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Books in Pharmacology

Elsevier's Pharmacology collection studies how drugs interact with biological systems to improve health and treat disease. It covers pharmacodynamics, exploring drug effects on biology, and pharmacokinetics, studying how the body affects drugs. Branches like Pharmacogenetics. Essential for pharmacologists, this collection offers invaluable insights into drug interactions, efficacy, and safety, crucial for advancing drug development and improving patient outcomes.

  • Exosome Communication

    Advances in Research and Therapeutics for Health and Disease
    • 1st Edition
    • November 15, 2024
    • Dalapathi Gugulothu + 3 more
    • English
    Exosome Communication: Advances in Research and Therapeutics for Health and Disease serves as a crucial reference for pharmaceutical scientists, focusing on the key qualities of exosomes as drug delivery vehicles. Exosomes are intracellular membrane-based vesicles with diverse compositions, offering significant advantages over traditional drug delivery systems such as liposomes and polymeric nanoparticles, due to their nonimmunogenic nature. This book provides a comprehensive exploration of exosomes, starting with their history and development, understanding extracellular vesicles and biogenesis, and techniques for isolation and characterization. This book also addresses critical considerations like quality control, heterogeneity reduction, regulatory and ethical aspects, clinical trials, and scale-up manufacturing.

  • Emerging Therapeutic Targets and Drug Delivery Approaches in IBD

    • 1st Edition
    • Volume 101
    • November 12, 2024
    • English
    Emerging Therapeutic Targets and Drug Delivery Approaches in IBD, Volume 101 in this ongoing series, highlights new advances, with this volume presenting interesting chapters on timely topics, including Fibrosis in IBD – AXL as a Promising Therapeutic Target, Developing a pathway to test anti-fibrotic drugs in Crohn’s disease, Emerging therapeutics for the management of intestinal fibrosis and strictures, GCPII for IBD, Fistulas/stem cell products for IBD/Crohn’s, The landscape of new therapeutic opportunities for IBD, TL1A : A Model For The Use Of Precision Medicine For The Treatment of Crohn’s Disease and Ulcerative Colitis, Dectin-1 as a therapeutic target for IBD, and more.Additional sections cover BRD4 as an Emerging Epigenetic Therapeutic Target for Inflammatory Bowel Diseases, Scripps - S1P, The potential of targeting TREM-1 in Inflammatory Bowel Disease, and Microbiome therapies.

  • Traditional Medicines and Natural Products as Preventive and Therapeutic Agents Against COVID-19

    A Promising Response to the Global Unprecedented Pandemic
    • 1st Edition
    • November 6, 2024
    • Nabeelah Bibi Sadeer + 1 more
    • English
    Traditional Medicines and Natural Products as Preventive and Therapeutic Agents Against COVID-19: A Promising Response to the Global Unprecedented Pandemic presents comprehensive coverage of the pharmacological effects of natural products on the prevention and treatment of COVID-19. Sections provide traditional medicine approaches and their potential to prevent and treat COVID-19 infection, including traditional Chinese, Ayurvedic, Persian, and Kampo medicine, alongside an overview of nutritional regimens and their therapeutic potential. Other sections cover natural molecules such as flavonoids, saponins, coumarins, alkaloids, terpenes, polysaccharides, and several microbial natural products of relevant action against viruses. Final chapters cover nanotherapeutic approaches.This is a valuable resource for researchers and academics in the fields of herbal medicine, pharmacology, pharmacognosy and for professionals in the pharmaceutical industries and anyone interested in natural products and their application for therapeutic purposes.

