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Elsevier

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • Epigenetic Regulations in Gastrointestinal Cancers

    • 1st Edition
    • Ganji Purnachandra Nagaraju + 1 more
    • English
    Epigenetic Regulations in Gastrointestinal Cancers offers a comprehensive exploration of the genomic and epigenomic alterations that underpin the aggressive nature of gastrointestinal (GI) cancers. . By synthesizing the latest research and insights into the role of the tumor microenvironment and cellular signaling pathways, this book aims to elucidate the multifaceted nature of GI cancer neoplasia and propose innovative therapeutic strategies. Addressing critical challenges in GI cancer research and treatment, this book serves as a vital resource for researchers and clinicians striving to bridge the gap between basic research and clinical application. It tackles the complexities of GI cancer mechanisms by integrating knowledge from diverse fields, thereby providing a holistic understanding essential for effective therapeutic development. Through real-world case studies and expert contributions, the book highlights successful treatment regimens that leverage epigenetic insights, thereby fostering dialogue among multidisciplinary teams and promoting collaborative approaches to cancer care. Moreover, the book emphasizes the importance of staying abreast of rapid advancements in the field of cancer research. With contributions from leading experts and an accompanying online platform featuring interactive resources, readers will have access to the latest insights and developments in GI cancer research. By identifying specific epigenetic targets and innovative strategies for overcoming treatment resistance, this book aspires to enhance patient outcomes in GI cancers and contribute to the ongoing evolution of personalized medicine in oncology.

  • Cell Shape and Position during Development

    • 1st Edition
    • Volume 166
    • English
    Cell Shape and Position during Development, Volume 166 provides a comprehensive overview of the fundamental roles that cell morphology and spatial organization play in the development of multicellular organisms. This volume brings together leading experts in developmental biology, cell biology, and biophysics to explore how cells acquire specific shapes. Chapters in this new release include Cell shape changes during sperm-egg interactions, Cell shape and position during organ development, Regulation of shape and position during asymmetric cell division, Cell shape dynamics during mouse peri-implantation development and embryo dormancy, Shaping the intestine: the role of cell morphology and spatial dynamics in development, and more.Additional sections Intermediate filaments in cell shape and position, Regulation of adult stem cell behavior by cytoskeletal dynamics and cell shape, Shape changes in gastrulation, and more.

  • Genetics of Bone Biology and Skeletal Disease

    • 3rd Edition
    • Rajesh V. Thakker + 3 more
    • English
    Genetics of Bone Biology and Skeletal Disease, Third Edition is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid, and related disorders, and vitamin D and renal disorders.Sections cover bone biology and structure, joint and cartilage biology, principles of endocrine regulation, the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasia, rarer bone disorders, and much more.

  • Group B Streptococcus in Pregnancy, Childbirth, and the Neonatal Period

    • 1st Edition
    • Philip Steer + 1 more
    • English
    Group B Streptococcus (GBS) in Pregnancy, Childbirth, and the Neonatal Period brings together field experts to provide a comprehensive understanding of group B streptococcus (GBS), the most common cause of perinatal infection today. It discusses this important bacterium and infection within pregnancy, both obstetric and fetal aspects during labor, and in the infant.The book opens with a global view of GBS, recounting the history and variation in risk factors and outcomes across regions. Subsequent chapters cover not only the biology, epidemiology and pathology, but also intricately describe infection management, treatment, and prevention options. Both early onset as well as late onset GBS disease are discussed.Further, written accounts of lived experiences with varying outcomes are included, along with strategies to aid practitioners in improving care and understanding of babies and families impacted by GBS. The book concludes with clarification of common misconceptions and discussion of future directions in prevention and treatment options. This comprehensive reference offers evidence-based insights aimed at enhancing practice and ultimately improving perinatal outcomes.

  • Retinoic Acids in Cancer Therapy

    Mechanisms of Sensitivity, Resistance, and Methods of Delivery
    • 1st Edition
    • Volume 23
    • Saeid Ghavami + 2 more
    • English
    Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides an overview of how All-Trans Retinoic Acid (ATRA) kills cancer cells and how some cells survive treatment. Focusing on the cellular pathways and compartments involved in ATRA-mediated inhibition of proliferation, this book also discusses how aggressive tumors develop escape routes conferring retinoic acid resistance.Across 15 chapters, it describes the molecular structure and biological properties of ATRA, explains mechanisms of resistance, and defines ATRA’s efficacy in seven cancer types. It concludes with chapters on ATRA and cancer stem cell biology, strategies to improve treatment, future therapeutic perspectives, and delivery methods to reduce toxicity and enhance anticancer efficacy.Each chapter includes Learning Objectives and a “What We Learn” section, making the book highly accessible for undergraduate, graduate trainees, scientists, physicians, and biotech companies. Adding simple, attractive schemes and informative tables makes it ideal for all interested in the current status of Retinoic Acids in Cancer Therapy. This book serves as a valuable resource for health professionals, scientists, researchers, clinical practitioners, and all those seeking to broaden their knowledge and develop new drugs or therapeutic strategies to improve ATRA’s efficacy in the treatment of resistant cancers.

  • Deep Learning Applications in Neuroinformatics

    Advances, Methods, and Perspectives
    • 1st Edition
    • Karthik Ramamurthy
    • English
    Deep Learning Applications in Neuroinformatics: Advances, Methods, and Perspectives explores how deep learning revolutionizes neuroinformatics, covering the latest methods and applications of deep learning in analyzing neuroimaging data from EEG, MRI, PET, and more. The book addresses critical neurological disorders like Alzheimer’s disease, Mild Cognitive Impairment, Stroke, and Autism Spectrum Disorder, bridging the gap between neuroscience and artificial intelligence. It is an ideal resource for researchers, practitioners, and students with insights from leading experts.

