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Books in Pharmacology

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Hemodynamics and Immune Defense

  • 2nd Edition
  • Michael J. Parnham, Clive Page + 1 more
  • Michael J. Parnham, Clive Page and Jacques Bruinvels
  • October 23, 2023
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 8 4 4 2 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 4 4 3 - 7
Haemodynamics and Immune Defence: Discoveries in Pharmacology, Second Edition, Volume Three presents selected articles from the historic Discoveries in Pharmacology series that are enhanced with commentary from contemporary scholars who discuss the reception and importance of each chapter along with an updated bibliography on the subject and contributions from those involved in Nobel Prize winning discoveries and pioneering advancements in Pharmacology. This volume brings forth discussions on key discoveries in hemodynamics and immune defense, including chapters on penicillin by Dr. Selwyn and asthma by Dr. Brocklehurst. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area, will find this useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.
Hemodynamics and Immune Defense

Deprescribing and Polypharmacy in an Aging Population

  • 1st Edition
  • Ali Elbeddini
  • Ali Elbeddini
  • August 22, 2023
  • English
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 3 8 1 - 4
Deprescribing and Polypharmacy in an Aging Population supports healthcare professionals across global healthcare institutions in reducing polypharmacy-related drug replated problems (DRPs) by working with patients, families, interprofessional healthcare professionals, and educational institutions to develop, implement, test, improve upon, and educate on strategies for deprescribing and optimizing patient safety. Polypharmacy, the use of multiple medications at the same time by one person, is very common in various patient populations, including those who lack primary physicians, patients with mental health conditions, patients with multiple chronic conditions, and in the aging population.
Deprescribing and Polypharmacy in an Aging Population

Surfactants in Biopharmaceutical Development

  • 1st Edition
  • Atanas V. Koulov + 1 more
  • Atanas V. Koulov and Satish K Singh
  • August 12, 2023
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 2 5 0 3 - 8
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 2 5 6 9 - 4
Surfactants in Biopharmaceutical Development addresses the progress, challenges, and opportunities in surfactant research in the context of the development of biologic therapeutics. It has been widely recognized that surfactants provide protection to therapeutic proteins against interfacial stresses, which is the reason that nearly all therapeutic proteins in development and on the market today contain surfactants. Despite the fact that the very mechanism of protein stabilization by surfactants has not been completely understood, surfactants are universally regarded as critical functional excipients for biopharmaceuticals by the industry and by regulators.This book provides a broad range of important surfactant-related topics as they relate directly to biopharmaceutical development. The initial chapters of the book address fundamental topics, like synthesis of surfactants, mechanisms of protein stabilization by surfactants, as well as practical considerations for the use of surfactants in biomanufacturing. Later chapters provide overview of the state-of-the-art analytical technology and methods for quantification and characterization of surfactants, as well as a deep-dive in one of the hottest topics in biopharmaceutical development today – surfactant degradation and its impact to drug product quality and stability. The book concludes with forward-looking chapters on control strategies with a special focus on current regulatory aspects of paramount importance for biopharmaceutical companies and regulators.
Surfactants in Biopharmaceutical Development

Modulation of Oxidative Stress

  • 1st Edition
  • Luciano Saso, Alessandro Giuffre + 2 more
  • Luciano Saso, Alessandro Giuffre, Giuseppe Valacchi + 1 more
  • August 4, 2023
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 9 2 4 7 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 9 2 4 8 - 7
Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.
Modulation of Oxidative Stress

Pulmonary Pharmacology

  • 1st Edition
  • Volume 98
  • W.S Fred Wong
  • W.S Fred Wong
  • August 1, 2023
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 8 8 8 0 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 8 8 1 - 7
Pulmonary Pharmacology, Volume 98 provides in-depth reviews on the latest progresses about respiratory drug discovery and development. Topics covered in this volume include corticosteroids, monoclonal antibodies, tyrosine kinase inhibitors and phosphodiesterase inhibitors for the treatments of asthma, COPD or pulmonary fibrosis, with perspective on the development of novel therapeutic strategies such as renin-angiotensin system modulators, mitochondrial function modulators, and non-antibacterial macrolides. Part of the volume is devoted to senotherapy for lung ageing in respiratory diseases, and novel pulmonary delivery technologies, including inhaled biologics.
Pulmonary Pharmacology

