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Academic Press

  • Immunodiffusion

    • 2nd Edition
    • Alfred J. Crowle
    • English
    Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed. Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data. The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.

  • Philosophy and Archaeology

    • 1st Edition
    • Merrilee H. Salmon
    • English
    Studies in Archaeology: Philosophy and Archaeology presents the circumstances under which archeological hypotheses can be considered confirmed or disconfirmed. This book discusses the role of analogy in archeological reasoning, particularly in ascribing functions to archeological items. Organized into seven chapters, this book begins with an overview of the relationship between archeology and philosophy. This text then examines the importance of laws for archeology and discusses some essential features of law statements. Other chapters consider the strong claims for the hypothetico–deductiv... method of confirmation in various works by archeologists. This book discusses as well the different uses of analogical reasoning in archeology and provides a discussion of the structure of analogical arguments, criteria for evaluating them, and their relations to the Bayesian arguments for confirmation. The final chapter deals with several issues related to the development of a theory of archeology. This book is a valuable resource for archeologists and philosophers.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 15
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 15 is a four-chapter text that covers important aspects of lipid chemistry, including biomembranes and fungal lipids. The first chapter is devoted to the long-range order in biomembranes. This chapter presents evidence that the proteins and lipids of biological membranes are partitioned into functional and structural aggregates in the plane of the membrane. The second chapter surveys the pharmacology and toxicology of steroids and related compounds. This chapter also provides the methodology, physiologic and transport mechanisms, and effects on the central nervous system. The third chapter explores all aspects of lipid composition of all classes of fungi. This chapter also discusses the intracellular distribution and biosynthesis of the lipid components of fungi. The fourth chapter considers the biochemistry of plant sterols, including structure, stereochemistry, biosynthesis, metabolism, and function. This book will be of value to lipid chemists, biochemists, and researchers.

  • Current Topics in Cellular Regulation

    • 1st Edition
    • Volume 20
    • Bernard L. Horecker + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 20 evaluates the basic mechanisms involved in the regulation of diverse cellular activities. This book discusses the role of glutamine in the flow of nitrogen, regulation of glycogen synthase activity by covalent phosphorylation, and physiological role of PFK phosphorylation. The in vivo modulation of HMG-CoA reductase activity, hypotheses on the role of eIF-2 phosphorylation, and ADP-ribosyltransfera... from turkey erythrocytes are also elaborated. This text likewise covers the non-enzymic effects of vanadate and phosphorylation of liver and muscle PFK. This volume is a good source for biologists and researchers interested in advances in the general area of cellular regulation.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 7
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research reviews advances in lipid research and covers topics ranging from lipid histochemistry and control of plasma and liver triglyceride kinetics by carbohydrate metabolism and insulin. Lipid metabolism in tissue culture cells is also discussed, along with the carcinogenicity of steroids and the chemical and biological properties of heated and oxidized fats. Comprised of five chapters, this volume begins with an introduction to the histochemistry of lipids in both its qualitative and quantitative aspects, followed by an analysis of the roles of carbohydrate metabolism and insulin in relation to their control of the metabolism of plasma and liver triglycerides. Lipid metabolism in many tissue culture systems is the subject of the next chapter. The experimental and theoretical aspects of the connection between cancer and steroids are also examined. The last chapter deals with the possible harmful effects of heating dietary fats and how heating may alter the chemical and biological properties of fats. Attention is paid to auto-oxidation, carcinogenicity, and the interaction of heated fats with other dietary components. This monograph will be useful to students, practicing professionals, and research workers in biology and biochemistry.

  • Trade, Stability, Technology, and Equity in Latin America

    • 1st Edition
    • Moshé Syrquin + 1 more
    • English
    Trade, Stability, Technology, and Equity in Latin America provides information pertinent to the substantial social and economic progress in Latin America. This book covers a variety of topics, including international trade, technology, equity, external instability, and stabilization and growth. Organized into five parts encompassing 21 chapters, this book begins with an overview of the purchasing power parity theory of exchange rate determination and the law of one price. This text then provides a discussion of extending the monetary approach to the balance of payments to incorporate terms of trade effects. Other chapters consider the experience with the promotion of labor-intensive exports of manufacturers. This book discusses as well the pros and cons of external debt in Latin American development. The final chapter deals with economic development and provides an examination of basic needs, income distribution, and employment. This book is a valuable resource for policy makers, industrialists, economists, and structuralists.

