Advanced Nanoformulations

Theranostic Nanosystems, Volume 3

1st Edition - March 22, 2023
Editors: Md Saquib Hasnain, Amit Kumar Nayak, Tejraj M. Aminabhavi
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 7 8 5 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 8 5 7 9 - 9

Advanced Nanoformulations: Theranostic Nanosystems, Volume Three examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosyste… Read more

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Advanced Nanoformulations: Theranostic Nanosystems, Volume Three examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the last decade, numerous biopolymers have been utilized to prepare polymeric nanosystems for therapeutic applications. These biopolymers include polylactic acid, polylactide-co-glycolide, polycaprolactone, acrylic polymers, cellulose and cellulose derivatives, alginates, chitosan, gellan gum, gelatin, albumin, chontroitin sulfate, hyaluronic acid, guar gum, gum Arabic, gum tragacanth, xanthan gum, and starches. Besides these biopolymers, grafted polymers are also being used as advanced polymeric materials to prepare many theranostic nanocarriers and nanoformulations. This book explores the array of polymeric nanosystems to understand therapeutic potentials.

It will be useful to pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals, and regulatory scientists actively involved in the pharmaceutical product and process development of tailor-made polysaccharides in drug delivery applications.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Advanced Nanoformulations
Chapter 1. Advanced nanoformulations for theranostics: current status and challenges
Abstract
1.1 Introduction
1.2 Nanoformulations as potential theranostic agents
1.3 Clinical status of nanotheranostics in disease management
1.4 Challenges related to the transport of nanotheranostics
1.5 Conclusions and future perspectives
References
Chapter 2. Chitosan-based nanosuspensions for ocular diagnosis and therapy
Abstract
2.1 Introduction
2.2 Chitosan, the “biopolymer of the 21st century”
2.3 Chitosan at the service of nanotechnology
2.4 Methodologies for chitosan-based nanosuspension synthesis
2.5 The eye is “the sensory organ responsible for the visual perception of the world”
2.6 Chitosan-based nanosuspension for ocular therapy and diagnosis
2.7 Conclusions
Acknowledgments
References
Chapter 3. Nanoemulsions in theranostics
Abstract
3.1 Introduction to emulsion systems
3.2 “Nano” emulsion systems
3.3 Nano- and microemulsion use in theranostics
3.4 Advantages of nano- and microemulsions in theranostic applications
3.5 Design and development of theranostic nanoemulsions
3.6 Applications of nano- and microemulsions in theranostics
3.7 Diagnostic purposes
3.8 Fluorescent materials
3.9 Sonic-sensitive materials
3.10 Targeting purposes
3.11 The future of nano- and microemulsion technology in theranostic applications
References
Chapter 4. Self-nanoemulsifying systems for drug delivery therapeutics
Abstract
4.1 Introduction
4.2 Life applications and market updates
4.3 Types of nanoemulsions
4.4 Chemical preparation methods of nanoemulsion systems
4.5 Characterization of nanoemulsion systems
4.6 Applications of nanoemulsion systems
Further reading
Chapter 5. Polymeric micelles for therapeutics and diagnosis
Abstract
5.1 Introduction
5.2 General characteristics of block copolymer micelles
5.3 Micellar systems for therapy
5.4 Micellar systems for bioimaging
5.5 Conclusions
References
Chapter 6. Dendrimers for theranostic applications
Abstract
6.1 Introduction
6.2 Covalent dendrimer-based theranostic systems
6.3 Self-assembled dendrimer-based theranostic systems
6.4 Theranostic systems based on dendrimers or dendrons bound to a nanoparticle
6.5 Outlook
References
Chapter 7. Nanogels as theranostic platforms: drug delivery, targeting, and imaging
Abstract
7.1 Introduction
7.2 Structure and properties of nanogels
7.3 Nanogels for theranostic applications
7.4 Conclusion and future perspective
References
Chapter 8. Nanocrystals as a versatile platform for theranostic applications
Abstract
8.1 Introduction
8.2 Versatile platform development