  • The Gut Microbiome in Precision Medicine

    From Research to Clinical Practice
    • 1st Edition
    • S. Rehan Ahmad
    • English
    The Gut Microbiome in Precision Medicine: From Research to Clinical Practice explores the significant role of the gut microbiome in health and disease, particularly within gastrointestinal conditions such as inflammatory bowel disease, irritable bowel syndrome, and colorectal cancer. It covers how understanding and analyzing the gut microbiome can lead to personalized treatments, dietary plans, and precision medicine approaches in gastroenterology. Chapters explore multi-omics integration, examining complex techniques for gut microbiome profiling, including genomics, transcriptomics, proteomics, and metabolomics. Users will find updates on microbiome-based interventions, such as probiotics, prebiotics, and personalized nutrition that highlight practical applications in gastrointestinal disease management. Real-world examples and case studies discuss strategies for overcoming barriers to implementing microbiome analysis. Additionally, it addresses the challenges and opportunities of implementing microbiome analysis in clinical practice, with a special emphasis on its implications for developing countries. Finally, the book covers emerging technologies in microbiome research and their applications in gastroenterology, emphasizing future directions and research priorities.

  • Lipids and Membranes: Dynamics and Interorganelle Lipid Transport

    • 1st Edition
    • Volume 727
    • English
    Lipids and Membranes: Dynamics and Interorganelle Lipid Transport, Volume 728 covers lipids, a chemically diverse set of biological molecules subject to rapid metabolism and transport. This dynamic behavior has motivated the development of methods across multiple disciplines for their detection and manipulation. Split into three parts, the book's chapters include topics such as Assay of phospholipid scrambling, Tracking lipid transport with bifunctional lipids, Tracking interorganelle lipid transport using genetically encoded mass tags, Molecular Dynamics Simulation of Lipid and Ligand Binding in ORD Domains, Imaging lipid droplet-organelle membrane contact sites using fluorogenic complementation, Studying interactions of amphipathic helices with lipid droplets, and more.Additional chapters cover Metabolic labeling of to trace changes in sphingolipid metabolism, Imaging intracellular lipid heterogeneity with fluorogen-activated coincidence sensing, Tagging lipoproteins in mycobacteria, Probes for studying sphingolipid dynamics, Measuring Flipper-TR Lifetime with Multiple Analysis Strategies, Reconstitution approaches to understanding cellular lipid dynamics, Prediction and characterization of the bacterial lipid handling machinery, From Molecular Dynamics to Cryo-EM: Imaging Liposomes in Silico, and much more.

  • Cutting Edge Advances in Transplantation

    • 1st Edition
    • Dai Dao Nghiem
    • English
    Cutting Edge Advances in Transplantation presents the current state of the science of transplantation. With a unique interdisciplinary approach, this reference collects contributions from selected transplant surgeons, scientists, and immunologists who have worked in the field for the last thirty years. Coverage includes transplantation tolerance, the molecular approach to transplant monitoring, sensitized transplant recipients, xenotransplantation, biologics, and regifted organs. This is the perfect reference for transplant surgeons and nephrologists that want to find new approaches and solutions to serve their patients. It is also ideal for transplantation researchers looking for the most up-to-date scientific information related to the field which can be built upon.

  • Encyclopedia of Endocrine Diseases

    • 3rd Edition
    • Ilpo Huhtaniemi
    • English
    The Encyclopedia of Endocrine Diseases, Third Edition, Five Volume Set is an essential one-stop reference exploring physiological, clinical diagnostic and therapeutic aspects of a wide range of endocrine and endocrine-related metabolic diseases. This edition incorporates ground-breaking research that has occurred in the last 8 years particularly in molecular mechanisms such as mutations, epigenetics and signaling, environmental effects on homeostasis, and the pathogenesis of common endocrine diseases including endocrine malignancies, obesity, and diabetes.Among the most complex constructs in the body, the endocrine system sends chemical signals to specific receptors in other parts of the body, eliciting intracellular signaling pathways as their biological effect. The endocrine system regulates numerous processes including metabolism, biological cycles, internal fluid volume, reproduction and growth to maintain body homeostasis. However, the ways in which endocrine functioning can go awry are numerous. Providing over 420 updated articles, this 5 volume edition of Encyclopedia of Endocrine Diseases explores the extensive spectrum of metabolic and endocrine disease, capturing new diagnosis techniques, treatment methods and understanding of endocrine pathogenesis.This text, unique in its vast coverage and clear layout, is not only an indispensable resource for clinical professionals and researchers in endocrinology, but also accessible to advanced and undergraduate students.

  • The Story of GLP-1

    A Historical Journey in the Treatment of Diabetes and Obesity
    • 1st Edition
    • Jens Juul Holst
    • English
    The Story of GLP-1: A Historical Journey in the Treatment of Diabetes and Obesity offers a compelling narrative about the discovery and development of the hormone GLP-1, which has revolutionized modern approaches to diabetes and obesity. Award-winning scientist Professor Jens Juul Holst, alongside co-authors Professor Sten Madsbad, Professor Jens Meldgaard Bruun, and Novo Nordisk Foundation CEO Mads Krogsgaard Thomsen, trace the scientific breakthroughs and clinical advances that have made GLP-1 therapies, such as Ozempic and Wegovy, essential tools for improving blood sugar control and promoting meaningful, lasting weight loss in patients worldwide.The book explores the rising global prevalence of obesity and diabetes, emphasizing the urgent need for innovative solutions. It critically examines traditional treatments, noting their limitations in sustaining weight loss or reducing complications. The narrative details the paradigm shift brought by GLP-1 medications, including liraglutide and semaglutide, which offer improved cardiovascular outcomes and significant health benefits. The authors also address ongoing challenges of accessibility and affordability, prompting important societal discussions about equitable distribution and funding for these lifechanging therapies.

