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Elsevier

Books in Drug delivery

This portfolio encompasses innovative methods for targeted, controlled, and sustained drug delivery systems. Supporting researchers, pharmaceutical scientists, and clinicians, it features advances in nanotechnology, biomaterials, and device engineering that enhance therapeutic efficacy and patient compliance. Covering oral, injectable, transdermal, and implantable systems, these resources address critical challenges in precision medicine and chronic disease management, fostering developments that optimize drug performance and reduce side effects.

  • Green Polymeric Materials in Drug Delivery

    Sustainable Solutions for Therapeutic Applications
    • 1st Edition
    • Parteek Prasher + 5 more
    • English
    Green Polymeric Materials in Drug Delivery: Sustainable Solutions for Therapeutic Applications addresses the critical intersection of polymer science, pharmaceutical technology, and environmental sustainability. This reference responds to the urgent need for eco-friendly drug delivery systems that improve therapeutic outcomes while minimizing ecological impact. It offers researchers and professionals a detailed exploration of green polymers derived from renewable sources and their transformative potential in healthcare. The comprehensive contents cover fundamental principles, synthesis, biocompatibility, formulation strategies, and innovative applications including nanomaterials, hydrogels, vesicular systems, and vaccine delivery. Chapters authored by leading experts examine targeted delivery routes such as mucosal, ocular, transdermal, and neural pathways. Regulatory frameworks and clinical trial insights further support translation from research to practice. Emerging technologies like AI-assisted formulation and 3D printing of implants are also discussed. This reference benefits polymer chemists, pharmaceutical scientists, regulatory experts, and clinicians by providing authoritative knowledge on sustainable materials for drug delivery. It equips readers with the scientific foundation and practical case studies necessary to advance green polymeric technologies in therapeutic development, fostering a sustainable future in pharmaceutical innovation and patient care.

  • Biopolymer Based Nano Drug Delivery for Cancer Wound Healing

    • 1st Edition
    • Vipan Kumar + 5 more
    • English
    Biopolymer Based Nano Drug Delivery for Cancer Wound Healing explores groundbreaking advancements in nanomedicine's role in treating cancer and promoting wound healing. The book delves into the pathophysiology of cancerous wounds, introduces biopolymer-based nanomedicine, and examines drug delivery systems using biopolymer-based nanoparticles. It concludes with future prospects of biopolymers in antitumor drug delivery systems. This resource is invaluable for researchers, advanced students, and R&D personnel across various fields, including cancer research, polymer science, biomaterials, biomedicine, pharmaceutics, biotechnology, and chemistry. Each chapter bridges theoretical concepts with practical applications, providing examples to illustrate key points.The book covers the pathophysiology of cancer and wounds, biopolymer-based nanomedicine for cancerous wounds, and drug delivery systems for healing. This is an essential reference for scientists and students focusing on pharmacy, drug delivery, and biomedicine.

  • Membrane Transporters and Drug Delivery

    A Comprehensive and Multidisciplinary Guide
    • 1st Edition
    • Elena Puris + 3 more
    • English
    Membrane Transporters and Drug Delivery: A Comprehensive and Multidisciplinary Guide is a comprehensive reference on the rapidly evolving field of membrane transporters and their role in drug delivery. The book begins with a comprehensive introduction to membrane transporters and their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery, examines the roles of both efflux and influx transporters in drug pharmacokinetics, and covers different strategies for utilizing membrane transporters for drug delivery and targeting specific tissues and cell types.It concludes with a discussion on the regulatory and industrial aspects of transporter-related projects, explores the potential of artificial intelligence in transporter and drug delivery research, and offers a glimpse into future challenges and perspectives in this field.

  • Targeting Intercellular Communication with Nanomedicine and Advanced Therapeutics

    • 1st Edition
    • Lara Scheherazade Milane + 1 more
    • English
    Targeting Intercellular Communication with Nanomedicine and Advanced Therapeutics delves into the complex world of intercellular communication biology and its implications on therapeutics. This book covers all areas of intercellular communication and therapeutics in development for different forms of communication, including their role in diseases such as cancer, neurological disorders, metabolic diseases, and inflammatory/immune diseases. Sections provide an introduction, biological targets, challenges, and approaches to overcoming biological barriers and the significance of contact points and mechanisms of internalization. Specifics of tunneling nanotubes, extracellular vesicles, and the immune and non-immune interface in various diseases are covered.Furthermore, the book explores the crosstalk of different forms of intercellular communication and the implications of mitochondrial exchange in the four primary pathological areas. This is an essential resource for researchers, students, and professionals in the field of drug development and delivery. By connecting the dots between extracellular vesicles, tunneling nanotubes, and cell-cell junctions, this book serves as a foundation for further advancements in the science of intercellular communication and it's applications to new drug discovery and delivery.

  • Cellular Therapies for Cancer Treatment

    Advancements in Drug Delivery Strategies
    • 1st Edition
    • Arun Kumar Singh + 3 more
    • English
    Cellular Therapies for Cancer Treatment: Advancements in Drug Delivery Strategies explores the innovative use of cellular therapy to combat cancer, placing an emphasis on state-of-the-art delivery approaches. By covering a variety of cellular therapies for cancer, such as stem cells, immune cells, and others, this book provides a comprehensive introduction to the field. It describes ways to deliver drugs that target cancer cells more efficiently, decrease off-target effects, and enhance therapy outcomes. Sections provide a brief overview of cancer cell biology, describe the need for advance drug delivery systems, and address challenges and future directions.The book also goes into the ideas behind cellular therapies and how they may overcome drug resistance and make existing cancer treatments more effective. By elaborating on the value of diversity and inclusion in cancer research and treatment, the book also emphasizes the importance of all patients having equal access to innovative therapies. All things considered, this book is a great tool for researchers, doctors, and students in the cancer treatment sector.

