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Elsevier

Woodhead Publishing

  • Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals

    Technology, Validation and Current Regulations
    • 1st Edition
    • Tim Sandle
    • English
    Failure to adequately control any microbial challenge associated within process or product by robust sterilisation will result in a contaminated marketed product, with potential harm to the patient. Sterilisation is therefore of great importance to healthcare and the manufacturers of medical devices and pharmaceuticals. Sterility, sterilisation and sterility assurance for pharmaceuticals examines different means of rendering a product sterile by providing an overview of sterilisation methods including heat, radiation and filtration. The book outlines and discusses sterilisation technology and the biopharmaceutical manufacturing process, including aseptic filling, as well as aspects of the design of containers and packaging, as well as addressing the cleanroom environments in which products are prepared. Consisting of 18 chapters, the book comprehensively covers sterility, sterilisation and microorganisms; pyrogenicity and bacterial endotoxins; regulatory requirements and good manufacturing practices; and gamma radiation. Later chapters discuss e-beam; dry heat sterilisation; steam sterilisation; sterilisation by gas; vapour sterilisation; and sterile filtration, before final chapters analyse depyrogenation; cleanrooms; aseptic processing; media simulation; biological indicators; sterility testing; auditing; and new sterilisation techniques.

  • Biomaterials for Cancer Therapeutics

    Diagnosis, Prevention and Therapy
    • 1st Edition
    • Kinam Park
    • English
    Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials.

  • Geological Storage of Carbon Dioxide (CO2)

    Geoscience, Technologies, Environmental Aspects and Legal Frameworks
    • 1st Edition
    • Jon Gluyas + 1 more
    • English
    Geological storage and sequestration of carbon dioxide, in saline aquifers, depleted oil and gas fields or unminable coal seams, represents one of the most important processes for reducing humankind’s emissions of greenhouse gases. Geological storage of carbon dioxide (CO2) reviews the techniques and wider implications of carbon dioxide capture and storage (CCS).Part one provides an overview of the fundamentals of the geological storage of CO2. Chapters discuss anthropogenic climate change and the role of CCS, the modelling of storage capacity, injectivity, migration and trapping of CO2, the monitoring of geological storage of CO2, and the role of pressure in CCS. Chapters in part two move on to explore the environmental, social and regulatory aspects of CCS including CO2 leakage from geological storage facilities, risk assessment of CO2 storage complexes and public engagement in projects, and the legal framework for CCS. Finally, part three focuses on a variety of different projects and includes case studies of offshore CO2 storage at Sleipner natural gas field beneath the North Sea, the CO2CRC Otway Project in Australia, on-shore CO2 storage at the Ketzin pilot site in Germany, and the K12-B CO2 injection project in the Netherlands.Geologic... storage of carbon dioxide (CO2) is a comprehensive resource for geoscientists and geotechnical engineers and academics and researches interested in the field.

  • Chalcogenide Glasses

    Preparation, Properties and Applications
    • 1st Edition
    • J-L Adam + 1 more
    • English
    The unique properties and functionalities of chalcogenide glasses make them promising materials for photonic applications. Chalcogenide glasses are transparent from the visible to the near infrared region and can be moulded into lenses or drawn into fibres. They have useful commercial applications as components for lenses for infrared cameras, and chalcogenide glass fibres and optical components are used in waveguides for use with lasers, for optical switching, chemical and temperature sensing and phase change memories. Chalcogenide glasses comprehensively reviews the latest technological advances in this field and the industrial applications of the technology.Part one outlines the preparation methods and properties of chalcogenide glasses, including the thermal properties, structure, and optical properties, before going on to discuss mean coordination and topological constraints in chalcogenide network glasses, and the photo-induced phenomena in chalcogenide glasses. This section also covers the ionic conductivity and physical aging of chalcogenide glasses, deposition techniques for chalcogenide thin films, and transparent chalcogenide glass-ceramics. Part two explores the applications of chalcogenide glasses. Topics discussed include rare-earth-doped chalcogenide glass for lasers and amplifiers, the applications of chalcogenide glasses for infrared sensing, microstructured optical fibres for infrared applications, and chalcogenide glass waveguide devices for all-optical signal processing. This section also discusses the control of light on the nanoscale with chalcogenide thin films, chalcogenide glass resists for lithography, and chalcogenide for phase change optical and electrical memories. The book concludes with an overview of chalcogenide glasses as electrolytes for batteries.Chalcogeni... glasses comprehensively reviews the latest technological advances and applications of chalcogenide glasses, and is an essential text for academics, materials scientists and electrical engineers working in the photonics and optoelectronics industry.