  • Diabetes, Aging, and Management Strategies

    Cellular Mechanisms for Healthy Aging
    • 1st Edition
    • Younis Ahmad Hajam + 2 more
    • English
    Diabetes, Aging, and Management Strategies: Cellular Mechanisms for Healthy Aging is a comprehensive guide that explores the complex interplay between diabetes and the aging process. The book dives deeply into the scientific mechanisms underlying diabetes and aging, offering insights into how aging accelerates disease processes and affects metabolic pathways, organ function, and overall health. With a focus on the biological, clinical, and practical aspects of diabetes in the elderly, this book provides actionable information on the pathophysiology of diabetes in aging individuals, evidence-based mitigation strategies, and effective management approaches.As populations worldwide grow older, the prevalence of diabetes continues to rise, presenting new challenges in understanding, managing, and mitigating the effects of this condition on older adults. This book is designed to support healthcare professionals, researchers, and policymakers in creating and implementing strategies that address the unique needs of this population.

  • Harnessing the Potential of Blockchain Technology in the Smart Healthcare

    • 1st Edition
    • Pankaj Bhambri + 2 more
    • English
    Harnessing the Potential of Blockchain Technology in the Smart Healthcare explores a groundbreaking shift in how healthcare data are managed, shared, and secured. This book is an essential guide for anyone seeking a deep understanding of the intersection between blockchain and healthcare. It breaks down complex blockchain concepts and reveals their transformative impact on the industry.Across 27 insightful chapters, the readers will discover how blockchain can not only revolutionize electronic health records, strengthen data security and privacy, and streamline healthcare operations, but also empower patients with greater control over their health information.Through real-world case studies, expert insights, and practical strategies, the book equips healthcare professionals, technologists, and policymakers with the tools to leverage blockchain for a more efficient, transparent, and patient-centered healthcare system.By examining real-world applications and implementations, this book not only informs but also inspires action—paving the way for a future where healthcare is smarter, safer, and more equitable.

  • Sports Biomechanics

    Theories, Examples, and Data Analysis
    • 1st Edition
    • Boyi Dai + 2 more
    • English
    Sports Biomechanics: Theories, Examples, and Data Analysis provides mechanical theories, data-based examples, and step-by-step analyses in MATLAB, giving a comprehensive understanding of the process of performing biomechanical analysis in sports. The book connects theories with principles of data collection and offers specific data analysis techniques. It addresses gaps among theories, raw data from various collection methods, different calculations to process raw data in MATLAB, and the extraction of variables of interest to quantify sports performance and injury risk. Sample raw data, videos, figures, and MATLAB scripts are provided, along with theories to calculate key parameters in different sporting events and movements.Readers are encouraged to replicate the data collection and data analyses listed in the book and translate the knowledge and skills to a different setting. While this book covers the data analyses in MATLAB, programming skills can be related to other software with similar language environments to help readers ask questions and understand different parameters when using software performing automatic data processing.

  • Artificial Intelligence and Brain-Computer Interfaces in Healthcare

    • 1st Edition
    • Chandra P. Sharma + 3 more
    • English
    Artificial Intelligence and BCIs in Healthcare discusses the essentials of state-of-the-art brain signal analysis, AI, and BCIs available today. This book is an ideal bridge of these emerging technologies. Divided into three sections, the chapters cover the Fundamentals, Applications, and Regulatory Issues facing healthcare systems today. Artificial Intelligence and BCIs in Healthcare fills a gap in literature available to researchers and may also be of interest to clinicians.

  • Biomechanics of the Human Spine

    Basic Concepts, Spinal Disorders and Treatments
    • 2nd Edition
    • Fabio Galbusera + 1 more
    • English
    Biomechanics of the Human Spine: Basic Concepts, Spinal Disorders and Treatments, Second Edition is an essential resource for both biomedical engineers and spinal surgeons. The book is divided into four key sections, each building on the previous to offer a thorough understanding of spine biomechanics. It starts with the functional anatomy of the spine, emphasizing often overlooked aspects of clinical literature. The second section details the mechanics of spinal tissues, including testing setups and mathematical models. The third section explores contemporary spine research methods, while the final section addresses biomechanical aspects of spinal pathologies and their surgical treatments.Contribut... from leading institutions worldwide ensure the inclusion of the latest research and expertise in spine biomechanics. Highlights include in-depth experimental testing, numerical simulation, and in vivo studies, such as imaging and motion analysis. The book stands out for its comprehensive approach, bridging the gap between biomechanical knowledge and clinical application. It is indispensable for professionals in the field, offering valuable insights and practical guidance for understanding and treating spinal disorders.

  • Robotic Platforms for Minimally Invasive Surgery

    • 1st Edition
    • Francisco M. Sánchez-Margallo + 1 more
    • English
    Robotic Platforms for Minimally Invasive Surgery provides a concise and solid overview of the primary robotic systems currently employed in minimally invasive surgical practice. Combiningtechnical description with clinical insights, the book serves as a practical reference for surgeons,researchers... and healthcare professionals beginning to engage with robot-assisted procedures.This book examines established platforms across laparoscopic, endoscopic, and microsurgicalapproac... It describes system design and functionality, complemented by a thorough review ofsafety, feasibility, and clinical outcomes. By seamlessly integrating engineering concepts with surgical applications, its content equips readers with a well-de ned framework for understanding both the potential and limitations of robotic technologies in minimally invasive surgery.