  • Topical Dermal Drug Delivery

    Concepts and Advances
    • 1st Edition
    • Jitender Madan + 4 more
    • English
    Topical Dermal Drug Delivery: Concepts and Advances compiles, in a single volume, the most recent advances in topical and dermal formulations for the treatment of skin disorders.The book covers three major concepts. The skin anatomy and physiology part includes chapters focused on relevant information for drug delivery. The second part of the book deals with several recent topical dermal drug delivery systems, including computational methods, permeation enhancers, bio precursors, hydrogels, emugels, exosomes and several nanotechnology enabled systems. The third and final part covers scaling up, toxicity, clinical trials, and regulatory considerations.This is a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the skin. Medical & Health Sciences researchers would also benefit from understanding the delivery systems covered in this book.

  • Basic Principles of Drug Discovery and Development

    • 3rd Edition
    • Benjamin E. Blass
    • English
    **Selected for 2026 Doody's Core Titles in Pharmacy**Basic Principles of Drug Discovery and Development, Third Edition presents a unique overview of the drug discovery and development program not available elsewhere. Each chapter provides sufficient technical details on the topics covered so that non-experts will have the tools and information necessary to interact and exchange information with colleagues across the entire spectrum of the drug discovery and development process. The drug discovery and development process involves individuals and teams with a wide array of expertise ranging from basic sciences (medicinal chemistry, biology) to applied science (pharmacology, pharmacokinetics, clinical sciences) to business driven fields (regulatory affairs, intellectual property experts, marketing specialists).The success or failure of a program focused on bringing a new medication to market often depends on clear communication between individuals and teams with vastly different expertise. As a result, it is critical that experts in one aspect of drug discovery and development (e.g., medicinal chemists) have a working understanding of the wide range of disciplines that take part in the overall process.

  • Drug Targeting Complexity

    Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy
    • 1st Edition
    • Lalit Kumar + 2 more
    • English
    Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-β, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology.

  • Innovative Nanocarriers for Stimulated Drug Delivery

    A Comprehensive Guide to Stimuli-responsive Nanoparticles
    • 1st Edition
    • Prashant Kesharwani
    • English
    Innovative Nanocarriers for Stimulated Drug Delivery: A Comprehensive Guide to Stimuli-responsive Nanoparticles summarizes recent advances and achievements in nanocarriers responsive to external or internal stimuli. The book presents different stimuli-sensitive strategies and their applications in drug delivery, therapy, and theranostics. Sections provide fundamental knowledge on the experiential and experimental aspects of stimuli-responsive nanocarriers, discuss external-responsive nanocarriers for biomedical applications, such as ultrasound, thermal, magnetic, light, and electric field-response systems, and describe internal stimuli-responsive nanocarriers for biomedical applications, including pH, hypoxia, redox potential, enzyme, glucose, and microRNA-responsive nanocarriers. Additionally, the book covers dual and multimodal-responsiv... nanocarriers and the therapeutic aspects of stimuli-responsive nanocarriers, such as metallic and non-metallic stimuli-responsive nanocarriers in the treatment of various cancer and noncancerous diseases. Finally, recent advances and regulatory aspects of stimuli-responsive nanocarriers, including clinical translation, challenges, biological toxicity, safety issues, clinical trials, and future perspectives are covered.

  • Protein-Based Nanoparticles in Drug Delivery

    • 1st Edition
    • Prashant Kesharwani
    • English
    Protein-based Nanoparticles in Drug Delivery is a comprehensive book aimed at pharmaceutical scientists and researchers both in academia and corporate environments focused on nanotechnology drug delivery and pharmaceutical-relat... disciplines. The book covers the design and characterization of various protein nanoparticles, sheds light on the power of an endogenous substance as a drug delivery system, and highlights the possible future trends in the use of protein-based drug delivery. It covers in-depth novel applications of protein-based drug delivery from fundamental to most current use cases. The book comprises three parts. Part one is devoted to the foundations of protein-based drug delivery, including nanocarriers development, drug encapsulation, targetability, and in vivo properties. Part two explores the applications of protein-based nanoparticles in drug delivery, covering topics such as protein nanoparticles in cancer therapy, genetic material delivery, and nanocarriers based on milk protein, silk, and gliadin. Part three addresses recent advances and regulatory aspects of protein-based nanoparticles in drug delivery, including clinical translation, challenges, biological toxicity, and environmental hazards associated with protein-based nanoparticles. Protein-based Nanoparticles in Drug Delivery provides a complete journey of protein-based drug delivery, offers an in-depth understanding of the design and characterization of various protein nanoparticles, and highlights possible future trends in this field. Pharmaceutical scientists will benefit from the novel applications of protein-based nanoparticles drug delivery approaches in the biological field. Nanotechnologists, biologists, chemists, physicists, engineers, and clinicians will also benefit from the foundational content provided as a basis to support communication and tackle the multidisciplinary challenges associated with research in this exciting field.

  • Multifunctional Nano pharmaceuticals for Biomedical Applications

    • 1st Edition
    • Sushil K. Kashaw + 3 more
    • English
    Multifunctional Nanopharmaceuticals for Biomedical Applications covers the latest advancements in multifunctional nanopharmaceuticals while also addressing the pressing need for innovative solutions for unmet medical challenges. Each chapter explores key topics such as the fundamentals of nanotechnology and drug delivery, PEGylated lipid carriers for cancer theranostics, and the latest in biomimetic nanomicells and nanorobots. With detailed discussions on design strategies, formulation techniques, and regulatory aspects, readers will gain a thorough understanding of the complexities and innovations in this dynamic field. The exploration of clinical applications and future trends also equips readers with the knowledge to navigate the evolving landscape of nanomedicine.This is an essential resource for researchers interested in the transformative potential of nanotechnology in drug delivery and disease treatment. It empowers readers to harness cutting-edge technologies for effective therapies, paving the way for a new era of personalized, precise, and potent medicine. With the rapid evolution of nanomedicine, this book serves as a crucial tool for researchers, students, healthcare professionals, and industry experts alike, bridging the gap between fundamental concepts and their real-world applications.

