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Elsevier Science

Molecular Dynamics
From Classical to Quantum Methods
1st Edition
Volume 7
Perla Balbuena + 1 more
English
The latest developments in quantum and classical molecular dynamics, related techniques, and their applications to several fields of science and engineering. Molecular simulations include a broad range of methodologies such as Monte Carlo, Brownian dynamics, lattice dynamics, and molecular dynamics (MD).Features of this book:• Presents advances in methodologies, introduces quantum methods and lists new techniques for classical MD• Deals with complex systems: biomolecules, aqueous solutions, ice and clathrates, liquid crystals, polymers• Provides chemical reactions, interfaces, catalysis, surface phenomena and solidsAlthough the book is not formally divided into methods and applications, the chapters are arranged starting with those that discuss new algorithms, methods and techniques, followed by several important applications.
Protein, Volume 2
1st Edition
G. Allen
English
In the first volume of this series, the structures of protein molecules were described, together with computational methods linking sequence data to folded structure and function. The determination of protein structure by nuclear magnetic resonance spectroscopy was also presented. Volume 2 begins by continuing the theme of protein structure with an outline of methods of crystallographic structure determination. Subsequent chapters describe various strucure-related properties of proteins. This book provides a valuable contribution to those new to the field of protein science as well as to those already expert in the field.
The Biology of the Pancreatic Cell
1st Edition
Volume 29
S.L. Howell
English
As a result of the key advances made more than 30 years ago, specifically the ability to isolate islets of Langerhans from the pancreas, the ability to measure insulin accurately by immunoasay, and the development of microchemical techniques for studying cells and their components, many research volumes, symposium reports, and original papers have been produced. This explosion of interest has probably had at least three stimuli: 1. the inherent scientific interest in understanding secretion of the pancreatic ß-cell2. the ß-cells relevance to a very common disease3. the availability of funding from specific sources related to diabetes research, for instance, Juvenile Diabetes Foundation International and the British Diabetic Association. As a result of all this activity, detailed scientific literature including research reviews are readily available. Surprisingly enough, there are relatively few attempts to summarize this great bulk of knowledge in a way that is accessible to the newcomer to this field and this book is intended to bridge this gap.
Engineering Turbulence Modelling and Experiments - 4
1st Edition
D. Laurence + 1 more
English
These proceedings contain the papers presented at the 4th International Symposium on Engineering Turbulence Modelling and Measurements held at Ajaccio, Corsica, France from 24-26 May 1999. It follows three previous conferences on the topic of engineering turbulence modelling and measurements. The purpose of this series of symposia is to provide a forum for presenting and discussing new developments in the area of turbulence modelling and measurements, with particular emphasis on engineering-related problems.Turbulence is still one of the key issues in tackling engineering flow problems. As powerful computers and accurate numerical methods are now available for solving the flow equations, and since engineering applications nearly always involve turbulence effects, the reliability of CFD analysis depends more and more on the performance of the turbulence models. Successful simulation of turbulence requires the understanding of the complex physical phenomena involved and suitable models for describing the turbulent momentum, heat and mass transfer. For the understanding of turbulence phenomena, experiments are indispensable, but they are equally important for providing data for the development and testing of turbulence models and hence for CFD software validation.
Environmental Analytical Chemistry
1st Edition
Volume 32
D. Pérez-Bendito + 1 more
English
Notwithstanding the vast amount of environmental analytical chemical literature available, publications dealing with environmental analytical chemistry in a general, integrated manner are rather scant. In fact, most literature on such a relevant topic appears to touch on individual aspects such as water or air pollution, applicable conventional or special equipment used with given matrices and specific pollutant groups. Most of these books are of interest to experts and only a few, if any, provide less experienced readers with a systematic, comprehensive description of environmental analytical issues. This book, which is intended to fill the gap, approaches the subject by focusing on the sample and its handling.The fourteen chapters that make up the book follow a logical sequence of sample matrices and analyte types. The first six are of paramount importance, as they lay the foundations for a basic, yet comprehensive coverage of the subject in the others. Following the required introduction to environmental chemistry, Chapters 2 to 6 deal sequentially with environmental quality assurance, quality control fundamentals and practical aspects of environmental sampling, the preconcentration of environmental samples and environmental control standards. Chapters 7 to 12 are concerned with the analytical control of inorganic and organic pollutants in air, water and soil. Finally, the last two chapters are devoted to speciation and chemometrics in environmental analysis. Each chapter presents the state-of-the-art of the environmental topic covered, and illustrates it with a wealth of practical examples. Overall, the book contains about one hundred tables, almost two hundred figures and more than 1700 references, all of which make it a pedagogical, current reference work.On the borderline between a textbook and a monograph, it is intended to be useful both as an academic text for the burgeoning number of undergraduate and postgraduate courses on the subject, as a reference book for those starting work in the environmental field and as a source of first-hand information on environmental science and its practical laboratory aspects.
Fossil Nonmarine Ostracoda of the United States
1st Edition
Volume 16
F.M. Swain Jr.