  • Comprehensive Integrative Oncology

    • 1st Edition
    • Suzanna Zick + 1 more
    • English
    Comprehensive Integrative Oncology is a vital resource for clinicians who seek to blend integrative therapies with conventional oncology care to enhance patient outcomes. This book, authored by experts in both conventional and integrative medicine, emphasizes a holistic approach to cancer treatment. It provides practical guidance on incorporating scientifically-backe... therapies like botanicals, supplements, mind-body practices, lifestyle changes, nutrition, and exercise into standard cancer care, all while prioritizing patient safety, prevention, and overall wellness. The book delves into the philosophy of integrative oncology, offers tools for practical application, and presents integrative strategies for cancer prevention and symptom management.Additiona... it explores the needs of special populations within oncology. It serves as an indispensable textbook for oncology researchers and practitioners who aim to provide holistic and patient-centered care.

  • Fetal Programming

    The Connection between Nutrition and Disease
    • 1st Edition
    • Miljana Z. Jovandaric
    • English
    Fetal Programming: The Connection between Nutrition and Disease covers the intestinal microbiota of newborns, how it is extremely prone to changes influenced by the method of delivery, diet, use of antibiotics and probiotics by the mother, environment, socioeconomic status of the mother, geographical location, infections with pathogenic microorganisms, and more. The book describes the root of disease—oxidative stress and improper nutrition—and how they specifically effect pregnancy. In recent years, it has become more and more evident that nutrition is crucial for the proper development of the immune system of the fetus, and its disruption can lead to disease.This period in a newborn’s life is crucial for interventions on the intestinal microbiota in order to reduce the risks of developing chronic diseases by correcting dysbiosis.

  • Cognitive and Meta Learning Strategies in Biomedical Research and Healthcare

    • 1st Edition
    • Chinmay Chakraborty + 2 more
    • English
    Cognitive and Meta Learning Strategies in Biomedical Research and Healthcare examines the dynamic intersection of cognitive science and meta-learning within the realm of biomedical research. It addresses how to overcome the complexities of contemporary health challenges by harnessing the power of advanced learning methodologies, such as cognitive processes and meta learning.

  • Animal Models of Disease Part E

    • 1st Edition
    • Volume 203
    • English
    Animal Models of Disease, Part E, Volume 203 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

  • Profiles of Drug Substances, Excipients, and Related Methodology

    • 1st Edition
    • Volume 51
    • English
    Profiles of Drug Substances, Excipients, and Related Methodology, Volume 51 provides comprehensive profiles of four pharmaceutical compounds: Vortioxetine, Rosuvastatin Calcium, Perindopril, and Ferulic Acid. In addition, it includes a review article concerning Drugs and Polymer Based Local Delivery Systems in the Treatment of Periodontal Diseases. Chapters in this new release include Vortioxetine: A Comprehensive Profile, Rosuvastatin Calcium: A Comprehensive Profile, Ferulic Acid: A Comprehensive Profile, Perindopril: A Comprehensive Profile, Drugs and Polymer Based Local Delivery Systems in the Treatment of Periodontal Diseases, Kinetic Exclusion Assay Technology: Theory, Experimental Aspects, and Applications in Concentration Measurements Across Diverse Fields, and more.No other book series provides this essential information as promptly and pertinently. Sections provide review articles and database compilations categorized into five primary domains: Physical Profiles of Drug Substances and Excipients; Analytical Profiles of Drug Substances and Excipients; ADME Profiles of Drug Substances and Excipients; Methodology Pertaining to the Characterization of Drug Substances and Excipients; and Methods of Chemical Synthesis.

  • Live Biotherapeutics: Advancing Microbial Medicine

    • 1st Edition
    • Volume 220
    • English
    Microbial therapeutics are rapidly reshaping modern medicine, with live biotherapeutics emerging as a promising frontier. By harnessing the power of beneficial microbes, these innovative treatments offer new hope for conditions that resist conventional drugs, including metabolic disorders and antimicrobial-resist... infections. As the demand for safer, more effective alternatives grows, understanding this field becomes increasingly vital. The upcoming book, Live Biotherapeutics: Advancing Microbial Medicine, will provide a comprehensive and accessible overview of the science, applications, and future potential of live biotherapeutics in transforming healthcare.

  • Lipids and Membranes: Detection by Imaging and Lipidomics

    • 1st Edition
    • Volume 726
    • English
    Lipids and Membranes: Detection by Imaging and Lipidomics, Volume 727 covers lipids, a chemically diverse set of biological molecules subject to rapid metabolism and transport. This dynamic behavior has motivated the development of methods across multiple disciplines for their detection and manipulation. Split into three parts, the chapters in this new release include Measurement of fatty acid esters of hydroxy fatty acids, Superresolution organelle imaging with lipophilic HIDE probes, Ultra-high resolution analysis of membrane lipids from 15N metabolically labeled mice, Superresolution lipid imaging with expansion microscopy, High-resolution phosphoinositide analysis in healthy versus disease cells, and much more.Additional chapters focus on Alkyne lipids as tracers of lipid metabolism, Imaging oxidative stress in biomembranes, Imaging the dynamics of phosphatidylinositol 4-phosphate metabolism, Lipidomics for studying sphingolipids in cell death, Non-invasive imaging of phosphoinositides with genetically encoded lipid biosensors, Profiling lipotypes at the single cell level in heterogenous populations, MS imaging of phosphoinositides, and much more.