8.3 Theranostic applications of nanocrystals
8.4 Conclusions and outlook
References
Chapter 9. Niosome as a promising vesicular tool for therapy and diagnosis
Abstract
9.1 Introduction
9.2 Benefits of niosomes over other carriers
9.3 Formulation considerations for niosomes
9.4 Development of niosomes
9.5 Loading of the drug in niosomes
9.6 Vesicle purification
9.7 Characterization of niosomes
9.8 Application of niosomes in different drug delivery systems
9.9 Application of niosomes in targeting
9.10 Conclusion and prospects
References
Chapter 10. Cubosomes for enhanced drug delivery and targeting therapeutics
Abstract
10.1 Introduction
10.2 Narration/the past
10.3 Theories of the self-assembling of amphiphilic lipids
10.4 Components of cubosomes
10.5 Manufacture of cubosomes
10.6 Applications of cubosomes in drug delivery
10.7 Conclusion and future perspective
References
Chapter 11. Aquasomes: a novel nanocarrier system for drug delivery
Abstract
11.1 Introduction
11.2 Composition of aquasomes
11.3 Polyhydroxyl carbohydrate layer
11.4 Outer layer
11.5 Preparation of aquasomes
11.6 Preparation of the inner core material
11.7 Coating of the inner core with polyhydroxy carbohydrate
11.8 Loading of the bioactive agent or drug
11.9 Properties of aquasomes
11.10 Characterization of aquasomes
11.11 Particle size and distribution
11.12 Particle crystallinity
11.13 Particle structure
11.14 Polyhydroxy carbohydrate coating
11.15 Drug loading of aquasomes
11.16 Zeta potential measurements of aquasomes
11.17 Formulation of aquasomes
11.18 Applications of aquasomes as a system for drug delivery
11.19 Antigen nanocarriers
11.20 Insulin carrier
11.21 Oxygen carrier
11.22 Drug carrier
11.23 Fate of aquasomes
11.24 Conclusion
Acknowledgments
References
Chapter 12. Nanostructured lipid carriers: a novel platform for therapeutics
Abstract
12.1 Introduction
12.2 Therapeutic exhibitions of nanostructured lipid carriers
12.3 Marketed product of nanostructured lipid carriers
12.4 Patents related to nanostructured lipid carrier
12.5 Conclusions and future perspectives
References
Chapter 13. Self-assembled protein-drug nanoparticles for enhanced drug delivery and targeting cancer therapeutics
Abstract
13.1 Introduction
13.2 Fabrication methods of self-assembled protein nanoparticles
13.3 Factors affecting the formation of self-assembled protein nanoparticles
13.4 Implications of the self-assembled protein nanoparticles
13.5 Conclusion
References
Chapter 14. Stimuli-responsive nanosystems as smart nanotheranostics
Abstract
14.1 Introduction
14.2 Plasmonic-based nanotheranostics
14.3 Silica and zeolite-based nanotheranostics
14.4 Magnetic-based nanotheranostics
14.5 Carbon-based nanotheranostics
14.6 Multicomponent nanotheranostics
14.7 Conclusion and perspectives
References
Chapter 15. Nanoconjugates and nanoconjugate formulations for improving drug delivery and therapeutic efficacy
Abstract
15.1 Introduction
15.2 Drug delivery
15.3 Biomedical applications
15.4 Concluding remarks
References
Chapter 16. Nanophytomedicines: a novel approach for improving therapeutics via delivery of herbal medicine
Abstract
16.1 Introduction
16.2 Human skin
16.3 Drug penetration
16.4 Nanocarriers
16.5 Methods used in the formulation of nanophytomedicines
16.6 Applications of nanophytomedicines
16.7 Combination of antipsychotics with herbal drugs
16.8 Nanotechnology for combinational delivery of antipsychotics
16.9 Perspectives and conclusions
References
Chapter 17. Multifunctional nanocomposites for theranostics
Abstract
17.1 Introduction
17.2 Nanocomposites
17.3 The dual approach of theranostics
17.4 Perspectives
References
Chapter 18. Nanofibers for diagnosis, drug delivery, and therapy
Abstract
18.1 Introduction
18.2 Classification of nanofibers
18.3 Nanofiber fabricating techniques
18.4 Nanofibers in drug delivery
18.5 Nanofibers in disease diagnosis
18.6 Nanofibers in therapeutic applications
18.7 Conclusion and future perspectives
References
Chapter 19. Nanovectors for theranostic applications
Abstract
19.1 Introduction
19.2 Features of nanovectors
19.3 History of nanovectors
19.4 Conclusion
References
