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Elsevier

Books in Diabetes

  • Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities

    Evidence-Based Molecular Mechanisms and Clinical Outcomes
    • 1st Edition
    • Debidas Ghosh + 3 more
    • English
    Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities: Evidence-Based Molecular Mechanisms and Clinical Outcomes is a comprehensive, interdisciplinary reference addressing the complex link between diabetes mellitus and infertility in both men and women. This edited volume synthesizes molecular insights into diabetes-induced reproductive dysfunction—such as oxidative stress, inflammation, endocrine disruption, and tissue damage—with evidence-based evaluations of medicinal plants and their bioactive phytochemicals. It bridges laboratory research and clinical trials to highlight how plant-derived compounds can regulate glycemic control, restore hormonal balance, reduce oxidative damage, and improve gametogenesis. Targeting clinicians, researchers, and postgraduate students in biomedical and pharmaceutical sciences, the book offers detailed therapeutic profiles, safety assessments, and translational applications. By consolidating fragmented knowledge, it empowers healthcare professionals and scientists to develop integrative, cost-effective strategies for managing diabetes-related infertility.

  • Fetal Metabolic Programming in Obesity and Diabetes

    From Mechanisms to Preventive Therapy
    • 1st Edition
    • Luis Sobrevia
    • English
    Fetal Metabolic Programming in Obesity and Diabetes: From Mechanisms to Preventive Therapy describes the consequences of cellular and molecular aspects of maternal obesity (before and during pregnancy), diabetes mellitus (pregestational and gestational), and gestational diabesity (i.e., women with pre-pregnancy obesity that developed GDM). The book covers the clinical aspects of mothers and children and the protocols for treating these diseases during pregnancy. Since the patients' clinical information correlates with metabolic parameters at a cellular and systemic level, it covers several pieces of evidence, addressing the pathophysiology of obesity and diabetes in pregnancy. This is an important resource for health professionals, researchers, and postdocs in obesity diabetes, as well as public health, physiology, biochemistry, cell biology, cell physiology, cell metabolism, and clinical and translational medicine.

  • Insights and Implications of Pseudo Esterase Activity of Human Serum Albumin in Diabetic Kidney Disease

    • 1st Edition
    • Dibyajyoti Banerjee
    • English
    Insights and Implications of Pseudo Esterase Activity of Human Serum Albumin in Diabetic Kidney Disease provides a comprehensive exploration of diabetic nephropathy, emphasizing the critical need for early detection methods prior to the onset of microalbuminuria. The book's primary focus is on the study of pseudoesterase activity in urinary albumin and other proteins as a potential biomarker for early diagnosis of diabetic kidney disease. This resource bridges a significant gap in current literature by providing an in-depth analysis of how this enzymatic activity can inform the classification and management of diabetic nephropathy.Chapters cover foundational knowledge of diabetes and its complications, the mechanisms of diabetic nephropathy, and detailed discussions on human serum albumin and its enzymatic activities. Each chapter covers the biochemical characterization of pseudoesterase activity, methods for its detection, and the significance of urinary proteomic profiling. Final chapters highlight future research opportunities and the potential for developing point-of-care testing tools, positioning this work as a critical resource for advancing the field of diabetic kidney disease research and clinical practice.

  • Diabetic Neuropathy

    • 1st Edition
    • Shahidul Islam
    • English
    "Recent Therapeutic Targets for the Prevention and Management of Diabetic Complications: Neuropathy" covers recent research and therapeutic approaches of this diabetic complication for the management of diabetes. It is a detailed reference to understand the pathogenesis of diabetes to alleviate the overall complications of neuropathy to improve patient care. It is uniquely focused on the different aspects of neuropathy with a focus on the molecular and biological pathways (therapeutic target) to detect an early diagnosis to better manage the disease and improve patient care. The book is useful to anyone in the field particularly those who do research investigations, and day-to-day practice in the area of diabetes.

