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Elsevier

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • Metagenomics

    Perspectives, Methods, and Applications
    • 2nd Edition
    • Muniyandi Nagarajan
    • English
    Metagenomics: Perspectives, Methods, and Applications, second edition, provides thorough coverage of the growing field of metagenomics. A diverse range of chapters from international experts offer an introduction to the field and examine methods for metagenomic analysis of microbiota, metagenomic computational tools, and recent metagenomic studies in various environments and clinical settings. The emphasis on application makes this text particularly useful for applied researchers, practitioners, clinicians, and students seeking to employ metagenomic approaches to advance knowledge in the biomedical and life sciences. Case study-based application chapters include topics ranging from metagenome tools, metagenomics in oral disease and health, metagenomic insights into the human gut microbiome and metabolic syndromes, and more. This new edition has been fully updated to address the rapid growth and development of metagenomics applications, featuring expert discussion of recent developments and fresh case studies. Newly added chapters instruct in methods and implications of metagenomics in areas of growing focus, such as microbiome research, clinical diagnosis, metagenomic epidemiology, and plant microbe interaction. Data analysis is explained in simple terms for effective use of computational tools, software, and sequencing pipelines.

  • Concepts and Methodology in Cancer Diagnostics

    An Immunological, Biochemical and Molecular Approach
    • 1st Edition
    • Seema Nayak + 1 more
    • English
    Concepts and Methodology in Cancer Diagnostics: An Immunological, Biochemical and Molecular Approach provides an exclusive combination of all basics and recent techniques, methodology, and advancements in the field of cancer diagnostics. With a strong focus on the procedures and techniques involved in cancer diagnostics, content also gives insights into the molecular tests required for different tumors for the administration of targeted drugs and precision medicine. In 11 chapters. The book also introduces the methods and technologies based on DNA and RNA based biomarkers, biochemical and immunological markers, genetic signatures, epigenetic changes and exosomes in blood, and tissue and body fluids.Readers will find a compilation of imperative topics and lists of the necessary materials and reagents needed, step-by-step instructions, readily reproducible laboratory protocols, as well as tips on troubleshooting and known pitfalls. This book is a valuable resource for medical professionals and researchers who want to understand the concepts of validated protocols and methodologies in diagnosing cancer, its prognosis, and predictive value.

  • Anterior Segment Optical Coherence Tomography

    A Clinically-Oriented Atlas
    • 1st Edition
    • Mehmet Baykara + 2 more
    • English
    Anterior Segment Optical Coherence Tomography: A Clinically-Oriented Atlas introduces a wide range of clinical applications of anterior segment OCT for the diagnosis, follow up, and assessment of medical and surgical treatments and critical interventions. Though there is research on imaging the anterior segment of the eye using OCT, there have not been attempts to compile the implications of these findings into a single source. Rather, this book avoids focusing on generic descriptions of the technology, providing a unique perspective on the clinical aspects of OCT. This atlas will translate research into practice in a way that has never been achieved before.For those wishing to apply the theoretical aspects of OCT to their daily practice, this book provides a unique how-to guide that has thus far been missing from literature. While other books offer significant background on OCT, only this one will serve as a go-to reference for treatment of real patients.

  • Mitochondrial Translocases Part B

    • 1st Edition
    • Volume 707
    • English
    Mitochondrial Translocases Part B series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an internation.

  • Systems Biology and In-Depth Applications for Unlocking Diseases

    Principles, Tools, and Application to Disease
    • 1st Edition
    • Babak Sokouti
    • English
    Systems Biology and In-Depth Applications for Unlocking Diseases provides the essence of systems biology approaches in a practical manner illustrating the basic principles essential to develop and model in real life science applications. Methodologies covered show how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment.Systematic... written in 4 parts, this book first provides an introduction and history of systems biology; second, it provides the tools and resources needed for the structure and function of biological systems; next, it provides the evidence of systems biology in action to better understand disease connections; and finally, it provides the extensions of systems biology in various scientific fields including pharmacology, immunology, vaccinology, neuroscience, virology, and medicine. Examples include big data techniques, scale networks, mathematical model development, and much more.This is the perfect reference to provide the fundamental base of knowledge needed for systems biologists, professionals in systems medicine, computational biologists, and bioinformaticians, whether needed for immediate application or for building a comprehensive understanding of the field.

  • IoMT Applications in Healthcare 5.0

    • 1st Edition
    • Bitan Misra + 2 more
    • English
    IoMT Applications in Healthcare 5.0 introduces the concept of Healthcare 5.0, emphasizing the transformative potential of intelligent diagnosis, remote treatment, and smart health management. Sections define IoMT and its multi-tiered architecture, discussing its pivotal role in improving electronic device productivity in healthcare, explore IoMT applications in Healthcare 5.0, discuss remote physical therapy using IoMT in Healthcare 5.0, delve into the security and privacy considerations of IoMT in healthcare, and address how to overcome challenges and future directions in IoMT. The book concludes by summarizing key findings, providing a comprehensive overview of the discussed topics.Written by experts in the field, this is a key text for Biomedical Engineers, Data Scientists, and IoT Developers and specialists who work in the Internet of Medical Things. Graduate students of IoT engineering, biology, biostatistics, biomedical sciences, bioinformatics, health-informatics, and Interdisciplinary sciences will also find this an invaluable resource.

  • Machine Learning Models and Architectures for Biomedical Signal Processing

    • 1st Edition
    • Suman Lata Tripathi + 3 more
    • English
    Machine Learning Models and Architectures for Biomedical Signal Processing presents the fundamental concepts of machine learning techniques for bioinformatics in an interactive way. The book investigates how efficient machine and deep learning models can support high-speed processors with reconfigurable architectures like graphic processing units (GPUs), Field programmable gate arrays (FPGAs), or any hybrid system. This great resource will be of interest to researchers working to increase the efficiency of hardware and architecture design for biomedical signal processing and signal processing techniques.