  • Circulating Biomarkers for Diagnosis, Prognosis and Treatment Response Prediction in Cancer - Part B

    • 1st Edition
    • Volume 399
    • English
    Circulating Biomarkers for Diagnosis, Prognosis and Treatment Response Prediction in Cancer Patients, Part B delves into the crucial role of circulating biomarkers in cancer diagnosis and treatment monitoring. Specific chapters in this new release include Liquid biopsy approaches to capture minimal residual disease and therapy response in patients with early stage cancers, Identification of circulating biomarkers for cancer therapy-related cardiovascular toxicity, Extracellular Vesicles as Dynamic Biomarkers: Monitoring Therapeutic Responses and Drug Resistance in Cancer, and more.This comprehensive work explores the various types of biomarkers, their significance in early cancer detection, prognostication, and evaluation of therapeutic responses. It covers cutting-edge research on circulating tumor cells, cell-free DNA, exosomes, and other biomarkers that can revolutionize cancer management. Additionally, it discusses the challenges, advancements, and future prospects of utilizing circulating biomarkers in personalized cancer care.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 131
    • English
    Advances in Clinical Chemistry, Volume 131 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Advances in Volatile Organic Compound Biomarker Detection, 2D-DIGE proteomics, Interacting partners of Tau protein in Alzheimer’s disease, Biosensors for Detection of Autoimmune Disease, Small Molecule Biomarkers in Infectious Disease, and Diagnosis and Risk Factors in Pancreatogenic Diabetes. Each chapter is written by an international board of authors.

  • Mathematical Modeling and AI-Driven Computational Techniques for Epidemiology and Disease Dynamics

    • 1st Edition
    • Sayooj Aby Jose + 2 more
    • English
    Mathematical Modeling and AI-Driven Computational Techniques for Epidemiology and Disease Dynamics offers a comprehensive exploration of innovative methodologies at the intersection of mathematics, biology, and medicine. This book delves into advanced mathematical modeling, artificial intelligence, and computational intelligence, providing essential tools for understanding and managing complex disease dynamics. Covering a wide range of topics, including fractional-order modeling, optimal control strategies, and privacy-preserving technologies, it addresses critical challenges in public health and healthcare systems. With contributions from leading experts, this volume bridges theoretical advancements and practical applications, making it an invaluable resource for researchers, healthcare professionals, and academics seeking interdisciplinary solutions to global health issues.

  • Cutting-Edge Nanocarrier-Based Strategies in the Management of Leukaemia

    • 1st Edition
    • Devesh U. Kapoor + 2 more
    • English
    Cutting-edge Nanocarrier-Based Strategies in the Management of Leukaemia addresses the importance of nanocarriers in leukemia treatment. The book explores advancements in nanotechnology, highlighting therapies like siRNA, miRNA, and gene therapy that improve patient outcomes. Sections provide an introduction to leukemia, covering its epidemiology and risk factors, discuss innovative therapies and the use of various nanocarriers, such as polymeric nanoparticles, liposomes, dendrimers, and hydrogels, and discuss precision medicine, AI in leukemia care, and strategies to overcome treatment resistance. The book is enriched with tables, figures, and images, giving healthcare providers, including physicians, immunologists, oncologists, and pharmacists an invaluable resource on cutting-edge therapies.

  • Episodes in the History of Medical Science

    Discovery Meets Orthodoxy
    • 1st Edition
    • Anthony R. Rees
    • English
    Episodes in the History of Medical Science: Discovery Confronts Orthodoxy highlights key moments in history where scientific and medical advances faced acceptance and rejection by the prevailing orthodoxy. This book places present-day disease protection in context by exploring significant medical and scientific theories, their success stories, challenges, and the frequent resistance to new ideas. It shows how acceptance of scientific discoveries often lags due to conservatism within the scientific community and broader socio-political and cultural influences. The book examines the origins of medical theory and practice, from the revolutionary ideas of Hippocrates and Galen to the rise of Islamic Medicine and the scholasticism of the Middle Ages. It covers the arrival of syphilis in Europe and the ensuing medical debates, the historical battle against smallpox through variolation and vaccination, and the skepticism faced by groundbreaking discoveries in the 19th and 20th centuries. Key topics include the gene debate, the thalidomide tragedy, the antibody revolution, and the paradigm shift in understanding stomach ulcers. The narrative also addresses the modern era's anti-vaccinationism and vaccine hesitancy, emphasizing the ongoing tension between scientific integrity and public acceptance. Episodes in the History of Medical Science: Discovery Confronts Orthodoxy is a valuable resource for medical professionals, researchers, historians, and students. It underscores the importance of scientific and medical integrity, the pursuit of truth, and validated scientific communication. By providing historical insights and examples of perseverance in the face of skepticism, this book offers valuable lessons for improving public health and understanding the dynamic journey of medical science.

  • Translational Cardiothoracic Surgery

    • 1st Edition
    • Adam E.M. Eltorai
    • English
    Translational research is essential to the advancement of medicine. This Cardiothoracic-speci... instructional guide to translational medical research serves as a practical, step-by-step roadmap for taking a biomedical device, potential therapeutic agent, or research question from idea through demonstrated clinical benefit. Fundamentally, the volume aims to help bridge the gap between current research and practice. Written by a team of expert medical, biomedical engineering, and clinical research experts in cardiothoracic surgery, this volume provides a clear process for understanding, designing, executing, and analyzing clinical and translational research within the field.

  • Comprehensive Chemistry and Biology of Coumarins Scaffold

    • 1st Edition
    • Shehryar Hameed + 2 more
    • English
    Comprehensive Chemistry and Biology of Coumarins Scaffold covers detailed methods and protocols to synthetize Coumarin derivatives and different applications and future perspectives for these compounds. Coumarin-Based Scaffolds plays an important role in organic, bioorganic, and medicinal chemistry as they act as a bridge between chemistry, life sciences, and biochemical investigations. Coumarin is an important scaffold for designing, generating a wide variety of chemical libraries and drug-like candidates to obtain desired therapeutic and pharmacological properties. Specific functional groups are covered as well as the synthesis of bioactive compounds against specific pathological conditions.The discovery of new coumarin-based drug candidates during the last decades has been covered to assist the pharmaceutical, bioorganic and medicinal chemists for their further research on coumarin-based molecules.