  • Formulation Tools for Pharmaceutical Development

    • 1st Edition
    • J E Aguilar
    • English
    A range of new and innovative tools used for preformulation and formulation of medicines help optimize pharmaceutical development projects. Such tools also assist with the performance evaluation of the pharmaceutical process, allowing any potential gaps to be identified. These tools can be applied in both basic research and industrial environment. Formulation tools for pharmaceutical development considers these key research and industrial tools.Nine chapters by leading contributors cover: Artificial neural networks technology to model, understand, and optimize drug formulations; ME_expert 2.0: a heuristic decision support system for microemulsions formulation development; Expert system for the development and formulation of push-pull osmotic pump tablets containing poorly water-soluble drugs; SeDeM Diagram: an expert system for preformulation, characterization and optimization of tables obtained by direct compression; New SeDeM-ODT expert system: an expert system for formulation of orodispersible tablets obtained by direct compression; and 3D-cellular automata in computer-aided design of pharmaceutical formulations: mathematical concept and F-CAD software.

  • Satiation, Satiety and the Control of Food Intake

    Theory and Practice
    • 1st Edition
    • John E Blundell + 1 more
    • English
    With growing concerns about the rising incidence of obesity, there is interest in understanding how the human appetite contributes to energy balance and how it might be affected by the foods we consume, as well as other cultural and environmental factors. Satiation, satiety and the control of food intake provides a concise and authoritative overview of these areas. Part one introduces the concepts of satiation and satiety and discusses how these concepts can be quantified. Chapters in part two focus on biological factors of satiation and satiety before part three moves on to explore food composition factors. Chapters in part four discuss hedonic, cultural and environmental factors of satiation and satiety. Finally, part five explores public health implications and evaluates consumer understanding of satiation and satiety and related health claims.

  • Lasers for Medical Applications

    Diagnostics, Therapy and Surgery
    • 1st Edition
    • Helena Jelínková
    • English
    Lasers have a wide and growing range of applications in medicine. Lasers for Medical Applications summarises the wealth of recent research on the principles, technologies and application of lasers in diagnostics, therapy and surgery.Part one gives an overview of the use of lasers in medicine, key principles of lasers and radiation interactions with tissue. To understand the wide diversity and therefore the large possible choice of these devices for a specific diagnosis or treatment, the respective types of the laser (solid state, gas, dye, and semiconductor) are reviewed in part two. Part three describes diagnostic laser methods, for example optical coherence tomography, spectroscopy, optical biopsy, and time-resolved fluorescence polarization spectroscopy. Those methods help doctors to refine the scope of involvement of the particular body part or, for example, to specify the extent of a tumor. Part four concentrates on the therapeutic applications of laser radiation in particular branches of medicine, including ophthalmology, dermatology, cardiology, urology, gynecology, otorhinolaryngology (ORL), neurology, dentistry, orthopaedic surgery and cancer therapy, as well as laser coatings of implants. The final chapter includes the safety precautions with which the staff working with laser instruments must be familiar.With its distinguished editor and international team of contributors, this important book summarizes international achievements in the field of laser applications in medicine in the past 50 years. It provides a valuable contribution to laser medicine by outstanding experts in medicine and engineering.