  • AI Powered Drug delivery to Neuro and Cardiovascular Systems

    Perspectives and Future Challenges
    • 1st Edition
    • Chandra P. Sharma + 2 more
    • English
    AI-Powered Drug Delivery to Neuro and Cardiovascular Systems: Perspectives and Future Challenges is a definitive reference exploring the transformative influence of Artificial Intelligence (AI) in neuro and cardiovascular drug delivery. This book integrates cutting-edge research to explain how AI is poised to reshape clinical protocols, therapeutic strategies, and regulatory standards. By examining advancements in robotics and intelligent systems, it demonstrates how AI enhances precision, personalization, and efficiency in drug delivery for heart and neurological conditions, providing readers with a thorough understanding of these innovations and their potential to revolutionize healthcare practices.The book delves into AI-driven drug design and testing for cardiovascular diseases and explores the application of AI in cardiac drug delivery vehicles. It discusses bioengineered heart and vessel therapeutics, redox homeostasis, and targeted drug replenishment in cardiac matrix remodeling. Additionally, it addresses mitochondrial drug retention, AI-assisted gene therapy for neurodegenerative disorders, and the role of AI in optimizing heart health. The text highlights smart systems for managing cerebrovascular accidents and neuromodulation with pharmacotherapy. Finally, it covers translational challenges, future directions, and the significance of AI-driven prediction models and robotic delivery mechanisms.

  • Lipid Nanoparticles-Based mRNA Delivery System

    • 1st Edition
    • Raj Kumar
    • English
    Lipid Nanoparticles-Based mRNA Delivery System offers a comprehensive exploration of lipid nanoparticles (LNPs), the most promising delivery vehicles for mRNA. The book consolidates current knowledge, identifies research gaps, and provides insights into the latest developments in LNP technologies, making it an essential resource for researchers, pharmaceutical developers, and clinicians at the forefront of mRNA therapeutics. Exploring the intricacies of LNP formulation, the book covers a wide range of topics, including the fundamental principles of lipid nanoparticles, design strategies for effective mRNA encapsulation, and the unique challenges associated with various routes of administration—such as intravenous, oral, transdermal, and intranasal delivery.The book also examines the therapeutic applications of lipid-based systems, particularly in vaccines and cancer immunotherapy, while addressing critical challenges like immunogenicity and regulatory considerations. Final sections provide a forward-looking perspective on future trends and innovations in lipid-based mRNA delivery systems, ensuring that readers are well-equipped to navigate this rapidly evolving field.

  • Nanotechnology-Based Innovations in Chronic Obstructive Pulmonary Disease (COPD) Treatment and Management

    • 1st Edition
    • Harish Dureja + 5 more
    • English
    Nanotechnology-Based Innovations in Chronic Obstructive Pulmonary Disease (COPD) Treatment and Management explores innovative drug delivery systems utilizing nanotechnology to revolutionize the treatment and management of COPD. By presenting the latest advancements in nanotechnologies—inc... polymeric nanoparticles, liposomes, and theranostic nanoparticles—this volume aims to enhance patient outcomes, alleviate symptoms, and improve lung function, thereby addressing the urgent need for more effective therapies. Structured to cater to a diverse audience, from beginners to advanced researchers, this comprehensive text begins with an overview of COPD, its epidemiology, and current limitations in treatment. The core chapters explore a wide range of nanotechnological applications for diagnosis and disease management, including cutting-edge topics such as nano-immunotherapy and green nanotechnology. Each chapter was developed by a multidisciplinary team of experts from academia and industry, ensuring a comprehensive approach that integrates insights from pharmaceutical sciences, respiratory health, and bioinformatics. Nanotechnology-based Innovations in Chronic Obstructive Pulmonary Disease (COPD) Treatment and Management not only fills a critical gap in COPD literature but also serves as an invaluable resource for researchers, clinicians, and students alike. It promises to be a definitive guide on how innovative drug delivery systems can transform COPD care, paving the way for future advancements in respiratory health management.

  • Harnessing Endogenous Mechanisms for Targeted Drug Delivery

    • 1st Edition
    • Anisha A. D’Souza + 2 more
    • English
    Harnessing Endogenous Mechanisms for Targeted Drug Delivery presents a comprehensive exploration of the evolving landscape of targeted drug delivery, emphasizing the strategic utilization of the body's intrinsic biological pathways. This authoritative two-volume reference addresses the critical need for precision in therapeutic delivery, overcoming physiological, anatomical, and immunological barriers through innovative endogenous mechanisms. By integrating foundational concepts with advanced methodologies, the work underscores the transition from traditional passive and active targeting to sophisticated endogenous strategies that enhance drug specificity and efficacy.The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes.