  • Laboratory Diagnosis of Inherited Metabolic Diseases

    • 2nd Edition
    • Uttam Garg + 2 more
    • English
    Laboratory Diagnosis of Inherited Metabolic Diseases, Second Edition provides the most up-to-date guidance on laboratory test selection and interpretation, illustrated metabolic pathways, and information on clinical presentation, genetics, pathogenesis, treatment, and prognosis of these diseases. Since the first edition and the expansion of newborn screening, an increasing number of healthcare providers are encountering metabolic disorders, so selecting and interpreting tests can be challenging. This fully revised edition offers simple and practical approaches to understanding metabolic diseases, assisting in the selection of tests for confirmatory diagnosis and clinical follow-up.Biochemica... genetic testing is a key laboratory medicine discipline for evaluating, diagnosing, and treating inherited metabolic diseases (IMDs). These tests are complex and specialized, and use a variety of specimens, including blood, urine, plasma, and cerebrospinal fluid. The tests evaluate enzyme activity, protein function, and metabolite levels, such as fatty acids, amino acids, and organic acids.

  • Quick Guide to Diabetes Mellitus

    • 2nd Edition
    • William E. Winter + 3 more
    • English
    Quick Guide to Diabetes Mellitus, Second Edition provides essential knowledge on the pathophysiology, etiology, epidemiology, diagnosis, laboratory evaluation, and basic clinical management of diabetes and its complications targeted to laboratory scientists and technicians. Eleven percent of the U.S. population have been diagnosed with diabetes mellitus, and laboratory scientists play an essential role in the diagnosis, monitoring, and management of this disease. This reference presents an easy-to-read question-and-answer format that will provide fundamental knowledge and aid in commonly encountered clinical challenges.This updated release includes new information on genetic and environmental risk factors for type 1 and 2 diabetes, pediatric glucose targets per American Diabetes Association Standards, type 2 diabetes management sections, including treatment guidelines and information on glucagon-like peptide-1 receptor agonists and gastric bypass surgery.

  • Type 2 Diabetes Mellitus

    Exploring Immunogenetic Pathways
    • 1st Edition
    • Haamid Bashir + 2 more
    • English
    Type 2 Diabetes Mellitus: Exploring Immunogenetic Pathways is a novel reference to gain a deep understanding of the genetic underpinnings and immune system dynamics in Type 2 Diabetes Mellitus (T2DM). It addresses a fundamental gap in the current literature by synthesizing complex information into accessible chapters serving as a roadmap for those needing to navigate the intricate landscape of immunogenetics. It equips readers with the tools to comprehend the underlying mechanisms, discover potential therapeutic strategies, and contribute to the ongoing dialogue in this rapidly advancing field. Real-world case studies and clinical scenarios are throughout the book to illustrate the practical applications of immunogenetics in diagnosing, treating, and managing Type 2 Diabetes Mellitus to help bridge the gap between theory and practice and enhance the relevance of the content for healthcare professionals. The book Explore the integration of multi-omics approaches, including genomics, transcriptomics, proteomics, and metabolomics, to provide a comprehensive understanding of the complex interactions between genetic and immunological factors in Type 2 Diabetes Mellitus. This holistic approach can offer insights into novel biomarkers and therapeutic targets. In addition, discussions on the ethical, legal, and social implications of immunogenetics research in Type 2 Diabetes Mellitus, such as genetic privacy, informed consent, and equity in healthcare access. Addressing these considerations is essential for promoting responsible research practices and ensuring equitable healthcare outcomes. The book is essential for seasoned researchers in T2DM, healthcare professionals, or a student entering the field; this book offers invaluable insights into the future of T2DM research and treatment.

  • Yoga and Prevention of Type 2 Diabetes

    An Integrated Approach to Wellness
    • 1st Edition
    • S.V. Madhu
    • English
    Yoga and Prevention of Type 2 Diabetes: An Integrated Approach to Wellness is a unique reference to approaching yoga, its principles, and how its various practices contribute to overall health and wellness and to understanding the scientific evidence and impact of yoga on glycemic control, insulin sensitivity, and stress reduction. The book lays the foundation to understanding the pathophysiology, epidemiology, and risk factors associated with type 2 diabetes while exploring the physiological and biochemical pathways by which yoga influences glucose metabolism and mitigates diabetes risk factors.Collectively... the book's chapters equip readers with a thorough understanding of Type 2 diabetes and the multifaceted role of yoga in its prevention and management. By combining theoretical knowledge with practical applications, this work will empower individuals and healthcare providers to take proactive steps toward better metabolic health through yoga.

