Green Analytical Methods and Miniaturized Sample Preparation techniques for Forensic Drug Analysis provides a comprehensive overview of GAMs in forensic drug analysis including green sample preparation techniques, in-situ analytical platforms (such as DIC and µPADs) and on-site sample preparation.This book discusses not only eco-friendly GAM’s. but also methods which provide high sample throughput and cost-effective analysis, and therefore will be of immense use in resource limited laboratories of developing countries.Green analytical methods and miniaturized sample preparation technologies for forensic drug analysis is a comprehensive source of literature for analytical scientists in this developing area of sustainable and affordable analytical methods.
Bacterial Enzymes as Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance addresses the gap between medical microbiology, structural biology, and genomic science in the development of new antibacterial drug development. This book consolidates detailed profiling of bacterial target enzyme families for the drug discovery process and methodologies for use and validation of the potential drug targets. The content covers the foundations of antibiotic drug discovery process and focuses on bacterial enzymes as drug targets, building a bridge between microbiology, structural biology, and genomic science.This is the ideal reference for antibiotic drug discovery researchers in the pharma industry and academia. Biochemists, microbiologists, and medicinal chemists will also benefit from this books’ content.
Intelligent Nanobiosystems in Medicine and Healthcare, Volume One: Fundamentals, Fabrication and Commercialization provides an overview of recent progress in the nanobiosystems arena, helping readers design and develop novel drug delivery systems and devices that take advantage of recent advances in nanomedical technologies. The book explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advancement in cutting-edge nanomedical technologies. It highlights established research and technology on intelligent nanobiosystems, their rapidly emerging aspects, and future research directions. Sections cover nanobiosystems, explore nano candidates and fabrication aspects, and delve into the challenges of commercialization.This book will be a useful resource for researchers and postgraduate students in pharmaceutical sciences and biotechnology as well as medical professionals, biologists, chemists, materials scientists, clinical researchers, biochemical and biomedical engineers working both in academia and industry.
Intelligent Nanobiosystems in Medicine and Healthcare, Volume 2: Applications of Intelligent Nanobiosystems provides recent progress in the nanobiosystems arena, helping readers better design and develop novel drug delivery systems and devices that take advantage of recent advances in nanomedical technologies. The book explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advancements in cutting-edge nanomedical technologies. This updated volume includes chapters by experts in the field, featuring an exploration of targeted therapy and drug delivery systems, analytical and imaging tools, theranostics, tissue engineering and regenerative medicines, dentistry tools and modern developments.This book will be a useful resource for researchers and postgraduate students in pharmaceutical sciences and biotechnology industries as well as medical professionals, biologists, chemists, materials scientists, clinical researchers, and biochemical and biomedical engineers working both in industry and academia.
Physico-Chemical Aspects of Dosage Forms and Biopharmaceutics: Recent and Future Trends in Pharmaceutics, Volume Two explores aspects of pharmaceutics with an original approach that focuses on technology, novelties and future trends. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day, so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. Readers will find practical information for conducting research in pharmaceutics that is ideal for researchers in academia and industry as well as advanced graduate students in pharmaceutics. In addition, the book discusses the most recent developments in biopharmaceutics, including important and exciting areas such as solubility of drugs, pharmaceutical granulation, routes of drug administration, drug absorption, bioavailability and bioequivalence.
Application of Nutraceuticals for the Management of COVID-19 provides evidence-based findings in the therapeutic role and mechanisms of phytochemicals for better prevention and treatment of patients with COVID-19. Coverage includes a scientific and evidence-based approach to a wide range of nutraceuticals that have been identified due to their anti-inflammatory and immune system-modulating properties.This is the perfect reference for pharmaceutical researchers with practical ideas for research on the effective therapeutic role of phytochemicals in COVID-19; as well as clinical experts looking to make better decisions in the use of effective supplements for the management of COVID-19.
Design and Applications of Microneedles in Drug Delivery and Therapeutics details the design, characterization, and applications of this novel drug delivery system. Microneedles offer several advantages over traditional oral and parenteral approaches due to their ability to be fabricated and altered in shape, size and material type, and their convenience to be matched to specific treatment needs. This book covers the materials selection, design and fabrication approaches, and clinical translation of microneedles for a range of therapeutic applications, including cancer therapy, gene and vaccine delivery, wound healing, and more.This book is a forward-thinking resource for those working in the development of materials and devices for novel drug delivery.
Therapeutic Monoclonal Antibodies: From Lot Release to Stability Testing is a highly topical resource on a subject of interest for scientists and researchers working on monoclonal antibodies' characterization, release testing, stability testing and similarity assessments of monoclonal antibodies in the biopharmaceutical industry. Monoclonal antibodies (mAbs) are large, extremely complex and dynamic biomolecules, so it can be challenging to develop well-characterized therapeutic antibodies that meet regulatory expectations that are also in-line with commercialized standards for different drug markets.Lot release testing and understanding the stability of the mAb over a period of time, and in different environmental conditions, is an indispensable aspect of mAb physicochemical characterization. This book covers the process, including extensive analysis that starts with quantifying the purity attribute to glycan profiling and identifying the mAb primary structure. The book has a primary purpose of focusing on both Lot release testing and stability testing of monoclonal antibodies (subjects not covered in any great detail in other books).
Elke Gasthuys, Karel Allegaert, Lien Dossche + 1 more
June 1, 2024
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Essentials of Translational Pediatric Drug Development: From Past Needs to Future Opportunities provides integrated and up-to-date insights relevant for both translational researchers and clinicians active in the field of pediatric drug development. The book covers all key aspects from different stakeholder perspectives, providing a literature overview and careful reflection on state-of-the-art approaches. It will be an ideal guide for researchers in the field who are designing and performing high quality, innovative pediatric-adapted drug development by helping them define needs/challenges and possible solutions that advance and harmonize pediatric drug development.Despite the broad consensus that children merit the same quality of drug treatment as any other age group, children remain frequently neglected during drug research and development. Even with the adoption of multiple legislations addressing this problem, the lack of efficacy and safety data of marketed as well as newly developed drugs still remain in the pediatric population.
Mark Ashton, Paul W. Groundwater, Sophie Stocker + 1 more
June 1, 2024
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An Integrated Guide to Human Drug Metabolism: From Basic Chemical Transformations to Drug-Drug Interactions uses the chemistry of each of the metabolic transformations to underpin the discussion of drug interactions with foods, herbal medicines and other drugs. Each of the human metabolic processes are covered, employing examples drawn from known metabolic transformations of drugs used clinically. The clinical relevance of metabolism is discussed, focusing on appropriate prescribing (adverse drug reactions, age-related dosage adjustments, and personalized medicines). Appropriate for use in the classroom or for self-study, An Integrated Guide to Human Drug Metabolism is useful for students and researchers needing a reference for interdisciplinary information on drug interactions.Metabolism is at the center of the personalization of medicines, as it is a governing factor in the response of a patient to a drug. For example, does the patient express the genes, and so enzymes, which are responsible for the metabolism of a drug? Do they express the genes responsible for the bioactivation of a prodrug into its active form? Examples of clinically used agents for which metabolic phenotyping is essential are used to highlight the increasing importance of understanding the pharmacogenomic profile of individual patients. This book includes questions and answers to gauge learning of each chapter, real-life case studies, and the basic science as a foundation to inform discussion of the clinical implications of drug metabolism.