  • Functionalized Drug Delivery Systems

    • 1st Edition
    • Umesh Gupta + 1 more
    • English
    Functionalized Drug Delivery Systems delves into the potential of various functionalized drug delivery systems, such as polymeric micelles, dendrimers, metallic nanoparticles, and SMEDDS. It offers a comprehensive guide from basic concepts to advanced surface engineering techniques. The book covers liposomes, dendrimers, metal nanoparticles, polymeric micelles, niosomes, and ethosomes, concluding with a chapter on the regulatory framework. This invaluable resource is perfect for pharmaceutical researchers and graduate students keen on advancing their understanding and application of these innovative drug delivery methods. The book also provides consolidated literature reviews, making it a foundational text for new researchers.Its chapters are dedicated to specific techniques, offering detailed insights into each method. Readers will gain knowledge on improving drug absorption and targeted delivery, supported by practical examples and case studies. The final chapter on regulatory frameworks ensures compliance and best practices in developing functionalized drug delivery systems. This book is an essential read for anyone in the field of pharmaceutical research.

  • Inorganic Biomaterials for Drug Delivery

    • 1st Edition
    • Amit Kumar Nayak + 2 more
    • English
    Inorganic Biomaterials for Drug Delivery covers a wide range of inorganic biomaterial types and their properties, from traditional materials like ceramics, metallics, and bioglasses to novel composites and nano-engineered inorganic biomaterials. Biocompatibility, toxicity, and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science, pharmacology, chemical engineering, and clinical science.

  • NanoPDT

    Nanomaterials-Enhanced Photodynamic Therapy
    • 1st Edition
    • Saeid Moghassemi + 2 more
    • English
    NanoPDT: Nanomaterials-Enhanc... Photodynamic Therapy covers extensively the therapeutic potential of multifunctional nanosystems that has made so much progress within the biomedical and pharmaceutical research communities over recent decades. Traditional photodynamic therapy (PDT), however, faces several limitations, primarily due to the hydrophobic nature of photosensitizers (PS), which tend to aggregate in aqueous environments, resulting in inadequate biodistribution and limited bioavailability. These constraints significantly reduce the efficacy of photodynamic therapy. The book also explores the most relevant combination therapies available. Four chapters are dedicated to the combination of NanoPDT with other approaches like Immunotherapy, Radiotherapy, chemotherapy, and photothermal therapy. NanoPDT: Nanomaterials-Enhanc... Photodynamic Therapy is an essential resource for pharmaceutical researchers, clinicians, and students in the fields of nanomedicine, oncology, and photodynamic therapy. It offers a thorough exploration of the latest advancements and future directions, providing valuable insights for those looking to enhance the efficacy and specificity of PDT through nanotechnology and its combined applications. The book's comprehensive coverage of both oncological and non-oncological applications makes it a crucial addition to the literature, bridging the gap between fundamental research and clinical practice.

  • Ophthalmic Drug Delivery

    Advancement, Industrialization Prospect and Applications
    • 1st Edition
    • Neelesh Kumar Mehra
    • English
    Ophthalmic Drug Delivery: Advancement, Industrialization Prospect and Applications delves into the complexities and potential of scaling up and commercializing pharmaceutical innovations within ophthalmology. This book serves as a complete guide through research findings, industry insights, and regulatory guidelines, offering a thorough roadmap for the future of drug delivery systems targeting the eye. The importance of understanding the eye's physiology and anatomy is emphasized, laying the foundational knowledge necessary for developing effective treatments. The book continues by exploring various aspects such as novel formulations, fixed-dose combinations, and microbiological considerations.It also discusses cutting-edge research in reverse engineering approaches, the significance of Quality by Design (QbD), and the treatment of eye-related diseases like glaucoma, age-related macular degeneration, uveal melanoma, cataracts, and fungal keratitis. Corporate researchers will find the manufacturing insights particularly beneficial, making this an essential resource for professionals in the field of ophthalmic drug delivery.

  • Oral Delivery of Insulin

    • 2nd Edition
    • T.A. Sonia + 1 more
    • English
    Oral delivery of Insulin, Second Edition is a complete reference on non-invasive insulin delivery systems, focusing on the prospect of oral delivery of peptides. The chapters in the revised edition present a comprehensive evaluation of the insulin therapy approaches, with an emphasis on insulin delivery strategies and current advances in engineered insulin delivery systems such as nano/microcarriers and hydrogels. Chapters provides an overview of diabetes mellitus, cover technological innovations, explore artificial intelligence and machine learning approaches to manage diabetes, explore a wide range of non-invasive and alternative routes of insulin administration, and much more.Other chapters cover challenges and strategies in oral insulin delivery, the experimental techniques used to develop oral insulin carriers, the use of polymeric nano and microparticles for insulin delivery, and the use of lipids and inorganic nanoparticles in insulin delivery. The final chapter provide an overview of current clinical trials on insulin delivery and future perspectives in the area. Clinicians can benefit from this information to develop a clear understanding about the research carried out worldwide in the field of oral delivery of insulin, including those in the clinical phase.

  • Theranostics in Cancer Management

    Integrating Diagnostics and Therapeutic Strategies
    • 1st Edition
    • Kuttiappan Anitha + 2 more
    • English
    Theranostics in Cancer Management: Integrating Diagnostics and Therapeutic Strategies introduces a transformative paradigm in clinical oncology, heralding a new era of precision and personalized cancer care. This comprehensive guide empowers clinicians by seamlessly integrating advanced diagnostics with targeted therapeutic approaches. The book provides an extensive exploration of theranostics across diverse clinical scenarios, ensuring that healthcare professionals are equipped with the knowledge to navigate the complexities of cancer management effectively. Beyond the introductory insights, the book delves into several types of cancer and the utilization of Artificial Intelligence in cancer detection tools.Comprising 15 chapters, it offers an invaluable resource for health professionals, scientists, researchers, practitioners, and students who seek to expand their understanding in this evolving field. The emphasis on practical applications and emerging technologies makes it a timely addition to the field of oncology.

