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Elsevier

Elsevier Science

  • The Aging Brain

    • 1st Edition
    • Volume 2
    • J.W. Geddes + 1 more
    • English
    The brain is the most complex organ system in the human, both in the intricacy of its cellular architecture and in the extent of its repertoire of macromolecules. The Aging Brain presents the current state of understanding of molecular, cellular, and functional changes that occur in normal brain aging, and compares and contrasts those changes with events occurring in age-related neurodegenerative disorders. The chapters, written by world leaders in the field of brain aging, provide a timely and comprehensive consideration of key areas of this rapidly growing field of aging research. The topics covered include structural, functional, biochemical and molecular changes that occur during usual aging and in age-related neurological disorders. An emphasis is placed on emerging findings at the cellular and molecular levels. The roles of oxidative stress and perturbed energy metabolism in aging and neurodegenrative disorders are covered in considerable detail. In addition, the impact of aging and disease on specific neurotransmitter, neurotrophic factor and cytokine signaling pathways is reviewed. Finally, recent findings concerning possible approaches to reduce risk for age-related neurodegenerative disorders, such as caloric restriction, are presented. The collective body of information presented in The Aging Brain will provide those stepping into the field of brain aging with an overview of our current understanding of fundamental changes that occur in the aging brain, and their molecular and cellular underpinnings. At the same time, the book delves deeply into critical mechanistic details of brain aging that should prove valuable to experts in the field.

  • Protein Structural Biology in Biomedical Research, Part A

    • 1st Edition
    • Volume 22
    • C. Woodward
    • N.M. Allewell
    • English
    Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject. The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.

  • Geology and hydrogeology of carbonate islands

    • 1st Edition
    • Volume 54
    • Leonard H.L. Vacher + 1 more
    • English
    The Geology and Hydrogeology of Carbonate Islands presents a survey of more than 30 selected islands such as Bermuda, the Bahamas, the Florida Keys, coastal Yucatan, Barbados, the Caymans, Isla de Mona, islands of Polynesia, the Cooks, Guam, Niue, Nauru, Rottnest Island, the Houtman Abrolhos, islands of the Great Barrier Reef and many atolls including Enewetak, Tarawa, Diego Garcia, Mururoa, and the Cocos Islands. The book provides a wealth of observational data and a survey of interpretations on the issues within the intersection of carbonate geology (depositional architecture, diagenetic processes and dolomitization, Cenozoic sea-level history, karstification and blue holes) and island hydrology (distribution of fresh and brackish groundwater, dual-aquifer conceptualizations, modeling of island lenses, water budgets and water resources, effects of climatic variations, island karst, endo-upwelling).

  • Pneumatic Handbook

    • 8th Edition
    • A. Barber
    • English
    Accepted as the standard reference work on modern pneumatic and compressed air engineering, the new edition of this handbook has been completely revised, extended and updated to provide essential up-to-date reference material for engineers, designers, consultants and users of fluid systems.

  • Computational Wind Engineering 2

    • 1st Edition
    • R.N. Meroney + 1 more
    • English
    The Second International Computational Wind Engineering Symposium was held in Colorado, USA during August 1996 and presented papers on the popular application of CFD concepts. These proceedings contain a set of invited papers providing state-of-the-art reviews on subjects such as CFD turbulence models, bluff body aerodynamics, terrain aerodynamics and building aerodynamics. Individual session papers reflect on recent methodologies and innovations on CFD techniques applied to flow about bluff bodies immersed in shear layers, bridge aerodynamics, air pollution aerodynamics, mesoscale predictions of flow over complex terrain and the application of advanced numerical method strategies to these topics.

  • Stable Isotopes in Pharmaceutical Research

    • 1st Edition
    • Volume 26
    • T.R. Browne
    • English
    Stable isotope techniques offer advantages in safety, sensitivity, specificity, and economy for many types of pharmaceutical investigations when compared to conventional techniques. Nevertheless, pharmaceutical researchers are slow to embrace stable isotope techniques.This book assembles in one place comprehensive reviews of the many applications of stable isotopes and the background material necessary to understand the application. This approach is a deliberate attempt to encourage the usage of stable isotopes in pharmaceutical research. A bonus to the reader is the high standard of contributions from a very talented and diverse group of investigators.

