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Elsevier

Elsevier Science

  • Handbook of Chemometrics and Qualimetrics

    • 1st Edition
    • Volume AB
    • English

  • The Histamine H<INF>3</INF> Receptor

    A Target for New Drugs
    • 1st Edition
    • Volume 30
    • R. Leurs + 1 more
    • English
    In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.

  • Handbook of Chemometrics and Qualimetrics

    Part B
    • 1st Edition
    • Volume 20B
    • English

  • Studies in Natural Products Chemistry

    Structure and Chemistry (Part F)
    • 1st Edition
    • Volume 20
    • Atta-ur Rahman
    • English
    Natural Products Chemistry continues to grow at an increasing pace and this growth is reflected in the present volume of Studies in Natural Products Chemistry, which is the 20th of this series. The first 20 volumes were largely devoted to structure and synthesis of various classes of natural products, irrespective of their bioactivity. Subsequent volumes of this series will however be devoted to the chemistry of bioactive natural products and will therefore a departure from the earlier volumes.The present volume contains contributions from a number of eminent scientists and covers interesting reviews on terpenes, alkaloids and other types of natural products reported from terrestrial and marine sources. Comprehensive indexes covering all the 20 volumes have been prepared which include a Cumulative General Subject Index along with more focused Cumulative Indices on Organic Synthesis, Pharmacological Activity and Biological Source. This comprehensive indexing of the volumes should make the entire series much more valuable and user-friendly.

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 21
    • English
    The Side Effects of Drugs Annual has been published each year since 1977. It is designed to provide a critical and up-to date account of new information relating to adverse drug reactions and interactions from the clinician's point of view. The Annual can be used independently or as a supplement to the standard encyclopedic work in this field, Meyler's Side Effects of Drugs, of which, the http://www.elsevier.... Edition was published in December 2000.The present Annual reviews all reports presenting significant new information on adverse reactions to drugs from July 1996 to June 1997. During the production of this Annual, more recent papers have been included. The use of the book is enhanced by two separate indexes, allowing the reader to enter the text by drug name, adverse effect name, or drug interaction.

  • Biomaterials and Biodegradable Polymers and Macromolecules: Current Research and Industrial Applications

    • 1st Edition
    • Volume 72
    • F. Burny + 1 more
    • English

  • Thin-Walled Structures

    Research and Development
    • 1st Edition
    • J.Y. Richard Liew + 2 more
    • English
    Thin-plated structures are used extensively in building construction, automobile, aircraft, shipbuilding and other industries because of a number of favourable factors such as high strength-weight ratio, development of new materials and processes and the availability of efficient analytical methods. This class of structure is made by joining thin plates together at their edges and they rely for their rigidity and strength upon the tremendous stiffness and load-carrying capacity of the flat plates from which they are made. Many of the problems encountered in these structures arise because of the effects of local buckling. The knowledge of various facets of this phenomenon has increased dramatically since the 1960s. Problem areas which were hitherto either too complex for rigorous analysis or whose subtleties were not fully realized have in these years been subjected to intensive study. Great advances have been made in the areas of inelastic buckling. The growth in use of lightweight strong materials, such as fibre-reinforced plastics has also been a contributory factor towards the need for advances in the knowledge of the far post-buckling range. The conference is a sequel to the international conference organised by the University of Strathclyde in December 1996 and this international gathering will provide the opportunity for discussion of recent developments and trends in design of thin-walled structures.

  • Numerical Methods for Solids (Part 3) Numerical Methods for Fluids (Part 1)

    • 1st Edition
    • Volume 6
    • P.G. Ciarlet
    • English

  • Analysis of RNA-Protein Complexes in vitro

    • 1st Edition
    • Volume 26
    • J. Kjems + 2 more
    • English
    The central role of RNA in many cellular processes, in biotechnology, and as pharmaceutical agents, has created an interest in experimental methods applied to RNA molecules. This book provides scientists with a comprehensive collection of thoroughly tested up-to-date manuals for investigating RNA-protein complexes in vitro. The protocols can be performed by researchers trained in standard molecular biological techniques and require a minimum of specialized equipment. The procedures include recommendation of suppliers of reagents.

  • Practical Ship Design

    • 1st Edition
    • Volume 1
    • D.G.M. Watson
    • English
    The ever-growing demand for commercial activities at sea has meant that ships are rapidly developing and that the rules governing their construction and operation are changing. Practical Ship Design records these changes, their outcomes and the reasoning behind them.It deals with every aspect of ship design and handles a wide range of both merchant ships and naval ships with authority. It provides coverage of cargo ships and passenger ships, tugs, dredgers and other service craft. It also includes concept design, detail design, structural design, hydrodynamics design, the effect of regulations, the preparation of specifications and matters of costs and economics.Drawing on the author's extensive practical experience, Practical Ship Design is likely to interest everybody involved in the design, construction, repair and operation of ships. Students and the most experienced professionals will all benefit from the book's vast store of design data and its conclusions and recommendations.

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