  • Strategies to Modify the Drug Release from Pharmaceutical Systems

    • 2nd Edition
    • Marcos Luciano Bruschi
    • English
    Strategies to Modify the Drug Release from Pharmaceutical Systems, Second Edition serves as a vital reference on contemporary models aimed at achieving the precise therapeutic dosage and timing of drug release. The book provides updated strategies, mathematical models, routes of administration, and technologies, all presented succinctly and objectively. This six-chapter guide covers general concepts of drug release modification and classification of therapeutic systems, including passive versus active targeting. It delves into mechanisms to control drug release, discussing materials and technologies, and introduces mathematical and physicochemical models of drug release.Furthermore, it reviews drug delivery systems like 3D printing, nose-to-brain delivery, environmentally responsive systems, and new lipid systems, making it indispensable for pharmaceutical scientists, graduate students, materials scientists, and chemists.

  • Advances in Probiotic Delivery Systems

    Strategies for Enhanced Viability, Targeted Delivery and Efficacy
    • 1st Edition
    • Tanmay Sarkar + 2 more
    • English
    Advances in Probiotic Delivery Systems: Strategies for Enhanced Viability, Targeted Delivery and Efficacy covers the complex world of probiotics, offering a comprehensive exploration of innovative delivery mechanisms designed to overcome challenges of stability and efficacy. From oral administration to alternative delivery routes, each chapter provides insights into cutting-edge formulation strategies, encapsulation techniques, and emerging technologies, equipping readers with the knowledge to explore the full potential of probiotics for health and wellness. Bridging the gap between theory and practice in probiotic delivery systems, this book delivers insights into the most effective delivery strategies.Despite the growing interest in probiotics and their potential health benefits, challenges such as poor stability and limited efficacy hinder their widespread application. This book fills this critical gap by providing readers with a thorough understanding of the underlying principles, latest advancements, and practical solutions in probiotic delivery. By consolidating the expertise of leading researchers and practitioners, the book empowers professionals across various industries to develop and implement effective probiotic formulations that make a difference in health outcomes.

  • Ligands for Targeted Drug Delivery

    Basic Fundamentals and Applications
    • 1st Edition
    • Vikas Pandey + 3 more
    • English
    Ligands for Targeted Drug Delivery: Basic Fundamentals and Applications is a comprehensive reference focused on the many ways drug carriers can be functionalized to target specific organs, tissues, cells, and sub-cellular compartments. Chapters cover the basic concepts of targeted drug delivery, describing multiple levels of targets and challenges, along with approaches for target-specific drug delivery and a thorough overview of the challenges in design and application of ligands. Following sections discuss nanoparticles and the main ligand classes with their respective applications. The final chapters discuss future prospects of the technology and clinical aspects of ligand modified drug delivery systems.This is a key reference to drug delivery researchers dealing with the application of ligands to overcome challenges in delivering their active principles to the target structure. Biomedical engineers, materials scientists, and chemists can also benefit from the through description of ligand classes and their potential to improve drug delivery efficiency.

  • Emerging Paradigms in Delivery Systems for Antitubercular Therapy

    • 1st Edition
    • Rajeev Sharma + 3 more
    • English
    Emerging Paradigms in Delivery Systems for Antitubercular Therapy provides an up-to-date and thorough overview of the state-of-the-art of concepts, design, and recent advances in nanomedicines and nanobiotechnology-ba... strategies for the treatment of tuberculosis. The book enables researchers to prepare a variety of nanotechnology-based strategies, investigate their properties, and discover their uses and applications in antitubercular therapy, focusing on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, and tuberculosis vaccination.This book covers all major topics that have shaped the development of nanomedicine and propelled it to its current place at the forefront of Nanotechnology based treatment innovation. It will be a welcomed resource for researchers and readers with more and more challenging therapy and biologicals with their possible modifications to be used for the effective therapy of tuberculosis.

  • Nanocarriers Based Colon Targeting

    Design, Development, Mechanism and Case Studies
    • 1st Edition
    • Lalit Kumar + 1 more
    • English
    Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein–peptide-base... nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.

  • Intelligent Nanobiosystems in Medicine and Healthcare, Volume 2

    Applications of Intelligent Nanobiosystems
    • 1st Edition
    • Vijay Mishra + 2 more
    • English
    Intelligent Nanobiosystems in Medicine and Healthcare, Volume 2: Applications of Intelligent Nanobiosystems provides recent progress in the nanobiosystems arena, helping readers better design and develop novel drug delivery systems and devices that take advantage of recent advances in nanomedical technologies. The book explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advancements in cutting-edge nanomedical technologies. This updated volume includes chapters by experts in the field, featuring an exploration of targeted therapy and drug delivery systems, analytical and imaging tools, theranostics, tissue engineering and regenerative medicines, dentistry tools and modern developments.This book will be a useful resource for researchers and postgraduate students in pharmaceutical sciences and biotechnology industries as well as medical professionals, biologists, chemists, materials scientists, clinical researchers, and biochemical and biomedical engineers working both in industry and academia.

  • Intelligent Nanobiosystems in Medicine and Healthcare, Volume 1

    Fundamentals, Fabrication and Commercialization
    • 1st Edition
    • Vijay Mishra + 2 more
    • English
    Intelligent Nanobiosystems in Medicine and Healthcare, Volume One: Fundamentals, Fabrication and Commercialization provides an overview of recent progress in the nanobiosystems arena, helping readers design and develop novel drug delivery systems and devices that take advantage of recent advances in nanomedical technologies. The book explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advancement in cutting-edge nanomedical technologies. It highlights established research and technology on intelligent nanobiosystems, their rapidly emerging aspects, and future research directions. Sections cover nanobiosystems, explore nano candidates and fabrication aspects, and delve into the challenges of commercialization.Th... book will be a useful resource for researchers and postgraduate students in pharmaceutical sciences and biotechnology as well as medical professionals, biologists, chemists, materials scientists, clinical researchers, biochemical and biomedical engineers working both in academia and industry.