English
The geographic and stratigraphic distribution of fossil nonmarine Ostracoda in the United States are summarized in this book, followed by diagnoses of the subject species, references to literature and 34 plates of illustrations.This work shows the great diversity and usefulness of this interesting class of organisms which are small bivalved aquatic crustaceans that occupy both marine and nonmarine environments. Many are characteristic of estuarine and other tidal habitats, but only a few occupy hypersaline waters. One or two kinds are found in wet soils, or in leaf or flower cups in tropical rain forests. A few live in caves and others are commensal in gills of fish and other aquatic animals. Micropaleontologists have found their shells in many types of sedimentary rocks and have used them for stratigraphic and paleoenvironmental interpretations.Thei... relatively rapid rates of evolution have made them useful in subsurface stratigraphy and their sensitivity to environmental changes has provided a means of recognizing variations in rock facies. In nonmarine aquatic rocks they are commonly the most easily recoverable microfossils, and have been widely used in petroleum exploration, notably in China, Russia, Brazil and the western United States.
Advances in Developmental Biochemistry
1st Edition
Volume 5b
Paul Wassarman
English
This series provides annual reviews of research topics in developmental biology/biochemistry... written from the perspectives of leading investigators in these fields. This volume of Advances in Developmental Biochemistry consists of seven chapters that review specific aspects of development in several different organisms including mollusks, flies and mice.
Advances in Medicinal Chemistry
1st Edition
Volume 4
B.E. Maryanoff + 1 more
English
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
Pauling's Legacy
Modern Modelling of the Chemical Bond
1st Edition
Volume 6
Z.B. Maksic + 1 more
English
Theory and experiment in chemistry today provide a wealth of data, but such data have no meaning unless they are correctly interpreted by sound and transparent physical models. Linus Pauling was a grandmaster in the modelling of molecular properties. Indeed, many of his models have served chemistry for decades and that has been his lasting legacy for chemists all over the world.The aim of this book is to put such simple models into the language of modern quantum chemistry, thus providing a deeper justification for many of Pauling's ideas and concepts. However, it should be stressed that many contributions to this work, written by some of the world's most prominent theoretical chemists, do not merely follow Pauling's footprints. By taking his example, they made bold leaps forward to overcome the limitations of the old models, thereby opening new scientific vistas.This book is an important contribution to the chemical literature. It is an almost obligatory textbook for postgraduate students and postdoctoral researchers in physical chemistry, chemical physics and advanced physical organic chemistry.
The Adhesive Interaction of Cells
1st Edition
Volume 28
David Garrod + 2 more
English
The aim of "The Adhesive Interaction of Cells" has been to assemble a series of reviews by leading international experts embracing many of the most important recent developments in this rapidly expanding field. The purpose of all biological research is to understand the form and function of living organisms and, by comprehending the normal, to find explanations and remedies for the abnormal and for disease conditions. The molecules involved in cell adhesion are of fundamental importance to the structure and function of all multicellular organisms. In this book, the contributors focus on the systems of vertebrates, especially mammals, since these are most relevant to human disease. It would have been equally possible to concentrate on developmental processes and adhesion in lower organisms. A major function of adhesion molecules is to bind cells to each other or to the extracellular matrix, but they are much more than "glue". Adhesions in animal tissues must be dynamic-forming, persisting, or declining in regulated fashion- to facilitate the mobility and turnover of tissue cells. Moreover, the majority of adhesion molecules are transmembrane molecules and thus provide links between the cells and their surroundings. This gives rise to another major function of adhesion molecules, the capacity to transduce signals across the hydrophobic barrier imposed by the plasma membrane. Such signal transduction is crucially important to many aspects of cellular function including the regulation of cell motility, gene expression, and differentiation. The work in this book progresses through four sections. Part I discusses the four major families of adhesion molecules themselves, the integrins (Green and Humphries), the cadherins (Stappert and Kemler), the selectins (Tedder et al.) and the immunoglobulin superfamily (Simmons); part 2 considers junctional complexes involved in cell interactions: focal adhesions and adherens junctions (Ben Ze'ev), desmosomes (Garrod et al.), and tight junctions (Citi and Cordenonsi). The signaling role of adhesion molecules is the focus of part 3, through integrins and the extracellular matrix (Edwards and Streuli), through platelet adhesion (Du and Ginsberg), and in the nervous system (Hemperley). In part 4, the aim is to show how adhesive phenomena contribute to important aspects of cell behavior and human health. Leukocyte trafficking (Haskard et al.), cancer metastasis (Marshall and Hart), cell migration (Paleck et al.), and implantation and placentation (Damsky et al.) are the topics considered in depth.The different sections are, of course, not mutually exclusive: it is both undesirable and impossible to separate structure from function when considering cell adhesion. Each chapter has its unique features, but some overlap is both invevitable and valuable since it provides different perspectives on closely related topics. We hope that the whole contributes a valuable and stimulating consideration of this important topic.

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