  • Microglial Aging

    Basic, Translational and Clinical Advances
    • 1st Edition
    • Marie-Eve Tremblay
    • English
    Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.

  • Hematological Insights and Clinical Implications of Platelet Functions in Lymphatic Filariasis

    • 1st Edition
    • Jyotsna Kailashiya
    • English
    Hematological Insights and Clinical Implications of Platelet Functions in Lymphatic Filariasis is a groundbreaking resource that delves into the impact of filarial parasites on platelet functions in humans. This comprehensive work explores the intricate signaling and immunological pathways affected by these interactions, filling a significant gap in the existing literature. The book is particularly valuable for researchers, scientists, and clinicians involved in the management and study of lymphatic filariasis, commonly known as elephantiasis; and also human platelets. With limited prior information on the interplay between human platelets and filarial parasites, this text offers a fresh perspective that could enhance patient management strategies. By understanding these interactions, healthcare professionals may unlock new avenues for effective treatment and prevention of lymphatic filariasis. This book is essential for anyone looking to deepen their understanding of the disease and contribute to its potential elimination.

  • Mitochondria and Cancer

    From Basic Science to Clinical Applications – Understanding Pathogenesis, Therapy Resistance, and Disease Relapse
    • 1st Edition
    • Farzad Taghizadeh-Hesary + 3 more
    • English
    Mitochondria and Cancer: From Basic Science to Clinical Applications—Underst... Pathogenesis, Therapy Resistance, and Disease Relapse offers comprehensive perspectives about the role of mitochondria in cancer biology and treatment. This book integrates fundamental scientific knowledge with clinical relevance, presenting recent findings that will engage oncology researchers and provide valuable recommendations for cancer prevention and prognosis. In response to the rising global cancer incidence, this book serves as a comprehensive guide to mitochondrial metabolism in oncology, furthering cancer study and management. It explores a wide range of topics that highlight the multifaceted role of mitochondria in cancer, including tumor microenvironment, cancer stem cells, microbiota, resistance mechanisms, mitochondria-enhanci... strategies, and targeted therapies. It includes technical details, research findings, and discussions on the implications of mitochondrial research in cancer treatment and management. Its distinguishing aspects include its comprehensive coverage and diverse perspectives from global experts, providing a well-rounded view of current research.

  • ATP

    From Neurotransmission to Cancer Therapy
    • 1st Edition
    • Ronald Sluyter + 5 more
    • English
    ATP: From Neurotransmission to Cancer Therapy delivers a comprehensive discussion of extracellular ATP biology and its communication role in both homeostasis and pathologic states. It explores the function of ATP across the nervous, sensory, musculoskeletal, cutaneous cardiovascular, pulmonary, gastrointestinal, urinary, reproductive, exocrine, haematopoietic and immune systems. The book considers ATP in the context of various disease states, including cardiovascular, respiratory, psychiatric, inflammatory and neurodegenerative disorders, as well as pain and sensory disorders, infectious diseases, and cancer. ATP in humans is explored alongside other species, including rodents, fish, and plants. This is the latest volume in the “Molecular Mediators in Health and Disease” series. With contributions from specialists across pharmacology, physiology, biophysics, biochemistry, immunology, anatomy, molecular biology, therapeutics, and other critical fields, this volume provides a broad and detailed overview of ATP which will be helpful to researchers working in these areas and beyond.

  • Marine Microbial Products

    Applications and Opportunities
    • 1st Edition
    • Sesan Abiodun Aransiola + 2 more
    • English
    Marine Microbial Products: Applications and Opportunities delves into the extensive world of marine microbes, an assemblage of organisms that contain a broad array of bioactive chemicals. Written and edited by a diverse team of environmental microbiologists, this book provides readers with a foundational understanding of marine microbial taxa, the products that may be synthesized from these organisms, technological innovations, and future directions of research. Chapters collate the most current research in healthcare, sustainability, and commercial production, presenting readers with the latest information on antibiotics, antivirals, anticancer therapeutics, immunosuppressive chemicals, bioremediation, food processing, biofertilizers, biopesticides, cosmetics, pigments, probiotics, and functional foods.The book is structured for accessibility to academic and professional audiences, spanning a variety of sectors. It is an indispensable resource for students, professors, researchers, and industry professionals in biology, biotechnology, sustainable development, food, healthcare sciences, and adjacent industries.

  • Immuno-oncology and Immunotherapy Part G

    • 1st Edition
    • Volume 202
    • English
    Immuno-oncology and Immunotherapy, Part G, Volume 202 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including In situ imaging of pulmonary invariant Natural Killer T cells in precision cut lung slices, Immunofluorescent microscopy to quantify and characterize chromosomal instability, Spatial techniques for understanding the tumor microenvironment, Very high-flex immunophenotyping using co-linear cytofluorometric evaluation, Large-scale CRISPR-Cas9 screens to define regulators of immune checkpoint biology, Assessment of cytoplasmic dsDNA for cellular immunogenicty, and much more.Additional sections cover Harmonization of a multiparametric flow cytometry panel for immunological monitoring on PBMC and whole blood samples: a real-life example, Quantitative assessment of arterial remodeling from confocal microscopy image analysis of the mid-gestation mouse decidua, Phenotypic characterization and function of tumor infiltrating and peripheral B cells in cancer patients, Methodological Advances to analyze Cancer-Associated Fibroblast-derived ECM effects on Macrophage Polarization, and many other topics that will be of interest to readers.

  • Endocrine and Metabolic Emergencies, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 55-1
    • George C. Willis + 1 more
    • English
    In this issue of Emergency Medicine Clinics, guest editors Drs. George Willis and Bennett A. Myers bring their considerable expertise to the topic of Endocrine and Metabolic Emergencies. Endocrine and metabolic emergencies, both those that are commonly encountered in day-to-day emergency medicine and those that are rarely seen, can result in serious complications that can be life-threatening if not recognized, diagnosed, and appropriately managed. In this issue, top experts in the field cover key topics such as diabetic ketoacidosis; hyperosmolar hyperglycemic state; disorders of sodium and potassium; hypoglycemia; and more.

