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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Alcohol and Aldehyde Metabolizing Systems

      • 1st Edition
      • May 10, 2014
      • Ronald G. Thurman + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 7 5 4 0
      • eBook
        9 7 8 1 4 8 3 2 6 5 4 6 9
      Alcohol and Aldehyde Metabolizing Systems, Volume II: Enzymology and Subcellular Organelles contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues ranging from the molecular structure of enzymes to the clinical actions of alcohol in humans. Comprised of 43 chapters, this volume begins by comparing the enzymatically catalyzed oxidation of glyceraldehyde-3-pho... and lactate, followed by an analysis of liver alcohol dehydrogenase and its mechanism of action. The reader is methodically introduced to the kinetics and mechanism of activated liver alcohol dehydrogenase; structural and functional changes in different alcohol dehydrogenases during evolution; and localization and properties of aldehyde reductase. Subsequent chapters deal with the correlation between the activity of acetaldehyde dehydrogenase and the structure of mitochondria; the distribution of subcellular organelles; and peroxisomes and microsomes. This book will be of value to practitioners and researchers from a variety of disciplines, including biochemistry, physiology, cell biology, and pharmacology.

    • Clinical Genomics

      • 1st Edition
      • November 7, 2014
      • Shashikant Kulkarni + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 4 0 4 7 4 8 8
      • eBook
        9 7 8 0 1 2 4 0 5 1 7 3 7
      Clinical Genomics provides an overview of the various next-generation sequencing (NGS) technologies that are currently used in clinical diagnostic laboratories. It presents key bioinformatic challenges and the solutions that must be addressed by clinical genomicists and genomic pathologists, such as specific pipelines for identification of the full range of variants that are clinically important. This book is also focused on the challenges of diagnostic interpretation of NGS results in a clinical setting. Its final sections are devoted to the emerging regulatory issues that will govern clinical use of NGS, and reimbursement paradigms that will affect the way in which laboratory professionals get paid for the testing.

    • Biotechnology Entrepreneurship

      • 1st Edition
      • April 8, 2014
      • Craig Shimasaki
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 0 0 3 5
      • Hardback
        9 7 8 0 1 2 4 0 4 7 3 0 3
      • eBook
        9 7 8 0 1 2 4 0 4 7 4 7 1
      As an authoritative guide to biotechnology enterprise and entrepreneurship, Biotechnology Entrepreneurship and Management supports the international community in training the biotechnology leaders of tomorrow. Outlining fundamental concepts vital to graduate students and practitioners entering the biotech industry in management or in any entrepreneurial capacity, Biotechnology Entrepreneurship and Management provides tested strategies and hard-won lessons from a leading board of educators and practitioners. It provides a ‘how-to’ for individuals training at any level for the biotech industry, from macro to micro. Coverage ranges from the initial challenge of translating a technology idea into a working business case, through securing angel investment, and in managing all aspects of the result: business valuation, business development, partnering, biological manufacturing, FDA approvals and regulatory requirements. An engaging and user-friendly style is complemented by diverse diagrams, graphics and business flow charts with decision trees to support effective management and decision making.

    • Development of Auditory and Vestibular Systems

      • 1st Edition
      • May 23, 2014
      • Raymond Romand + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 2 6 3 3
      • Hardback
        9 7 8 0 1 2 4 0 8 0 8 8 1
      • eBook
        9 7 8 0 1 2 4 0 8 1 0 8 6
      Development of Auditory and Vestibular Systems fourth edition presents a global and synthetic view of the main aspects of the development of the stato-acoustic system. Unique to this volume is the joint discussion of two sensory systems that, although close at the embryological stage, present divergences during development and later reveal conspicuous functional differences at the adult stage. This work covers the development of auditory receptors up to the central auditory system from several animal models, including humans. Coverage of the vestibular system, spanning amphibians to effects of altered gravity during development in different species, offers examples of the diversity and complexity of life at all levels, from genes through anatomical form and function to, ultimately, behavior. The new edition of Development of Auditory and Vestibular Systems will continue to be an indispensable resource for beginning scientists in this area and experienced researchers alike.

    • Protides of the Biological Fluids

      • 1st Edition
      • Volume 31
      • November 26, 2014
      • H. Peeters
      • English
      • eBook
        9 7 8 1 4 8 3 2 7 9 6 5 7
      Protides of the Biological Fluids: Metal Binding Proteins, Tumor Markers, Monoclonal Antibodies covers the proceedings of the 31st Colloquium by the same title, held in Brussels, Belgium in 1983. This work is composed of three sections encompassing 245 chapters. The first section describes first the structure, physiological function, and physiopathology of metal binding proteins. This section also considers the metal binding mechanism and a series of iron binding and copper binding proteins, as well as hemopexin proteins. The second section is concerned with the physiopathology, screening, monitoring, tumor localization, and biomarkers of tumor. This section also explores the field of immunohistochemistry of biomarkers for tumor monitoring. The third section discusses drug targeting, immunohistochemistry... the identification of lymphocytes and other antigens. Considerable chapters are devoted to clinical assays of monoclonal antibodies. This book will prove useful to oncologists, protein scientists, clinicians, and researchers.