  • Balancing a Sauropod

    The Physiology of a Dinosaur
    • 1st Edition
    • Brant E Isakson
    • English
    One completely unexplored area in terms of physiology is the era of dinosaurs—with good reason, they lived over 100 million years ago and we’re left to make inference based on fossilized bones. However, by merging classical, comparative, and extreme physiology and applying it to current paleontological knowledge of dinosaurs, Balancing a Sauropod: The Physiology of a Dinosaur will for the first time begin to provide a sound physiological underpinning for how they may have lived 100 million years ago. Sauropods were the largest land animals to ever walk the earth with an incredible distance from heart to brain, begging the question, how did they maintain blood flow in their brain? Also, the climate sauropods lived in was hypoxic compared to what we live in now, so how did the dinosaurs breathe in the hypoxic Jurassic era? These questions and others expand to multiple fascinating questions the book will dissect in order of organ systems. The topics focus on major organ systems and apply them to potential sauropod physiology. Less emphasis is given to the skeletal system, as that has been discussed extensively in other literature. Each organ system will be discussed in terms of function and current understanding of how they work in a comparative environment. Balancing a Sauropod: The Physiology of a Dinosaur is written at a technical level to both inform the lay reader and provide a sound argument to scientists in the field.

  • Laccase and Polyphenol Oxidase

    Biochemistry and Biotechnological Applications
    • 1st Edition
    • Ivanhoe K.H. Leung
    • English
    Laccase and Polyphenol Oxidase: Biochemistry and Biotechnological Applications, a new volume in the Foundations and Frontiers in Enzymology series, provides a thorough discussion of the laccase and polyphenol oxidase enzyme families, which play key roles in the oxidation of phenolic substrates and are involved in a range of important biological functions in many organisms. In recent years, significant advances have been made in understanding these enzymes, but few resources exist on their fundamental biology, mechanisms, and applications. In this book, leading world experts discuss the biochemistry of laccase and polyphenol oxidases, research methods, and uses across industries, offering mechanistic and practical overviews of these important enzyme classes and empowering researchers to develop their own studies and hone applications. This book deftly connects topics across these intricate enzyme systems, with early chapters on the physicochemical properties of PPO and laccase, followed by separate sections on these related enzyme classes’ function in biological and industrial systems, production, purification, active assays, and application areas from food and wine to bioremediation to green chemistry.

  • Resistance in Hematologic Malignancies and Cancer

    • 1st Edition
    • Volume 22
    • Lucia Messingerova + 1 more
    • English
    Resistance in Hematologic Malignancies and Cancer brings together the molecular, cellular, and biochemical basis/principles of various mechanisms of resistance to treatment in hematologic malignancies.Even though main mechanisms of resistance are the same in different types of tumours there are specific signalling pathways involved in resistance in hematological malignancies and of course specific treatmentsIn 11 chapters, Resistance in Hematologic Malignancies and Cancer describes the development of treatment resistance in hematological malignancies, the role of MiRNA in resistance, the role of the immune system in resistance prediction, as well as the latest knowledge from clinical research.It gives insight in the complex information about different mechanisms linkage in final loss of cell sensitivity to drug treatment, the orientation in metabolic pathways that could be involved in depressed leukemia cell resistance to drugs and gives information about causes of drug resistance in leukemia cells.By the multidisciplinary approach of the processing this book is a valuable resource for both health professionals, scientists and researchers, health practitioners, students, but will also enable members of the general professional public to orientate themselves in issues that are not directly in their area of expertise

  • Molecular Pathway Analysis Using High-Throughput OMICS Molecular Data

    Analysis of molecular pathway composition, architecture, and activation using high-throughput genomic, epigenetic, transcriptomic, proteomic, and metabolomic data
    • 1st Edition
    • Anton Buzdin
    • English
    The field molecular pathway analysis evolves rapidly, and many progressive methods have recently been discovered. Molecular Pathway Analysis Using High-Throughput OMICS Data contains the largest collections of molecular pathways. For the first time, guidelines on how to do genomic, epigenetic, transcriptomic, proteomic, and metabolomic data analysis in real-world research practice are given. Molecular Pathway Analysis Using High-Throughput OMICS Molecular Data also focuses on the pathway analysis applications for solving tasks in biotechnology, pharmaceutics, and molecular diagnostics ​​It demonstrates how pathway analysis can be applied for the research and treatment of chronic and acute diseases, for next-generation molecular diagnostics, for drug design and preclinical testing; relevant real-world examples, molecular tests, and web resources will be reviewed in-depth.​ ​​The book shows a tendency of erasing the borders between chemistry, physics, informatics, mathematics, biology, and medicine by means of novel research approaches and instruments, providing a truly multidisciplinary approach.

  • Customized Ob/Gyn Management for Diverse Populations

    • 1st Edition
    • Gloria Bachmann + 1 more
    • English
    Customized Ob/Gyn Management for Diverse Populations provides tailored options of management for optimal clinical care of the major preventive and interventive Ob/Gyn issues. Case scenarios highlight and discuss the need for customized care and inclusive protocols that depend on each woman's race, gender, sexual orientation, culture and socio-economic factors. As health disparities adversely affect groups of people who have systematically experienced greater social and economic obstacles to health based on their racial or ethnic group, socioeconomic status, gender, sexual orientation or other characteristics historically linked to discrimination or exclusion, this book provides a welcomed resource.The book highlights the fact that in order to change the current scenario the health care community needs more information and awareness of health care data regarding diverse groups, population health and well-being.