Chapter 20. Nanoprobes for advanced nanotheranostic applications
Abstract
20.1 Introduction
20.2 Theranostic nanomedicine
20.3 Gold nanoparticles
20.4 Drug-polymer conjugates
20.5 Carbon nanomaterials
20.6 Polymeric nanoparticles
20.7 Dendrimers
20.8 Micelles
20.9 Liposomes
20.10 Solid lipid nanoparticles
20.11 Modular development of hybrid nanoplatforms
20.12 Newly developed hybrid nanoplatforms
20.13 Conclusion and outlook
References
Chapter 21. Nanorobots for improved theranostic applications
Abstract
21.1 Introduction
21.2 What are nanorobots?
21.3 Fabrication/design of nanorobots
21.4 Actuation methods
21.5 Locomotion
21.6 Motion control and navigation
21.7 Classification of nanorobots
21.8 Conclusion and future prospects
Acknowledgments
Conflict of interest
References
Chapter 22. Nanoghosts for therapeutic applications
Abstract
22.1 Introduction
22.2 Formation of nanoghosts
22.3 Characterization of nanoghosts
22.4 Source of cell membranes
22.5 Approaches for surface chemistry
22.6 Application of nanoghosts
References
Chapter 23. Biomimetic nanosystems in theranostics
Abstract
23.1 Introduction
23.2 Fabrication of biomimetic nanosystems
23.3 Fabrication strategies using the real cell membrane
23.4 Biomimetic nanosystems for the treatment of cancer
23.5 Bacterial diseases
23.6 Inflammatory sicknesses
23.7 Conclusion
References
Chapter 24. Nanoformulations for cardiovascular therapy
Abstract
24.1 Introduction
24.2 Natural polymers
24.3 Synthetic polymers
References
Chapter 25. Advanced nanoformulations for neurological therapeutics
Abstract
25.1 Introduction
25.2 Biomaterials for formulating nanosystems for drug delivery across the nervous system
25.3 Nanoformulations for neurological therapeutics
25.4 Neurotoxicity of nanosystem
25.5 Conclusions and future perspectives
References
Chapter 26. Advanced nanoformulations for targeting, imaging, and therapy
Abstract
26.1 Introduction
26.2 Theranostic nanoformulation
26.3 Inorganic nanoparticles for theranostics
26.4 Polymeric nanoformulations
26.5 Stimuli-responsive nanotheranostics clinical usage
26.6 Conclusion and final remarks
References
Chapter 27. Cell-penetrating peptide(s): Design, synthesis, and site-specific nanotheranostic applications in cancer therapy
Abstract
27.1 Introduction
27.2 Peptide synthesis
27.3 Conclusion
Acknowledgment
References
Chapter 28. Development of nanographene oxide/2-hydroxyethyl methacrylate/gelatin/alginate and nanotitanium dioxide/2-hydroxyethyl methacrylate/gelatin/alginate polymeric systems for biomedical applications
Abstract
28.1 Graphene oxide-based materials for biomedical applications
28.2 Design of hybrid polymeric hydrogels platform based on nanographene oxide, alginate, gelatin, and 2-hydroxyethyl methacrylate
28.3 Titanium dioxide-based materials for biomedical applications
28.4 Design of hybrid polymeric hydrogels platform based on nanotitanium dioxide, alginate, gelatin, and 2-hydroxyethyl methacrylate
28.5 Summary and future perspectives
28.6 GOHGA hybrid hydrogels
28.7 TiHGA hybrid hydrogels
Acknowledgments
References
Index

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 13 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 100 publications in various high impact peer-reviewed journals, more than 100 book chapters and 30 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record. He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Tejraj M. Aminabhavi

Tejraj M. Aminabhavi is the Director of Research at the Center for Energy and Environment , School of Advanced Sciences, KLE Technological University, Hubballi, India. He works in the area of membrane transport processes, molecular modeling of polymer surfaces, wastewater treatment technologies, drug delivery polymers and sustainable environmental engineering.

Affiliations and expertise

Director of Research, Center for Energy and Environment, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Advanced Nanoformulations

Theranostic Nanosystems, Volume 3

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Institutional subscription on ScienceDirect

Md Saquib Hasnain

Amit Kumar Nayak

Tejraj M. Aminabhavi