will find the book invaluable.

  • Biochemical Immunological Pharmacology

    Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981
    • 1st Edition
    • February 6, 2016
    • H. Yoshida + 2 more
    • English
    Advances in Pharmacology & Therapeutics II, Volume 4: Biochemical Immunological Pharmacology covers papers on the developments in pharmacology and therapeutics. The book contains invited lectures on the effect of drugs on immunological control mechanisms; the pharmacology of specific, pure and potent serotonin 5-HT2 or S2-antagonists; and the pharmacology of phospholipases A2 isolated from snake venoms. The text also contains papers on leukotrienes; the guanine nucleotide-binding regulatory component of adenylate cyclase; and the pharmacological and toxicological implications of multiple cytochromes P-450. The impact of the emerging biotechnologies on pharmacology; the action of antipsychotics on LSD-induced neurochemical and behavioral effects in rats; and the effect of histamine and related compounds on the immune response are also considered. The book also presents papers on inflammation; prostacyclin; prostaglandins; and chemical hazards to humans.

  • Receptors

    Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
    • 1st Edition
    • January 26, 2016
    • J. Jacob
    • English
    Advances in Pharmacology and Therapeutics, Volume l: Receptors contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of receptors, their pharmacology, and their therapeutic applications. Topics covered range from opiate receptors and their endogenous ligands to membrane receptors in eukaryotic cells. Applications of binding to pharmacological research are also discussed. This volume is comprised of 29 chapters and opens with an overview of the chemistry and biochemistry of pituitary endorphins, paying particular attention to the correlation between the analgesic potency, receptor binding properties, preferred solution conformation, and metabolic stability of natural and synthetic opioid peptides. The reader is then introduced to the biosynthesis and release of the enkephalins; opiate receptors and their endogenous ligands; denervation supersensitivity in skeletal muscle; and biochemistry and physiology of dopaminergic and beta-adrenergic receptors in mammalian central nervous system. The following chapters explore the role of guanylnucleotides in the regulation of hormonally stimulated adenylate cyclase; interactions of cholera toxin with cell membranes; problems in studying hormone receptor binding; and the mechanism of action of anti-hormones. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

  • The Prostaglandins

    Pharmacological and Therapeutic Advances
    • 1st Edition
    • January 26, 2016
    • M. F. Cuthbert
    • English
    The Prostaglandins: Pharmacological and Therapeutic Advances provides a concise account of the more important theoretical developments and areas in which the prostaglandins are being introduced into clinical practice or have potential clinical application. Chapters I to IV of this book deal with the chemistry and classification, distribution and metabolism, general pharmacology, and mechanism of action. The rest of the chapters discuss the relationship of the prostaglandins to the reproductive, cardiovascular, respiratory, and gastro-intestinal systems with an emphasis on the human pharmacology and potential therapeutic applications. This text also includes the speculations and suggestions of contributors regarding the possible and further use of the prostaglandins. This publication is a good reference for biochemists and medical students concerned with the potential of prostaglandins.

  • Preclinical Psychopharmacology

    • 1st Edition
    • January 22, 2016
    • D.G. Grahame-Smith
    • English
    Psychopharmacology, Volume 2: Preclinical Psychopharmacology presents the mechanism of action of antidepressant drugs and neuroleptics. This book discusses the significance of the interaction between various neurotransmitter system in both biochemical and functional consequences of repeated drug administration. Organized into 12 chapters, this volume begins with an overview of the effects of antidepressant drugs on norepinephrine metabolism. This text then discusses the different aspects of monoamine oxidase and its inhibitors. Other chapters consider the mechanism of action of lithium, which requires consideration of some of the general characteristics of periodic behavior. This book discusses as well the preclinical aspects of tranquilizers, particularly those dealing with benzodiazepines and non-benzodiazepines acting through the benzodiazepine receptor. The final chapter deals with the various behavioral and electrophysiological effects of cocaine in animals, which presumably reflect both local anesthetic properties and action on monoamine mechanisms. This book is a valuable resource for neuropharmacologists and practicing psychiatrists.

  • Engineered Nanoparticles

    Structure, Properties and Mechanisms of Toxicity
    • 1st Edition
    • November 24, 2015
    • Ashok K. Singh
    • English
    Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity is an indispensable introduction to engineered nanomaterials (ENM) and their potential adverse effects on human health and the environment. Although research in the area of pharmacology and toxicology of ENM is rapidly advancing, a possible correlation between their physicochemical properties and biomedical properties or toxicity is not yet fully understood. This understanding is essential to develop strategies for the safe applications and handling of ENM. The book comprehensively defines the current understanding of ENM toxicity, first describing these materials and their physicochemical properties, and then discussing the toxicological theory and methodology before finally demonstrating the potential impact of ENM on the environment and human health. It represents an essential reference for students and investigators in toxicology, pharmacology, chemistry, material sciences, medicine, and those in related disciplines who require an introduction to ENM and their potential toxicological effects.

  • Forensic Toxicology

    Principles and Concepts
    • 1st Edition
    • November 14, 2015
    • Nicholas T. Lappas + 1 more
    • English
    Forensic Toxicology: Principles and Concepts takes the reader back to the origins of forensic toxicology providing an overview of the largely unchanging principles of the discipline. The text focuses on the major tenets in forensic toxicology, including an introduction to the discipline, fundamentals of forensic toxicology analysis, types of interpretations based on analytical forensic toxicology results, and reporting from the laboratory to the courtroom. Forensic Toxicology also contains appendices covering the principles of pharmacokinetics and pharmacodynamics, immunology and immunological assays, toxicogenomics, and case studies.

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