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Stem Cell Bioprocessing

For Cellular Therapy, Diagnostics and Drug Development

1st Edition - October 31, 2013

Authors: Tiago G. Fernandes, M. Margardia Diogo, Joaquim M.S. Cabral

Language: English
Hardback ISBN:
9 7 8 - 1 - 9 0 7 5 6 8 - 8 8 - 6
eBook ISBN:
9 7 8 - 1 - 9 0 8 8 1 8 - 3 0 - 0

Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for… Read more

Stem Cell Bioprocessing

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Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell types are described, alongside the molecular mechanisms underlying their self-renewal and differentiation. The book also focuses on methodologies currently used for in vitro stem cell culture under static conditions, including the challenge of xeno-free culture conditions, as well as culture parameters that influence stem cell culture. Approaches for both stem cell culture and separation in micro-scale conditions are presented, including the use of cellular microarrays for high-throughput screening of the effect of both soluble and extracellular matrix molecules. A further section is dedicated to application of stem cells for regenerative medicine.