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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Joining and Assembly of Medical Materials and Devices

      • 1st Edition
      • May 31, 2013
      • Y N Zhou + 1 more
      • English
      • Hardback
        9 7 8 1 8 4 5 6 9 5 7 7 4
      • eBook
        9 7 8 0 8 5 7 0 9 6 4 2 5
      As medical devices become more intricate, with an increasing number of components made from a wide range of materials, it is important that they meet stringent requirements to ensure that they are safe to be implanted and will not be rejected by the human body. Joining and assembly of medical materials and devices provides a comprehensive overview of joining techniques for a range of medical materials and applications.Part one provides an introduction to medical devices and joining methods with further specific chapters on microwelding methods in medical components and the effects of sterilization on medical materials and welded devices. Part two focuses on medical metals and includes chapters on the joining of shape memory alloys, platinum (Pt) alloys and stainless steel wires for implantable medical devices and evaluating the corrosion performance of metal medical device welds. Part three moves on to highlight the joining and assembly of medical plastics and discusses techniques including ultrasonic welding, transmission laser welding and radio frequency (RF)/dielectric welding. Finally, part four discusses the joining and assembly of biomaterial and tissue implants including metal-ceramic joining techniques for orthopaedic applications and tissue adhesives and sealants for surgical applications.Joining and assembly of medical materials and devices is a technical guide for engineers and researchers within the medical industry, professionals requiring an understanding of joining and assembly techniques in a medical setting, and academics interested in this field.

    • The Hip Resurfacing Handbook

      • 1st Edition
      • April 22, 2013
      • K De Smet + 2 more
      • English
      • Hardback
        9 7 8 1 8 4 5 6 9 9 4 8 2
      • eBook
        9 7 8 0 8 5 7 0 9 6 2 0 3
      Hip resurfacing arthroplasty (HRA) using metal-on-metal bearings is an established but specialised technique in joint surgery. Based on the experience of leading experts in the field, The hip resurfacing handbook provides a comprehensive reference for all aspects of this important procedure.The first part of the book reviews and compares all the major hip resurfacing prostheses, their key design features, relevant surgical techniques and clinical results. Part two discusses clinical follow-up of the hip resurfacing patient, including pre- and post-operative examination, acoustic phenomena and rehabilitation. It also covers the use of techniques such as radiography and metal ion measurement, as well as bone scans, ultrasound, CT, MRI, PET and DEXA, to evaluate hip resurfacings. Part three reviews best practice in surgical technique, including the modified posterior and anterior approaches, as well as instrumentation, anaesthesia and revision surgery. Based on extensive retrieval studies, Part four includes examples of the main failure modes in HRA. The final part of the book includes patients’ own experiences, a comparison of HRA with total hip arthroplasty (THA), regulatory issues and relevant web sites.Comprehensive in its scope and authoritative in its coverage, The hip resurfacing handbook is a standard work for orthopaedic surgeons and all those involved in HRA.

    • Microfluidic Devices for Biomedical Applications

      • 1st Edition
      • October 31, 2013
      • Xiujun (James) Li + 1 more
      • English
      • Hardback
        9 7 8 0 8 5 7 0 9 6 9 7 5
      • eBook
        9 7 8 0 8 5 7 0 9 7 0 4 0
      Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications.The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.Microfluid... devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.

    • Diamond-Based Materials for Biomedical Applications

      • 1st Edition
      • March 19, 2013
      • Roger Narayan
      • English
      • Hardback
        9 7 8 0 8 5 7 0 9 3 4 0 0
      • eBook
        9 7 8 0 8 5 7 0 9 3 5 1 6
      Carbon is light-weight, strong, conductive and able to mimic natural materials within the body, making it ideal for many uses within biomedicine. Consequently a great deal of research and funding is being put into this interesting material with a view to increasing the variety of medical applications for which it is suitable. Diamond-based materials for biomedical applications presents readers with the fundamental principles and novel applications of this versatile material.Part one provides a clear introduction to diamond based materials for medical applications. Functionalization of diamond particles and surfaces is discussed, followed by biotribology and biological behaviour of nanocrystalline diamond coatings, and blood compatibility of diamond-like carbon coatings. Part two then goes on to review biomedical applications of diamond based materials, beginning with nanostructured diamond coatings for orthopaedic applications. Topics explored include ultrananocrystalline diamond for neural and ophthalmological applications, nanodiamonds for drug delivery systems, and diamond nucleation and seeding techniques for tissue regeneration. Finally, the book concludes with a discussion of diamond materials for microfluidic devices.With its distinguished editors and international team of expert contributors, Diamond-based materials for biomedical applications is an authoritative guide for all materials scientists, researchers, medical practitioners and academics investigating the properties and uses of diamond based materials in the biomedical environment.

    • Stem Cell Bioprocessing

      • 1st Edition
      • October 31, 2013
      • Tiago G. Fernandes + 2 more
      • English
      • Hardback
        9 7 8 1 9 0 7 5 6 8 8 8 6
      • eBook
        9 7 8 1 9 0 8 8 1 8 3 0 0
      Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell types are described, alongside the molecular mechanisms underlying their self-renewal and differentiation. The book also focuses on methodologies currently used for in vitro stem cell culture under static conditions, including the challenge of xeno-free culture conditions, as well as culture parameters that influence stem cell culture. Approaches for both stem cell culture and separation in micro-scale conditions are presented, including the use of cellular microarrays for high-throughput screening of the effect of both soluble and extracellular matrix molecules. A further section is dedicated to application of stem cells for regenerative medicine.