Privileged Scaffolds in Drug Discovery

  • 1st Edition
  • Bin Yu, Ning Li + 1 more
  • Bin Yu, Ning Li and Caiyun Fu
  • July 19, 2023
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 8 6 1 1 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 6 1 2 - 7
Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development.The editors recruited experts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years.Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable.
Privileged Scaffolds in Drug Discovery

Phytopharmaceuticals and Herbal Drugs

  • 1st Edition
  • Manju Rawat Singh + 1 more
  • Manju Rawat Singh and Deependra Singh
  • July 15, 2023
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 9 1 2 5 - 4
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 3 6 9 - 2
Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products explores the delivery aspects of plant-based drugs, providing insights into formulation constraints associated with plant-based drugs, the development of novel delivery systems based on polymers or lipids, and how combining natural products with technological advancements in drug delivery is making large strides. Some of the best-selling drugs for the treatment of diseases like cancer, ulcers and malaria are either natural products or their derivatives, all of which are covered in this comprehensive resource. This book will be useful to researchers working in plant-derived medicines and the development of their delivery systems, including sections on their derivatives and analogs that represent over 50% of all drugs in clinical use. Active ingredients originated from plant resources generally exhibit compromised desired effects limited by issues such as stability, solubility, molecular size, bioavailability and toxicity.
Phytopharmaceuticals and Herbal Drugs

Polymer-Drug Conjugates

  • 1st Edition
  • Jitender Madan, Ashish Baldi + 2 more
  • Jitender Madan, Ashish Baldi, Monika Chaudhary + 1 more
  • July 5, 2023
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 1 6 6 3 - 9
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 6 9 0 - 5
Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ‘Linker Chemistry’ in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding. The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.
Polymer-Drug Conjugates

Pharmacogenomics

  • 1st Edition
  • Showkat Ahmad Ganie, Aarif Ali + 2 more
  • Showkat Ahmad Ganie, Aarif Ali, Muneeb U Rehman + 1 more
  • June 13, 2023
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 5 3 3 6 - 5
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 3 3 7 - 2
Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area. The book's chapters over the foundational aspects of pharmacogenomics, including drug metabolism, drug discovery, development, and testing, and then detail studies of key health conditions and the potential therapeutic applications of pharmacogenomics. Diseases covered include diabetes, cardiovascular diseases, psychiatric disease, cancer, pulmonary and respiratory diseases, viral diseases, gastroenterology, autoimmune diseases, immunosuppressants, and, finally, an overview of computational resources. This is the perfect resource for pharmaceutical science graduate students to learn the key concepts of the area. However, researchers and graduate students in the related fields of genetics, pharmacoepidemiology, molecular biology, and medicinal chemistry will also benefit from the structured approach of the book.
Pharmacogenomics

Bioactive Lipid Mediators in Cardiopulmonary Pharmacology

  • 1st Edition
  • Volume 97
  • Darryl C Zeldin + 1 more
  • Darryl C Zeldin and John Seubert
  • May 24, 2023
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 5 0 5 7 - 2
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 5 0 5 8 - 9
Bioactive Lipid Mediators in Cardiopulmonary Pharmacology, Volume 97 updates readers on topics surrounding Bioactive lipid mediators. These mediators are involved in a vast array of signaling pathways that regulate both physiological and pathophysiological responses. Chapters in this new release include Cyclooxygenases and Vascular Function, Cyclooxygenases and Platelet Function, Eicosanoids and Cardiomyopathies, Cytochrome P450 Bioactive Lipids in the Heart, Epoxide Hydrolase and Leukotoxin in the Heart and Lung, Role of cytochrome P450-epoxygenase and soluble epoxide hydrolase in the regulation of vascular response, Bioactive Lipids in Hypertension, Cytochrome P450 Metabolites and Angiogenesis, 20-Hydroxyeicosatetraenoic Acid and Vascular Function, and more. Other critical sections cover Cytochrome P450 Eicosanoids and the Brain, Omega-3 Oxylipids, Resolvins, Lipoxins and Inflammation, Endocannabinoids as Bioactive Metabolites, and Oxylipins and Aspirin Exacerbated Respiratory Disease.
Bioactive Lipid Mediators in Cardiopulmonary Pharmacology