  • Lipid-Drug Conjugates

    Innovation and Applications
    • 1st Edition
    • Malay K. Das
    • English
    Lipid-Drug Conjugates: Innovation and Applications highlights the most recent advances and clinical applications of nano lipid-drug conjugates for enhanced drug delivery and targeting in the treatment of cancer, glioblastoma, Alzheimer’s, AIDS, and bacterial diseases. In addition, various conjugation methods to prepare lipid-drug conjugates and their pharmacokinetics in vivo are explored, together with the production and characterization of various delivery carriers for lipid-drug conjugates. The contents of this book provide pharmaceutical science researchers with the tools to explore targeted drug delivery leveraging the unique characteristics of lipid conjugates. Scientists in the corporate setting can benefit of the cases and techniques presented in developing new formulations and products.

  • Natural Biopolymers for Drug Delivery

    • 1st Edition
    • Amit Kumar Nayak + 2 more
    • English
    Natural Biopolymers for Drug Delivery thoroughly details the properties, benefits and challenges of using these biomaterials in drug delivery, with a strong focus on biocompatibility and reduction of unwanted interactions. An extensive range of natural biopolymers are explored, such as cellulose, chitosan, casein, gelatin, cashew gum, and many more. Biocompatibility, toxicity and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science and pharmacology, chemical engineering and clinical science.

  • Challenges in Delivery of Therapeutic Genomics and Proteomics

    • 2nd Edition
    • Aliasgar Shahiwala + 1 more
    • English
    Challenges in Delivery of Therapeutic Genomics and Proteomics, Second Edition is a complete reference on the biological principles involved in gene and protein delivery to cells and tissues. Highlighting the various chemical, physical, and biological approaches to protein and gene delivery, the book provides guidelines for pharmaceutical researchers in academia and corporate R&D. This new edition brings updates on the delivery of therapeutic proteomics and genomics in each chapter, and newly developed chapters on the regulatory aspects of related products, CRISPR/Cas9 gene editing, and computational tools in genomics and proteomics.After an overview of the barriers to genomics and proteomics delivery, the book dives into physical, chemical, and biological methods of gene delivery. Further chapters extensively discuss the delivery of proteins and therapeutic peptides through the respiratory, oral, parenteral, transdermal, topical, uterine, and rectal pathways. This book is the ideal reference for pharmaceutical scientists dealing with gene and protein/peptide delivery. Regulators and corporate researchers can also benefit from the wide coverage of delivery methods presented.

  • Lipids in Pulmonary Drug Delivery

    • 1st Edition
    • Md Faiyazuddin + 3 more
    • English
    Lipid in Pulmonary Drug Delivery explores the most recent advancements, strategies, and state-of-the-art technological progress in the development of lipid-based nanocarriers for pulmonary administration. The book presents wide coverage of various lipid-based nano-drug carriers such as liposomes, solid lipid nanoparticles, and nanoemulsions intended for the administration of drugs through the pulmonary route to treat different conditions. It also includes a general description of the formulation aspects of various lipid-based drug delivery vehicles, post-production processing, and biofate aspects with special emphasis on the pulmonary microenvironment.In addition, the authors include an update on the clinical status of the potential lipid nanocarriers used for effective management of the pulmonary related diseases. Written in a technical way covering the latest advancements in lipid-based drug delivery for pulmonary administration, this book is a useful reference for researchers, scientists, and graduate and postgraduate students working on, or planning, research in the field of lipid-based nano-drug pulmonary delivery platforms.

  • Recent Advances in Nanomedicines Mediated Wound Healing

    • 1st Edition
    • Prashant Kesharwani
    • English
    Recent Advances in Nanomedicines Mediated Wound Healing presents an overview of various nanotechnology-based drug delivery systems explored widely for wound healing. The book provides a comprehensive review of thriving strategies used for wound healing and thoroughly describes the most recent developments in emerging modern drug delivery systems with a focus on nanotechnology. It serves as a complete package for a holistic understanding of molecular pathways, conventional therapy, and novel nanocarrier-mediated drug delivery for wound healing while also exploring advanced strategies like siRNA and aptamer mediated approaches and nanomedicines to treat diabetic and full thickness wounds.This book will help researchers, undergraduates, graduate students, and experts in nanotechnology drug delivery and pharmaceutical related disciplines design and develop novel drug delivery systems and devices for wound healing that take advantage of recent advances in nanomedical technologies.

  • Drug Delivery

    Advances and Emerging Strategies
    • 1st Edition
    • Kevin Ita
    • English
    Drug Delivery: Advances and Emerging Strategies begins with an overview on drug delivery, setting the stage for detailed discussions on oral, pulmonary, vaginal, ocular, and nasal dedicated sections. Chapters cover colonic, transdermal, transungual, brain, and nose-to-brain delivery, but also focus on vaccine delivery and organ specific delivery routes via the myocardium, kidney, liver, pancreas, buccal, sublingual, and injectable drug delivery systems. The book offers an integrated, up-to-date overview of drug delivery methods, technologies, and approaches, targeting body systems and organs. Researchers and advanced students in pharmaceutical science will benefit from this consolidated outlook.

  • Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders

    • 1st Edition
    • Gabriele De Rubis + 5 more
    • English
    Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders focuses on 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling. The book, written by a team of leading experts in the field, is an essential resource for anyone interested in the future of CRD treatment. Chapters discuss the emerging therapeutic approaches for CRDs, including biologicals and phytoceuticals. Core chapters of the book then cover the application of 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling to different CRDs. The book concludes with a discussion of the current clinical trials and future prospects for the management of CRDs.This is a valuable resource for researchers, clinicians, and other healthcare professionals who are interested in the latest technological advances in the field of CRDs. It will also be of interest to students and scientists working in the fields of pharmaceutical sciences, microfluidics, bioinformatics, drug design, drug delivery, and 3D printing.

