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Books in Pharmaceutical sciences

Elsevier's Pharmaceutical Science collection helps pharmaceutical scientists striving to optimize drug design and improve healthcare outcomes by offering comprehensive coverage of every aspect of drug development, integrating disciplines like organic chemistry, biology, and biotechnology. Focused on safety, efficacy, and formulation design, it includes specialized fields such as Clinical Pharmacology and Translational Research, providing valuable insights into the latest advancements in drug discovery.

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Smart Therapeutics

  • 1st Edition
  • August 1, 2099
  • Müberra Koşar + 1 more
  • English
Smart Therapeutics: Synergistic Combinations presents the state-of-the-art on smart therapeutics, helping researchers develop new approaches for less toxic and more effective drug combinations. The book demonstrates that highly-toxic synthetic drugs may be rendered safe through synergistic combinations with natural products. The volume consists in six parts, giving a historical overview and covering drug development, drug interactions, synergic relations in drug discovery and combination therapy, calculations in designing synergistic combinations, and clinical approaches to synergistic combinations. This volume presents the latest work in combining natural and synthetic drugs for more effective, less toxic pharmaceuticals of use in clinical practice. Historically, the use of natural medicine was followed by the discovery of synthetic drugs, and in recent years, a resurgence in the use of natural substances which may have fewer negative side-effects when compared with synthetic drugs.

A Chemometrics Guide for Chromatographers

  • 1st Edition
  • Volume 34
  • February 1, 2099
  • Gabriel Vivo-Truyols
  • English
A Chemometrics Guide for Chromatographers, Volume 33 in the Data Handling in Science and Technology series, helps bring chemometrics and statistics to the chromatographic field, with the aim of making the statistical tools understandable and useful for this community. There are excellent textbooks about chemometrics and chromatography available on the market, but none are devoted solely to bringing both fields together in a simple language. The nature of the data arising from chromatography deserves special attention (e.g., data alignment, hyphenation or two-dimensional chromatography) and is thoroughly covered in this comprehensive resource, along with other specialized chapters. Over recent decades, chemometricians have been busy developing algorithms and smart statistical techniques to (i) Optimize analytical instruments and (ii) Extract the maximum information out of the data generated by the instruments. It is no longer possible for separation scientists and chemometricians to work in isolation, as both spheres of knowledge must go hand-in-hand.

Intestinal Barrier in Health and Disease

  • 1st Edition
  • November 1, 2029
  • Driton Vllasaliu
  • English
Intestinal Barrier in Health and Disease: Implications for Personalized Oral Drug Delivery fills a gap in the literature on oral drug absorption and drug delivery to the gastrointestinal tract in situations where the gastrointestinal (GIT) barrier is abnormal, for example, due to disease, aging or malnutrition. Topics in the book include physiological barriers to oral drug absorption & delivery to GIT, physiological regulation of the intestinal epithelial barrier, and disease-associated (e.g. Inflammatory Bowel Disease) remodelling of the intestinal epithelial barrier and effect on oral drug bioavailability & delivery to the GIT including microbiota-associated (dysbiosis) effects on oral drug bioavailability. Also covered is malnutrition-associated effect on the intestinal epithelial barrier and effect on oral drug absorption/bioavailability age-Associated Remodeling of the intestinal epithelial barrier and effect on oral drug bioavailability. Intestinal Barrier in Health and Disease: Implications for Personalized Oral Drug Delivery will be of interest to pharmaceutical scientists working in the pharmaceutical industry and academia, as well as undergraduate and postgraduate students studying relevant biomedical sciences such as pharmacy/pharmaceutical science and medicine.

Extracellular Vesicle-Based Therapeutics

  • 1st Edition
  • October 1, 2029
  • Tushar Patel
  • English
Extracellular Vesicles-Based Therapeutics presents the exciting prospect of targeted delivery of drugs through exosomes. Taking a critical perspective, the Editor gathered worldwide experts both in academia and corporate settings to cover all aspects of the subject, from fundamental biological aspects to scaling up production, and regulation. The book is structured in six sections, each covering a distinct topic. Within each section, the authors and chapters were selected to provide a balanced coverage. Section I deals with the fundamentals of EV biology: types, formation, interactions and effects. Section II covers Extracellular Vesicles (EVs) isolation, and purification approaches. Section III presents EV production platforms, providing a framework and guidelines by which clinically usable and consistent EV therapeutics could be manufactured. Section IV covers preclinical studies and applications, reviewing studies that provide opportunities to identify disease-relevant indications for EV therapeutics and to guide their translation to clinical trials. Section V presents drug development and commercialization of EV therapeutics, covering considerations in regulatory approvals and market access for EV based therapeutics. Section VI covers clinical trials of EV therapeutics, outlining a framework for clinical evaluation, including study design and clinical trials strategies and examples of on-going trials of EV-based therapeutics. Extracellular Vesicles-Based Therapeutics is a complete resource for researchers in this exciting area. Its breadth of coverage makes it particularly interesting to pharmaceutical researchers exploring the potential of this platform for targeted drug delivery. Physicians, Regulators, Laboratory directors and Industry executives in biotechnology would also benefit from the contents in this book.

