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Elsevier

Academic Press

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 30
    • Bernard L. Horecker + 2 more
    • English
    Current Topics in Cellular Regulation: Volume 30 is a collection of papers that deals with eukaryotic DNA methylation, gene expression, regulation of nitrogenase activity, and the recognition of DNA by Type II restriction enzymes. Other papers discuss the mitochondrial Krebs cycle, enzyme mechanisms, transducin, and calcium-dependent cellular processes. One paper explains that methylation and demethylation of the DNA are complicated active processes, involving many aspects of the genome. The paper also notes that within the gross changes in methylation patterns, specific CpG sites play important roles in the expression or shutdown of target genes. Another paper concludes that, mono-ADP ribosylation being a mechanism of action of the diphtheria toxin, ADP ribosylation plays a role in normal cell metabolism by regulating the activity of key enzymes. One paper explains the significance of restriction enzymes into the nature of DNA-protein interactions; as well as the enzyme's possible role in discriminating between alternative DNA sequences. Biochemists, cellular researchers, micro-biologists, bio-physicists, and academicians involved in the study of cellular biology will find the collection very useful.

  • Microbial Iron Metabolism

    A Comprehensive Treatise
    • 1st Edition
    • J. B. Neilands
    • English
    Microbial Iron Metabolism: A Comprehensive Treatise provides a comprehensive treatment of microbial iron metabolism. It aims to contribute to an increased understanding of the path of iron in microbial species and, eventually, in the plant and animal. The book is organized into five parts. Part I describes some features of iron and its function in the microbial world. These include a historical sketch of the recognition of the importance of iron in cellular physiology; a description of certain physical properties of ferrous and ferric ions; and a list of various known biocoordination derivatives grouped by ligand atom. Metabolism under iron-limited conditions is also examined. Part II presents studies on iron transport, biosynthesis, and storage in microorganisms. Part III examines iron enzymes and proteins, including ferredoxin, rubredoxin, nitrogenase, and hydrogenase. Part IV deals with reactions of inorganic substrates. Part V presents a study on the role of bacterial iron metabolism in infection and immunity.

  • Molecular Approaches to Neurobiology

    • 1st Edition
    • Ian R. Brown
    • English
    Molecular Approaches to Neurobiology deals with molecular approaches to the analysis of the nervous system. This book surveys the current state of knowledge in a number of areas of molecular neurobiology that includes the subcellular level of chromatin structure, complexity of RNA synthesis, role of hormones in cell differentiation, and molecular correlates between neuropeptides and behavior. A comprehensive review of procedures for the isolation of specific brain cells and their experimental use is also provided at the end of this text. This publication is useful to those working in the field of neurochemistry and those engaged in morphological and physiological approaches to the analysis of the nervous system, as well as molecular biologists and biochemists working with non-neural tissues.

  • Horizons of Bioenergetics

    Proceedings of a Symposium held at Bloomington, Indiana October 12-15, 1970
    • 1st Edition
    • Anthony San Pietro + 1 more
    • English
    Horizons of Bioenergetics provides information pertinent to the fundamental aspects of bioenergetics. This book covers a variety of topics, including oxidative phosphorylation, energy conservation, ATP formation, metabolic regulation, glycolysis, and photosynthesis efficiency. Organized into five sessions encompassing 23 chapters, this book begins with an overview of the major landmarks in biochemical evolution that are most relevant to the discussion on bioenergetics. This text then reviews the knowledge about ATP generation by substrate level phosphorylation by anaerobic bacteria that ferment organic compounds. Other chapters consider the resolution and reconstitution of oxidative phosphorylation. This book discusses as well another energy-requiring activity associated with electron transport in mitochondria that may take primacy over oxidative phosphorylation. The final chapter deals with the possibility that conformational change can induce major shifts in electro-chemical potential and provide a mechanism for energy storage and conversion. This book is a valuable resource for biochemists, scientists, and research workers.

