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    • Therapeutic Antibody Engineering

      Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry
      • 1st Edition
      • William R Strohl + 1 more
      • English
      The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering.

    • Leveraging Information Technology for Optimal Aircraft Maintenance, Repair and Overhaul (MRO)

      • 1st Edition
      • Anant Sahay
      • English
      Aircraft maintenance, repair and overhaul (MRO) requires unique information technology to meet the challenges set by today’s aviation industry. How do IT services relate to aircraft MRO, and how may IT be leveraged in the future?Leveraging Information Technology for Optimal Aircraft Maintenance, Repair and Overhaul (MRO) responds to these questions, and describes the background of current trends in the industry, where airlines are tending to retain aircraft longer on the one hand, and rapidly introducing new genres of aircraft such as the A380 and B787, on the other. This book provides industry professionals and students of aviation MRO with the necessary principles, approaches and tools to respond effectively and efficiently to the constant development of new technologies, both in general and within the aviation MRO profession. This book is designed as a primer on IT services for aircraft engineering professionals and a handbook for IT professionals servicing this niche industry, highlighting the unique information requirements for aviation MRO and delving into detailed aspects of information needs from within the industry.

    • Protein Folding in Silico

      Protein Folding Versus Protein Structure Prediction
      • 1st Edition
      • Irena Roterman-Konieczna
      • English
      Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The opening chapters discuss the early stage intermediate and late stage intermediate models, followed by a discussion of structural information that affects the interpretation of the folding process. The second half of the book covers a variety of topics including ligand binding site recognition, the "fuzzy oil drop" model and its use in simulation of the polypeptide chain, and misfolded proteins. The book ends with an overview of a number of other ab initio methods for protein structure predictions and some concluding remarks.

    • Functional Materials for Sustainable Energy Applications

      • 1st Edition
      • J A Kilner + 3 more
      • English
      Global demand for low cost, efficient and sustainable energy production is ever increasing. Driven by recent discoveries and innovation in the science and technology of materials, applications based on functional materials are becoming increasingly important. Functional materials for sustainable energy applications provides an essential guide to the development and application of these materials in sustainable energy production.Part one reviews functional materials for solar power, including silicon-based, thin-film, and dye sensitized photovoltaic solar cells, thermophotovoltaic device modelling and photoelectrochemical cells. Part two focuses on functional materials for hydrogen production and storage. Functional materials for fuel cells are then explored in part three where developments in membranes, catalysts and membrane electrode assemblies for polymer electrolyte and direct methanol fuel cells are discussed, alongside electrolytes and ion conductors, novel cathodes, anodes, thin films and proton conductors for solid oxide fuel cells. Part four considers functional materials for demand reduction and energy storage, before the book concludes in part five with an investigation into computer simulation studies of functional materials.With its distinguished editors and international team of expert contributors, Functional materials for sustainable energy applications is an indispensable tool for anyone involved in the research, development, manufacture and application of materials for sustainable energy production, including materials engineers, scientists and academics in the rapidly developing, interdisciplinary field of sustainable energy.

    • Sterilisation of Biomaterials and Medical Devices

      • 1st Edition
      • Sophie Lerouge + 1 more
      • English
      The effective sterilisation of any material or device to be implanted in or used in close contact with the human body is essential for the elimination of harmful agents such as bacteria. Sterilisation of biomaterials and medical devices reviews established and commonly used technologies alongside new and emerging processes.Following an introduction to the key concepts and challenges involved in sterilisation, the sterilisation of biomaterials and medical devices using steam and dry heat, ionising radiation and ethylene oxide is reviewed. A range of non-traditional sterilisation techniques, such as hydrogen peroxide gas plasma, ozone and steam formaldehyde, is then discussed together with research in sterilisation and decontamination of surfaces by plasma discharges. Sterilisation techniques for polymers, drug-device products and tissue allografts are then reviewed, together with antimicrobial coatings for ‘self-sterilisation’ and the challenge presented by prions and endotoxins in the sterilisation of reusable medical devices. The book concludes with a discussion of future trends in the sterilisation of biomaterials and medical devices.With its distinguished editors and expert team of international contributors, Sterilisation of biomaterials and medical devices is an essential reference for all materials scientists, engineers and researchers within the medical devices industry. It also provides a thorough overview for academics and clinicians working in this area.

    • Probabilistic Safety Assessment for Optimum Nuclear Power Plant Life Management (PLiM)

      Theory and Application of Reliability Analysis Methods for Major Power Plant Components
      • 1st Edition
      • Gennadij V Arkadov + 2 more
      • English
      Probabilistic safety assessment methods are used to calculate nuclear power plant durability and resource lifetime. Successful calculation of the reliability and ageing of components is critical for forecasting safety and directing preventative maintenance, and Probabilistic safety assessment for optimum nuclear power plant life management provides a comprehensive review of the theory and application of these methods.Part one reviews probabilistic methods for predicting the reliability of equipment. Following an introduction to key terminology, concepts and definitions, formal-statistical and various physico–statistical approaches are discussed. Approaches based on the use of defect-free models are considered, along with those using binomial distribution and models based on the residual defectiveness of structural materials. The practical applications of probabilistic methods for strength reliability are subsequently explored in part two. Probabilistic methods for increasing the reliability and safety of nuclear power plant components are investigated, as are the use of such methods for optimising non-destructive tests, hydraulic tests, technical certification and planned-preventative maintenance. Finally, the book concludes with information on the use of probabilistic methods in ensuring leak tightness of nuclear power plant steam generator heat exchanger pipes.With its distinguished authors, Probabilistic safety assessment for optimum nuclear power plant life management is a valuable reference for all nuclear plant designers, operators, nuclear safety engineers and managers, as well as academics and researchers in this field.