  • The Story of GLP-1

    A Historical Journey in the Treatment of Diabetes and Obesity
    • 1st Edition
    • Jens Juul Holst
    • English
    The Story of GLP-1: A Historical Journey in the Treatment of Diabetes and Obesity offers a compelling narrative about the discovery and development of the hormone GLP-1, which has revolutionized modern approaches to diabetes and obesity. Award-winning scientist Professor Jens Juul Holst, alongside co-authors Professor Sten Madsbad, Professor Jens Meldgaard Bruun, and Novo Nordisk Foundation CEO Mads Krogsgaard Thomsen, trace the scientific breakthroughs and clinical advances that have made GLP-1 therapies, such as Ozempic and Wegovy, essential tools for improving blood sugar control and promoting meaningful, lasting weight loss in patients worldwide.The book explores the rising global prevalence of obesity and diabetes, emphasizing the urgent need for innovative solutions. It critically examines traditional treatments, noting their limitations in sustaining weight loss or reducing complications. The narrative details the paradigm shift brought by GLP-1 medications, including liraglutide and semaglutide, which offer improved cardiovascular outcomes and significant health benefits. The authors also address ongoing challenges of accessibility and affordability, prompting important societal discussions about equitable distribution and funding for these lifechanging therapies.

  • Diabetes, Aging, and Management Strategies

    Cellular Mechanisms for Healthy Aging
    • 1st Edition
    • Younis Ahmad Hajam + 2 more
    • English
    Diabetes, Aging, and Management Strategies: Cellular Mechanisms for Healthy Aging is a comprehensive guide that explores the complex interplay between diabetes and the aging process. The book dives deeply into the scientific mechanisms underlying diabetes and aging, offering insights into how aging accelerates disease processes and affects metabolic pathways, organ function, and overall health. With a focus on the biological, clinical, and practical aspects of diabetes in the elderly, this book provides actionable information on the pathophysiology of diabetes in aging individuals, evidence-based mitigation strategies, and effective management approaches.As populations worldwide grow older, the prevalence of diabetes continues to rise, presenting new challenges in understanding, managing, and mitigating the effects of this condition on older adults. This book is designed to support healthcare professionals, researchers, and policymakers in creating and implementing strategies that address the unique needs of this population.

  • Myopathies and Tendinopathies of the Diabetic Foot

    Anatomy, Pathomechanics, and Imaging
    • 1st Edition
    • Claude Pierre-Jerome
    • English
    Myopathies and Tendinopathies of the Diabetic Foot: Anatomy, Pathomechanics, and Imaging is a unique reference of valuable instructive data that reinforces the understanding of myopathies and tendinopathies related to diabetes-induced Charcot foot. Diabetic myopathies usually precede other complications (i.e., deformity, ulceration, infection) seen in the diabetic foot. Oftentimes, these myopathies may be isolated especially during their initial stage. In the absence of clinical information relevant to diabetes, the solitaire occurrence of myopathies may lead to confusion, misinterpretation, and misdiagnosis. The misdiagnosis can cause delay of management and consequent high morbidity. This book emphasizes the complications of diabetic myopathies and tendinopathies and all their aspects, including pathophysiology, pathomechanics, imaging protocols, radiological manifestations, histological characteristics, and surgical management.Diabetes type II and its complications (diabetic myopathies and tendinopathies) have reached a dreadful high incidence worldwide. Likewise, the need for better understanding of these complications becomes indispensable. In this book, the readers of all genres will find all they need to know about these conditions. This book serves as a classic academic reference for educators, healthcare specialists, healthcare givers, and healthcare students.

  • Diabetes Digital Health, Telehealth, and Artificial Intelligence

    • 1st Edition
    • David C. Klonoff + 2 more
    • English
    Diabetes Digital Health, Telehealth, and Artificial Intelligence explains how to develop and use the emerging technologies of digital health, telehealth, and artificial intelligence to address this important public health problem to deliver new hardware, software, and processes. The book explores trends in developing and deploying the three most important emerging technologies for diabetes: digital health, telehealth, and artificial intelligence. This book is essential to clinicians, scientists, engineers, industry professionals, regulators, and investors, offering the tools that will be used to create the next generation products to support a precision medicine approach to manage diabetes.According to the CDC, in the US there are 37 million people with diabetes and 96 million people with prediabetes. Diabetes triples the risk of myocardial infarction and stroke and is the leading cause of blindness, end stage renal failure, and amputations. The management of diabetes is becoming increasingly dominated by digital health tools consisting of wearable sensors, mobile applications providing decision support software, and wireless communication tools. Digital health provides new data streams that can be combined to create unique approaches for diabetes based on a precision medicine paradigm.