  • Colorectal Cancer Treatment Resistance

    Mechanisms, Insights, Advances, and Solutions
    • 1st Edition
    • Zodwa Dlamini
    • English
    Colorectal Cancer Treatment Resistance: Mechanisms, Insights, Advances and Solutions provide insights, knowledge, and potential solutions for healthcare professionals, researchers, and individuals affected by colorectal cancer. The book discusses innovative therapies, personalized medicine, and the latest scientific advancements in the field, all aimed at enhancing the effectiveness of treatment and improving the prognosis for colorectal cancer patients. It elucidates on the broader context of cancer research and treatment strategies that have the potential to impact the overall approach to managing colorectal cancer and, by extension, other types of cancer that may exhibit similar resistance challenges.By studying and addressing resistance mechanisms, researchers and healthcare professionals can work towards improving patient outcomes and the overall quality of cancer care.

  • Mitochondrial Translocases Part A

    • 1st Edition
    • Volume 706
    • English
    Mitochondrial Translocases Part A series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • The 50th Anniversary Issue of Fish Physiology

    Physiological Applications
    • 1st Edition
    • Volume 40B
    • English
    Fish Physiology, Volume 40B recently celebrated its 50th Anniversary. The editors of the series have produced a total of 47 books (several volumes have two books) that contain almost 500 chapters since the inaugural volume published in 1969. Initial volumes were devoted to understanding the basic mechanisms and principles of fish physiology, with a focus on a few model species and some application to natural environmental conditions. Then, as the field better understood mechanisms, the approach was broadened to not only delve deeper into system physiology (e.g., chapters in early volumes were expanded to become books), but also interspecific differences in physiology.Finally, as interspecific physiological mechanisms were further resolved, it became possible to discuss physiology in light of a changing world. Thus, physiology can now inform on conservation, sustainability and management, as exemplified with the most recent volumes. This anniversary issue celebrates the series by highlighting some of the very important early work in the field that was published in the series.

  • Cancer Immunotherapy

    • 1st Edition
    • Volume 209
    • English
    Cancer Immunotherapy, Volume 209 covers the progress that has been made in cancer immunotherapy. This volume surveys exciting developments in the field while also highlighting its promise and problems. Chapters in this release include The Promise, Progress, and Challenges of In Situ Immunization Agents in Cancer Immunotherapy, Breakthroughs in Synthetic Controlling Strategies for Precision in CAR-T Therapy, Non-coding RNAs in cancer immunotherapy: a solution to overcome immune resistance?, Rational Design of adjuvants boosts cancer vaccines, Emerging Drug delivery systems to alter Tumor immunosuppressive microenvironment: overcoming the challenges in immunotherapy for Glioblastoma.Other chapters cover Magnetic Nanoparticles: An Emerging Nanomedicine for Cancer Immunotherapy and Clinical and basic science aspects of innate lymphoid cells as novel immunotherapeutic targets in cancer treatment.

  • Equity, Diversity, and Inclusion in Healthcare

    From Knowledge to Practice
    • 1st Edition
    • Faisal Khosa + 2 more
    • English
    Equity, Diversity, and Inclusion in Healthcare: From Knowledge to Practice offers a comprehensive text on the landscape of equity, diversity, and inclusion (EDI) in the health professions. Each chapter is dedicated to a health profession and is authored by an expert in EDI and workforce diversity in their respective discipline (such as medicine, dentistry, nursing, pharmacy, physiotherapy, and so on). Chapters characterize the present state of workforce diversity in the discipline, chronicle historical developments, provide rationale for systemic action, and include possible solutions and interventions in an evidence-based manner.By serving as an all-in-one reference text, this resource is meant for students, healthcare professionals, and organizational leadership who wish to understand and implement EDI in the health professions.

  • Intelligent Medicine on Prediction of Pelvic Lymph Node Metastasis

    • 1st Edition
    • Haixian Zhang + 2 more
    • English
    Intelligent Medicine on Prediction of Pelvic Lymph Node Metastasis focuses on leveraging intelligent medical techniques to predict lymph node metastasis, using pelvic cancer as a primary case study. Combined with the actual clinical application scenarios, this book introduces deep neural network models, application systems, and carries out method concentrated on the four major links of lymph node location, partition, segmentation and metastasis prediction, aiming to provide theoretical and experimental reference for researchers in this field. In 8 chapters this title introduces the reader to intelligent medicine and deep neural networks, summarises the intelligent biological neural network and the classical artificial neural network, introduces several commonly used network architectures and a new neural network model, and introduces the deep learning based algorithms on lymph nodes metastasis prediction, summarising the method and experimental results. This book is a friendly learning tool, providing beginners and researchers with an in-depth knowledge of deep learning and how to develop intelligent medicine methods in lymph node metastasis prediction.

  • Nature-Inspired Sensors

    • 1st Edition
    • Hossam Haick
    • English
    Nature-Inspired Sensors presents and discusses the basic principles and latest developments in nature-inspired sensing and biosensing materials as well as the design and mechanisms for analyzing their potential in multifunctional sensing applications.The book starts with a comprehensive review of certain fundamental mechanisms in different living creatures, including humans, animals, and plants. It presents and discusses ways for imitating various nature-inspired structural features and their functional properties, such as hierarchical, interlocked, porous, and bristle-like structures and hetero-layered brick-and-mortar structures.It also highlights the utility of these structures and their properties for sensing functions, which include static coloration, self-cleaning, adhesive, underwater navigation and object detection, electric charge generation, and sensitive olfactory functions for detecting various substances. This is followed by an appraisal of accumulating knowledge and its translation from the laboratory to the point-of-care phase, using selective sensors as well as desktop and wearable artificial sensing devices, for example, electronic noses and electronic skins, in conjunction with AI-assisted data processing and decision-making in the targeted field of application.In addition, the book offers an insight into the challenges of continuing the development of nature-inspired smart sensing and biosensing technology and their wider availability, which can be substantially improved. It is a valuable reference for graduates, undergraduates, researchers, and working professionals in the fields of chemistry, materials science, and biomedical and environmental science.