  • Theranostics Nanomaterials in Drug Delivery

    • 1st Edition
    • Prashant Kesharwani + 1 more
    • English
    Theranostics Nanomaterials in Drug Delivery presents the most recent advances in the development of theranostic nanomaterials for drug delivery. This book compiles reports and studies on the latest changes and improvements of theranostic nanocarriers such as nanoemulsions, liposomes, exosomes, polymeric micelles, PLGA nanoparticles, chitosan nanoparticles, dendrimer, quantum dots, silica nanoparticles, gold nanoparticles, silver nanoparticles, magnetic nanoparticles, and many more, all of which can help in the sensitive diagnosis, precise targeting, and efficient and controlled delivery of nanomaterials to control various diseases at different clinical stages.Theranostics nanomaterials in drug delivery will serve as a solid foundation and reference for pharmaceutical scientists, undergraduate and postgraduate students, researchers, and experts in the medical field involved in the development of advanced drug delivery systems.

  • Novel Drug Delivery Systems in the management of CNS Disorders

    • 1st Edition
    • Pooja A Chawla + 4 more
    • English
    Novel Drug Delivery Systems in the Management of CNS Disorders offers a comprehensive source of information on delivering drugs to the central nervous system to treat various diseases and conditions. The book covers a wide range of CNS disorders, including epilepsy, Parkinson's, Alzheimer's, Huntington's, multiple sclerosis, schizophrenia, cerebral palsy, autism, ALS, and others.The book begins by presenting the foundations of drug delivery to the brain and addressing the associated challenges. It then delves into clinical trials and explores the future potential of the presented technologies.This reference is designed for drug delivery researchers in academia and corporations, providing them with the essential knowledge about overcoming the Brain-Blood Barrier and achieving targeted drug delivery to the central nervous system.

  • Liposomes in Drug Delivery

    What, Where, How and When to deliver
    • 1st Edition
    • Sophia G. Antimisiaris
    • English
    Liposomes in Drug Delivery: What, Where, How and When to Deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps readers understand if liposomes can be of benefit for their particular need, what is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/chara... liposome properties for a particular application.The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvant... and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/techno... for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication.

  • Concepts and Models for Drug Permeability Studies

    Cell and Tissue based In Vitro Culture Models
    • 2nd Edition
    • Bruno Sarmento + 2 more
    • English
    Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs.This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-deriv... tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route.Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models.Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.

  • Polymers for Pharmaceutical and Biomedical Applications

    Fundamentals, Selection, and Preparation
    • 1st Edition
    • Vandana Patravale + 2 more
    • English
    Polymers for Pharmaceutical and Biomedical Applications: Fundamentals, Selection, and Preparation supports the successful selection, design, and development of polymers with the required properties and performance for a range of advanced pharmaceutical and biomedical applications. The book begins by introducing polymers for pharmaceutical and biomedical applications, examining classification, basic properties, structures, and grades. This is followed by in-depth chapters on synthesis and modification, characterization techniques, and dissolution and solubility of polymers for pharmaceutical applications. Key applications are highlighted, with chapters explaining the preparation of polymers for conventional dosage, modified drug delivery, conjugates, advanced drug and gene delivery, medical devices, pharmaceutical packaging, and more. Throughout the book, the aim is to provide accessible, step-by-step coverage supported by diagrams and case studies. This is a valuable resource for all those who are newly approaching the field of polymers and product development for pharmaceutical and biomedical applications. This includes researchers and advanced students across polymer science, pharmaceutical science, biomaterials, biomedicine, healthcare, and chemistry, and scientists and R&D professionals in an industrial setting.

  • Alzheimer's Disease and Advanced Drug Delivery Strategies

    • 1st Edition
    • Bhupendra G. Prajapati + 2 more
    • English
    Alzheimer's Disease and Advanced Drug Delivery Strategies compiles under a single volume the most recent advances in drug delivery to the brain as related to AD treatment. The book's editors recruited scientists from around the world to produce high quality chapters covering not only nanotechnological approaches, but also microsphere, niosomes, and liposomes. Among the topics covered are synthetic molecules, nobiletin, nose to brain delivery, natural biomaterials, cationic nanoformulations, dendrimers, microbubbles, and more. This book represents a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the brain.

  • Silver Nanoparticles for Drug Delivery

    • 1st Edition
    • Prashant Kesharwani
    • English
    Silver Nanoparticles for Drug Delivery is a complete reference that provides comprehensive coverage of the principle behind the formation, characterization, application, regulation, toxicity, and challenges and future perspectives of silver nanoparticles in drug delivery for the treatment of various diseases. Sections cover the synthesis and characterization of silver nanoparticles (AgNPs), historical introductions to developments, methods and characterization parameters, green and biological synthesis methods, biofate and cellular interactions of AgNPs, drug delivery for the treatment of several diseases and conditions, targeting strategies, applications in cancer diagnosis and treatment, and much more. This is a complete reference for graduate students in nanotechnology drug delivery.