  • Environmental Pollution and Type 2 Diabetes Mellitus

    • 1st Edition
    • Sultan Ayoub Meo
    • English
    Environmental Pollution and Type 2 Diabetes Mellitus elucidates on the global impact of environmental pollution and how it increases diabetes mellitus. Swift urbanization and the industrial revolution have increased environmental pollution to a hazardous level. Environmental pollution is a leading risk factor for several well-known diseases. This book opens venues for students, physicians, researchers, the science community, and policymakers to enhance their knowledge about environmental pollution, weather conditions, climate change, and their impact on insulin resistance and mechanisms allied to Type 2 diabetes mellitus (T2DM).Moreover, this book will provide knowledge about the green space environment and its impact on T2DM.

  • Biochemical Immunology of Diabetes and Associated Complications

    • 1st Edition
    • Pratima Tripathi + 2 more
    • English
    Biochemical Immunology of Diabetes and Associated Complications offers in-depth coverage of the association of biochemical and immunological aspects of the human body in diabetes. It discusses the suppression and modulation of the immune system and the impact of immunochemicals on the biochemical pathways in diabetes, along with associated complications. The book enumerates the exigency in knowledge about the immunomodulators as therapeutic targets to cure the syndrome. It will serve as an important reference for medical practitioners, researchers, medical students, masters and doctoral students. In addition, it could also be used as a reference for science graduates, science teachers, and researchers.

  • BIDE's Diabetes Desk Book

    For Healthcare Professionals
    • 1st Edition
    • Abdul Basit + 4 more
    • English
    BIDE’s Diabetes Desk Book: For Healthcare Professionals offers a holistic approach to diabetes management, including the most current evidence-based recommendations for diagnosing and treating adults and children with all forms of diabetes. The book offers guidelines on the management of infections in diabetes and the management of diabetes. It is based on a successful cost-effective model for countries to utilize at the national level to address important issues such as diabetic foot, gestational diabetes, and diabetes education. This is an essential international resource that provides information on primary prevention strategies to encourage diabetes-related research.

  • Metabolic Syndrome

    From Mechanisms to Interventions
    • 1st Edition
    • Satinath Mukhopadhyay + 1 more
    • English
    Metabolic Syndrome: From Mechanisms to Interventions covers all aspects of this complex and multifactorial disease, providing a cutting-edge understanding of the problem of MetS, with a particular focus on its prevention and clinical management. The book discusses practical implementable approaches to its reversal in clinical practice, encompassing the entire spectrum of MetS, from molecular understanding to clinical therapeutics and prevention. This book is a valuable resource for clinicians in multiple specialties, including endocrinologists, diabetologists, hepatologists, gynecologists and researchers in related fields who need a deep understanding of the full range of scientific and clinical aspects of metabolic syndrome.

  • Tutorials in Clinical Chemistry

    • 1st Edition
    • Ibrahim A. Hashim
    • English
    Tutorials in Clinical Chemistry is designed for trainee pathology residents, clinical chemists, medical students, and clinical laboratory scientists, in addition to those preparing for board and postgraduate examination. It is helpful to those in training as well as a teaching aid for mentors, faculty, and directors. The book is organized into 17 system-based chapters covering essential pathophysiology, biochemical investigation, and technical aspects of relevance to results interpretation. Tutorials in Clinical Chemistry is a must-have, didactic and essential knowledge as well as practical resource for learning and review.

  • Inflammation and Obesity

    A New and Novel Approach to Manage Obesity and its Consequences
    • 1st Edition
    • Raman Mehrzad
    • English
    Inflammation and Obesity: A New and Novel Approach to Manage Obesity and its Consequences is a comprehensive and up-to-date exploration of the correlation between obesity and inflammation. From the pathophysiology of obesity and inflammation, to the molecular mechanisms of obesity induced chronic inflammation, the book discusses how obesity and inflammation interact with other diseases. It highlights the hidden risk factors of obesity induced chronic inflammation, provides specific patient management guidelines regarding the higher inflammatory response in patients, and concludes with new therapeutic strategies to address inflammation in obese patients.

