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Elsevier

Woodhead Publishing

  • Lean Biomanufacturing

    Creating Value through Innovative Bioprocessing Approaches
    • 1st Edition
    • Nigel J Smart
    • English
    With decreasing profit margins, increasing cost pressures, growing regulatory compliance concerns, mounting pressure from generic drugs and increasing anxiety about the future of healthcare reimbursement, pharmaceutical manufacturers are now forced to re-examine and re-assess the way they have been doing things. In order to sustain profitability, these companies are looking to reduce waste (of all kinds), improve efficiency and increase productivity. Many of them are taking a closer look at lean manufacturing as a way to achieve these goals. Lean biomanufacturing re-visits lean principles and then applies them sympathetically - in a highly practical approach - to the specific needs of pharmaceutical processes, which present significantly different challenges to more mainstream manufacturing processes. A major goal of the book is to highlight those problems and issues that appear more specific or unique to biopharmaceutical manufacturing situations and to provide some insights into what challenges are the important ones to solve and what techniques, tools and mechanisms to employ to be successful.Following an introduction to lean biomanufacturing, the book goes on to discuss lean technologies and methods applied in biomanufacturing. Later chapters cover the creation and implementation of the Transition Plan, issues facing the biopharmaceutical industry, creating a lean approach towards biopharmaceutical processes and the contribution of simulation models in developing these processes. The final chapter covers examples of new technology innovations which help facilitate lean biomanufacturing.

  • Electricity Transmission, Distribution and Storage Systems

    • 1st Edition
    • Ziad Melhem
    • English
    Electricity transmission and distribution systems carry electricity from suppliers to demand sites. During transmission materials ageing and performance issues can lead to losses amounting to about 10% of the total generated electricity. Advanced grid technologies are therefore in development to sustain higher network efficiency, while also maintaining power quality and security.Electricity transmission, distribution and storage systems presents a comprehensive review of the materials, architecture and performance of electricity transmission and distribution networks, and the application and integration of electricity storage systems.The first part of the book reviews the fundamental issues facing electricity networks, with chapters discussing Transmission and Distribution (T&D) infrastructure, reliability and engineering, regulation and planning, the protection of T&D networks and the integration of distributed energy resources to the grid. Chapters in part two review the development of transmission and distribution system, with advanced concepts such as FACTS and HVDC, as well as advanced materials such as superconducting material and network components. This coverage is extended in the final section with chapters reviewing materials and applications of electricity storage systems for use in networks, for renewable and distributed generation plant, and in buildings and vehicles, such as batteries and other advanced electricity storage devices.With its distinguished editor, Electricity transmission, distribution and storage systems is an essential reference for materials and electrical engineers, energy consultants, T&D systems designers and technology manufacturers involved in advanced transmission and distribution.

  • Subsea Optics and Imaging

    • 1st Edition
    • John Watson + 1 more
    • English
    The use of optical methodology, instrumentation and photonics devices for imaging, vision and optical sensing is of increasing importance in understanding our marine environment. Subsea optics can make an important contribution to the protection and sustainable management of ocean resources and contribute to monitoring the response of marine systems to climate change. This important book provides an authoritative review of key principles, technologies and their applications.The book is divided into three parts. The first part provides a general introduction to the key concepts in subsea optics and imaging, imaging technologies and the development of ocean optics and colour analysis. Part two reviews the use of subsea optics in environmental analysis. An introduction to the concepts of underwater light fields is followed by an overview of coloured dissolved organic matter (CDOM) and an assessment of nutrients in the water column. This section concludes with discussions of the properties of subsea bioluminescence, harmful algal blooms and their impact and finally an outline of optical techniques for studying suspended sediments, turbulence and mixing in the marine environment. Part three reviews subsea optical systems technologies. A general overview of imaging and visualisation using conventional photography and video leads onto advanced techniques like digital holography, laser line-scanning and range-gated imaging as well as their use in controlled observation platforms or global observation networks. This section also outlines techniques like Raman spectroscopy, hyperspectral sensing and imaging, laser Doppler anemometry (LDA) and particle image velocimetry (PIV), optical fibre sensing and LIDAR systems. Finally, a chapter on fluorescence methodologies brings the volume to a close.With its distinguished editor and international team of contributors, Subsea optics and imaging is a standard reference for those researching, developing and using subsea optical technologies as well as environmental scientists and agencies concerned with monitoring the marine environment.

  • Transporters in Drug Discovery and Development

    Detailed Concepts and Best Practice
    • 1st Edition
    • Yurong Lai
    • English
    Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

  • Surface Modification by Solid State Processing

    • 1st Edition
    • Rosa M. Miranda + 4 more
    • English
    Surface Modification by Solid State Processing describes friction-based surfacing techniques for surface modification to improve resistance to corrosion and wear, also changing surface chemistry. Surface conditions are increasingly demanding in industrial applications and surface modification can reduce manufacturing and maintenance costs, leading to improved component performance, reliability and lifetime. Friction-based technologies are promising solid state processing technologies, particularly for light alloys, in the manufacturing of composite surface and functionally graded materials This title is divided into five chapters, and after an introduction the book covers friction surfacing; friction stir processing; surface reinforcements of light alloys; and characterization techniques based on eddy currents.

