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Books in Pharmacotherapy

  • Advanced Cancer Therapeutics

    Strategies and Technologies for Targeted Drug Delivery
    • 1st Edition
    • Manish Kumar + 2 more
    • English
    Advanced Cancer Therapeutics: Strategies and Technologies for Targeted Drug Delivery explores the heterogeneity of tumors and microenvironmental factors that influence cancer treatment and contribute to drug resistance. The book discusses critical elements such as tumor stroma, vasculature, pH, hypoxia, and enzymatic activity that impact therapeutic efficacy. Sections cover advanced drug formulations, including supramolecular systems, metal-organic frameworks, and nanomedicine, focusing on their roles in selective drug delivery for early detection, diagnosis, and treatment of various cancers. In addition, it reviews the current status and future perspectives of these formulations, highlighting their potential to enhance therapeutic outcomes while minimizing side effects.Readers will also find discussions on the limitations of nanocarriers, along with regulatory and ethical considerations related to anticancer formulations. This resource is invaluable for researchers, clinicians, and students, offering insights into the latest advancements in drug delivery systems.

  • Nanotechnology in Cosmeceuticals

    Advances, Challenges and Future Perspectives
    • 1st Edition
    • Chin Wei Lai + 1 more
    • English
    Nanotechnology in Cosmeceuticals: Advances, Challenges and Future Perspectives explores the fundamental principles of nanotechnology in cosmetics required to understand chemistry related formulation and the dermatological effects of these products. This book by provides an in-depth analysis of nanotechnology in cosmeceuticals, covering pharmaceutical, chemical, and toxicological aspects. The contents of this book are divided in seven parts. The first lays the foundations of cosmetics, and nanotechnology applications. The second part focuses no nano-metaloxides, including titanium, zinc, gold, silver and others. The third part covers carbon-based products in cosmeceuticals with chapters on graphene, nano-hydroxyapatite, and general carbon-based products. The next part focuses on nano-organics, nanocellulose and biodegradable materials. Part five is dedicated to formulations of liposomes, lipids in drug delivery. Part six covers recent trends, advances, applications and progress of nanotechnology and nano products in cosmeceuticals. The final part focuses on safety and toxicity aspects of nano-cosmeceuticals. Nanotechnology in Cosmeceuticals: Advances, Challenges and Future Perspectives is an ideal reference for pharmacologists, cosmetic scientists, and chemists in academic research and corporate settings looking into leveraging nanoscience to improve the performance of cosmetics. Dermatologists and food scientists may also benefit from the foundational content present in the first part of the book.

  • Drug Delivery Systems for Wound Healing

    • 1st Edition
    • Pedro Fonte + 1 more
    • English
    Drug Delivery Systems for Wound Healing explores the different delivery systems and drugs used in wound healing, outlining the many pharmaceutical approaches in wound healing and management. Bringing together interdisciplinary research on wound healing and management, this book offers the theory behind wound healing, but also has a strong focus on the practical approach where scientists involved in medication development can find suggestions. Where appropriate, clinical outcomes are given so the book can be useful as a guide for the choice by medication prescription or use.Topics in the book include types of drugs used in wound healing; types of carriers used in wound healing; clinical outcomes; biocompatibility and toxicity problems, and pipeline products. Researchers working in the pharmaceutical sciences, biomedical sciences and engineering fields will find this a useful resource.

  • Polymer-Drug Conjugates

    Linker Chemistry, Protocols and Applications
    • 1st Edition
    • Jitender Madan + 3 more
    • English
    Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ‘Linker Chemistry’ in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding. The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.

  • Formulation of Monoclonal Antibody Therapies

    From Lab to Market
    • 1st Edition
    • Amal Ali Elkordy
    • English
    Formulation of Monoclonal Antibody Therapies: From Lab to Market covers a wide range of topics about therapeutic monoclonal antibodies (mAbs) with a focus on formulation aspects. Therapeutic monoclonal antibodies are used for treatment of chronic diseases. It brings together a comprehensive knowledge in one accessible volume. Starting with foundational information on monoclonal antibodies, the book then discusses the importance of biopharmaceutical products, monoclonal antibodies, and biosimilars in treatment of chronic diseases, pharmaceutical aspects of mAbs, and how it can be administered. It also covers the industrial point of view and the clinical application of mAbs including in oncology, general medicine, rheumatology, hematology, dermatology, gastrointestinal tract, metabolic diseases, and dentistry. Formulation of Monoclonal Antibody Therapies: From Lab to Market is essential reading for researchers in biotechnology and biopharmaceutical fields, academics and pharmaceutical industrial scientists, and university students in pharmaceutical and biopharmaceutical sciences.