  • Human and Animal Microbiome Engineering

    • 1st Edition
    • Dharumadurai Dhanasekaran + 2 more
    • English
    Human and Animal Microbiome Engineering provides both basic and detailed information about microbiome engineering for the health enhancement of humans and animal populations. The book provides updated information about current research topics in this emerging field, including microbiome gene therapy, engineered probiotics, and smart living biotic machines for the release of therapeutics. The book is divided into 4 sections covering microbiome engineering application with a focus on future perspectives in human health and enhancement; microbiome engineering in human health and disease including real-world case studies; animal microbiome engineering essentials; and microbiome engineering for livestock improvement.This is the perfect reference for researchers and scientists to further explore the relationship between host and microbiome and discover novel ideas about the concepts of microbiome engineering in the health enhancement of humans and animal populations.

  • Mechanical Circulatory and Respiratory Support

    • 2nd Edition
    • Shaun D. Gregory + 4 more
    • English
    Mechanical Circulatory and Respiratory Support, Second Edition, continues to provide a comprehensive overview of the past, present and future development of mechanical circulatory and respiratory support devices. This new edition provides an update on the field while also introducing new elements within the field such as ex-vivo perfusion, devices for HFpEF, design for manufacture, oxygenator design, and more content on route to market.Chapters from over 60 internationally-reno... experts focuses on the entire life-cycle of mechanical circulatory and respiratory support – from the descent into heart and lung failure, alternative medical management, device options, device design, implantation techniques, complications and medical management of the supported patient, patient-device interactions, cost effectiveness, route to market and a view to the future.This second edition is a useful resource for biomedical engineers and clinicians who are designing new mechanical circulatory or respiratory support devices, while also providing a comprehensive guide of the entire field for those who are already familiar with some areas and want to learn more. Reviews of the most cutting-edge research are provided throughout each chapter, along with guides on how to design new devices and which areas require specific focus for future research and development.

  • Genetic Disease Discovery and Therapeutics

    • 1st Edition
    • Moyra Smith
    • English
    **Selected for 2026 Doody's Core Titles in Clinical Genetics**Genetic Disease Discovery and Therapeutics presents information on the methods used to determine how specific gene defects influence pathology and phenotype and to review novel therapeutic approaches designed for the treatment of specific genetic and genomic disorders.This book investigates methodologies applied to the characterization of downstream functional effects of specific gene mutations associated with altered phenotypes and clinical disease. It documents evidence of how specific mutations influence pathology and lead to disease manifestations. This book also reviews information on therapeutic approaches that could potentially be applied in diseases due to gene defects. Genetic Disease Discovery and Therapeutics is a valuable reference for scientists and graduate students involved in laboratory research related to genetics, physiology, pathology, and pharmacology as well as clinicians who encounter patients with genetic disorders.

  • Pathophysiological Aspects of Proteases in Cancer

    • 1st Edition
    • Sajal Chakraborti + 2 more
    • English
    Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development.Multidis... in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.

  • Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics

    Developmental Disorders
    • 7th Edition
    • Reed E. Pyeritz + 2 more
    • English
    **Selected for 2026 Doody's Core Titles as an Essential Purchase in Clinical Genetics**For decades, Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics and genomics into medical practice. With detailed coverage in contributions from more than 250 of the world’s most trusted authorities in medical genetics and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for students, health providers, and researchers involved in the care of patients with genetic conditions, and increasingly, all areas of health and disease. This comprehensive yet practical resource emphasizes theory and research fundamentals related to the applications of medical genetics and genomics across the full spectrum of inherited disorders and applications to medicine more broadly.In this volume, leading physicians and researchers thoroughly examine medical genetics and genomics as applied to developmental disorders, as well as genetic conditions that affect hearing and vision. Here genetic researchers, students, and health professionals will find new and fully revised chapters on human developmental genetics, disorders affecting craniofacial development, chromosomal abnormalities, including aneuploidies and structural abnormalities, hereditary hearing impairment, and various genetic conditions of the eye.With regular advances in genomic technologies propelling precision medicine into the clinic, Emery and Rimoin’s Principles and Practice of Medical Genetics and Genomics, Seventh Edition bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for health professionals and researchers.

  • Digital Health

    Telemedicine and Beyond
    • 1st Edition
    • Dipu Patel
    • English
    Digital Health: Telemedicine and Beyond describes practical ways to use digital health tools in clinical practice. With a strong focus on case studies and patient outcomes, this title provides an overview of digital medicine, terms, concepts, and applications for the multidisciplinary clinical practitioner. Chapters provide a concise, yet comprehensive understanding of digital health, including telemedicine, mHealth, EHRs, and the benefits and challenges of each. The book gives insights on risks and benefits associated with storing and transmitting patient information via digital tools and educates clinicians in the correct questions to ask for advocacy regarding state laws, scope of practice, and medicolegal implications.It also addresses the ethical and social challenges that digital health raises, how to engage patients to improve shared decision-making models and how digital health tools can be integrated into clinical practice. This book is a valuable resource for clinicians and medical educators of all health professions, including physicians, physician associates, nurses, pharmacists, physical therapists, occupational therapists, speech therapists, students, and all those who wish to broaden their knowledge in the allied field.

