Chronic Complications of Diabetes Mellitus

Current Outlook and Novel Pathophysiological Insights

1st Edition - March 21, 2024
Imprint: Academic Press
Editors: Didac Mauricio, Nuria Alonso
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 8 4 2 6 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 4 4 3 - 8

Chronic Complications of Diabetes Mellitus: Current Outlook and Novel Pathophysiological Insights provides a holistic view of the disease, discussing not only its classical… Read more

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Chronic Complications of Diabetes Mellitus: Current Outlook and Novel Pathophysiological Insights provides a holistic view of the disease, discussing not only its classical complications but also the under recognized and managed conditions associated with diabetes. Chapters also discuss advances in our understanding of the genomic architecture of diabetes complications and how precision medicine can be used to personalize their management. Endocrinologists, diabetologists, primary care physicians and researchers interested in complications of diabetes mellitus and cutting-edge information will find this to be a comprehensive tome on the topic.

Diabetes complications include pathological changes usually related to the vascular system and classical target organs. However, there are also nonclassical complications independent or partially independent from vascular damage that are often overlooked.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter 1. Overview on chronic complications of diabetes mellitus
1. Introduction
2. Microvascular disease
3. Macrovascular complications of diabetes
4. Nonvascular complications of diabetes
5. Concluding remarks
Chapter 2. Epidemiology of chronic complications of diabetes: A global perspective
1. Introduction
2. Global epidemic of diabetes
3. Epidemiology of chronic complications in diabetes
4. Conclusion
Chapter 3. Molecular mechanisms involved in hyperglycemia-induced cellular damage
1. Introduction
2. Mechanisms of hyperglycemia-induced cell damage
3. Convergent element linking hyperglycemia-induced damage: Mitochondrial dysfunction?
4. Concluding remarks
Chapter 4. Vascular calcification in diabetes mellitus: Molecular mechanisms and clinical implications
1. Introduction
2. Types and sites of vascular calcification
3. Risk factors for vascular calcification
4. Molecular mechanisms of vascular calcification
5. Clinical implications
6. Antidiabetic drugs and vascular calcification
7. Conclusions
Chapter 5. Pathogenesis of diabetic atherosclerotic cardiovascular disease
1. Introduction
2. Mechanisms of vascular damage in diabetes
3. Conclusions
Chapter 6. Diabetic retinopathy: New insights
1. Introduction
2. New insights in epidemiology
3. New insights in pathophysiology
4. New insights in diagnosis and imaging
5. New insights in staging and classification
6. New insights in screening
7. New insights in systemic treatment
8. New insights in ocular treatment
9. Emerging and future research
Chapter 7. Macular edema: A fearful complication of diabetic eye disease
1. Prevalence
2. Risk factors
3. Normal retinal fluid homeostasis
4. Pathogenesis of DME
5. Treatment
6. Conclusion
Chapter 8. Retinal neurodegeneration: Importance in diabetes management
1. Introduction
2. The neurovascular unit and its impairment in diabetic retinal disease
3. Methods to assess neurodegeneration
4. Clinical implications
5. Therapeutic implications
6. Concluding remarks
Chapter 9. Diabetic neuropathy: Current issues in diagnosis and prevention
1. Introduction
2. Clinical relevance of diabetic polyneuropathies
3. Diagnosis of diabetic polyneuropathies
4. Prevention of diabetic neuropathy
Chapter 10. Pathophysiological and clinical aspects of nonclassical targets of microangiopathy
1. Microangiopathy in nonclassical target organs and tissues in subjects with DM
2. Conclusions
Chapter 11. Diabetic bone disease: Metabolic and microvascular damage
1. Introduction
2. Fracture risk in diabetes
3. Mechanisms underlying bone loss and fragility
4. Evaluation of bone health in patients with diabetes
5. Treatment of bone fragility in patients with diabetes
6. Conclusions
Chapter 12. Nonalcoholic fatty liver disease: What comes before and what are the consequences?
1. Definitions
2. Epidemiology
3. NAFLD and diabetes: A killer duet?
4. Pathogenesis of NAFLD
5. Systemic conditions associated with NAFLD
6. Diagnosis
7. Management of patients with NAFLD and diabetes
8. Conclusions
Chapter 13. The diabetic lung
1. Introduction
2. Baseline spirometric values in patients with T2DM
3. What we know about mechanisms leading to pulmonary dysfunction in T2DM?
4. Histopathological changes in lung parenchyma in T2DM
5. Therapeutic implications: How to treat pulmonary dysfunction in T2DM?
6. Future directions and final remarks
Chapter 14. Diabetes-related cognitive impairment and dementia
1. Introduction
2. Epidemiological evidence
3. Molecular pathways linking T2D and AD
4. Pathways linking dementia, AD, and DR
5. Assessment of cognitive decline
6. New methods for diagnosis and monitoring of cognitive
7. Conclusions
Chapter 15. Cancer in diabetes: Who is who?
1. Introduction
2. Epidemiological association between diabetes and cancer
3. Factors that link diabetes to cancers
4. How can knowledge on diabetes-cancer associations improve the management of patients with diabetes and cancer together?
5. Future perspectives
Chapter 16. Role of glycemic legacy and glycemic variability in the development and progression of complications of diabetes
1. Introduction
2. Glucotoxicity
3. Glycemic variability
4. Glycemic variability and complications of diabetes
5. Glycemic legacy
6. Glycemic legacy and complications of diabetes
7. Conclusions
Chapter 17. Prevention and management of chronic kidney disease in diabetes
1. Chronic kidney disease is a common complication in diabetes
2. Clinical manifestation of CKD in diabetes
3. Is kidney disease due to diabetes reversible?
4. Who are at risk of CKD?
5. Screening for CKD in diabetes
6. Screening challenges
7. Why is it important to recognize the presence of CKD?
8. Special issue: Increased risk of hypoglycemia
9. “The 5-finger rule” for the prevention and treatment of kidney disease
10. Conclusion
Chapter 18. Heart failure in diabetes: Current clinical management
1. Epidemiology
2. Definition and diagnosis
3. Treatment of diabetes mellitus in patients with heart failure
4. Medical therapy for heart failure in patients with diabetes mellitus
Chapter 19. Diabetic eye disease: novel therapeutic strategies
1. Introduction
2. Current therapeutic strategies
3. Novel therapeutic strategies
4. Neuroprotection
5. Biosimilars
6. Conclusion
Chapter 20. Management of diabetic foot disease
1. Introduction
2. Diabetic neuropathy
3. Peripheral arterial disease
4. Charcot foot/Charcot neuroarthropathy
5. Diabetic foot ulcer
6. Osteomyelitis
Index