  • Bio-Tribocorrosion in Biomaterials and Medical Implants

    • 1st Edition
    • Yu Yan
    • English
    During their service life, most biomaterials and medical implants are vulnerable to tribological damage. In addition, the environments in which they are placed are often corrosive. The combination of triobology, corrosion and the biological environment has been named ‘bio-tribocorrosion’... Understanding this complex phenomenon is critical to improving the design and service life of medical implants. This important book reviews recent key research in this area.After an introduction to the topography of bio-tribocorrosion, Part one discusses different types of tribocorrosion including fatigue-corrosion, fretting-corrosion, wear-corrosion and abrasion-corrosion. The book also discusses the prediction of wear in medical devices. Part two looks at biological effects on tribocorrosion processes, including how proteins interact with material surfaces and the evolution of surface changes due to bio-tribocorrosion resulting from biofilms and passive films. Part three reviews the issue of bio-tribocorrosion in clinical practice, including dental applications and joint replacement as well the use of coatings and test methods for bio-tribocorrosion.W... its international team of contributors, Bio-tribocorrosion in biomaterials and medical implants is a standard reference for those researching and developing medical devices as well as clinicians in such areas as dentistry and orthopaedic surgery.

  • Functional Ingredients from Algae for Foods and Nutraceuticals

    • 1st Edition
    • Herminia Dominguez
    • English
    Algae have a long history of use as foods and for the production of food ingredients. There is also increasing interest in their exploitation as sources of bioactive compounds for use in functional foods and nutraceuticals. Functional ingredients from algae for foods and nutraceuticals reviews key topics in these areas, encompassing both macroalgae (seaweeds) and microalgae.After a chapter introducing the concept of algae as a source of biologically active ingredients for the formulation of functional foods and nutraceuticals, part one explores the structure and occurrence of the major algal components. Chapters discuss the chemical structures of algal polysaccharides, algal lipids, fatty acids and sterols, algal proteins, phlorotannins, and pigments and minor compounds. Part two highlights biological properties of algae and algal components and includes chapters on the antioxidant properties of algal components, anticancer agents derived from marine algae, anti-obesity and anti-diabetic activities of algae, and algae and cardiovascular health. Chapters in part three focus on the extraction of compounds and fractions from algae and cover conventional and alternative technologies for the production of algal polysaccharides. Further chapters discuss enzymatic extraction, subcritical water extraction and supercritical CO2 extraction of bioactives from algae, and ultrasonic- and microwave-assisted extraction and modification of algal components. Finally, chapters in part four explore applications of algae and algal components in foods, functional foods and nutraceuticals including the design of healthier foods and beverages containing whole algae, prebiotic properties of algae and algae-supplemented products, algal hydrocolloids for the production and delivery of probiotic bacteria, and cosmeceuticals from algae.Functional ingredients from algae for foods and nutraceuticals is a comprehensive resource for chemists, chemical engineers and medical researchers with an interest in algae and those in the algaculture, food and nutraceutical industries interested in the commercialisation of products made from algae.

  • Marine Enzymes for Biocatalysis

    Sources, Biocatalytic Characteristics and Bioprocesses of Marine Enzymes
    • 1st Edition
    • Antonio Trincone
    • English
    Marine bioprospecting is a highly topical subject - in both applied and basic research - but, as yet, the marine ecosystem is a relatively unexplored source of natural bioactive substances with potential therapeutic activity. This book addresses the use of marine enzymes in biocatalysis through a series of chapters from leading scientists within academic and industrial fields. Biocatalytic processes can take advantage of the habitat-related properties of marine enzymes, such as salt tolerance, hyperthermostability... barophilicity, cold adaptivity, and so on, whilst also taking into consideration substrate specificity and affinity. These evolved properties are linked to the metabolic functions of the enzymes and to the ecological aspects of the natural source. New properties can also be discovered at the molecular level of catalysis, particularly concerning the stereochemical characteristics of products.Marine enzymes for biocatalysis initially examines the nature and level of interest in marine biological diversity, and outlines the fundamentals of biocatalysis. It goes on to detail sources of marine enzymes, and to analyse examples from both chemical and stereochemical viewpoints of catalysis, including microbial enzymes and animal or plant sources. The book goes on to explore the future potential of marine bioprospecting in biocatalysis.

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