    • Biotextiles as Medical Implants

      • 1st Edition
      • October 31, 2013
      • M W King + 2 more
      • English
      • Paperback
        9 7 8 0 0 8 1 0 1 3 9 2 2
      • Hardback
        9 7 8 1 8 4 5 6 9 4 3 9 5
      • eBook
        9 7 8 0 8 5 7 0 9 5 6 0 2
      Textiles play a vital role in the manufacture of various medical devices, including the replacement of diseased, injured or non-functioning organs within the body. Biotextiles as medical implants provides an invaluable single source of information on the main types of textile materials and products used for medical implants. The first part of the book focuses on polymers, fibers and textile technologies, and these chapters discuss the manufacture, sterilization, properties and types of biotextiles used for medical applications, including nanofibers, resorbable polymers and shaped biotextiles. The chapters in part two provide a comprehensive discussion of a range of different clinical applications of biotextiles, including surgical sutures, arterial prostheses, stent grafts, percutaneous heart valves and drug delivery systems.This book provides a concise review of the technologies, properties and types of biotextiles used as medical devices. In addition, it addresses the biological dimension of how to design devices for different clinical applications, providing an invaluable reference for biomedical engineers of medical textiles, quality control and risk assessment specialists, as well as managers of regulatory affairs. The subject matter will also be of interest to professionals within the healthcare system including surgeons, nurses, therapists, sourcing and purchasing agents, researchers and students in different disciplines.

    • Biomaterials and Medical Tribology

      • 1st Edition
      • July 31, 2013
      • J. Paulo Davim + 1 more
      • English
      • Hardback
        9 7 8 0 8 5 7 0 9 0 1 7 1
      • eBook
        9 7 8 0 8 5 7 0 9 2 2 0 5
      Medical tribology can be defined as the science of tribological phenomena in the human body, both those that naturally occur in the tissues or organs and those that arise after implantation of an artificial device, while biomaterials are inert substances designed to be incorporated into living systems. Biomaterials and medical tribology brings together a collection of high quality articles and case studies focussing on new research and developments in these two important fields.The book provides details of the different types of biomaterial available and their applications, including nanoparticles for biomedical applications, synergism effects during fiction and fretting corrosion experiments, application of biomedical-grade titanium alloys in trabecular bone and artificial joints, fatigue strengthening of an orthopaedic Ti6AI4V alloy, wear determination on retrieved metal-on-metal hip arthoplasty, natural articular joints, the importance of bearing porosity in engineering and natural lubrication, tribological characterization of human tooth enamel, and finally, liposome-based carrier systems and devices used for pulmonary drug delivery.Biomaterial... and medical tribology is an essential reference for materials scientists, engineers, and researchers in the field of medical tribology. The title also provides an overview for academics and clinicians in this area.

    • Gene therapy

      • 1st Edition
      • October 31, 2013
      • Surendra Nimesh
      • English
      • Hardback
        9 7 8 1 9 0 7 5 6 8 4 0 4
      • eBook
        9 7 8 1 9 0 8 8 1 8 6 4 5
      Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy.

    • The Funding of Biopharmaceutical Research and Development

      • 1st Edition
      • October 31, 2013
      • David R Williams
      • English
      • Hardback
        9 7 8 1 9 0 7 5 6 8 9 4 7
      • eBook
        9 7 8 1 9 0 8 8 1 8 3 8 6
      The funding of biopharmaceutical research and development provides a comprehensive critical review of the funding of research and development (R&D) in the human biopharmaceutical market sector. It addresses both private and public funding sources available in the US and internationally. The biopharmaceutical market is among the most research-intensive market sectors globally. Clinical researchers face a multitude of public and private funding options with respect to bringing their idea or innovation to market. These funding options are continually changing and complex, and are expected to decrease in the near future. A lack of understanding of the scale, scope, and inner workings of the funding aspects of R&D can, at times, act as a barrier for all involved, and can slow down or even eliminate the R&D process. The book lessens these barriers by describing the theoretical underpinnings, present practice, and trends in R&D funding in this market sector, both in the US and internationally. This includes a review and discussion of public-private partnership activity and their inner-workings, noting the complementary relationship between public and private funding. The book also contains an overview of the inner-workings of strategic alliance activity, including the advantages and disadvantages for each party. It goes on to provide an outline of venture capital activity, detailing the methods by which venture capital firms raise capital and are organized, a description of the venture capital-entrepreneur arrangement, and the effects of this arrangement. The book also presents an overview of the IPO process and the various fates of firms going public.

    • Bioinformatics for Biomedical Science and Clinical Applications

      • 1st Edition
      • July 31, 2013
      • K-H Liang
      • English
      • Hardback
        9 7 8 1 9 0 7 5 6 8 4 4 2
      • eBook
        9 7 8 1 9 0 8 8 1 8 2 3 2
      Contemporary biomedical and clinical research is undergoing constant development thanks to the rapid advancement of various high throughput technologies at the DNA, RNA and protein levels. These technologies can generate vast amounts of raw data, making bioinformatics methodologies essential in their use for basic biomedical and clinical applications.Bioinfo... for biomedical science and clinical applications demonstrates what these cutting-edge technologies can do and examines how to design an appropriate study, including how to deal with data and address specific clinical questions. The first two chapters consider Bioinformatics and analysis of the human genome. The subsequent three chapters cover the introduction of Transcriptomics, Proteomics and Systems biomedical science. The remaining chapters move on to critical developments, clinical information and conclude with domain knowledge and adaptivity.

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