Didac Mauricio

Dr. Didac Mauricio - Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III,

Barcelona, Spain; DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Institut Universitari per a la Recerca a l’Atencio´ Prima`ria Jordi Gol i

Gurina (IDIAP Jordi Gol), Barcelona, Spain; Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau & Sant Pau

Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Faculty of Medicine, University of Vic

(UVIC/UCC), Vic, Spain

Affiliations and expertise

Chief Physician and Acting Head, Department of Endocrinology and Nutrition, University Hospital Germans Trias i Pujol, Barcelona, Spain; Associate Professor, School of Medicine, University of Lleida, Lleida, Spain; CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Spain

Nuria Alonso

Núria Alonso, MD PhD is a staff endocrinologist and head of the diabetes section at the Department of Endocrinology & Nutrition at University Hospital Germans Trias i Pujol Badalona, Spain. She is Assistant Professor at the Faculty of Medicine, Autonomous University of Barcelona. N. Alonso has published a total of 66 scientific articles in indexed journals. Currently, her clinical activity is mainly focused on those conditions that are associated with an increased risk of atheromatous CV disease, with special focus on diabetes mellitus (type 1 and type 2) and familial hypercholesterolemia. In the clinical research field, she is focused on the study of subclinical atheromatosis in patients with diabetes, as well as its association with microvascular complications. In recent years, her scientific activity has also developed on the study of lipotoxicity in diabetes and its association with ectopic fat deposition. She has been principal investigator of several research projects funded by national and international agencies.

Affiliations and expertise

Staff endocrinologist and head of the diabetes section at the Department of Endocrinology & Nutrition at University Hospital Germans Trias i Pujol Badalona, Spain. She is Assistant Professor at the Faculty of Medicine, Autonomous University of Barcelona

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