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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Medical Modelling

      • 1st Edition
      • September 28, 2006
      • Richard Bibb + 2 more
      • English
      • Hardback
        9 7 8 1 8 4 5 6 9 1 3 8 7
      • eBook
        9 7 8 1 8 4 5 6 9 2 0 0 1
      Research into medical modelling and the application of design and product development technologies in medicine and surgery requires a multidisciplinary approach. Designed to be accessible to all disciplines, with medical and technical terms explained as clearly and simply as possible, Medical modelling provides a genuinely useful text to help the broadest possible range of professionals to understand not only the technologies, techniques and methods, but also what is required to apply them in medical treatments.Medical modelling describes steps in the process from acquisition of medical scan data, transfer and translation of data formats, methods of utilising the data and finally using the information to produce physical models using rapid prototyping techniques for use in surgery or prosthetic rehabilitation. Technologies are fully described, highlighting their key characteristics, advantages and disadvantages. A series of case studies illustrates a broad range of medical applications. These case studies are taken from the collective experience of the National Centre for Product Design & Development Research, Medical Applications Group and their clinical partners, and have been chosen to reflect the widest possible variety of techniques used. Future developments in technology and applications in this dynamic and fast-moving field are also considered.This book will appeal to the wide variety of professionals who undertake collaborative research, development and treatment of human physical conditions using advanced computer-aided design and manufacturing techniques and technologies, including medical and clinical engineers and physicists, clinical technologists, rehabilitation engineers, design engineers in medical device design and manufacture, consultant surgeons and specialists in, for example, orthopaedics, orthodontics, and prosthetics.

    • The Road to Success

      • 1st Edition
      • September 27, 2006
      • Alexander R. Margulis
      • English
      • Paperback
        9 7 8 0 1 2 3 7 0 5 8 7 7
      • eBook
        9 7 8 0 0 8 0 4 6 6 0 0 2
      The exciting new follow-up to Alexander Margulis' Be in Charge this book offers a guide for those who desire advancement to top positions in business and academia. It discusses and presents advantages of progress and presents the inherent sacrifices to the individual and family in that pursuit. Essential 'do-s' and 'don’t-s' are included as well as some hilarious items from the Internet and illustrated with 14 cartoons by Tom Reese a respected US cartoonist.

    • Target Validation in Drug Discovery

      • 1st Edition
      • September 22, 2006
      • Brian W. Metcalf + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 3 6 9 3 9 3 8
      • eBook
        9 7 8 0 0 8 0 4 6 5 9 7 5
      This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

    • Principles of Clinical Pharmacology

      • 2nd Edition
      • September 20, 2006
      • Arthur J. Atkinson Jr. + 4 more
      • English
      • eBook
        9 7 8 0 0 8 0 4 6 6 4 2 2
      This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.

    • International Review of Cytology

      • 1st Edition
      • Volume 252
      • September 19, 2006
      • Kwang W. Jeon
      • English
      • Paperback
        9 7 8 0 1 2 4 1 1 2 9 8 8
      • Hardback
        9 7 8 0 1 2 3 6 4 6 5 6 9
      • eBook
        9 7 8 0 0 8 0 4 6 4 8 2 4
      International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address cell biology of membrane trafficking in human disease; the biology of the gaucher cell; intracellular signals and events activated by cytokines of the TNF superfamily; cellular and molecular biology of orphan G-protein coupled receptors; organization and function of the actin; cytoskeleton in developing root cells.