  • Gold Nanoparticles for Drug Delivery

    • 1st Edition
    • Prashant Kesharwani
    • English
    Gold Nanoparticles for Drug Delivery discusses the synthesis and characterization of gold nanoparticles (AuNPs), presenting an historical introduction to the developments in the area, discussing methods and characterization parameters, covering targeted delivery strategies, treatment of cancer, CNS conditions, infectious diseases, HIV/AIDS infection, wound healing and tissue regeneration, dentistry, gene delivery, and its photo properties used in diagnostic and therapies, and finally presenting regulatory aspects such as theranostic applications, vaccine development, toxicity, and the translation of research to marketable products. This book is a complete reference for researchers in nanotechnology drug delivery and pharmaceutical disciplines. Researchers in pharmaceutical industries, especially those involved in the use of gold nanoparticles in the field of drug delivery, diagnosis, targeted and early therapies will also benefit from this book.

  • Advanced Drug Delivery Systems for Colonic Disorders

    • 1st Edition
    • Harish Dureja + 4 more
    • English
    Advanced Drug Delivery Systems for Colonic Disorders presents state-of-the-art methods for targeted drug delivery to the colon. These methods can prolong drug half-lives, improve bioavailability, optimize pharmacokinetics, and reduce medication dosing frequency. Chapters allow readers to not only become familiar with advancements, but also understand concepts by providing illustrations, figures, and informative tables. Contents cover an overview of colonic diseases, the cellular and molecular mechanisms involved, current and traditional therapeutic approaches, biomaterials, oral drug delivery methods, targeted drug delivery, nutraceuticals and herbal medicine approaches, prebiotics, probiotics and symbiotics, nanomedicine approaches, and the status of clinical trials.This book is the perfect resources for researchers in pharma, biomaterials, and nutrition to help familiarize them with new and upcoming therapeutic methods. Research physicians in GI can also benefit from reading this book for its clinical applications.

  • Nanostructured Materials

    Physicochemical Fundamentals for Energy and Environmental Applications
    • 1st Edition
    • Zesheng Li + 1 more
    • English
    Nanostructured Materials: Physicochemical Chemistry Fundamentals for Energy and Environmental Applications summarizes research knowledge and helps advanced students, researchers and industrial technicians understand specific applications of nanomaterials in energy and the environment. Sections bring a strong foundational focus on the physicochemical basis of nanomaterials for these applications, the basic theory and physicochemical basis of nanomaterials, an energy and environment applications examination of typical cases, and progress. This book will appeal to researchers in the chemical sciences (inorganic and physical chemistry, coordination chemistry, molecular dynamics, electrochemistry, photocatalysis, thermocatalysis, thermodynamics, etc.), nanoscience (graphene, carbon nanotubes, nanocrystals, nano catalysis, energy, and environment-nano science), and more. Efficient use of energy, eco-friendly environmental systems, and technologies play an important role in global sustainable development. Multifunctional nanocomposites have excellent properties and can meet the practical needs of energy development and environmental treatment. They have been gradually applied in chemical materials, energy preparation, pollution control and other fields and have achieved impressive development.

  • Nucleic Acids

    A Natural Target for Newly Designed Metal Chelate Based Drugs
    • 1st Edition
    • Irshad Ul Haq Bhat + 1 more
    • English
    Nucleic Acids: A Natural Target for Newly Designed Metal Chelate Based Drugs discusses how human diseases are becoming more costly to treat, along with updates on the resistance offered by disease-causing agents. The abundance of drugs in the market has provided great relief to patients, but side effects can destroy the immune system of the body. Patients need to boost their immune system, and at the same time cover expenses incurred to cure disease. Thus, a paradigm shift is needed to design a drug molecule with low cost and easy availability. Metal complexes can be a great example of such a shift, as metal ions are components of biological molecules and can achieve good binding capability to specific targets while not allowing them to damage healthy cell system. Therefore, in this book, a comprehensive compilation of recent data is provided, including the structural elucidation of metal complexes by advanced techniques and the binding pattern of metal complexes with specific targets.

  • Nanotechnology in Ophthalmology

    • 1st Edition
    • Mahendra Rai + 2 more
    • English
    **Selected for 2026 Doody's Core Titles in Ophthalmology**Nanot... in Ophthalmology is a comprehensive and up-to-date reference on the role and applications of nanotechnology in ophthalmology, from drug delivery and treatment of ocular diseases to toxicity issues. Written by experts from the nanotechnology, ophthalmology, and pharmacology fields, this book has a unique, broad and diverse scope, including chapters on nanosensor-based diagnostic tools, delivery of nanobiomaterials, implantable materials and devices, delivery of nanobiomaterials, nanotechnology for medical and surgical treatment, regenerative medicine, and more. This book provides a valuable reference to researchers working in the areas of ophthalmology, nanoscience and pharmacology, and clinical fellows who are interested in nanoophthalmology as a reference for their practice and research.

  • Polymer-Drug Conjugates

    Linker Chemistry, Protocols and Applications
    • 1st Edition
    • Jitender Madan + 3 more
    • English
    Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ‘Linker Chemistry’ in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding. The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.

  • Overcoming Obstacles in Drug Discovery and Development

    Surmounting the Insurmountable—Case Studies for Critical Thinking
    • 1st Edition
    • Kan He + 2 more
    • English
    Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development.

  • Theoretical and Computational Photochemistry

    Fundamentals, Methods, Applications and Synergy with Experimental Approaches
    • 1st Edition
    • García Iriepa Cristina + 1 more
    • English
    Theoretical and Computational Photochemistry: Fundamentals, Methods, Applications and Synergy with Experimental Approaches provides a comprehensive overview of photoactive systems and photochemical processes. After an introduction to photochemistry, the book discusses the key computational chemistry methods applied to the study of light-induced processes over the past decade, and further outlines recent research topics to which these methods have been applied. By discussing the synergy between experimental and computational data, the book highlights how theoretical studies could facilitate understanding experimental findings. This helpful guide is for both theoretical chemists and experimental photochemistry researchers interested in utilizing computational photochemistry methods for their own work.