  • Developments in Statistics

    • 1st Edition
    • Volume 1
    • Paruchuri R. Krishnaiah
    • English
    Development in Statistics, Volume 1 is a collection of papers that deals with theory and application of parameter estimation in stochastic differential systems, the comparative aspects of the study of ordinary time series, and real multivariate distributions. Some papers discuss covariance analysis of nonstationary time series, nonparametric repeated significance tests, as well as discrete optimal factorial designs for statisticians and investigators of experiments. One paper cites an application of parameter estimation in stochastic differential systems in approximates of stability and control derivatives from flight test data. Another paper cites cases where procedures of ordinary time series (or point processes) have direct analogs in the study of point processes (or ordinary time series). One paper explains the applications of multivariate distributions in simultaneous tests on the equality of eigenvalues toward the covariance matrix, canonical correlation matrix, and a matrix associated with the multivariate analysis of variance. Another paper reviews two types of repeated significance tests, namely, the genuinely distribution-free tests based on a broad class of nonparametric statistics; and the asymptotically distribution-free tests based on a broad class of parametric statistics but having asymptotically nonparametric behavior. Both types can provide a unified solution to a broad class of problems. The collection can be valuable for mathematicians, students, and professors of calculus, statistics, or advanced mathematics.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 10
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 10 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into six chapters, this volume begins with an overview of the enzymes that exhibit half-of-the-sites activity. This text then examines the two different aspects of cyclic AMP-mediated systems. Other chapters consider the possible role of citrate synthase in the regulation of the citric acid cycle. This book discusses as well the regulation of the pentose phosphate pathway. The final chapter reviews the evidence for the occurrence of futile cycles at three control points in the metabolism of glucose, namely, at the level of glucose phosphorylation, at the interconversion of fructose mono- and biophosphates, and between pyruvate and phosphenol pyruvate. This book is a valuable resource for biochemists, biologists, and research workers.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 7
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 7 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into six chapters, this volume begins with an overview of the activity of RuDP carboxylase in plant photosynthesis that appears to be controlled by the relative concentrations of F6P and FDP. This text then examines the glycolate pathway of metabolism in plants and algae. Other chapters consider the sequence of events as well as the mechanisms of regulation that are involved in the formation of the fibrin clot. This book discusses as well the biology of spermatogenesis. The final chapter deals with the mechanism of enzyme synthesis and its regulation at the gene level. This book is a valuable resource for biochemists, biologists, and research workers.

  • Viscoelasticity and Rheology

    Proceedings of a Symposium Conducted by the Mathematics Research Center, the University of Wisconsin–Madison, October 16–18, 1984
    • 1st Edition
    • Arthur S. Lodge + 2 more
    • English
    Viscoelasticity and Rheology covers the proceedings of a symposium by the same title, conducted by the Mathematics Research Center held at the University of Wisconsin-Madison on October 16-18, 1984. The contributions to the symposium are divided into four broad categories, namely, experimental results, constitutive theories, mathematical analysis, and computation. This 16-chapter work begins with experimental topics, including the motion of bubbles in viscoelastic fluids, wave propagation in viscoelastic solids, flows through contractions, and cold-drawing of polymers. The next chapters covering constitutive theories explore the molecular theories for polymer solutions and melts based on statistical mechanics, the use and limitations of approximate constitutive theories, a comparison of constitutive laws based on various molecular theories, network theories and some of their advantages in relation to experiments, and models for viscoplasticity. These topics are followed by discussions of the existence, regularity, and development of singularities, change of type, interface problems in viscoelasticity, existence for initial value problems and steady flows, and propagation and development of singularities. The remaining chapters deal with the numerical simulation of flow between eccentric cylinders, flow around spheres and bubbles, the hole pressure problem, and a review of computational problems related to various constitutive laws. This book will prove useful to chemical engineers, researchers, and students.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 22
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 22 provides information pertinent to the fundamental aspects of lipid research. This book covers a variety of topics, including lipid secretion, lipids in platelet function, lipid transfer proteins, serum cholesterol, and cholesterol metabolism. Organized into five chapters, this volume begins with an overview of the lipid secretion of the meibomian glands, with emphasis on its chemical composition and physical properties. This text then explains the influence of lipids in platelet function and considers the metabolism of arachidonic acid in disease states, such as diabetes, nephrosis, and atherosclerosis. Other chapters examine the manner in which dietary cholesterol contributes to regulation of cholesterol metabolism. This book discusses as well the identification, isolation, and metabolism of sterol carrier proteins and lipid transfer proteins. The final chapter deals with the underlying problems that militate against a simple dose–response relationship. This book is a valuable resource for biologist, biochemists, and clinicians.

  • Methods in Virology

    Volume VIII
    • 1st Edition
    • Karl Maramorosch + 1 more
    • English
    Methods in Virology, Volume VIII focuses on the methods used in virology, including microscopy, hybridization, viruses, and fingerprint analysis. The selection first offers information on the hybridization of viral nucleic acids; applications of oligonucleotide fingerprinting to the identification of viruses; and immunosorbent electron microscopy in plant virus studies. Discussions focus on the detection of double-stranded RNA, principles and mechanisms of fingerprint analysis, preparation of labeled nucleic acid probes, and basic methods of nucleic acid hybridization. The text then elaborates on quantitative transmission electron microscopy for the determination of mass-molecular weight of viruses and use of thin sectioning for visualization and identification of plant viruses. Topics include technical procedures for processing plant tissues, cytological modifications of diagnostic value, procedure and treatment of data to obtain the average mass of virus particles, and applications in virology. The book takes a look at the detection of genome-linked proteins of plant and animal viruses; methods for assay, purification, and characterization of prions; and the use of mosquitoes to detect and propagate viruses. The selection is a valuable source of information for researchers interested in the methods employed in virology.

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