    • Bacteriocins of Lactic Acid Bacteria

      • 1st Edition
      • June 28, 2014
      • Dallas G. Hoover + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 0 6 7 1
      • eBook
        9 7 8 1 4 8 3 2 7 3 6 7 9
      Bacteriocins of Lactic Acid Bacteria is based on the 1990 Annual Meeting of the Institute of Food Technologists held in Dallas, Texas. It describes a number of well-characterized bacteriocins and, where possible, discusses practical applications for those that have been defined thus far from the lactic acid bacteria. The book begins with an introductory overview of naturally occurring antibacterial compounds. This is followed by discussions of methods of detecting bacteriocins and biochemical procedures for extraction and purification; genetics and cellular regulation of bacteriocins; bacteriocins based on the genera of lactic acid bacteria Lactococcus, Lactobacillus, Pediococcus, and Leuconostoc, and related bacteria such as Carnobacterium and Propionibacterium; and the regulatory and political aspects for commercial use of these substances. The final chapter sets out the prognosis for the future of this dynamic area. The information contained in this book should benefit those with interest in the potential for industrial use of bacteriocins as preservative ingredients. Anyone interested in lactic acid bacteria or the biosynthesis, regulation, and mechanisms of inhibition of these proteinaceous compounds will also appreciate the material presented. These include food scientists, microbiologists, food processors and product physiologists, food toxicologists, and food and personal product regulators.

    • Alcohol and Aldehyde Metabolizing Systems

      • 1st Edition
      • May 10, 2014
      • Ronald G. Thurman + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 7 5 5 7
      • eBook
        9 7 8 1 4 8 3 2 6 5 3 8 4
      Alcohol and Aldehyde Metabolizing Systems, Volume III: Intermediary Metabolism and Neurochemistry contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues such as the effects of alcohol and aldehydes on intermediary metabolism. Comprised of 64 chapters, this volume begins with an analysis of the non-equilibrium behavior of biochemical systems, followed by a discussion on the configurational specificity of glycolytic enzymes. The reader is methodically introduced to redox compartmentation and the measurement of intracellular compartmentation of metabolites in rat liver; effect of chronic alcohol and oxygen tension on the development of hepatic necrosis in rats; and actions of ethanol metabolism on fatty acid synthesis in the liver. Subsequent chapters focus on regional metabolic rate in the central nervous system as related to function; effects of tetrahydroisoquinoli... derivatives of catecholamines and aldehydes on tyrosine hydroxylase; and lowering of blood acetaldehyde levels as a therapeutic approach to alcoholism. This book will be of value to practitioners and researchers from a variety of disciplines, including neurochemistry, biochemistry, physiology, cell biology, and pharmacology.

    • Diet-Microbe Interactions in the Gut

      • 1st Edition
      • August 4, 2014
      • Kieran Tuohy + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 4 0 7 8 2 5 3
      • Paperback
        9 7 8 0 1 2 8 1 0 1 1 4 8
      • eBook
        9 7 8 0 1 2 4 0 7 9 4 1 0
      Drawing on expert opinions from the fields of nutrition, gut microbiology, mammalian physiology, and immunology, Diet-Microbe Interactions for Human Health investigates the evidence for a unified disease mechanism working through the gut and its resident microbiota, and linking many inflammation-related chronic diet associated diseases.State of the art post-genomic studies can highlight the important role played by our resident intestinal microbiota in determining human health and disease. Many chronic human diseases associated with modern lifestyles and diets — including those localized to the intestinal tract like inflammatory bowel disease and celiac disease, and more pervasive systemic conditions such as obesity, diabetes and cardiovascular disease — are characterized by aberrant profiles of gut bacteria or their metabolites. Many of these diseases have an inflammatory basis, often presenting with a chronic low-grade systemic inflammation, hinting at persistent and inappropriate activation of inflammatory pathways.Through the presentation and analysis of recent nutrition studies, this book discusses the possible mechanisms underpinning the disease processes associated with these pathologies, with high fat diets appearing to predispose to disease, and biologically active plant components, mainly fiber and polyphenols, appearing to reduce the risk of chronic disease development.

    • Regulatory Proteolytic Enzymes and Their Inhibitors

      • 1st Edition
      • May 18, 2014
      • Staffan Magnusson + 2 more
      • English
      • Hardback
        9 7 8 0 0 8 0 2 2 6 2 8 6
      • Paperback
        9 7 8 1 4 8 3 1 2 1 4 7 5
      • eBook
        9 7 8 1 4 8 3 1 5 3 8 9 6
      Regulatory Proteolytic Enzymes and Their Inhibitors consists of contributed papers from the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. This collection describes the role of proteases in the physiological regulation, a matter of the activation and de-activation of enzymes. The text also discusses the activation mechanism of pepsinogen and other acid protease zymogens. One paper reviews a discovery — that of a separate and distinct class of precursors, the pre-secretary proteins, and then discusses other studies on preproinsulin. The text then discusses the primary structures and presumed functions of immunoglobulin precursors. Another paper continues with the work of Reich and co-workers who found that transformation of cultured fibroblasts from different species by oncogenic viruses is related to the production and release of proteases that are responsible in activating the proenzyme plasminogen into plasmin. Another paper discusses plasminogen activation as having some relationship with pathological processes. The book also reviews the plasminogen activator secretion by normal and neoplastic human tissues. The text discusses the results when primary cultures established from biopsies of normal kidneys secreted plasminogen activators in amounts over those secreted by actual malignant tissues. The book then notes the role of neutral and acid proteinases in male reproduction and the role of plasminogen activators in female ovulation. This collection can be useful for micro-biologists, research biologists, molecular scientists, and students of molecular biology.

    • Post-Genomic Cardiology

      • 2nd Edition
      • May 9, 2014
      • José Marín-García
      • English
      • Hardback
        9 7 8 0 1 2 4 0 4 5 9 9 6
      • eBook
        9 7 8 0 1 2 4 0 4 6 4 2 9
      In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA.

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