  • Small Lungs and Obstructed Airways

    Reassessing Chronic Obstructive Pulmonary Disease
    • 1st Edition
    • Peter Burney
    • English
    Small Lungs and Obstructed Airways: Reassessing Chronic Obstructive Pulmonary Disease proposes an alternative perspective to current explanations for the distribution of chronic lung disease. The book considers the link between chronic respiratory disease and associated mortality with smaller lungs rather than obstructed airways and explores other factors contributing to poor lung health besides the current emphasis on the roles of air pollution, occupational exposures, and cardio-metabolic disease. It presents the findings of the Burden of Obstructive Lung Disease (BOLD) study, sharing new views on the prevalence of obstructive lung disease and risk factors across various global regions. Sections cover decreased lung function, including the prevalent views on the impact of both household and external air pollution, occupational exposure, and the prenatal and postnatal/childhood environment in the etiology of impaired lung function and COPD. The book then moves on to discussions on the impact poverty and nutrition has on lung health, sharing the findings of the BOLD study regarding its effect on lung function and risk of COPD in lower-income countries. The book closes with a chapter outlining the clinical and public health implications of the findings discussed in the book.

  • The multitasking molecular chaperone Hsp60

    Structure, function, and impact on health and disease
    • 1st Edition
    • Francesco Cappello + 2 more
    • English
    The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies.Mol... mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies.

  • Marine Molecules from Algae and Cyanobacteria

    Extraction, Purification, Toxicology and Applications
    • 1st Edition
    • Paz Otero Fuertes + 1 more
    • English
    The marine environment is a rich but underexploited source of commercially interesting natural products with different applications. Several marine organisms, such as seaweeds, microalgae, sponges, cyanobacteria, ascidians, and fungi, are sources of natural valuable molecules. These chemical compounds range from small molecules and enzymes to highly complex secondary metabolites that show bioactivities in physiological systems. It is thus of great importance to collect information concerning the discovery of these molecules and their characterization and relation to human diseases. Gathering data about novel technologies and sources to obtain and isolate such as precious molecules as well as new applications for them is extremely appreciated in the chemical field. It is very useful for chemists to obtain these molecules with high purity to be used as analytical standards to calibrate the chromatography equipment. Many of these compounds are not commercially available, so the isolation methods of these molecules from microalgae, seaweeds, and cyanobacteria is a challenging task. The availability of some marine molecules has been a long-term problem due to the difficulty of their synthesis. Because of the complexity of their structure, the total synthesis has been shown to be difficult. Developing protocols to obtain reference standards from natural sources has shown satisfactory results in the chemical industry. Marine Molecules From Algae and Cyanobacteria addresses these topics, highlighting fundamentals of biomolecules, their roll in living organism, structure elucidation, sources, important characteristics, and the industrial applications of these biomaterials for educational (academic) as well as industrial purposes. This book covers all methodologies used in the search of marine natural products: screening of marine molecules by chemical methods like HPLC, LC-MS/MS, the isolation of high-value compounds with biotechnological potential, discovery of new molecules, and the optimization of green extraction procedures of these molecules, such as supercritical fluid extraction and pressurized solvent extraction, and other alternative chemical techniques applied in the exploration for marine compound.

  • γδ T Cell Cancer Immunotherapy

    Evidence-Based Perspectives for Clinical Translation
    • 1st Edition
    • Marta Barisa
    • English
    γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation sets out and critically discusses the current clinical and relevant preclinical γδ T cell immunotherapy landscape.In five chapters, field experts discuss the challenges facing γδ T cell oncoimmunotherapy, propose solutions, and map next steps.Particular attention is given to summarizing our understanding of the complex, translationally relevant human γδ T cell biology, the evidence basis for designing γδ T cell combination trials and data-driven perspectives on what is known—and what isn’t—about γδ T cell therapeutic persistence. Various perspectives are provided on how issues of cytotoxic effector function, functional exhaustion, and cytokine addiction can be mitigated using gene engineering.A chapter is dedicated to the systematic review of all γδ T cell immunotherapy trials to date, and the cell therapy products that were used in these trials. The final chapter discusses allograft persistence-enhancem... techniques in the context of γδ T cell therapy, covering lymphodepleting chemotherapy and synthetic stealth engineering.γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation gives an updated and comprehensive insight into the current state of γδT cell immunotherapy, which is of interest to existing translational γδ T cell specialists, the proliferating range of academic scientists and commercial scientists entering the field, as well as clinicians who may encounter γδ T cell immunotherapy in the clinic, or are wishing to familiarize themselves with noncanonical lymphocyte immunotherapy.

  • Deciding with Children in Pediatrics

    Children's Participation in Healthcare Decision-Making
    • 1st Edition
    • John Massie + 2 more
    • English
    **2026 PROSE Award Finalist in Clinical Medicine**Deciding with Children in Pediatrics: Children’s Participation in Healthcare Decision-making provides the ethical underpinning and offers practical strategies to foster meaningful participation of children in decisions affecting their healthcare. It will assist clinicians to bring forward the perspectives and values of the child, ensuring their preferences are incorporated into decision-making or appropriately justified when this is not possible. This is to both improve healthcare delivery and serve the best interests of children— now and as decision-makers in the future.This book reviews theories underpinning the concept of deciding with children and explores how pediatric decision-making is standardly managed. It then proposes a model for making healthcare decisions with children. A panel of experienced clinicians and ethicists demonstrate, via a series of case studies, how to promote children’s participation across a variety of clinical areas, child ages, and developmental stages. It concludes with a review of questions, concerns, and challenges. Deciding with Children in Pediatrics: Children’s Participation in Healthcare Decision-making helps bridge the gap between philosophy and practical clinical ethics and creates a frame of reference for children’s healthcare providers.