  • The Coal Handbook: Towards Cleaner Production

    Volume 1: Coal Production
    • 1st Edition
    • Dave Osborne
    • English
    Coal is an important fossil fuel resource for many nations due to its large remaining resources, relatively low production and processing cost and potential high energy intensity. Certain issues surround its utilisation, however, including emissions of pollutants and growing concern about climate change. The coal handbook: Towards cleaner production Volume 1 reviews the coal production supply chain from analysis to extraction and distribution.Part one explores coal characterisation and introduces the industrial use of coal as well as coal formation, petrography, reserves, sampling and analysis. Part two moves on to review coal extraction and preparation. Chapters highlight advances in coal mining technology, underground coal gas extraction, coal sizing, comminution and cleaning, and solid-liquid separation technologies for coal. Further chapters focus on economic factors affecting coal preparation, post-treatment of coal, coal tailings treatment, and the optimisation, simulation and control of coal preparation plants. Finally, part three considers aspects of the coal supply chain including the management approach and individual functions such as coal blending and homogenisation, transportation and handling along the entire supply chain.With its distinguished editor and international team of expert contributors, The coal handbook Volumes 1 and 2 is a comprehensive and invaluable resource for professionals in the coal mining, preparation, and utilisation industry, those in the power sector, including plant operators and engineers, and researchers and academics interested in this field.

  • Biotextiles as Medical Implants

    • 1st Edition
    • M W King + 2 more
    • English
    Textiles play a vital role in the manufacture of various medical devices, including the replacement of diseased, injured or non-functioning organs within the body. Biotextiles as medical implants provides an invaluable single source of information on the main types of textile materials and products used for medical implants. The first part of the book focuses on polymers, fibers and textile technologies, and these chapters discuss the manufacture, sterilization, properties and types of biotextiles used for medical applications, including nanofibers, resorbable polymers and shaped biotextiles. The chapters in part two provide a comprehensive discussion of a range of different clinical applications of biotextiles, including surgical sutures, arterial prostheses, stent grafts, percutaneous heart valves and drug delivery systems.This book provides a concise review of the technologies, properties and types of biotextiles used as medical devices. In addition, it addresses the biological dimension of how to design devices for different clinical applications, providing an invaluable reference for biomedical engineers of medical textiles, quality control and risk assessment specialists, as well as managers of regulatory affairs. The subject matter will also be of interest to professionals within the healthcare system including surgeons, nurses, therapists, sourcing and purchasing agents, researchers and students in different disciplines.

  • Drug-Biomembrane Interaction Studies

    The Application of Calorimetric Techniques
    • 1st Edition
    • Rosario Pignatello
    • English
    The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material.Drug-biomem... interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions.

  • The Funding of Biopharmaceutical Research and Development

    • 1st Edition
    • David R Williams
    • English
    The funding of biopharmaceutical research and development provides a comprehensive critical review of the funding of research and development (R&D) in the human biopharmaceutical market sector. It addresses both private and public funding sources available in the US and internationally. The biopharmaceutical market is among the most research-intensive market sectors globally. Clinical researchers face a multitude of public and private funding options with respect to bringing their idea or innovation to market. These funding options are continually changing and complex, and are expected to decrease in the near future. A lack of understanding of the scale, scope, and inner workings of the funding aspects of R&D can, at times, act as a barrier for all involved, and can slow down or even eliminate the R&D process. The book lessens these barriers by describing the theoretical underpinnings, present practice, and trends in R&D funding in this market sector, both in the US and internationally. This includes a review and discussion of public-private partnership activity and their inner-workings, noting the complementary relationship between public and private funding. The book also contains an overview of the inner-workings of strategic alliance activity, including the advantages and disadvantages for each party. It goes on to provide an outline of venture capital activity, detailing the methods by which venture capital firms raise capital and are organized, a description of the venture capital-entrepreneur arrangement, and the effects of this arrangement. The book also presents an overview of the IPO process and the various fates of firms going public.

  • Bioprocess Engineering

    An Introductory Engineering and Life Science Approach
    • 1st Edition
    • Kim Gail Clarke
    • English
    Biotechnology is an expansive field incorporating expertise in both the life science and engineering disciplines. In biotechnology, the scientist is concerned with developing the most favourable biocatalysts, while the engineer is directed towards process performance, defining conditions and strategies that will maximize the production potential of the biocatalyst. Increasingly, the synergistic effect of the contributions of engineering and life sciences is recognised as key to the translation of new bioproducts from the laboratory bench to commercial bioprocess. Fundamental to the successful realization of the bioprocess is a need for process engineers and life scientists competent in evaluating biological systems from a cross-disciplinary viewpoint. Bioprocess engineering aims to generate core competencies through an understanding of the complementary biotechnology disciplines and their interdependence, and an appreciation of the challenges associated with the application of engineering principles in a life science context. Initial chapters focus on the microbiology, biochemistry and molecular biology that underpin biocatalyst potential for product accumulation. The following chapters develop kinetic and mass transfer principles that quantify optimum process performance and scale up. The text is wide in scope, relating to bioprocesses using bacterial, fungal and enzymic biocatalysts, batch, fed-batch and continuous strategies and free and immobilised configurations.

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