  • Advanced Nanoformulations

    Theranostic Nanosystems, Volume 3
    • 1st Edition
    • Md Saquib Hasnain + 2 more
    • English
    Advanced Nanoformulations: Theranostic Nanosystems, Volume Three examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the last decade, numerous biopolymers have been utilized to prepare polymeric nanosystems for therapeutic applications. These biopolymers include polylactic acid, polylactide-co-glyco... polycaprolactone, acrylic polymers, cellulose and cellulose derivatives, alginates, chitosan, gellan gum, gelatin, albumin, chontroitin sulfate, hyaluronic acid, guar gum, gum Arabic, gum tragacanth, xanthan gum, and starches. Besides these biopolymers, grafted polymers are also being used as advanced polymeric materials to prepare many theranostic nanocarriers and nanoformulations. This book explores the array of polymeric nanosystems to understand therapeutic potentials. It will be useful to pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals, and regulatory scientists actively involved in the pharmaceutical product and process development of tailor-made polysaccharides in drug delivery applications.

  • Global Perspectives on Astaxanthin

    From Industrial Production to Food, Health, and Pharmaceutical Applications
    • 1st Edition
    • Gokare A. Ravishankar + 1 more
    • English
    Global Perspectives on Astaxanthin: From Industrial Production to Food, Health, and Pharmaceutical Applications explores the range of practical applications for this molecule, focusing on nutraceutical, pharmaceutical and cosmeceutical products, along with food and feed. This volume brings together the most relevant research, background and future thinking on astaxanthin, focusing on its health benefits. Chapters cover phytopharmaceuticals... industrial production, feeds, downstream processing, regulations, products, color, pigment, cosmetics, bioactive compounds, relationships to other carotenoids, and skin care. The detailed information on its production, processing, utilization and future applications will be of particular use to academic and industry researchers in pharmaceutical sciences, pharmacology and nutrition.

  • A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy

    • 1st Edition
    • Mariappan Rajan
    • English
    A Mechanistic Approach to Medicines for Tuberculosis Nanotherapy examines drug carrier development for controlled, targeted, pH and stimuli responsive drug releases for tuberculosis. The book provides in-depth information about mycobacterium tuberculosis, tuberculosis formation, and synthetic procedures for carrier synthesis, characterizations and mechanistic approaches. Key topics include the properties and functions of nanomedicines and how they might be applied for clinical diagnosis and treatment. Emphasis is placed on the basic fundamentals, biomaterial formulations, design principles, fabrication techniques, and transitioning bench-to-bed clinical applications. This book is useful for new researchers who focus on nanomedicine, stem cell therapy and bone tissue engineering. In addition, it introduces experienced researchers and clinicians to key trends, thus increasing their knowledge in drug discovery for tuberculosis and nanomedicine.

  • Taxaceae and Cephalotaxaceae

    Biodiversity, Chemodiversity, and Pharmacotherapy
    • 1st Edition
    • Da-Cheng Hao
    • English
    Taxaceae and Cephalotaxaceae: Biodiversity, Chemodiversity, and Pharmacotherapy accounts for the biodiversity and chemodiversity of these medicinal plants, examining and synthesizing existing research into their biology, chemistry and pharmacotherapy. The title examines how pharmacophylogeny allows sustainable conservation and exploitation, presents how these plants work from the chemical level upward, and examines associated microbe compounds. Chapters present a summary of biological and biochemical research of Taxaceae plants, progress in mining their chemodiversity, mining pharmacotherapy utility from their chemodiversity and biodiversity, drug metabolism and pharmacokinetic diversity of their medicinal compounds, mining pharmacotherapy utility from associated microbes, and more. Sections cover the biodiversity, chemodiversity and pharmacotherapy of Cephalotaxus medicinal plants, Amentotaxus, Pseudotaxus and Torreya medicinal plants. The book envisages that multiple omics platforms and advanced systems biology will allow further exploration of Taxaceae and Cephalotaxaceae, thus streamlining the future drug supply chain.

  • Considering the Patient in Pediatric Drug Development

    How Good Intentions Turned Into Harm
    • 1st Edition
    • Klaus Rose
    • English
    Considering the Patient in Pediatric Drug Development: How Good Intentions Turned into Harm addresses a fundamental challenge in drug development and healthcare for young patients. In clinical trials and clinical practice, the term "children" is used ambiguously to confer physiological characteristics to a chronological age limit, which in reality does not exist. This book outlines why the United States (US) and European Union's (EU) regulatory authorities, pediatric academia, and the pharmaceutical industry demand, support and perform pediatric drug studies, along with the key flaws of this demand that blurs the different administrative and physiological meanings of the term "child." In addition, the book covers why most pediatric regulatory studies lack medical sense and many even harm young patients and the conflicts of interest behind pediatric drug studies. It includes relevant information about the maturation of the human body regarding absorption, distribution, metabolism and excretion of food and drugs as well as key differences between newborns, infants, older children and adolescents.