  • Protocols in Biochemistry and Clinical Biochemistry

    • 2nd Edition
    • Buddhi Prakash Jain + 2 more
    • English
    Protocols in Biochemistry and Clinical Biochemistry, second edition, offers clear, applied instruction in fundamental biochemistry methods and protocols, from buffer preparation to nucleic acid purification, protein, lipid, carbohydrate, and enzyme testing, and clinical testing of vitamins, glucose, and cholesterol levels, among other diagnostics. Each protocol is illustrated with step-by-step instructions, labeled diagrams, and color images, as well as a thorough overview of materials and equipment, precursor techniques, safety considerations and standards, analysis and statistics, alternative methods, and troubleshooting, all to support a range of study types and clinical diagnostics. This fully revised edition has been expanded and enriched to feature 100 protocols, as well as chapter key term definitions and worked examples. All-new protocols added to this edition include identification of lipids by TLC, lipid per oxidation measurement by thiobarbituric acid assays, determination of serum amylase, catalase activity assay, superoxide dismutase assay, qualitative analysis of plant secondary metabolites, qualitative analysis of photochemicals, quantitative estimation of secondary metabolites, estimation of chlorophyll contents, and starch determination, among others. Each protocol is written to help researchers and clinicians easily reproduce lab methods and ensure accurate test results.

  • Artificial Intelligence in Urology

    Present and Future
    • 1st Edition
    • Andrew J Hung
    • English
    Artificial Intelligence in Urology: Present and Future summarizes the cutting-edge development and adoption of Artificial Intelligence (AI) technologies in urology. The book explores barriers that prevent the further adoption of AI technologies, provides ethical considerations, and investigates the future role AI is expected to play. In addition, it includes applications of AI technology in the diagnosis and treatment of cancers (prostate, bladder, and more) and kidney stones, and in both adult and pediatric care. This is the perfect reference for researchers developing AI technologies for clinical applications and for clinicians who aim to effectively adopt AI technologies to solve clinical questions.

  • Chemical and Genomic Methods in Nucleic Acid Biology

    • 1st Edition
    • Volume 705
    • English
    Chemical and Genomic Methods in Nucleic Acid Biology, Volume 704 highlights new advances in the field of nucleic acids, with this new volume presenting interesting chapters written by an international board of authors. Specific chapters in this new release include A real-time FRET-based biochemical assay for DNA deaminase enzymology and inhibition, DEER spectroscopy to probe DNA wrapping by protein complexes, PAR-dCLIP: Enhancing PhotoActivatable Ribonucleoside analog-enhanced CrossLinking and Immunoprecipitation through capture of bound 5’ terminal RNA fragments, Site-specific targeting of transgene cDNA insertion, Simultaneous Profiling of the RNA Targets of Two RNA-Binding Proteins Using TRIBE-STAMP, and much more.Additional chapters cover Ensemble FRET Approach to Directly and Continuously Monitor Protein? DNA Interactions, Utilizing nuclear extracts to characterize protein-DNA interactions at the single-molecule level, RNA-Guided Protease Activation in CRISPR-Cas, Activity-based profiling of RNA modifying enzymes, Purification of Cas9 and Cas12a for Peptide-Assisted Genome Editing, Studying the intersection of nucleoside modifications and SARS-CoV-2 RNA-dependent RNA transcription using an in vitro reconstituted system, and more.

  • Lipidología clínica

    • 3rd Edition
    • Christie M. Ballantyne
    • Spanish
    Lipidología clínica proporciona a los clínicos una guía clara y autorizada para el tratamiento de los pacientes con niveles elevados de colesterol y otros trastornos lipídicos aterogénicos. Un recurso inestimable para cardiólogos, lipidólogos, endocrinólogos e internistas, esta obra única cubre desde la ciencia básica y la patogenia de la enfermedad aterotrombótica hasta la evaluación del riesgo y las más recientes opciones terapéuticas. Totalmente actualizada, esta tercera edición ofrece una cobertura exhaustiva y completa de la lipidología.

  • Moving Towards Everlasting Artificial Intelligent Battery-Powered Implants

    • 1st Edition
    • Marvellous Moyo + 1 more
    • English
    Moving Towards Everlasting Artificial Intelligent Battery-Powered Implants presents the development process of new artificial intelligent (AI) charging systems for battery-powered implants that can last for a lifetime after implantation. This book introduces new strategies to address the limitations of technologies that have been employed to improve the lifespan of medical implants. This book also provides guidelines that medical implant manufacturers can adopt during their product development stages—this adds a new dimension of research on medical device implants that can be a game changer for the AI medical implants industry. Researchers, engineers, and graduate students in the elds of biomedical engineering, electrical engineering, and computer science will find this text helpful as they seek to understand the potential of AI systems to help achieve sustainability in healthcare and make current medical implants relevant in the future.