  • Diabetes Digital Health and Telehealth

    • 1st Edition
    • David C. Klonoff + 2 more
    • English
    Diabetes Digital Health and Telehealth explains, from technologic, economic and sociologic standpoints how digital health and telehealth have come to dominate the management of diabetes. The book also includes information on improved telemedicine tools and platforms for communicating with patients, reviewing medical records, and interpreting data from wearable devices. In addition, evolving wearable sensors such as continuous glucose monitors, closed loop automated insulin delivery systems, cuffless blood pressure monitors, exercise monitors and smart insulin pens are covered.

  • The Essentials of Charcot Neuroarthropathy

    Biomechanics, Pathophysiology, and MRI Findings
    • 1st Edition
    • Claude Pierre-Jerome
    • English
    The Essential Charcot Neuroarthropathy: Biomechanics, Pathophysiology, and MRI Findings provides a comprehensive analysis of Charcot neuroarthropathy (or Charcot Foot) in diabetic patients. All aspects are covered, including epidemiology, biomechanics, pathophysiology, socioeconomic impacts, radiological findings, and differential diagnosis, with an emphasis on MRI. Chapters address the challenges of pre-and-post surgical management of Charcot neuroarthropathy and the role of unconventional imaging modalities in diagnosis. The book presents an analysis of the normal biomechanics of the ankle and foot, the biomechanical derangements of the ankle-foot unit (including abnormal gait) caused by diabetes Type II, and more. Finally, there is also a reference of the pathophysiology of diabetes-induced peripheral neuropathy and its direct link with the development of Charcot neuroarthropathy foot. Diabetes-induced Charcot foot is frequently misunderstood, misinterpreted and misdiagnosed which can lead to confusion and detrimental management with reported high morbidity.

  • Diabetic Neuropathy

    • 1st Edition
    • Mitra Tavakoli
    • English
    Diabetic Neuropathy identifies the most accurate early biomarkers of nerve damage to better understand pathophysiology and diagnose diabetic neuropathy in the clinical care of patients, and in particular, permit an accurate evaluation of future therapies in clinical trials. This succinct reference focuses on the current data and research on diabetic neuropathy and is essential reading for researchers in endocrinology, neurology and pharmacology, along with clinicians that need to better understand the novel pathogenetic pathways leading to diabetic neuropathy and the treatments.

  • Diabetes Without Needles

    Non-invasive Diagnostics and Health Management
    • 1st Edition
    • Artur Rydosz
    • English
    Diabetes Without Needles: Non-invasive Diagnostics and Health Management provides a comprehensive and objective compilation of the most promising noninvasive methods for glucose monitoring, including an in-depth analysis of their advantages and disadvantages in terms of biochemical processes. The latest advances in the field are discussed, including methods such as optical measurements, electrochemical measurements, exhaled breath analysis, direct measurements of glucose in the blood using noninvasive techniques, and the indirect analysis of biomarkers that are related to the glycemia. The book's author also presents recommendations for future research directions in this field. This book is a valuable resource for researchers in the areas of diabetes, noninvasive methods and diagnostics development.

  • Understanding Insulin and Insulin Resistance

    • 1st Edition
    • Anil Gupta
    • English
    Understanding Insulin and Insulin Resistance is written in a simple and clear language illustrated with diagrams that show the complex interplay of various factors in the initiation of insulin resistance. The design is systematic and meticulous, portraying topics in a flow from simple to complex. This resource is intended for a broad audience spanning across biochemistry, medicine, dentistry, academia, physicians, and research scholars. It extends the approach to biochemistry, physiology, metabolism of insulin along with the coverage of pathophysiology of insulin resistance, its effects on the body tissues, and its analysis on insulin resistance syndrome.

  • Psychological and Medical Perspectives on Fertility Care and Sexual Health

    • 1st Edition
    • Kim Bergman + 1 more
    • English
    Psychological and Medical Perspectives on Fertility Care and Sexual Health provides the necessary specialized training of sexual dysfunction and sex therapy to those in reproductive medicine. Understanding and knowledge about these sexual dysfunctions is needed for reproductive specialists to identify sexual problems, provide treatment if they are able or make appropriate referrals, and coordinate care for more specialized and specific needs as part of the patients overall reproductive medical management. This must-have reference explores the intimate interface of sexuality and fertility, male and female sexual function, cultural influences on women, Eastern medicine, and more!