  • Annual Reports in Medicinal Chemistry: Roadmaps

    • 1st Edition
    • Volume 62
    • October 30, 2024
    • English
    Annual Reports in Medicinal Chemistry: Roadmaps, Volume 62 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. This release provides a compendium of information on newly approved drugs and compounds entering late-stage clinical trials, making it a valuable resource for graduate students pursuing research in medicinal chemistry

  • Quinone-Based Compounds in Drug Discovery

    Trends and Applications
    • 1st Edition
    • October 25, 2024
    • Umar Ali Dar + 2 more
    • English
    Quinone-Based Compounds in Drug Discovery: Trends and Applications provides a comprehensive and up-to-date overview of the latest advances in the field of drug discovery using quinone-based materials. The book covers various aspects of quinone-based materials such as their synthesis, characterization, and applications in drug discovery, consolidating current research. It introduces quinones in the pharmacology context and then describes current developments in drugs for key diseases and conditions. Final chapters deal with the regulatory and commercial framework to take quinone-based drugs to the market.This book will benefit a wide range of readers, including researchers, scientists, and graduate students in the field of drug discovery. Chemists and biochemists will also benefit from the contents of this book.

  • Human Microbiome Drug Targets

    Modern Approaches in Disease Management
    • 1st Edition
    • October 23, 2024
    • Genevieve Dable-Tupas + 3 more
    • English
    Human Microbiome Drug Targets: Modern Approaches in Disease Management presents fundamental information on the human microbiome, looking into the relationship between the microbiome and how it changes with specific diseases. Delving into the multifaceted roles of the microbiome in health and disease, the book's chapters discuss the role of the human microbiome in the pathophysiologic understanding of relevant diseases or disorders and their management. As changes in the human microbiome can provide clues to the probable cause and effect of diseases or disorders, as well as the impacts of therapy or intervention, this book is a welcomed addition to the existing research.Explaining how a better understanding of the microbiome and its impact on health and disease can pave the way for future discoveries leading to better health outcomes, this book will be of interest to drug developers, medicinal chemists, microbiologists, infectious disease specialists, biochemists, and students.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 63
    • October 4, 2024
    • English
    Progress in Medicinal Chemistry, Volume 63 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Specific chapters in this release include Harnessing conformational drivers in drug design, Recent Advances in the Medicinal Chemistry of Heterobifunctional Derivatives for Protein Homeostasis, and A Decade of Antimalarial Drug Discovery: New Targets, Tools and Molecules.

  • mRNA Therapeutics

    Foundations, Innovations, and Clinical Applications
    • 1st Edition
    • September 9, 2024
    • Anya Hillery
    • English
    mRNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of mRNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions. The book begins with foundational knowledge covering mRNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with mRNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome. The third section describes the current and future clinical applications of mRNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of mRNA vaccines for COVID-19 and other infectious diseases, as well as mRNA's role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of mRNA therapeutics for protein replacement therapy and gene-editing, as well as newer mRNA constructs, including self-amplifying mRNA. The final section addresses the safety and regulatory considerations of mRNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness. Currently, mRNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of mRNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of mRNA's role in therapeutics. This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences.

  • TRP Channels as Therapeutic Targets

    Advances in Basic Science and Clinical Use
    • 2nd Edition
    • August 22, 2024
    • Arpad Szallasi
    • English
    TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.

  • Essentials of Translational Pediatric Drug Development

    From Past Needs to Future Opportunities
    • 1st Edition
    • July 22, 2024
    • Elke Gasthuys + 3 more
    • English
    Essentials of Translational Pediatric Drug Development: From Past Needs to Future Opportunities provides integrated and up-to-date insights relevant for both translational researchers and clinicians active in the field of pediatric drug development. The book covers all key aspects from different stakeholder perspectives, providing a literature overview and careful reflection on state-of-the-art approaches. It will be an ideal guide for researchers in the field who are designing and performing high quality, innovative pediatric-adapted drug development by helping them define needs/challenges and possible solutions that advance and harmonize pediatric drug development.Despite the broad consensus that children merit the same quality of drug treatment as any other age group, children remain frequently neglected during drug research and development. Even with the adoption of multiple legislations addressing this problem, the lack of efficacy and safety data of marketed as well as newly developed drugs still remain in the pediatric population.

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