  • Targeting Signaling Pathways in Solid Tumors Part C

    • 1st Edition
    • Volume 389
    • English
    Targeting Signaling Pathways in Solid Tumors, Part C, Volume 389 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Drugging the Undruggable: Advances in Targeting KRAS Signaling in Solid Tumors, Emerging Trends in Gastrointestinal Cancers: Targeting Developmental Pathways in their Carcinogenesis and Tumor Progression, Importance of targeting various cell signaling pathways in solid cancers, Targeting signaling pathways in cancer stem cells: a potential approach for developing novel anticancer therapeutics, Factors affecting heterogeneity in breast cancer microenvironment: A narrative review, and much more.Additional sections cover Exploring TLR Signaling Pathways as Promising Targets in Cervical Cancer: The Road Less Travelled

  • COVID-19 and the Cardiovascular System

    From Pathophysiology to Clinical Management
    • 1st Edition
    • Brian C. Case + 1 more
    • English
    COVID-19 and the Cardiovascular System: From Pathophysiology to Clinical Management comprehensively covers COVID-19’s impact on the cardiovascular system. Coverage includes the pathophysiology, clinical manifestations, diagnostic approach, treatment options, and clinical outcomes of patients presenting with COVID-19 with cardiac involvement. In a concise but comprehensive manner, the book's content reviews the epidemiology, risk factors, pathophysiology of COVID-19, cardiovascular clinical manifestations, non-invasive and invasive diagnostic evaluation, therapeutic options, outcomes data, role of the COVID-19 vaccine, and long-term outcomes/management.... is the perfect reference for basic and clinical researchers in cardiovascular medicine as well as practicing clinical cardiologists who are dealing with COVID-19 patients with cardiac involvement.

  • Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes

    • 1st Edition
    • Volume 112
    • English
    Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes, Volume 112 in the Advances in Genetics series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as What we need in colorectal cancer research, and why?, Host Genetics and Microbiota procedures in colorectal cancer research, Host Genetics-associated mechanisms in colorectal cancer, Microbiota-associate... mechanisms in colorectal cancer, Inflammation regulation in colorectal cancer, Microbiota and detrimental protein metabolites in colorectal cancer, Microbiota and other detrimental metabolites in colorectal cancer, Microbiota and beneficial metabolites in colorectal cancer, and much more.

  • Immuno-oncology and immunotherapy Part A

    • 1st Edition
    • Volume 189
    • English
    Immuno-Oncology And Immunotherapy – Part A Volume 189, in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Specific chapters to this release include, Generation of transmitochondrial cybrids in cancer cells, Methods for flow cytometry analysis for tumor infiltrating cells functions and phenotype, Innovative 2D and 3D methods of tumor cells culture, and more.

  • Fungal Stress Mechanisms and Responses

    • 1st Edition
    • Volume 129
    • English
    AAM: Fungal Stress Mechanisms and Responses explores the adaptive strategies and biotechnological applications of fungi under stress conditions. This volume features an array of reviews by experts in the field, reviewing different aspects of fungal stress responses. The initial three chapters focus on stress in fungal insect pathogens, while chapters 4–6 address the impact of stressful environmental conditions on fungi used for bioremediation. The last chapter investigates the molecular aspects of copper homeostasis in human fungal pathogens. This volume offers a comprehensive collection of findings that help our understanding of fungal stress responses and their applications in agriculture, medicine, and the environment.

  • Extracellular Vesicles from Basic Research to Clinical Applications

    • 1st Edition
    • Volume 94
    • English
    Extracellular Vesicles from Basic Research to Clinical Applications, Volume 94 covers theses lipid bilayer particles containing proteins, glycoproteins, mRNA, other small RNA species, and lipids formed and released by various pathogens. Chapters in this update include Extracellular Vesicles release from protozoa parasite and animal model, EVs from parasite and biomarkers, Translational Medicine – Use of EVs as therapy, EVs and viruses and their interaction with cells, EVs and Toxoplasma gondii, EVs and Fungi, Biogenesis of EVs in parasites, Extracellular vesicles, EVs and Leishmania, EVs in neuropsychiatry, EVs and Bacteria.Other sections cover EVs and sleep deprivation, EVs and cancer, Extracellular vesicles and methods to isolation, purification, and characterization.

  • Next Generation eHealth

    Applied Data Science, Machine Learning and Extreme Computational Intelligence
    • 1st Edition
    • Miltiadis D. Lytras + 4 more
    • English
    Next Generation eHealth: Applied Data Science, Machine Learning and Extreme Computational Intelligence discusses the emergence, the impact, and the potential of sophisticated computational capabilities in healthcare. This book provides useful therapeutic targets to improve diagnosis, therapies, and prognosis of diseases, as well as helping with the establishment of better and more efficient next-generation medicine and medical systems. Machine learning as a field greatly contributes to next-generation medical research with the goal of improving medicine practices and medical Systems. As a contributing factor to better health outcomes, this book highlights the need for advanced training of professionals from various health areas, clinicians, educators, and social professionals who deal with patients. Content illustrates current issues and future promises as they pertain to all stakeholders, including informaticians, professionals in diagnostics, key industry experts in biotech, pharma, administrators, clinicians, patients, educators, students, health professionals, social scientists and legislators, health providers, advocacy groups, and more. With a focus on machine learning, deep learning, and neural networks, this volume communicates in an integrated, fresh, and novel way the impact of data science and computational intelligence to diverse audiences.

  • The Scientific Basis of Mpox (Monkeypox)

    Features, Prevention, and Treatments
    • 1st Edition
    • Rajkumar Rajendram + 2 more
    • English
    The Scientific Basis of Monkeypox: Features, Prevention, and Treatments advances understanding of monkeypox and provides a framework for future research with evidence-based and forward-looking content. Content makes use of modeling systems and current experiences derived from case studies to provide material that is cross-disciplinary, bridging interdisciplinary divides. Furthermore, consideration is given to the behavioral response to monkeypox infection, including barriers to vaccination. Each chapter contains structured content, including policy and procedures, applications to new or emerging communicable diseases, a mini dictionary of terms, and summary points.Chapter contributions are from leading national and international specialists, including those from world renowned institutions who provide a global perspective. The book is a perfect reference for specialists in infectious diseases, virologists, microbiologists, health scientists, public health workers, doctors, pharmacologists, and research scientists.

  • Translational Urology

    • 1st Edition
    • Anthony Atala + 3 more
    • English
    Translational Urology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts, including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in urology, and know what is needed for successful collaboration. Further, this title is an indispensable tool in grant writing and funding efforts.This practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in urology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care.