    • Optical Biomimetics

      Materials and Applications
      • 1st Edition
      • Maryanne Large
      • English
      Optical biomimetics, the study of natural systems to inspire novel solutions to problems in optical technologies, has attracted growing interest. Optical biomimetics reviews key research in this area, focusing on the techniques and approaches used to characterise and mimic naturally occurring optical effects.Beginning with an overview of natural photonic structures, Optical biomimetics goes on to discuss optical applications of biomolecules, such as retinylidene and bacteriorhodopsin, polarisation effects in natural photonic structures and their applications, and biomimetic nanostructures for anti-reflection (AR) devices. Control of iridescence in natural photonic structures is explored through the case of butterfly scales, alongside a consideration of nanostructure fabrication using natural synthesis. The investigation into silk optical materials is followed by a final discussion of the control of florescence in natural photonic structures.With its distinguished editor and international team of expert contributors, Optical biomimetics is a valuable guide for scientists and engineers in both academia and industry who are already studying biomimetics, and a fascinating introduction for those who wish to move into this interesting new field.

    • Handbook of Herbs and Spices

      • 1st Edition
      • K. V. Peter
      • English
      Herbs and spices are among the most versatile ingredients in food processing, and alongside their sustained popularity as flavourants and colourants they are increasingly being used for their natural preservative and potential health-promoting properties. An authoritative new edition in two volumes, Handbook of herbs and spices provides a comprehensive guide to the properties, production and application of a wide variety of commercially-signifi... herbs and spices.Volume 2 begins with a discussion of such issues as the medicinal uses of herbs and spices and their sustainable production. Herbs and spices as natural antimicrobials in foods and the effect of their natural antioxidants on the shelf life of food are explored, before the book goes on to look in depth at individual herbs and spices, ranging from ajowan to tamarind. Each chapter provides detailed coverage of a single herb or spice, and begins by considering origins, chemical composition and classification. The cultivation, production and processing of the specific herb or spice is then discussed in detail, followed by analysis of the main uses, functional properties and toxicity.With its distinguished editor and international team of expert contributors, the two volumes of the new edition of Handbook of herbs and spices are an essential reference for manufacturers using herbs and spices in their products. They also provide valuable information for nutritionists and academic researchers.

    • Nuclear Fuel Cycle Science and Engineering

      • 1st Edition
      • Ian Crossland
      • English
      The nuclear fuel cycle is characterised by the wide range of scientific disciplines and technologies it employs. The development of ever more integrated processes across the many stages of the nuclear fuel cycle therefore confronts plant manufacturers and operators with formidable challenges. Nuclear fuel cycle science and engineering describes both the key features of the complete nuclear fuel cycle and the wealth of recent research in this important field.Part one provides an introduction to the nuclear fuel cycle. Radiological protection, security and public acceptance of nuclear technology are considered, along with the economics of nuclear power. Part two goes on to explore materials mining, enrichment, fuel element design and fabrication for the uranium and thorium nuclear fuel cycle. The impact of nuclear reactor design and operation on fuel element irradiation is the focus of part three, including water and gas-cooled reactors, along with CANDU and Generation IV designs. Finally, part four reviews spent nuclear fuel and radioactive waste management.With its distinguished editor and international team of expert contributors, Nuclear fuel cycle science and engineering provides an important review for all those involved in the design, fabrication, use and disposal of nuclear fuels as well as regulatory bodies and researchers in this field.

    • Radionuclide Behaviour in the Natural Environment

      Science, Implications and Lessons for the Nuclear industry
      • 1st Edition
      • Christophe Poinssot + 1 more
      • English
      Understanding radionuclide behaviour in the natural environment is essential to the sustainable development of the nuclear industry and key to assessing potential environmental risks reliably. Minimising those risks is essential to enhancing public confidence in nuclear technology. Scientific knowledge in this field has developed greatly over the last decade.Radionuclide behaviour in the natural environment provides a comprehensive overview of the key processes and parameters affecting radionuclide mobility and migration.After an introductory chapter, part one explores radionuclide chemistry in the natural environment, including aquatic chemistry and the impact of natural organic matter and microorganisms. Part two discusses the migration and radioecological behavior of radionuclides. Topics include hydrogeology, sorption and colloidal reactions as well as in-situ investigations. Principles of modelling coupled geochemical, transport and radioecological properties are also discussed. Part three covers application issues: assessment of radionuclide behaviour in contaminated sites, taking Chernobyl as an example, estimation of radiological exposure to the population, performance assessment considerations related to deep geological repositories, and remediation concepts for contaminated sites.With its distinguished editors and international team of expert contributors, Radionuclide behaviour in the natural environment is an essential tool for all those interested or involved in nuclear energy, from researchers, designers and industrial operators to environmental scientists. It also provides a comprehensive guide for academics of all levels in this field.

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