  • Connected Diagnoses

    IoT, Healthcare, and Digital Forensics
    • 1st Edition
    • Keshav Kaushik + 1 more
    • English
    Connected Diagnoses: IoT, Healthcare, and Digital Forensics investigates the complex intersection of IoT, healthcare, and digital forensics. The book explores the intricate relationships between these fields, with a focus on cybersecurity, patient data ethics, and challenges in IoT investigations. It advances knowledge on leveraging IoT securely to enhance patient care and digital forensic analysis, providing significant insights from experts along with practical guidance for those operating at the crossroads of these critical disciplines. The book helps professionals grasp, adapt to, and capitalize on the interconnected nature of emerging technologies to ensure ethics, security, and safety. Users will find this to be a comprehensive resource that benefits researchers and practitioners who seek to understand the convergence of medical technology, interconnected devices, and digital forensics.

  • Cushing Syndrome

    History, Diagnosis and Treatment
    • 1st Edition
    • Constantine A. Stratakis
    • English
    Cushing Syndrome: History, Diagnosis, and Treatment is written by top experts on the latest in genetics, molecular advances, and the diagnosis and treatment of Cushing syndrome. The book takes a historical approach to discuss the tremendous and unprecedented research development for this rare condition and includes information on recently approved treatments. It attempts to provide information on most issues surrounding Cushing syndrome and how to deal with its complications, the widening understanding of functional hypercortisolemia and other causes of endogenous cortisol production and its old and new treatment modalities, from pituitary to adrenal tumors, ectopic ACTH production, subclinical, cyclical Cushing syndrome, to aging and metabolic syndrome.The book has a section dedicated to our patients with the patients’ experiences, which will add to the outcome research presented by the physicians. This is a must have reference for scientists and researchers with the latest information in diagnosing and treating this difficult-to-diagnos... and difficult-to-treat condition and gives the clinician, a patient-centric approach to communicate with this particular group of patients.

  • Molecular Horticulture & Advances in Production System Technology

    • 1st Edition
    • Volume 117
    • English
    This volume offers a comprehensive overview of cutting-edge developments in horticultural science. This authoritative collection features expert reviews on the molecular genetics and genomics of key species, including faba bean, tomato, celery, lily, and broccoli, elucidating the mechanisms behind yield, quality, and bioactive compounds. The volume also explores innovative and sustainable cultivation techniques, with in-depth analyses of controlled environment agriculture for leafy greens, the use of organic substrates, and the sensory implications of sustainable practices for Brassica oleracea. Crucial insights into the molecular control of pre- and post-harvest traits, this essential text provides researchers, students, and professionals with a forward-looking synthesis of modern horticultural science and its practical applications.

  • Design and Applications of Cell-Free Systems Part B

    • 1st Edition
    • Volume 219
    • English
    Design and Applications of Cell-Free Systems, Part B, Volume 219 offers the latest information on cell free systems for the expression of transmembrane proteins, enzymes, proteins, therapeutics, vaccines, and uses in the biotransformation, translational modification, self-assembly of nano-biomaterials, and in synthetic biology design, challenges, and opportunities. It will help students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners understand cell-free systems and their applications in many areas. The book represents an important component in the field of biochemistry, duly acknowledging the pioneering effort made by Nobel laureate Eduard Buchner for discovery of fermentation in yeast cell extracts (YCE).CFS requires core molecular machinery, including RNA polymerase, translational apparatus (ribosomes, tRNA synthases, and translation factors), energy-generating molecules, and their cofactors, substrates, and DNA or plasmid templates for obtaining desired products. CFS is a simple, rapid, and sensitive platform, which is devoid of membrane-bound barriers, yet contains all the mandatory substrates, biomolecules, and machineries required for the synthesis of the desired proteins.

  • Recent Advances in Bioelectromagnetism and Subtle Energies

    Implications for Health and Disease
    • 1st Edition
    • Jan Martel
    • English
    Recent Advances in Bioelectromagnetism and Subtle Energies: Implications for Health and Disease explores the new findings and emerging concepts in the fields of electromagnetism and human health. This book examines a range of topics from a biophysical and holistic perspective, including the effects of native and manmade electromagnetic fields on living organisms, the role of oxygen in cellular energy production, the intricacies of the human biofield, coherence in cellular and human health, quantum biology phenomena, the history and evolution of electrosensitivity, the development of electromagnetic hygiene, and promising healing modalities. Each chapter provides key insights about the biological effects of electromagnetic fields and their impact on human health and disease development, providing an ideal reference for scientists and readers interested in the recent advances in these areas.

  • Simulating Protein Folding in Variable Environmental Conditions

    Transformation from Globular Proteins to Amyloids
    • 1st Edition
    • Irena Roterman-Konieczna
    • English
    Simulating Protein Folding in Variable Environmental Conditions: Transformation from Globular Proteins to Amyloids delves into the effects of external conditions upon the protein folding process. The book considers how this can lead to amyloid formation and why proteins fold the way they do. It presents the fuzzy oil drop model (FOD-M), which enables the measurements of external factors influencing the folding process and considers changed external conditions as the source for the misfolding process. Sections provide an introduction to amyloid transformation and outline the hypothesis of the model simulation before considering the role of environmental factors, including the water environment and membrane environment. This book is a useful resource for researchers interested in investigating protein folding across molecular biology, structural biology, biochemistry, computational biology and related fields.