  • The Charnolosome as a Novel Nanothereranostic Biomarker

    Overcoming Future Challenges in Medicine
    • 1st Edition
    • Sushil Sharma
    • English
    The Charnolosome as a Novel Nanothereranostic Biomarker: Overcoming Future Challenges in Medicine provides an overview of the charnolosome and its potential as a biomarker of cell injury. Based on the author’s original discovery of the charnoly body in the developing, undernourished rat cerebellar Purkinje neurons, this book delves into the potential for utilizing this mitochondria and lysosomal-derived intracellular organelle as a nanotheranostic biomarker to prevent and cure various diseases.The book discusses the cellular, molecular, genetic, and epigenetic mechanisms of charnolosomes and charnolosome-derived nano-vesicles. It also investigates the molecular mechanisms underlying auto-inflammatory, autoimmune, and infectious diseases resulting from their compromised mitochondrial bioenergetics, and the potential use of the charnolosome in preventing and curing such conditions.

  • Cardiometabolic Diseases

    Molecular Basis, Early Detection of Risks, and Management
    • 1st Edition
    • Gundu H. R. Rao + 1 more
    • English
    Cardiometabolic Diseases: Molecular Basis, Early Detection of Risks, and Management provides detailed information on all aspects of metabolic dysfunctions and associated risks for cardiometabolic diseases, including a thoughtful discussion of cellular and molecular mechanisms involved in the progression of metabolic risks, approaches for the early detection, and robust management of metabolic risks. Written by a team of expert contributors, this book is useful reading for researchers and clinicians interested on recent advances in etiology of cardiometabolic diseases, the latest noninvasive approaches for diagnosis, risk assessment tools, therapeutic strategies, and also aspects of prevention of cardiometabolic diseases.

  • Artificial Intelligence in Biomedical and Modern Healthcare Informatics

    • 1st Edition
    • M. A. Ansari + 4 more
    • English
    Artificial Intelligence in Biomedical and Modern Healthcare Informatics provides a deeper understanding of the current trends in AI and machine learning within healthcare diagnosis, its practical approach in healthcare, and gives insight into different wearable sensors and its device module to help doctors and their patients in enhanced healthcare system.The primary goal of this book is to detect difficulties and their solutions to medical practitioners for the early detection and prediction of any disease.The 56 chapters in the volume provide beginners and experts in the medical science field with general pictures and detailed descriptions of imaging and signal processing principles and clinical applications.With forefront applications and up-to-date analytical methods, this book captures the interests of colleagues in the medical imaging research field and is a valuable resource for healthcare professionals who wish to understand the principles and applications of signal and image processing and its related technologies in healthcare.

  • Bio Refinery of Wastewater Treatment

    Way to Generate Waste to Value
    • 1st Edition
    • Maulin P. Shah + 1 more
    • English
    Bio Refinery of Wastewater Treatment: Way to Generate Waste to Value focuses on the exploitation of various wastewater treatment technologies and microbial, chemical, and physical processes as tools for simultaneous value generation during treatment, degradation, detoxification, and stabilization of toxic and hazardous contaminants and restoring contaminated sites. The book provides recents advancements in integrative and cost-effective wastewater treatment strategies and stipulates all pros and cons of each strategy.Bio Refinery of Wastewater Treatment: Way to Generate Waste to Value is valuable to researchers and scientists, who are working in the field of effluent treatment plants/biodegradatio... of environmental contaminants for environmental protection and sustainable development.

  • Predictive Analytics using MATLAB(R) for Biomedical Applications

    • 1st Edition
    • L. Ashok Kumar
    • English
    Predictive Analytics using MATLAB(R) for Biomedical Applications is a comprehensive and practical guide for biomedical engineers, data scientists, and researchers on how to use predictive analytics techniques in MATLAB(R) for solving real-world biomedical problems. The book offers a technical overview of various predictive analytics methods and covers the utilization of MATLAB(R) for implementing these techniques. It includes several case studies that demonstrate how predictive analytics can be applied to real-world biomedical problems, such as predicting disease progression, analyzing medical imaging data, and optimizing treatment outcomes.With a plethora of examples and exercises, this book is the ultimate tool for reinforcing one’s knowledge and skills.

  • The Physics of Protein Structure and Dynamics

    When and Why Proteins Fold or Don’t Fold
    • 1st Edition
    • Reinhard Schweitzer-Stenner
    • English
    The Physics of Protein Structure and Dynamics looks at various aspects of protein structure and dynamics from a physico-chemical point of view. It goes into some depth regarding the description of non-covalent forces that determine the relative stability of folded and unfolded proteins. Anharmonic protein dynamics involving motions between different minima of a rugged Gibbs energy landscape is described in great detail. The book combines various aspects of the protein folding/unfolding processes with an overview of intrinsically disordered proteins, which have attracted considerable interest of the protein community over the last 25 years but are thus far underrepresented in classroom-oriented textbooks. The book looks at protein folding and intrinsically disordered proteins as heavily interrelated topics that need to be viewed together. Furthermore, it presents some basic physico-chemical aspects of protein/peptide self-assembly into nanoscale fibrils. Intrinsically disordered peptides and proteins play a major role particularly in aggregation and self-assembly processes that lead to various diseases (Alzheimer, Parkinson, Huntington, Mad-Cow). Therefore, the relevance of protein disorder for protein self-assembly deserves a closer look. Protein self-assembly cannot be separated from protein folding since it is frequently the product of misfolding. With regard to modern theories, the folding processes are linked to insights on protein dynamics and the discovered relationship between proteins and spin glasses.

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