  • The Antibody Molecule

    • 1st Edition
    • Alfred Nisonoff + 2 more
    • F. J. Dixon + 1 more
    • English
    The Antibody Molecule reviews the literature leading to current knowledge of the structure of immunoglobulins. The book begins by outlining some of the basic structural characteristics of immunoglobulins without citing the references on which the information is based. Separate chapters follow covering the chemical nature of the active site of an antibody molecule and mechanisms of interaction with hapten; the general structural features and properties of the various classes of human immunoglobulin; and amino acid sequences of human and mouse L chains and of human and rabbit H chains. Subsequent chapters deal with the evolution of the immunoglobulin classes; special properties of mouse, guinea pig, rabbit, and horse immunoglobulins; idiotypic specificities of immunglobulins; and the genetic control of antibodies. This book is meant for immunologists who have not personally observed the development of this exciting period in the history of immunology. It will also provide useful supplemental reading for the serious student or investigator who wishes to become familiar with the nature of the antibody molecule, its genetic control, and mode of action.

  • Experimental Manipulation of Gene Expression

    • 1st Edition
    • Masayori Inouye
    • English
    Experimental Manipulation of Gene Expression discusses a wide range of host systems in which to clone and express a gene of interest. The aims are for readers to quickly learn the versatility of the systems and obtain an overview of the technology involved in the manipulation of gene expression. Furthermore, it is hoped that the reader will learn enough from the various approaches to be able to develop systems and to arrange for a gene of particular interest to express in a particular system. The book opens with a chapter on the design and construction of a plasmid vector system used to achieve high-level expression of a particular phage regulatory protein normally found in minute amounts in a phage-infected bacterial cell. This is followed by separate chapters on topics such as high-level expression vectors that utilize efficient Escherichia coli lipoprotein promoter as well as various other portions of the lipoprotein gene Ipp; DNA cloning systems for streptomycetes; and the design and application of vectors for high-level, inducible synthesis of the product of a cloned gene in yeast.

  • Enzymes of the Arterial Wall

    • 1st Edition
    • John Esben Kirk
    • English
    Enzymes of the Arterial Wall is a comprehensive up-to-date monograph, and is the first publication dealing specifically with quantitative determinations of enzyme activities in human and animal vascular tissue. All available information concerning this subject is included. This summary of all current knowledge will be very useful to scientists who lack extensive library facilities and knowledge of foreign languages necessary for a thorough and time-consuming personal search of the original literature. A systematic description is made of 98 different enzymes; nearly all enzymes in the carbohydrate metabolic pathways are included. Brevity of discussion has made it possible to incorporate all available data. The results represent 27,200 quantitative biochemical assays performed with reliable analytical techniques on both normal and arteriosclerotic tissue; 70 enzymic procedures are described. The framework for the arrangement of facts throughout the book was designed to make information easily accessible. Each enzyme is described separately, using the sequence of The Commission on Enzymes of The International Union of Biochemistry, and is followed by literature references with full titles.

  • Hormones

    • 1st Edition
    • Anthony W. Norman + 1 more
    • English
    Hormones provides a comprehensive treatment of human hormones viewed in the light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology. The book begins with discussions of the first principles of hormone action and the seven classes of steroid hormones and their chemistry, biosynthesis, and metabolism. These are followed by separate chapters that address either a classical endocrine system, e.g., hypothalamic hormones, posterior pituitary hormones, anterior pituitary hormones, ,thyroid hormones, pancreatic hormones, gastrointestinal hormones, calcium regulating hormones, adrenal corticoids, hormones of the adrenal medulla, androgens, estrogens and progestins, and pregnancy and lactation hormones; or newer domains of hormone action which are essential to a comprehensive understanding of hormone action, including prostaglandins, thymus hormones, and pineal hormones. The book concludes with a presentation of hormones of the future, i.e., cell growth factors. This book is intended for use by first-year medical students, graduate students, and advanced undergraduates in the biological sciences. It is also hoped that this book will fill the void that exists for resource materials for teaching cellular and molecular endocrinology and that it will be employed as an equal partner with most standard biochemistry textbooks to provide a comprehensive and balanced coverage of this realm of biology.

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