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Academic Press

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 23
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation: Volume 23 is a collection of papers that discusses pyruvate carboxylase, the regulation of carbohydrate metabolism, and the plasma membrane ATPase of fungi or plants. Other papers deal with adrenergic control of phosphofructokinase, protein phosphatase, as well as the regulation of polypeptide precursors of mature mitochondrial proteins. One paper explains the three dimensional structure of pyruvate carboxylase and its reaction mechanism. Electron microscopic analyses show that four monomers of pyruvate carboxylases isolated from vertebrate sources form a tight tetrahedron-like structure. Another paper describes the regulation of fructose 2,6-bisphosphate concentration in the liver and of the enzymes that are responsible for its metabolism, and the mechanism involved in fructose, particularly in the regulation of 6-phosphofructo-1-ki... and fructose-1,6-bisphos... activity. The paper also explains the role of this effector in the regulation of hepatic carbohydrate metabolism. One paper deals with the different levels of biological organization (whole cells, isolated plasma membranes, and purified enzyme) that characterizes the plasma membrane ATPase of fungi and plants as a novel type of proton pump. The collection can prove useful for biologists, microbiologists, students, and professors of biology and biophysics.

  • Insecticides

    Action and Metabolism
    • 1st Edition
    • R. D. O'Brien
    • English
    Insecticides: Action and Metabolism provides a comprehensive review of the action of insecticides and a survey of their metabolism. This book discusses the toxicology of insecticides. Organized into 17 chapters, this book begins with an overview of the mechanisms whereby toxicants exert their effects. This text then discusses the insecticidal action of organophosphates, which is described as the toxic organic compounds containing phosphorus. Other chapters consider the mode of action of organophosphates by inhibiting cholinesterase with consequent disruption of nervous activity caused by accumulation of acetylcholine at nerve endings. This book discusses as well the erratic patterns of selective toxicity to insects of the carbamates. The final chapter deals with the real hazard to human health as well as the effects upon wild life of insecticides and chlorinated pesticides. This book is a valuable resource for organic and agricultural chemists, as well as biologists, agriculturists, neurophysiologists, environmental scientists, and research workers.

  • Immunointervention in Autoimmune Diseases

    Papers Based on an International Meeting in Paris, France, in June 1988
    • 1st Edition
    • J. F. Bach
    • English
    Immunointervention in Autoimmune Diseases is a collection of papers presented at the 1988 International Meeting by the same title, held in Paris, France. This text contains 21 chapters and begins with surveys of the role of antigen in autoimmune responses and the moving boundaries between physiology and pathology of immunity. The succeeding chapters deal with the regulation, immunosuppressive therapy, infections, and immunointervention of autoimmune disorders. These topics are followed by discussions of specific immunosuppressive therapy for a particular disease, including type I diabetes, T-cell leukemia, and systemic lupus erythomatosus. This work also explores the principles of allograft, the use of monoclonal antibody, and OKT3. The remaining chapters consider the maintenance of autoimmunity and the risk/benefit in immunointervention for autoimmune diseases. This book will prove useful to immunologists, pathologists, physiologists, and researchers.

  • Agents Unleashed

    A Public Domain Look at Agent Technology
    • 1st Edition
    • Peter Wayner
    • English
    Agents Unleashed: A Public Domain Look at Agent Technology covers details of building a secure agent realm. The book discusses the technology for creating seamlessly integrated networks that allow programs to move from machine to machine without leaving a trail of havoc; as well as the technical details of how an agent will move through the network, prove its identity, and execute its code without endangering the host. The text also describes the organization of the host's work processing an agent; error messages, bad agent expulsion, and errors in XLISP-agents; and the simulators of errors, functions, and resources. Agent language, XLISP, TCL and other languages are also considered. The book further tackles security and encryption; commercial cash; and some ambitious and extreme examples of how people are attempting to create agents. The text also encompasses the instructions on how to use the XLISP agents. Software agents will find the book invaluable.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 2
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 2 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into eight chapters, this volume begins with an overview of the occurrence of the enzyme in plants and microorganisms. This text then examines the biosynthesis of aromatic amino acids and vitamins, which is proving an interesting model system for the study of regulation. Other chapters consider the control of cholesterol biosynthesis in normal tissues, with emphasis on the pathologic implications of derangements of cholesterol feedback control. This book discusses as well the aspects of the biogenesis of yeast mitochondria. The final chapter deals with regulation in the pyrimidine biosynthetic pathway at the level of enzyme activity. This book is a valuable resource for biochemists, biologists, and research workers.