  • Sarcopenia

    Molecular Mechanism and Treatment Strategies
    • 1st Edition
    • Kunihiro Sakuma
    • English
    Sarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disability and diminished quality of life. Written by experts around the world, this book is for all those that care for aging populations. As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment.

  • Diabetes Mellitus

    Impact on Bone, Dental and Musculoskeletal Health
    • 1st Edition
    • Meng Hee Tan
    • English
    Diabetes Mellitus: Impact on Bone, Dental and Musculoskeletal Health focuses on the under recognized and managed conditions associated with diabetes, including impacts on bone health, dental health, hand, and foot disorders, wounds, infections, and musculoskeletal disorders. A full understanding of the relationship of diabetes to skeletal disorders remains elusive and many physicians who deal with such issues are unclear about causes and management. While the macro- and microvascular complications associated with diabetes mellitus are well known, complications associated with bone, dental and musculoskeletal health are not. Endocrinologists, primary care physicians, geriatricians, podiatrists, dentists, and researchers interested in diabetes mellitus associated bone, dental and musculoskeletal disorders will find this to be a comprehensive tome on the topic.

  • Obesity

    Global Impact and Epidemiology
    • 1st Edition
    • Raman Mehrzad
    • English
    Obesity continues to accelerate resulting in an unprecedented epidemic that shows no significant signs of slowing down any time soon. The World Health Organization reports that in 2016, nearly 2 billion adults were overweight and that worldwide obesity has nearly tripled since 1975. Obesity: Global Impact and Epidemiology is an important tool in proving a link to new knowledge, serving researchers and clinicians. The field of obesity is evolving very quickly and there is an abundance of scientific data that has emerged and is emerging constantly. Researchers and physicians need new updated information about the epidemiology and global impact of obesity that come from authors that have a wide perspective in the field. For health professionals and researchers, there is a need to understand how obesity begins. While a simple question, the answer is very complex.

  • Diabetes and Retinopathy

    • 1st Edition
    • Ayman S. El-Baz + 1 more
    • English
    Diabetes and Retinopathy brings together the multifaceted information about the research and clinical application from academic, clinical, bioengineering and bioinformatics perspectives. The editors bring together a stellar cast of authors to pull together this diverse and interesting field. Academic researchers, bioengineers, new investigators and students interested in diabetes and retinopathy need an authoritative reference to bring this multidisciplinary field together to reduce the amount of time spent on source-searching and more time on actual research and the clinical application. This reference depicts the current clinical understanding of DR as well as the many scientific advances in understanding this condition.

  • Global Health Complications of Obesity

    • 1st Edition
    • Jahangir Moini + 3 more
    • English
    Global Health Complications of Obesity presents a valuable resource for research scientists and clinicians by covering the burden of obesity and related diseases and serving as a starting point for in-depth discussions in academic settings and for obesity-treatment specialists. Obesity is associated with a statistically higher risk of heart disease, hypertension, insulin resistance, type 2 diabetes and many other diseases. This succinct resource focuses on the current data, research and management of obesity. It is essential reading for healthcare professionals, endocrinologists, nutritionists, public health students and medical students.

  • Personalized Predictive Modeling in Type 1 Diabetes

    • 1st Edition
    • Eleni I. Georga + 2 more
    • English
    Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures.

  • Drug Metabolism in Diseases

    • 1st Edition
    • Wen Xie
    • English
    Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology.

  • Oral Delivery of Insulin

    • 1st Edition
    • T.A. Sonia + 1 more
    • English
    Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin.

  • Glucose Intake and Utilization in Pre-Diabetes and Diabetes

    Implications for Cardiovascular Disease
    • 1st Edition
    • Ronald Ross Watson + 1 more
    • English
    This important reference, edited by Ronald Ross Watson and Betsy Dokken, collects the research needed to make the distinct connection between pre-diabetes, diabetes, and cardiovascular disease. Glucose Intake and Utilization in Pre-Diabetes and Diabetes: Implications for Cardiovascular Disease explains the mechanisms of progression from pre-diabetes to diabetes to cardiovascular disease. Since pre-diabetes and diabetes are important cardiovascular disease risk factors, and impaired glucose metabolism among cardiac patients is extremely prevalent, the importance of reviewing pre-diabetes and its involvement in CVD complications is vital as one applies food and glycemic control to slow progress to diabetes and heart disease. The book further focuses on glucose intake and utilization in diabetes, including coverage of diabetes in the development and pathology of cardiovascular disease, risks and epidemiology of cardiovascular problems promoted by diabetes, macrovascular effects and their safety in therapy of diabetics, beta cell biology and therapy of diabetes, and nutrition to modulate diabetes.

