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Elsevier

Academic Press

  • Rapid Detection of Food Adulterants and Contaminants

    Theory and Practice
    • 1st Edition
    • Shyam Narayan Jha
    • English
    Rapid Detection of Food Adulterants and Contaminants: Theory and Practice contains solid information on common adulterants and contaminants in various foods, guidelines for different standards, permissible limits prescribed by food regulatory authorities, and related detection techniques. This is an essential reference for anyone interested in progressive research on detection methods for food safety, especially researchers engaged in developing fast, reliable, and often nondestructive methods for the evaluation of food safety.

  • Clinical Engineering

    From Devices to Systems
    • 1st Edition
    • Roberto Miniati + 2 more
    • English
    Clinical Systems Engineering: New Challenges for Future Healthcare covers the critical issues relating to the risk management and design of new technologies in the healthcare sector. It is a comprehensive summary of the advances in clinical engineering over the past 40 years, presenting guidance on compliance and safety for hospitals and engineering teams. This contributed book contains chapters from international experts, who provide their solutions, experiences, and the successful methodologies they have applied to solve common problems in the area of healthcare technology. Topics include compliance with the European Directive on Medical Devices 93/42/EEC, European Norms EN 60601-1-6, EN 62366, and the American Standards ANSI/AAMI HE75: 2009. Content coverage includes decision support systems, clinical complex systems, and human factor engineering. Examples are fully supported with case studies, and global perspective is maintained throughout. This book is ideal for clinical engineers, biomedical engineers, hospital administrators and medical technology manufacturers.

  • Laterality

    Exploring the Enigma of Left-Handedness
    • 1st Edition
    • Clare Porac
    • English
    Left-handedness has been connected to many different conditions, traits, and abilities. This is especially true for pathological syndromes, such as schizophrenia, along with learning disabilities and autism. The published research on handedness is vast and frequently contradictory, often raising more questions than providing answers. Questions such as: Is handedness genetic? Can handedness be changed? Are there consequences to training someone to switch handedness? Are there positive traits associated with left-handedness like creativity? Are there negative traits associated with left-handedness like trouble reading maps? Is it abnormal to do some things right-handed and other things left-handed? Are the brains of left-handers different from the brains of right-handers? Laterality: Exploring the Enigma of Left-Handedness examines the research conducted over the past 50 years with special emphasis on twenty-first century research on handedness and translates this literature into an accessible and readable form. Each chapter is based on a question or questions covering diverse topics such as genetic and biological origins of handedness, familial and hormonal influences on handedness, and the effects of a majority right-handed world on the behaviors of left-handers.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 8- Human Diseases
    • 1st Edition
    • M. A. Hayat
    • English
    Volume 8 Autophagy and Human Diseases, concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington’s disease, Parkin’s disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death.

  • Drug-Like Properties

    Concepts, Structure Design and Methods from ADME to Toxicity Optimization
    • 2nd Edition
    • Li Di + 1 more
    • English
    Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

  • Encyclopedia of Food Grains

    • 2nd Edition
    • Colin W Wrigley + 3 more
    • English
    The Encyclopedia of Food Grains, Four Volume Set is an in-depth and authoritative reference covering all areas of grain science. Coverage includes everything from the genetics of grains to the commercial, economic and social aspects of this important food source. Also covered are the biology and chemistry of grains, the applied aspects of grain production and the processing of grains into various food and beverage products. With the paramount role of cereals as a global food source, this Encyclopedia is sure to become the standard reference work in the field of science. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedire...

  • Multiphysics Modeling: Numerical Methods and Engineering Applications

    Tsinghua University Press Computational Mechanics Series
    • 1st Edition
    • Qun Zhang + 1 more
    • English
    Multiphysics Modeling: Numerical Methods and Engineering Applications: Tsinghua University Press Computational Mechanics Series describes the basic principles and methods for multiphysics modeling, covering related areas of physics such as structure mechanics, fluid dynamics, heat transfer, electromagnetic field, and noise. The book provides the latest information on basic numerical methods, also considering coupled problems spanning fluid-solid interaction, thermal-stress coupling, fluid-solid-thermal coupling, electromagnetic solid thermal fluid coupling, and structure-noise coupling. Users will find a comprehensive book that covers background theory, algorithms, key technologies, and applications for each coupling method.

  • The Fungi

    • 3rd Edition
    • Sarah C. Watkinson + 2 more
    • English
    The Fungi, Third Edition, offers a comprehensive and thoroughly integrated treatment of the biology of the fungi. This modern synthesis highlights the scientific foundations that continue to inform mycologists today, as well as recent breakthroughs and the formidable challenges in current research. The Fungi combines a wide scope with the depth of inquiry and clarity offered by three leading fungal biologists. The book describes the astonishing diversity of the fungi, their complex life cycles, and intriguing mechanisms of spore release. The distinctive cell biology of the fungi is linked to their development as well as their metabolism and physiology. One of the great advances in mycology in recent decades is the recognition of the vital importance of fungi in the natural environment. Plants are supported by mycorrhizal symbioses with fungi, are attacked by other fungi that cause plant diseases, and are the major decomposers of their dead tissues. Fungi also engage in supportive and harmful interactions with animals, including humans. They are major players in global nutrient cycles. This book is written for undergraduates and graduate students, and will also be useful for professional biologists interested in familiarizing themselves with specific topics in fungal biology.

  • Children Learn by Observing and Contributing to Family and Community Endeavors: A Cultural Paradigm

    • 1st Edition
    • Volume 49
    • English
    Children Learn by Observing and Contributing to Family and Community Endeavors, the latest in the Advances in Child Development and Behavior Series provides a major step forward in highlighting patterns and variability in the normative development of the everyday lives of children, expanding beyond the usual research populations that have extensive Western schooling in common. The book documents the organization of children’s learning and social lives, especially among children whose families have historical roots in the Americas (North, Central, and South), where children traditionally are included and contribute to the activities of their families and communities, and where Western schooling is a recent foreign influence. The findings and theoretical arguments highlight a coherent picture of the importance of the development of children’s participation in ongoing activity as presented by authors with extensive experience living and working in such communities.

  • Amphioxus Immunity

    Tracing the Origins of Human Immunity
    • 1st Edition
    • An-Long Xu
    • English
    Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: Amphioxus as a model for understanding the evolution of vertebrates basic knowledge of immunology immune organs and cells of amphioxus a genomic and transcriptomic view of the Amphioxus immunity pattern recognition system in Amphioxus transcription factors in Amphioxus the complement system of Amphioxus the oxidative burst system in Amphioxus immune effectors in Amphioxus lipid signaling of immune response in Amphioxus apoptosis in amphioxus; primitive adaptive immune system of Amphioxus and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity.

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