  • Clinical Immunobiology

    • 1st Edition
    • Volume 2
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 2 covers the advances in the field being made to apply bone marrow transplantation to the treatment of several diseases. This volume is divided into 11 chapters and begins with surveys of the clinical considerations of bone marrow transplantation. Considerable chapters are devoted to the application of this transplantation to the treatment of various diseases, including aplastic anemia, aregenerative pancytopenia, leukemia, uniformly fatal severe combined immunodeficiency diseases, and Wiskott-Aldrich syndrome. Other chapters examine the cellular engineering in the form of bone marrow and thymus transplantation. The remaining chapters consider the effects of exposure to excessive amounts of radiation or cytotoxic chemicals, as well as the hematopoietic failure based on malfunction of the complex process of normal hematological development and maintenance. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

  • The Chlorophylls

    • 1st Edition
    • Leo P. Vernon + 1 more
    • English
    The Chlorophylls reviews developments in study of chlorophylls, and at the same time summarizes the state of knowledge in the more established areas of the physics, chemistry, and biology of chlorophylls. The book is organized into four sections. The first section deals with the chlorophylls as chemical entities, and treats their isolation, analysis, chemistry, and synthesis. The second concerns chlorophylls in real and colloidal solution and in the solid state in vitro, and includes the effects of aggregation on visible, infrared, and NMR spectral properties. The third section treats the biosynthesis, organization, and properties of chlorophylls in the plant and bacterial cell, and the fourth is concerned with the photochemical and photophysical behavior of chlorophylls in vitro and in vivo. It is hoped that this work will help those investigating selected aspects of chlorophyll to keep abreast of other methods and approaches, and will provide the interested scientist with a modern, conceptually organized treatment of the subject.

  • Essentials of Error-Control Coding Techniques

    • 1st Edition
    • Hideki Imai
    • English
    Essentials of Error-Control Coding Techniques presents error-control coding techniques with an emphasis on the most recent applications. It is written for engineers who use or build error-control coding equipment. Many examples of practical applications are provided, enabling the reader to obtain valuable expertise for the development of a wide range of error-control coding systems. Necessary background knowledge of coding theory (the theory of error-correcting codes) is also included so that the reader is able to assimilate the concepts and the techniques. The book is divided into two parts. The first provides the reader with the fundamental knowledge of the coding theory that is necessary to understand the material in the latter part. Topics covered include the principles of error detection and correction, block codes, and convolutional codes. The second part is devoted to the practical applications of error-control coding in various fields. It explains how to design cost-effective error-control coding systems. Many examples of actual error-control coding systems are described and evaluated. This book is particularly suited for the engineer striving to master the practical applications of error-control coding. It is also suitable for use as a graduate text for an advanced course in coding theory.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 12
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 12 focuses on the binding of polypeptide hormones to the specific receptor sites on the cellular membrane. This book consists of six chapters. Chapter 1 describes how several polypeptide regulators, hormones, and growth factors act through very similar mechanisms. The second messenger roles of cAMP and cGMP in the regulation of various protein kinases are dealt with in Chapter 2. Chapter 3 discusses the experimental conditions employed in studying the characteristics of regulatory enzymes in vitro and in vivo, while Chapter 4 elaborates the intracellular compartmentation of enzymes, cofactors, and metabolic intermediates of glycolysis in various tissues from different organisms. The biochemical mechanisms that underlie the induction of enzymes in catabolic pathways are considered in Chapter 5. The last chapter is devoted to the role of T4 phage-induced covalent modification reactions in the transcriptional control of DNA-dependent RNA-polymerase in E. coli. This volume is suitable for biologists and researchers concerned with the basic mechanisms involved in the regulation of diverse cellular activities.

  • Protein Turnover and Lysosome Function

    • 1st Edition
    • Harold L. Segal + 1 more
    • English
    Protein Turnover and Lysosome Function comprises the proceedings of a symposium under the same title held at the State University of New York at Buffalo on August 21-26, 1977. The book discusses mechanisms of protein turnover, as well as the identification and characterization of intracellular proteases. The text also describes the internalization of macromolecules into the intracellular digestive system; the types of specificity entailed; and the fate of the membrane material involved in the vacuolization process. Biochemists, pathologists, cell biologists, molecular biologists, and physiologists will find the book invaluable.

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