  • Diabetes and the Nervous System

    • 1st Edition
    • Volume 126
    • Douglas W Zochodne + 1 more
    • English
    This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson’s disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system.

  • Diabetes

    Oxidative Stress and Dietary Antioxidants
    • 1st Edition
    • Victor R. Preedy
    • English
    Diabetes: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide among diabetologists, endocrinologists, and nutritionists in understanding and treating diabetes. The book covers, in a single volume, the science of oxidative stress in diabetes and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, receptor-mediated responses and more. This approach recognizes that diseases are usually multifactorial and that oxidative stress is a single component of this.Pharmacological treatments for diabetes are commonly marked by unwanted side effects, leading to treatment efforts using naturally occurring substances. But a plant-based approach alone is not sufficient; understanding the processes inherent in the oxidative stress of diabetes is vital for clinical workers, dietitians, and nutritionists.This translational work provides that understanding. The book begins by covering the basic biology of oxidative stress from molecular biology to imaging in relation to diabetes. There are chapters on neuropathy, nephropathy, atherosclerosis, cardiomyopathy, and retinopathy. The book then moves on to antioxidants in foods, including plants, components of the diet, and their relevance to diabetes.

  • Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome

    • 1st Edition
    • Debasis Bagchi + 1 more
    • English
    Diabetes mellitus affects approximately 20 million people in the US, or nearly 7% of the population. It is expected to increase by 70% within the next 25 years, and numerous epidemiologic studies have demonstrated that type 2 diabetes increases the risk of cardiovascular morbidity and mortality. It is estimated to cost over $92 billion in health care costs and lost productivity. The increased risk is due to the detrimental vascular effects of prolonged exposure to a hyperglycemic, oxidant-rich environment yielding associated cardiovascular risk factors: atherosclerosis, hypertension and clotting abnormalities. Hypertension and dyslipidemia in diabetic patients produces substantial decreases in cardiovascular and microvascular diseases. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome provides an overview of the current epidemic, outlines the consequences of this crisis and lays out strategies to forestall and prevent diabetes, obesity and other intricate issues of metabolic syndrome. The contributing experts from around the world give this book relevant and up-to-date global approaches to the critical consequences of metabolic syndrome and make it an important reference for those working with the treatment, evaluation or public health planning for the effects of metabolic syndrome and diabetes.

  • Immunopathogenesis of Type 1 Diabetes Mellitus

    • 1st Edition
    • Volume 100
    • Frederick W. Alt
    • English
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. This thematic volume focuses on the immunopathogenesis of type 1 diabetes mellitus. Edited and authored by the foremost scientists in this field, it provides up-to-date information and directions for future research.

  • New Transcription Factors and Their Role in Diabetes and Therapy

    • 1st Edition
    • Volume 5
    • Jacob E. Friedman
    • English
    This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins should provide the reader with a theoretical background to understanding the strategies for new potential therapeutic targets and their application to disease.

  • Antidiabetic Agents: Recent Advances in their Molecular and Clinical Pharmacology

    • 1st Edition
    • Volume 27
    • English
    Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.

  • Advances in Metabolic Disorders

    Volume 9
    • 1st Edition
    • Rachmiel Levine + 1 more
    • English
    Advances in Metabolic Disorders, Volume 9 provides information pertinent to the fundamental aspects the epidemiology of diabetes. This book discusses the relationship between possible environmental determinants and genetic predisposition to the disease. Organized into two parts encompassing 18 chapters, this volume begins with an overview of the prevalence rate for diabetes mellitus in the town of Oxford, Massachusetts in 1946–1947. This text then examines the available information on the rates of occurrence of diabetes mellitus in the United States, which has been limited to relative frequencies among clinical subgroups. Other chapters consider the five-year prospective study of 10,000 adult men to determine the incidence, prevalence, and major factors associated with the development of the condition. This book discusses as well the epidemiologic studies of diabetes to determine which environmental factors contribute to the risk of diabetes. The final chapter deals with somatic development in children. This book is a valuable resource for diabetologists, social anthropologists, and clinicians.