    • Modelling and Control in Biomedical Systems 2006

      • 1st Edition
      • September 19, 2006
      • David Dagan Feng + 1 more
      • English
      • Paperback
        9 7 8 0 0 8 0 4 4 5 3 0 4
      • eBook
        9 7 8 0 0 8 0 4 7 9 4 9 1
      Modelling and Control in Biomedical Systems (including Biological Systems) was held in Reims, France, 20-22 August 2006. This Symposium was organised by the University of Reims Champagne Ardenne and the Société de l’Electricité, de l’Electronique et des TIC (SEE). The Symposium attracted practitioners in engineering, information technology, mathematics, medicine and biology, and other related disciplines, with authors from 24 countries. Besides the abstracts of the four plenary lectures, this volume contains the 92 papers that were presented by their authors at the Symposium. The papers included two invited keynote presentations given by internationally prominent and well-recognised research leaders: Claudio Cobelli, whose talk is titled "Dynamic modelling in diabetes: from whole body to genes"; and Irving J. Bigio, whose talk is titled "Elastic scattering spectroscopy for non-invasive detection of cancer". Two prestigious industrial speakers were also invited to give keynote presentations: Terry O'Brien from LIDCO, whose talk is titled "LIDCO: From the laboratory to protocolized goal directed therapy"; and Lorenzo Quinzio of Philips, whose talk is titled "Clinical decision support in monitoring and information systems".

    • GERD

      • 1st Edition
      • September 18, 2006
      • Parakrama T. Chandrasoma + 1 more
      • English
      • Paperback
        9 7 8 1 4 9 3 3 0 0 7 3 0
      • Hardback
        9 7 8 0 1 2 3 6 9 4 1 6 4
      • eBook
        9 7 8 0 0 8 0 4 6 4 7 4 9
      Gastroesophageal Reflux Disease (GERD) is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux.Unfortunately... this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world.The increasing incidence of esophageal adenocarcinoma has created an enormous interest and stimulus for research in this area. GERD brings together a vast amount of disparate literature and presents the entire pathogenesis of reflux disease in one place. In addition to providing a new concept of how gastroesophageal reflux causes cellular changes in the esophagus, GERD also offers a complete solution to a problem that has confused physicians for over a century. Both clinical and pathological information about reflux disease and its treatment are presented. GERD is meant to be used as a comprehensive reference for gastroenterologists, esophageal surgeons, and pathologists alike.

    • Current Topics in Developmental Biology

      • 1st Edition
      • Volume 75
      • September 7, 2006
      • English
      • Paperback
        9 7 8 0 1 2 4 1 1 2 5 8 2
      • Hardback
        9 7 8 0 1 2 1 5 3 1 7 5 1
      • eBook
        9 7 8 0 0 8 0 4 6 4 6 1 9
      Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

    • Handbook of Biologically Active Peptides

      • 1st Edition
      • August 29, 2006
      • Abba Kastin + 1 more
      • English
      • eBook
        9 7 8 0 0 8 0 4 6 3 7 9 7
      Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.

    • DNA Microarrays, Part B: Databases and Statistics

      • 1st Edition
      • Volume 411
      • August 28, 2006
      • English
      • Hardback
        9 7 8 0 1 2 1 8 2 8 1 6 5
      • eBook
        9 7 8 0 0 8 0 4 6 4 6 6 4
      Modern DNA microarray technologies have evolved over the past 25 years to the point where it is now possible to take many million measurements from a single experiment. These two volumes, Parts A & B in the Methods in Enzymology series provide methods that will shepard any molecular biologist through the process of planning, performing, and publishing microarray results. Part A starts with an overview of a number of microarray platforms, both commercial and academically produced and includes wet bench protocols for performing traditional expression analysis and derivative techniques such as detection of transcription factor occupancy and chromatin status. Wet-bench protocols and troubleshooting techniques continue into Part B. These techniques are well rooted in traditional molecular biology and while they require traditional care, a researcher that can reproducibly generate beautiful Northern or Southern blots should have no difficulty generating beautiful array hybridizations. Data management is a more recent problem for most biologists. The bulk of Part B provides a range of techniques for data handling. This includes critical issues, from normalization within and between arrays, to uploading your results to the public repositories for array data, and how to integrate data from multiple sources. There are chapters in Part B for both the debutant and the expert bioinformatician.

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