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Elsevier

Woodhead Publishing

  • Monoclonal Antibodies

    Meeting the Challenges in Manufacturing, Formulation, Delivery and Stability of Final Drug Product
    • 1st Edition
    • Steven Shire
    • English
    Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies.

  • Regenerative Engineering of Musculoskeletal Tissues and Interfaces

    • 1st Edition
    • Syam Nukavarapu + 2 more
    • English
    Repair and regeneration of musculoskeletal tissues is generating substantial interest within the biomedical community. Consequently, these are the most researched tissues from the regeneration point of view. Regenerative Engineering of Musculoskeletal Tissues and Interfaces presents information on the fundamentals, progress and recent developments related to the repair and regeneration of musculoskeletal tissues and interfaces. This comprehensive review looks at individual tissues as well as tissue interfaces. Early chapters cover various fundamentals of biomaterials and scaffolds, types of cells, growth factors, and mechanical forces, moving on to discuss tissue-engineering strategies for bone, tendon, ligament, cartilage, meniscus, and muscle, as well as progress and advances in tissue vascularization and nerve innervation of the individual tissues. Final chapters present information on musculoskeletal tissue interfaces.

  • Electronic Textiles

    Smart Fabrics and Wearable Technology
    • 1st Edition
    • Tilak Dias
    • English
    The integration of electronics into textiles and clothing has opened up an array of functions beyond those of conventional textiles. These novel materials are beginning to find applications in commercial products, in fields such as communication, healthcare, protection and wearable technology. Electronic Textiles: Smart Fabrics and Wearable Technology opens with an initiation to the area from the editor, Tilak Dias. Part One introduces conductive fibres, carbon nano-tubes and polymer yarns. Part Two discusses techniques for integrating textiles and electronics, including the design of textile-based sensors and actuators, and energy harvesting methods. Finally, Part Three covers a range of electronic textile applications, from wearable electronics to technical textiles featuring expert chapters on embroidered antennas for communication systems and wearable sensors for athletes.

  • Modeling Food Processing Operations

    • 1st Edition
    • Serafim Bakalis + 2 more
    • English
    Computational modeling is an important tool for understanding and improving food processing and manufacturing. It is used for many different purposes, including process design and process optimization. However, modeling goes beyond the process and can include applications to understand and optimize food storage and the food supply chain, and to perform a life cycle analysis. Modeling Food Processing Operations provides a comprehensive overview of the various applications of modeling in conventional food processing. The needs of industry, current practices, and state-of-the-art technologies are examined, and case studies are provided. Part One provides an introduction to the topic, with a particular focus on modeling and simulation strategies in food processing operations. Part Two reviews the modeling of various food processes involving heating and cooling. These processes include: thermal inactivation; sterilization and pasteurization; drying; baking; frying; and chilled and frozen food processing, storage and display. Part Three examines the modeling of multiphase unit operations such as membrane separation, extrusion processes and food digestion, and reviews models used to optimize food distribution.

  • Grapevine Breeding Programs for the Wine Industry

    • 1st Edition
    • Andrew G. Reynolds
    • English
    Grapevine Breeding Programs for the Wine Industry: Traditional and Molecular Techniques summarizes recent trends in grapevine breeding, both in terms of research and practical programs. The first group of chapters covers the challenges faced by breeders and existing and emerging techniques used to combat them. Two further groups of chapters focus on grapevine breeding programs in different wine-producing countries around the world. With authoritative contributions from experts across the world’s winemaking regions, this book will be an essential reference for all those involved in viticulture and oeneology wanting to explore new methods, understand different approaches and refine existing practices.

  • Superconductors in the Power Grid

    Materials and Applications
    • 1st Edition
    • C. Rey
    • English
    Superconductors offer high throughput with low electric losses and have the potential to transform the electric power grid. Transmission networks incorporating cables of this type could, for example, deliver more power and enable substantial energy savings. Superconductors in the Power Grid: Materials and Applications provides an overview of superconductors and their applications in power grids. Sections address the design and engineering of cable systems and fault current limiters and other emerging applications for superconductors in the power grid, as well as case studies of industrial applications of superconductors in the power grid.

  • Reprocessing and Recycling of Spent Nuclear Fuel

    • 1st Edition
    • Robin Taylor
    • English
    Reprocessing and Recycling of Spent Nuclear Fuel presents an authoritative overview of spent fuel reprocessing, considering future prospects for advanced closed fuel cycles. Part One introduces the recycling and reprocessing of spent nuclear fuel, reviewing past and current technologies, the possible implications of Generation IV nuclear reactors, and associated safely and security issues. Parts Two and Three focus on aqueous-based reprocessing methods and pyrochemical methods, while final chapters consider the cross-cutting aspects of engineering and process chemistry and the potential for implementation of advanced closed fuel cycles in different parts of the world.

  • Global Legislation for Food Contact Materials

    • 1st Edition
    • J.S. Baughan
    • English
    Food contact materials such as packaging, storage containers and processing surfaces can pose a substantial hazard to both food manufacturer and consumer due to the migration of chemicals or other substances from the material to the food, which can cause tainting of flavours and other sensory characteristics, or even illness. This book reviews the main materials used for food contact in terms of the global legislation in place to ensure their safe and effective use. Part One provides an overview of food contact legislation issues such as chemical migration and compliance testing. Part Two looks in detail at the legislation for specific food contact materials and their advantages, hazards and use in industry.

  • Advances in Asphalt Materials

    Road and Pavement Construction
    • 1st Edition
    • Shin-Che Huang + 1 more
    • English
    The urgent need for infrastructure rehabilitation and maintenance has led to a rise in the levels of research into bituminous materials. Breakthroughs in sustainable and environmentally friendly bituminous materials are certain to have a significant impact on national economies and energy sustainability. This book will provide a comprehensive review on recent advances in research and technological developments in bituminous materials. Opening with an introductory chapter on asphalt materials and a section on the perspective of bituminous binder specifications, Part One covers the physiochemical characterisation and analysis of asphalt materials. Part Two reviews the range of distress (damage) mechanisms in asphalt materials, with chapters covering cracking, deformation, fatigue cracking and healing of asphalt mixtures, as well as moisture damage and the multiscale oxidative aging modelling approach for asphalt concrete. The final section of this book investigates alternative asphalt materials. Chapters within this section review such aspects as alternative binders for asphalt pavements such as bio binders and RAP, paving with asphalt emulsions and aggregate grading optimization.

  • Rechargeable Lithium Batteries

    From Fundamentals to Applications
    • 1st Edition
    • Alejandro Franco
    • English
    Rechargeable Lithium Batteries: From Fundamentals to Application provides an overview of rechargeable lithium batteries, from fundamental materials, though characterization and modeling, to applications. The market share of lithium ion batteries is fast increasing due to their high energy density and low maintenance requirements. Lithium air batteries have the potential for even higher energy densities, a requirement for the development of electric vehicles, and other types of rechargeable lithium battery are also in development. After an introductory chapter providing an overview of the main scientific and technological challenges posed by rechargeable Li batteries, Part One of this book reviews materials and characterization of rechargeable lithium batteries. Part Two covers performance and applications, discussing essential aspects such as battery management, battery safety and emerging rechargeable lithium battery technologies as well as medical and aerospace applications.

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