  • Hydrocarbon Seals

    Importance for Exploration and Production
    • 1st Edition
    • Volume 7
    • P. Møller-Pedersen + 1 more
    • English
    In January 1996 a total of 270 conference participants gathered for 3 days in Trondheim, Norway, to focus on and to discuss the complex topic of hydrocarbon seals particularly related to deformation zones and to caprocks. The conference was the first in Norway and one of the first in Europe to exclusively address this very important subject. The purpose of the conference was to present some of the most recent research results, to establish state-of-the-art with respect to understanding hydrocarbon seals and to discuss where to go from here to find some of the keys to successful future exploration and enhanced oil and gas recovery. Out of the presented papers and posters, 17 are compiled and published in this volume. These provide a good overview of and an introduction to the numerous aspects covered during the fruitful days in Trondheim.

  • Group IV Heterostructures, Physics and Devices (Si, Ge, C, Sn)

    • 1st Edition
    • Volume 61
    • J.-M. Lourtioz + 2 more
    • English
    These proceedings contain the majority of papers presented atSymposium D, "Group IV heterostructures, physics and devices(Si,Ge,C,&... of the Spring Meeting of the EuropeanMaterials Research Society, held at the Congress Centre,Strasbourg, France, 4-7 June 1996. This Symposium was attendedby about 150 scientists from throughout the world, among whom 18were invited speakers.The aim of the Symposium was to discussthe most recent results in all fields of Group IVheterostructures and devices from fundamental physics toindustrial applications. Regular and invited contributions werethen welcomed which addressed the different aspects of growth,the effects of strain relaxation, particularly in SiGeC alloys,the basic optical and electrical properties of heterostructuresand low-dimensional structures, the microelectronic andoptoelectronics, such as rare-earth doping techniques, was alsoselected. Except for minor changes, the order of papers presentedin this special issue of Thin Solid Films closely follows theorder of topics listed above as well as the order of sessions atthe Symposium.

  • Advanced Materials for Interconnections

    • 1st Edition
    • Volume 66
    • Th. Gessner
    • English
    The conference "Advanced Materials for Interconnections" took place in Strasbourg on 4-7 June 1996 hosted by the EMRS Society. Based on the recent trends in microelectronics the main topics of the conference were new materials for interconnects like special aluminum alloys, tungsten and copper as well as low k dielectric materials.64 Papers were presented at the conference and 51 of these are contained as full length papers within this volume of Microelectronic Engineering.The proceedings are divided into 5 chapters. Chapter 1 related to Metallization discusses cluster equipment for IC manufacturing, copper advanced technology, gap filling, mechanical reliability, deposition technology, electroless and electro-plating, copper metallization copper interconnects and patterning of aluminum. Chapter 2, Process Integration, discusses multilevel interconnect, study on thin-film SOI devices, wet cleanings, influence of material characteristics and deposition processes, copper contamination and metallization, plasma behaviour, CMP processes, sub-micron inverse metallisation, interconnect formation and mechanical polishing investigations. Chapter 3 covers Barriers, and chapter 4 studies, evaluates and monitors Dielectrics. The final chapter looks at modelling comparisons.

  • Magnetic Ultra Thin Films, Multilayers and Surfaces

    • 1st Edition
    • Volume 62
    • F. Petroff + 1 more
    • English
    The Symposium on Magnetic Ultrathin Films, Multilayers andSurfaces, hosted by the European Materials Research Society, washeld at the Palais de la Musique et des Congré inStrasbourg, France on June 4-7, 1996. Its central theme was therelationship of magnetic properties and device performance tostructure at the nano and micrometer length scale. Research onthe magnetism of surfaces, ultrathin films and multilayers hasincreased dramatically during recent years. This development wastriggered by the discovery of coupling between ferromagneticlayers across nonmagnetic spacer layers and of the giantmagnetoresistan... effect in systems of reduced dimension usingvarious micro and nanofabrication techniques has become a subjectof special interest. It is certainly the promising applicationpotential of these effects in new magnetic recording devicegeometries which causes this intensive research, which is doneboth by companies and at universities and researchinstitutes.A selection of invited and contributed paperspresented at the Symposium and accepted for publication iscontained in this volume. The contents of these proceedings areorganized into seven sections.A. Nanowires, Nanoparticles,Nanost... Ultrathin Films and Surfaces,Characteriz... Giant MagnetoresistanceD. Coupling,TunnelingE. Growth, Structure, MagnetismF. Growth,Structure, MagnetoresistanceG. Coupling, Magnetic processes,Magneto-op... first four sections contain invited andoral contributed papers in the listed research domains, while thelast three sections contain the contributions presented duringthree large poster sessions.

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