  • Proteomics: A Promising Approach for Cancer Research

    Proteome Signaling Dysregulation in Cancer, Therapeutic Interventions, and Future Perspectives, Volume 2
    • 1st Edition
    • Muneeb U Rehman + 3 more
    • English
    Proteomics: A Promising Approach for Cancer Research Volume 2 Proteome signaling dysregulation in cancer, therapeutic interventions, and future perspectives provides an updated overview of scientific knowledge, achievements, and findings in the field of cancer proteomics. The field of cancer proteomics is very dynamic, with emerging trends specifically related to clinical solutions. The book content was developed to help readers get up to speed on the topic and easily apply learnings into research or clinical practice.Volume 2 covers proteome signaling, their dysregulation to therapeutics options and future prospects in 17 different signaling pathways. It capitalizes the enormous interest in proteomics among academics and gives new viewpoints on this topic in cancer treatment. It is a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment.

  • How Sex and Gender Impact Clinical Practice

    An Evidence-Based Guide to Patient Care
    • 2nd Edition
    • Marjorie R. Jenkins + 1 more
    • English
    How Sex and Gender Impact Clinical Practice: An Evidence-Based Guide to Patient Care, Second Edition, is an essential resource for primary care clinicians seeking to integrate sex and gender differences into their practice. This edition emphasizes the unique framework that assists practitioners in providing personalized care. It aligns sex and gender medicine with precision medicine, helping healthcare providers attract patients who value clinicians that understand the nuances of sex and gender in healthcare.How Sex and Gender Impact Clinical Practice: An Evidence-Based Guide to Patient Care, Second Edition, includes updates on the evidence-based information on disease prevalence, diagnosis, testing, and treatment, as well as a new chapter on the sex and gender aspects of pain. Each chapter reflects how sex and gender impact disease presentation, physical examination, testing, treatment, and clinical decision-making.

  • Quantum Computing in Medicine

    Transforming Drug Discovery, Protein Folding, and Genomics Research through Artificial Intelligence Integration
    • 1st Edition
    • Don Roosan
    • English
    Quantum Computing in Medicine: Transforming Drug Discovery, Protein Folding, and Genomics Research through Artificial Intelligence Integration offers an insightful examination of the groundbreaking role of quantum computing in revolutionizing aspects of the medical industry. This book focuses on the profound impact that quantum computational capabilities are poised to have on drug discovery, protein folding, and, notably, genomics research. It outlines the fundamental principles of quantum computing and its complementary relationship with artificial intelligence (AI), highlighting their combined potential to solve intricate biological problems with unparalleled speed compared to traditional computational methods. Special emphasis is placed on the advancements and research efforts in leveraging quantum algorithms for the analysis of genetic data, the acceleration of genomic sequencing processes, and the enhancement of personalised medicine strategies. By providing a thorough exploration of practical applications and the current state of quantum computing in genomics, the book navigates through the challenges and ethical implications of integrating these forward-thinking technologies into healthcare systems. Aimed at professionals, scholars, and enthusiasts within the realms of medicine, computer science, and quantum physics, "Quantum Computing in Medicine" offers a forward-looking perspective on the future of genomics research and healthcare, illuminated by the innovative light of quantum computing and AI.

  • Translational Plastic Surgery

    • 1st Edition
    • Adam E.M. Eltorai + 4 more
    • English
    Translational Plastic Surgery provides a comprehensive overview reflecting the depth and breadth of the field of translational research focused on plastic surgery, with input from a distinguished team of basic and clinical investigators. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in translational plastic surgery research, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all.

  • Climate Change, Public Health, and Regional Security in the Indo-Pacific

    From Mitigation to Adaptation
    • 1st Edition
    • Sebastian Kevany
    • English
    Climate Change, Public Health, and Regional Security in the Indo-Pacific: From Mitigation to Adaptation addresses the absence of solutions to looming and inevitable regional security, health, and environmental threats. To date, there has not been a comprehensive solution-based focus on climate change in the region that includes subjects such as acceptance of the consequences; implications for humanitarian assistance and disaster relief; the role of defense forces in managing migration, climate refugees, infectious diseases, and related issues such as flooding or land use change; and a further focus on climate change and implications for public health in the Indo-Pacific. This book addresses these issues and provides strategies for those living and working in the region. Written by regional experts for public health, security, and climate change practitioners, researchers and experts, as well as regional and international policymakers and opinion leaders in the area.

  • Cutting-edge Computational Intelligence in Healthcare with Convolution and Kronecker Convolution-based Approaches

    • 1st Edition
    • Allam Jaya Prakash + 2 more
    • English
    Cutting-edge Computational Intelligence in Healthcare with Convolution and Kronecker Convolution-based Approaches focuses on the use of deep learning techniques in the field of medical imagine analysis. These advances offer promising progress in healthcare through improvements in diagnostic accuracy, efficiency in medical image interpretation, and breakthroughs in treatment planning. Divided into five sections, the book begins with foundational coverage of deep learning in medical imaging and fundamentals of Convolutional Neural Networks. Discover the role convolutions play in extracting meaningful features from images, aiding tasks such as diagnosis and segmentation. The second section takes a deep dive into Kronecker convolutions and their unique advantages, such as enhanced spatial hierarchy understanding, efficient parameter utilization, and improved adaptability to specific characteristics of medical images. Section three reviews specific applications in tumor detection, enhancing organ segmentation as well as disease classification, and section four explores real-world implementation of AI-driven diagnostic imaging, precision medicine via imaging analytics, and wearable devices and continuous health monitoring. The final section offers discussion on the unique challenges, trends, and potential future directions these innovative computational approaches have on medical image processing and advanced healthcare. In summary, this book takes an interdisciplinary approach to bridge the gap between theory and practice, fusing knowledge from the domains of medicine, computer science, and machine learning to address issues in healthcare through sophisticated image analysis techniques.

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