Understanding and Implementing CGMPs

  • 1st Edition
  • January 1, 2029
  • Steven Ostrove
  • English
Understanding and Implementing CGMPs present the current Good Manufacturing Practices (GMPs) in a new manner designed to help practical application and understanding. Each section of Part 211 of the GMPs are presented as a whole entity, not just individual requirements, allowing the reader to understand the reasoning behind them. The specific regulations are also presented, but they are integrated into the manufacturing process to ensure comprehension and enforcement. The volume in the Aspects of Pharmaceutical Manufacturing series covers all of the subsections of Part 211 (GMPs for Finished Pharmaceuticals). Understanding and Implementing CGMPs is essential reading for new employees working in the industry, employees changing positions or looking to advance their carriers in QA, production or other pharma area of manufacturing as well as university graduate classes in Pharmaceutical Engineering.

Pharmaceutical Compositions

  • 1st Edition
  • January 1, 2029
  • Thomas F. DeRosa
  • English
Pharmaceutical Compositions provides an in-depth review of chemical and polymer additives that are used to activate, deliver and maintain steady state concentrations of the next generation of pharmaceuticals. Descriptions of these additives were obtained from the most current US Patents and Patent Applications data bases to alert and assist medicinal and additive chemists, formulators, graduate students and business interests with additive trends that are utilized in drug formulations which are subsequently used in the treatment of twenty-six these broad subject areas including AIDS, diagnostics, obesity, addiction disorders, hormonal disorders, and anti-immune disorders. This book will be most useful researchers in the pharmaceutical industry including pharmaceutical chemists and researchers and advanced students in medicinal and organic chemistry. The successful identification of a drug or biological agent is the beginning arduous journey for medicinal, organic and pharmaceutical chemists. Unique chemical formulations are required and essential before the commercialization process begins. This book addresses the formulation component of that journey. This treatise addresses the how to for processing the drug with additives so that the drug can be administrated to the patient. Furthermore, the book illustrates how the unique physical and chemical properties can be exploited, diminished or enhanced.

The Impact of Regulation On Drug Development

  • 1st Edition
  • January 1, 2029
  • G H Hennings
  • English
The impact of regulation on drug development provides the reader with a basic understanding of the evolution of global regulatory standards relevant to the research and development process of medicinal products and the role regulatory science plays, i.e. the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of regulated products.In light of the high-growth expectations of international investors, the increasing costs of research and development, and the challenges to patent protection, the pharmaceutical industry is in urgent need of substantial improvements in research and development productivity.The global framework of national legislations, (partly) harmonised guidelines and their evolution provides challenges and opportunities to an efficient management of the R&D process, which should be targeted to receive timely marketing authorisations and viable pricing and reimbursement decisions.Standard R&D strategies established originally for small molecules have to be intensively reviewed against this regulatory frame. This is particularly true if development projects are derived from biotechnological processes such as recombinant DNA technology, controlled expression of genes coding for biologically active proteins in prokaryotes and eukaryotes including transformed mammalian cells, hybridoma and monoclonal antibody methods or advanced therapy medicinal products such as gene or somatic cell therapy or tissue engineered products.Scientific (and regulatory) advice provided by health authorities should be considered as a potential value-increasing instrument in order to focus and streamline the R&D process.This book provides practical guidance on how to obtain such advice efficiently and how it is incorporated in global regulatory planning and strategies.

Membrane Transporters and Drug Delivery

  • 1st Edition
  • August 1, 2026
  • Gert Fricker + 2 more
  • English
"Membrane Transporters and Drug Delivery: A Comprehensive and Multidisciplinary Guide" is a comprehensive reference on the rapidly evolving field of membrane transporters and their role in drug delivery. This book is designed to serve pharmaceutical researchers both academia and industry, providing in-depth coverage of all aspects of transporter-related drug delivery research. The book begins with a comprehensive introduction to membrane transporters, their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery. A unique feature of this book is its detailed exploration of the methodologies used in transporter research, providing readers with a comprehensive understanding of the strengths and limitations of each approach. It examines the roles of both efflux and influx transporters in drug pharmacokinetics and covers different strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types. The book concludes with a discussion on regulatory and industrial aspects of transporter-related projects and explores the potential of artificial intelligence in transporter and drug delivery research. It also offers a glimpse into future challenges and perspectives in this field. "Membrane Transporters and Drug Delivery: A Comprehensive and Multidisciplinary Guide" is an essential resource for anyone involved in drug development projects utilizing transporter-mediated drug delivery or targeting. It is a must-have for those seeking to design successful drug development projects and stay at the forefront of this rapidly developing field.