Principles of Clinical Pharmacology
- 2nd Edition - April 28, 2011
- Editors: Arthur J. Atkinson Jr., Darrell R. Abernethy, Charles E. Daniels, Robert Dedrick, Sanford P. Markey
- Language: English
This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals… Read more
This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.
- Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy
- Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course
- Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study
- Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry
- Expanded coverage of pharmacogenetics
- Expanded coverage of drug transporters and their role in interactions
- Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions
- A new chapter on drug discovery that focuses on oncologic agents
- Inclusion of therapeutic antibodies in chapter on biotechnology products
Clinical pharmacologists, pharmacologists, clinicians, pharmaceutical industry and government regulatory agencies
1. Introduction
PART 1: PHARMACOKINETICS
2. Clinical pharmacokinetics
3. Compartmental analysis of drug distribution
4. Drug absorption and bioavailability
5. Effects of renal disease on pharmacokinetics
6. Kinetics of hemodialysis and hemofiltration
7. Effects of liver disease on pharmacokinetics
8. Noncompartmental vs. compartmental approaches to pharmacokinetic analysis
9. Distributed models of drug kinetics
10. Population pharmacokinetics
PART 2: DRUG METABOLISM AND TRANSPORT
11. Pathways of drug metabolism
12. Biochemical mechanisms of drug toxicity
13. Chemical assay of drugs and drug metabolites
14. Equilibrative and concentrative transport
15. Pharmacogenetics
16. Drug interactions
PART 3: ASSESSMENT OF DRUG EFFECTS
17. Physiological and laboratory markers of drug effect
18. Dose response and concentration response analysis
19. Kinetics of pharmacologic effect
20. Disease progression models
PART 4: OPTIMIZING AND EVALUATING PATIENT THERAPY
21. Sex differences in pharmacokinetics and pharmacodynamics
22. Drug therapy in pregnant and nursing women
23. Drug therapy in neonates and pediatric patients
24. Drug therapy in the elderly
25. Clinical analysis of adverse drug reactions
26. Quality assessment of drug therapy
PART 5: DRUG DISCOVERY AND DEVELOPMENT
27. Project management
28. Drug discovery
29. Pre-clinical development
30. Animal scale up
31. Phase I studies
32. PK and PD considerations in the development of biotechnology products and large molecules
33. Design of clinical development programs
34. Good design practices for clinical trials
35. Role of the FDA in guiding drug development
Appendix
I. Table of Laplace Transforms
II. Answers to Study Problems
- Edition: 2
- Published: April 28, 2011
- Language: English
AA
Arthur J. Atkinson Jr.
Arthur J. Atkinson, Jr., M.D., M.A.C.P., is Adjunct Professor of Pharmacology at the Feinberg Medical School of Northwestern University. He has held leadership roles in clinical pharmacology for more than 50 years, working in both academia and the pharmaceutical industry, and for NIH. He founded and for 24 years directed a Clinical Pharmacology Center at Northwestern, rising to the rank of Professor of Pharmacology and Medicine. He was subsequently Corporate Vice President for Clinical Development and Medical Affairs at the Upjohn Company. Following the Upjohn-Pharmacia merger, he was recruited to be Senior Advisor in Clinical Pharmacology at the NIH Clinical Center. There, he initiated a clinical pharmacology course and served as lead editor for the previous three editions of Principles of Clinical Pharmacology, the required text for the course. Dr. Atkinson has been elected Master of the American College of Physicians and to membership in the American Association of Physicians. He received the Harry Gold Award from ASPET, the Oscar Hunter Award from ASCPT, and the Award in Excellence from the PhRMA Foundation.
Affiliations and expertise
Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesDA
Darrell R. Abernethy
Affiliations and expertise
National Institute on Aging, Baltimore, Maryland, U.S.A.CD
Charles E. Daniels
Affiliations and expertise
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USARD
Robert Dedrick
Affiliations and expertise
National Institute of Health, Bethesda, Maryland, U.S.A.SM
Sanford P. Markey
Affiliations and expertise
National Institute of Mental Health, Bethesda, Maryland, U.S.A.Read Principles of Clinical Pharmacology on ScienceDirect